{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:44:35Z","timestamp":1793472275684,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq (The National Council for Scientific and Technological Development\/Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico) PQ1C research fellow","award":["302999\/2024-8"],"award-info":[{"award-number":["302999\/2024-8"]}]},{"name":"CNPq (The National Council for Scientific and Technological Development\/Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico) PQ1C research fellow","award":["302545\/2025-5"],"award-info":[{"award-number":["302545\/2025-5"]}]},{"name":"CNPq PQ1C research fellow","award":["302999\/2024-8"],"award-info":[{"award-number":["302999\/2024-8"]}]},{"name":"CNPq PQ1C research fellow","award":["302545\/2025-5"],"award-info":[{"award-number":["302545\/2025-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Considering the increasing interest in strategies to prevent osteoporosis and other bone-related conditions, it is relevant to critically assess the existing evidence on the potential benefits of phenolic compounds in wine on bone metabolism. Objectives: This integrative review aims to evaluate clinical and animal studies investigating the influence of wine consumption on bone mineral density (BMD). Methods: The search was conducted in PubMed, Scopus, and Embase databases until April 2025. The key question was: \u201cDoes wine consumption influence BMD?\u201d. Results: After searching the identified databases, 108 studies were screened, and 7 were included in the final analysis. Conclusions: This review suggests a possible association between light to moderate wine consumption and favorable effects on BMD, particularly in the spine and femoral neck. However, these findings should be interpreted cautiously due to the predominance of observational studies. Future RCTs and systematic reviews must clarify wine\u2019s potential role in bone health and explore non-alcoholic or low-alcohol wine alternatives with similar polyphenol content.<\/jats:p>","DOI":"10.3390\/nu17121981","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T03:59:17Z","timestamp":1749700757000},"page":"1981","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Wine on Bone Mineral Density"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-6360","authenticated-orcid":false,"given":"Nath\u00e1lia Dantas","family":"Duarte","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-5093","authenticated-orcid":false,"given":"Paula Buzo","family":"Frig\u00e9rio","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe de Souza","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-1262","authenticated-orcid":false,"given":"Daniela Vieira","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ-USP), S\u00e3o Paulo 05508-270, Brazil"},{"name":"Department of Anatomy, Medical and Dentistry School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil"},{"name":"Department of Anatomy, Dentistry School, Faculty of the Midwest Paulista (FACOP), Piratininga 17499-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo Marco","family":"Rosa Junior","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Dentistry School, Faculty of the Midwest Paulista (FACOP), Piratininga 17499-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleuber Rodrigo de Souza","family":"Bueno","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Medical and Dentistry School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil"},{"name":"Department of Anatomy, Dentistry School, Faculty of the Midwest Paulista (FACOP), Piratininga 17499-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Henrique Bertoni","family":"Reis","sequence":"additional","affiliation":[{"name":"Beneficent Hospital (HBU), University of Marilia (UNIMAR), Marilia 17525-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-2218","authenticated-orcid":false,"given":"Rogerio Leone","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ-USP), S\u00e3o Paulo 05508-270, Brazil"},{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB-USP), University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-0795","authenticated-orcid":false,"given":"Jo\u00e3o Paulo Mardegan","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Basic and Oral Biology, Ribeir\u00e3o Preto School of Dentistry (FORP-USP), University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nemzer, B., Kalita, D., Yashin, A.Y., and Yashin, Y.I. 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