{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:07:30Z","timestamp":1792091250495,"version":"4.4.0"},"reference-count":115,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Context: Intermittent fasting (IF) and calorie restriction (CR) have gained interest as dietary strategies due to their potential for weight loss and multiple metabolic benefits. These strategies are often accompanied by exercise in an attempt to improve body composition and physical performance. However, further research is crucial to understanding whether or not physical performance is affected by the expected weight loss and related body composition changes in individuals on IF and CR, even when exercise is combined. Objective: We aimed to systematically evaluate the effects of IF and CR on exercise performance and body composition in adults aged 18 to 65 years. Data Source: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A systematic review was conducted up to April 2024 by searching electronic databases, including PubMed, Web of Science, and Scopus. There was no limit on publication dates. Data Extraction: The search explored the impact of IF and CR combined with exercise vs. exercise alone (control) on exercise performance outcomes: VO2max, handgrip strength, bench press strength, knee extensor strength, leg press strength, countermovement jump (CMJ), 400 m walk test, and gait speed; body weight, body mass index (BMI), and body composition: fat-free mass (FFM), fat mass (FM), and body fat percentage (BFP). Analyses included calculation of weighted mean difference (WMD), standardized mean difference (SMD), and 95% confidence intervals (CIs) to assess outcomes. Data Analysis: The meta-analysis included a total of 35 studies, ranging from 4 to 52 weeks and involving 1266 participants. The results showed that IF (hypocaloric or eucaloric diet) and CR combined with exercise increased handgrip strength [WMD = 1.707 kg, p = 0.01] compared to exercise alone. Moreover, IF and CR combined with exercise did not significantly affect VO2max [SMD = 0.005, p = 0.94], bench press strength [WMD = 0.377 kg, p = 0.778], knee extensor strength [WMD = \u22124.729 kg, p = 0.12], leg press strength [WMD = \u22122.874 kg, p = 0.415], countermovement jump [WMD = \u22120.226 cm, p = 0.80], 400 m walk test performance [WMD = \u22128.794 s, p = 0.06], or gait speed [WMD = 0.005 m\/s, p = 0.82] compared to exercise alone. Moreover, IF and CR combined with exercise decreased body weight [WMD = \u22124.375 kg, p = 0.001], BMI [WMD = \u22121.194 kg\u00b7m\u22122, p = 0.001], FFM [WMD = \u22121.653 kg, p = 0.001], FM [WMD = \u22122.858 kg, p = 0.001], BFP [WMD = \u22120.826%, p = 0.001] compared to exercise alone. Conclusions: IF (hypocaloric or eucaloric) and CR can be effectively integrated into exercise training without negatively impacting most measures of physical performance, while significantly enhancing weight loss and adiposity-related outcomes. The findings from this meta-analysis involving both athletes and non-athletes suggest that weight loss induced by IF and CR combined with exercise does not necessarily result in reduced physical performance. In real-world scenarios, however, different outcomes are conceivable, as body composition, physical capacity, diet and exercise can vary considerably based on individual conditions.<\/jats:p>","DOI":"10.3390\/nu17121992","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:19:28Z","timestamp":1749795568000},"page":"1992","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Intermittent Fasting and Calorie Restriction on Exercise Performance: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-3637","authenticated-orcid":false,"given":"Fatemeh","family":"Kazeminasab","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports Science, Faculty of Humanities, University of Kashan, Kashan 87317-53153, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4425-610X","authenticated-orcid":false,"given":"Fatemeh","family":"Sharafifard","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports Science, Faculty of Humanities, University of Kashan, Kashan 87317-53153, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bahrami Kerchi","sequence":"additional","affiliation":[{"name":"Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan 81551-39998, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1433-2906","authenticated-orcid":false,"given":"Reza","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, University of Isfahan, Isfahan 81746-73441, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4124-9470","authenticated-orcid":false,"given":"Randhall B.","family":"Carteri","sequence":"additional","affiliation":[{"name":"Methodist University Center, Porto Alegre Institute, Porto Alegre 28311, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-0077","authenticated-orcid":false,"given":"Richard","family":"Kirwan","sequence":"additional","affiliation":[{"name":"Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-9365","authenticated-orcid":false,"given":"Heitor O.","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculdade UNIGUA\u00c7U, Cascavel 85801-180, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-6029","authenticated-orcid":false,"given":"Fred","family":"Dutheil","sequence":"additional","affiliation":[{"name":"Preventive and Occupational Medicine, Universit\u00e9 Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Witty Fit, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/obesities2010001","article-title":"Intermittent fasting and fat mass: What is the clinical magnitude?","volume":"2","author":"Santos","year":"2022","journal-title":"Obesities"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Conde-Pip\u00f3, J., Mora-Fernandez, A., Martinez-Bebia, M., Gimenez-Blasi, N., Lopez-Moro, A., Latorre, J.A., Almendros-Ruiz, A., Requena, B., and Mariscal-Arcas, M. (2024). Intermittent fasting: Does it affect sports performance? A systematic review. Nutrients, 16.","DOI":"10.3390\/nu16010168"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11154-019-09524-w","article-title":"Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis","volume":"21","author":"Pellegrini","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"154336","DOI":"10.1016\/j.metabol.2020.154336","article-title":"Effect of alternate-day fasting on obesity and cardiometabolic risk: A systematic review and meta-analysis","volume":"111","author":"Park","year":"2020","journal-title":"Metabolism"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/oby.23568","article-title":"A Meta-Analysis comparing the effectiveness of alternate day fasting, the 5, 2 diet, and Time-Restricted eating for weight loss","volume":"31","author":"Rolands","year":"2023","journal-title":"Obesity"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zouhal, H., Bagheri, R., Triki, R., Saeidi, A., Wong, A., Hackney, A.C., Laher, I., Suzuki, K., and Ben Abderrahman, A. (2020). Effects of Ramadan intermittent fasting on gut hormones and body composition in males with obesity. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17155600"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/ajcn\/nqab433","article-title":"A scoping review of intermittent fasting, chronobiology, and metabolism","volume":"115","author":"Santos","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.arr.2016.08.005","article-title":"Calorie restriction in humans: An update","volume":"39","author":"Most","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chung, H.Y., Kim, D.H., Bang, E., and Yu, B.P. (2020). Impacts of calorie restriction and intermittent fasting on health and diseases: Current trends. Nutrients, 12.","DOI":"10.3390\/nu12102948"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"113453","DOI":"10.1016\/j.physbeh.2021.113453","article-title":"Effects of intermittent fasting combined with resistance training on body composition: A systematic review and meta-analysis","volume":"237","author":"Bagheri","year":"2021","journal-title":"Physiol. Behav."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1249\/JSR.0000000000000614","article-title":"Intermittent fasting and its effects on athletic performance: A review","volume":"18","author":"Levy","year":"2019","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Correia, J.M., Santos, I., Pezarat-Correia, P., Minderico, C., and Mendonca, G.V. (2020). Effects of intermittent fasting on specific exercise performance outcomes: A systematic review including meta-analysis. Nutrients, 12.","DOI":"10.3390\/nu12051390"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Grundler, F., Mesnage, R., Ruppert, P.M., Kouretas, D., and Wilhelmi de Toledo, F. (2024). Long-Term Fasting-Induced Ketosis in 1610 Subjects: Metabolic Regulation and Safety. Nutrients, 16.","DOI":"10.3390\/nu16121849"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/sms.14075","article-title":"Energy deficiency impairs resistance training gains in lean mass but not strength: A meta-analysis and meta-regression","volume":"32","author":"Murphy","year":"2022","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.physbeh.2014.11.068","article-title":"Transient decrements in mood during energy deficit are independent of dietary protein-to-carbohydrate ratio","volume":"139","author":"Karl","year":"2015","journal-title":"Physiol. Behav."},{"key":"ref_16","first-page":"5653739","article-title":"The effect of fasting on human metabolism and psychological health","volume":"2022","author":"Wang","year":"2022","journal-title":"Dis. Markers"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s40279-020-01257-0","article-title":"Effects of Ramadan fasting on physical performance: A systematic review with meta-analysis","volume":"50","author":"Abaidia","year":"2020","journal-title":"Sports Med."},{"key":"ref_18","first-page":"616","article-title":"Assessment of sleep patterns, daytime sleepiness, and chronotype during Ramadan in fasting and nonfasting individuals","volume":"26","author":"BaHammam","year":"2005","journal-title":"Saudi Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/07420520802397301","article-title":"Effects of Ramadan upon fluid and food intake, fatigue, and physical, mental, and social activities: A comparison between the UK and Libya","volume":"25","author":"Waterhouse","year":"2008","journal-title":"Chronobiol. Int."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hedrington, M.S., and Davis, S.N. (2015). Sexual dimorphism in glucose and lipid metabolism during fasting, hypoglycemia, and exercise. Front. Endocrinol., 6.","DOI":"10.3389\/fendo.2015.00061"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1210\/jc.2007-0552","article-title":"Gender-related differences in the metabolic response to fasting","volume":"92","author":"Soeters","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/17461391.2016.1223173","article-title":"Time-restricted feeding in young men performing resistance training: A randomized controlled trial","volume":"17","author":"Tinsley","year":"2017","journal-title":"Eur. J. Sport Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12967-016-1044-0","article-title":"Effects of eight weeks of time-restricted feeding (16\/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males","volume":"14","author":"Moro","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/ajcn\/nqz126","article-title":"Time-restricted feeding plus resistance training in active females: A randomized trial","volume":"110","author":"Tinsley","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41467-024-55418-0","article-title":"Effects of seven days\u2019 fasting on physical performance and metabolic adaptation during exercise in humans","volume":"16","author":"Kolnes","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Higgins, J.P., and Green, S. (2008). Cochrane Handbook for Systematic Reviews of Interventions, The Cochrane Collaboration.","DOI":"10.1002\/9780470712184"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0004-9514(09)70043-1","article-title":"The PEDro scale is a valid measure of the methodological quality of clinical trials: A demographic study","volume":"55","year":"2009","journal-title":"Aust. J. Physiother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref_30","first-page":"196","article-title":"Fixed or random effects meta-analysis? Common methodological issues in systematic reviews of effectiveness","volume":"13","author":"Tufanaru","year":"2015","journal-title":"JBI Evid. Implement."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.jand.2024.01.005","article-title":"Effects of Time-Restricted Eating on Aerobic Capacity, Body Composition, and Markers of Metabolic Health in Healthy Male Recreational Runners: A Randomized Crossover Trial","volume":"124","author":"Correia","year":"2024","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_32","first-page":"1084","article-title":"Effects of Caloric Restriction on Cardiorespiratory Fitness, Fatigue, and Disability Responses to Aerobic Exercise in Older Adults With Obesity: A Randomized Controlled Trial","volume":"74","author":"Nicklas","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1080\/02640410802422199","article-title":"The influence of Ramadan on physical performance measures in young Muslim footballers","volume":"26","author":"Kirkendall","year":"2008","journal-title":"J. Sports Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/gerona\/gly047","article-title":"Relationship of Physical Function to Single Muscle Fiber Contractility in Older Adults: Effects of Resistance Training With and Without Caloric Restriction","volume":"74","author":"Wang","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/JSM.0b013e318275d213","article-title":"Effect of Ramadan observance on maximal muscular performance of trained men","volume":"23","author":"Bouhlel","year":"2013","journal-title":"Clin. J. Sport Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12970-020-00396-z","article-title":"Time-restricted eating effects on performance, immune function, and body composition in elite cyclists: A randomized controlled trial","volume":"17","author":"Moro","year":"2020","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/gerona\/gln032","article-title":"Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults\u2014A randomized clinical trial","volume":"64","author":"Yassine","year":"2009","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1210\/jc.2008-2505","article-title":"Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin","volume":"95","author":"Christiansen","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1210\/jc.2008-2033","article-title":"The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity","volume":"94","author":"Coker","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Cooke, M.B., Deasy, W., Ritenis, E.J., Wilson, R.A., and Stathis, C.G. (2022). Effects of Intermittent Energy Restriction Alone and in Combination with Sprint Interval Training on Body Composition and Cardiometabolic Biomarkers in Individuals with Overweight and Obesity. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19137969"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1249\/00005768-198602000-00015","article-title":"The effects of aerobic conditioning and\/or caloric restriction in overweight men and women","volume":"18","author":"Hagan","year":"1986","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/ajh\/hpv139","article-title":"Effects of resistance training with and without caloric restriction on arterial stiffness in overweight and obese older adults","volume":"29","author":"Jefferson","year":"2016","journal-title":"Am. J. Hypertens."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e14868","DOI":"10.14814\/phy2.14868","article-title":"Time-restricted eating and concurrent exercise training reduces fat mass and increases lean mass in overweight and obese adults","volume":"9","author":"Kotarsky","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3945\/ajcn.114.105270","article-title":"Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: A randomized controlled trial","volume":"101","author":"Nicklas","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3945\/ajcn.116.131391","article-title":"Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: A randomized intervention trial","volume":"104","author":"Weiss","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Xu, R., Cao, Y.X., Chen, Y.T., and Jia, Y.Q. (2022). Differential effects of intermittent energy restriction vs. continuous energy restriction combined high-intensity interval training on overweight\/obese adults: A randomized controlled trial. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.979618"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1249\/MSS.0000000000002488","article-title":"Effects of 8 wk of 16, 8 Time-restricted Eating in Male Middle- and Long-Distance Runners","volume":"53","author":"Brady","year":"2021","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_48","first-page":"47","article-title":"Effects of Ramadan observance combined with two training programs on plasma lipids and testosterone\/cortisol ratio in male senior basketball players","volume":"72","author":"Brini","year":"2019","journal-title":"Med. Dello Sport"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1590\/1517-869220202603213948","article-title":"Small sided games vs repeated sprint training effects on agility in fasting basketball players","volume":"26","author":"Brini","year":"2020","journal-title":"Rev. Bras. Med. Esporte"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Brini, S., Castillo, D., Raya-Gonz\u00e1lez, J., Castagna, C., Bouassida, A., Khalifa, R., Chortane, S.G., and Clemente, F.M. (2021). Basketball-specific small-sided games training during Ramadan intermitting fasting: Do changes in body composition, sleep habits, and perceived exertion affect technical performance?. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph182212008"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/JSM.0b013e3182293891","article-title":"Effects of Ramadan intermittent fasting on middle-distance running performance in well-trained runners","volume":"21","author":"Brisswalter","year":"2011","journal-title":"Clin. J. Sport Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Correia, J.M., Santos, P.D.G., Pezarat-Correia, P., Minderico, C.S., Infante, J., and Mendonca, G.V. (2023). Effect of Time-Restricted Eating and Resistance Training on High-Speed Strength and Body Composition. Nutrients, 15.","DOI":"10.3390\/nu15020285"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/ajcn\/80.2.308","article-title":"Independent and additive effects of energy restriction and exercise on glucose and insulin concentrations in sedentary overweight men","volume":"80","author":"Cox","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1249\/MSS.0000000000002738","article-title":"Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors","volume":"53","author":"Moro","year":"2021","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Stratton, M.T., Hester, G.M., Alesi, M.G., Modjeski, A.S., King, K., Olmos, A.A., Serafini, P.R., Savage, S.N., Webb, A.T., and Tinsley, G.M. (2020). Four Weeks of Time-Restricted Feeding Combined with Resistance Training Does Not Differentially Influence Measures of Body Composition, Muscle Performance, Resting Energy Expenditure, and Blood Biomarkers. Nutrients, 12.","DOI":"10.3390\/nu12041126"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Tovar, A.P., Richardson, C.E., Keim, N.L., Van Loan, M.D., Davis, B.A., and Casazza, G.A. (2021). Four weeks of 16\/8 time restrictive feeding in endurance trained male runners decreases fat mass, without affecting exercise performance. Nutrients, 13.","DOI":"10.3390\/nu13092941"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/ajcn\/47.1.19","article-title":"Resistance weight training during caloric restriction enhances lean body weight maintenance","volume":"47","author":"Ballor","year":"1988","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Batitucci, G., Faria Junior, E.V., Nogueira, J.E., Brand\u00e3o, C.F., Abud, G.F., Ortiz, G.U., Marchini, J.S., and Freitas, E.C. (2022). Impact of Intermittent Fasting Combined With High-Intensity Interval Training on Body Composition, Metabolic Biomarkers, and Physical Fitness in Women With Obesity. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.884305"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1249\/MSS.0000000000000480","article-title":"No effect of caloric restriction or exercise on radiation repair capacity","volume":"47","author":"Habermann","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.cmet.2022.09.003","article-title":"Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight\/obesity: A randomized controlled trial","volume":"34","author":"Haganes","year":"2022","journal-title":"Cell Metab."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/ajcn\/49.1.77","article-title":"Calorie-restricted low-fat diet and exercise in obese women","volume":"49","author":"Hammer","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0022-3999(99)00066-5","article-title":"Psychological response to exercise training and\/or energy restriction in obese women","volume":"48","author":"Nieman","year":"2000","journal-title":"J. Psychosom. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.metabol.2019.01.002","article-title":"Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial","volume":"93","author":"Cho","year":"2019","journal-title":"Metabolism"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"100335","DOI":"10.1016\/j.advnut.2024.100335","article-title":"Are Lean Body Mass and Fat-Free Mass the Same or Different Body Components? A Critical Perspective","volume":"15","author":"Heymsfield","year":"2024","journal-title":"Adv. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/obr.12143","article-title":"Weight loss composition is one-fourth fat-free mass: A critical review and critique of this widely cited rule","volume":"15","author":"Heymsfield","year":"2014","journal-title":"Obes. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1748-1716.1970.tb04764.x","article-title":"Variation in total body water with muscle glycogen changes in man","volume":"80","author":"Olsson","year":"1970","journal-title":"Acta Physiol. Scand."},{"key":"ref_67","first-page":"772","article-title":"Carbohydrate loading practice in bodybuilders: Effects on muscle thickness, photo silhouette scores, mood states and gastrointestinal symptoms","volume":"18","author":"Cavalcante","year":"2019","journal-title":"J. Sports Sci. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jsams.2019.03.009","article-title":"Repeated muscle glycogen supercompensation with four days\u2019 recovery between exhaustive exercise","volume":"22","author":"Doering","year":"2019","journal-title":"J. Sci. Med. Sport"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.clnesp.2020.07.022","article-title":"Low-carbohydrate diets: Effects on metabolism and exercise\u2013A comprehensive literature review","volume":"40","author":"Macedo","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00394-024-03540-6","article-title":"Evaluating the evening carbohydrate dilemma: The effect of within-the-day carbohydrate periodization on body composition and physical fitness","volume":"64","author":"Vlahoyiannis","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Methenitis, S., Feidantsis, K., Kaprara, A., Hatzitolios, A., Skepastianos, P., Papadopoulou, S.K., and Panayiotou, G. (2022). Body Composition, Fasting Blood Glucose and Lipidemic Indices Are Not Primarily Determined by the Nutritional Intake of Middle-Aged Endurance Trained Men\u2014Another \u201cAthletes\u2019 Paradox\u201d?. J. Clin. Med., 11.","DOI":"10.3390\/jcm11206057"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12970-018-0242-y","article-title":"ISSN exercise & sports nutrition review update: Research & recommendations","volume":"15","author":"Kerksick","year":"2018","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/oby.23637","article-title":"Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial","volume":"31","author":"Parr","year":"2023","journal-title":"Obesity"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.clnu.2024.09.034","article-title":"Short-term intermittent fasting and energy restriction do not impair rates of muscle protein synthesis: A randomised, controlled dietary intervention","volume":"43","author":"Kouw","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1056\/NEJMoa2114833","article-title":"Calorie restriction with or without time-restricted eating in weight loss","volume":"386","author":"Liu","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/jamainternmed.2017.0936","article-title":"Effect of alternate-day fasting on weight loss, weight maintenance, and cardioprotection among metabolically healthy obese adults: A randomized clinical trial","volume":"177","author":"Trepanowski","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1001\/jamainternmed.2020.4153","article-title":"Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity: The TREAT randomized clinical trial","volume":"180","author":"Lowe","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1002\/oby.21653","article-title":"How strongly does appetite counter weight loss? Quantification of the feedback control of human energy intake","volume":"24","author":"Polidori","year":"2016","journal-title":"Obesity"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"102475","DOI":"10.1016\/j.eclinm.2024.102475","article-title":"Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: A post-treatment analysis of a randomised placebo-controlled trial","volume":"69","author":"Jensen","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/oby.21538","article-title":"Persistent metabolic adaptation 6 years after \u201cThe Biggest Loser\u201d competition","volume":"24","author":"Fothergill","year":"2016","journal-title":"Obesity"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Berg, S., Stickle, H., Rose, S.J., and Nemec, E.C. (2025). Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: A systematic review and meta-analysis. Obes. Rev., e13929.","DOI":"10.1111\/obr.13929"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"106452","DOI":"10.1016\/j.appet.2023.106452","article-title":"The impact of time restricted eating on appetite and disordered eating in adults: A mixed methods systematic review","volume":"183","author":"Vizthum","year":"2023","journal-title":"Appetite"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e3684","DOI":"10.1002\/dmrr.3684","article-title":"Is breakfast consumption detrimental, unnecessary, or an opportunity for health promotion? A review of cardiometabolic outcomes and functional food choices","volume":"40","author":"Santos","year":"2024","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1080\/10408398.2020.1819768","article-title":"Association of breakfast skipping with cardiovascular outcomes and cardiometabolic risk factors: An updated review of clinical evidence","volume":"62","author":"Santos","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e211","DOI":"10.1210\/clinem\/dgz311","article-title":"Twice as high diet-induced thermogenesis after breakfast vs dinner on high-calorie as well as low-calorie meals","volume":"105","author":"Richter","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.appet.2016.12.041","article-title":"A randomized controlled trial to study the effects of breakfast on energy intake, physical activity, and body fat in women who are nonhabitual breakfast eaters","volume":"112","author":"LeCheminant","year":"2017","journal-title":"Appetite"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s40279-021-01562-2","article-title":"The effect of resistance training in healthy adults on body fat percentage, fat mass and visceral fat: A systematic review and meta-analysis","volume":"52","author":"Wewege","year":"2022","journal-title":"Sports Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e2452185","DOI":"10.1001\/jamanetworkopen.2024.52185","article-title":"Aerobic Exercise and Weight Loss in Adults: A Systematic Review and Dose-Response Meta-Analysis","volume":"7","author":"Jayedi","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.cub.2015.12.046","article-title":"Constrained total energy expenditure and metabolic adaptation to physical activity in adult humans","volume":"26","author":"Pontzer","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/mrm.22550","article-title":"Effect of exercise intervention on thigh muscle volume and anatomical cross-sectional areas\u2014Quantitative assessment using MRI","volume":"64","author":"Hudelmaier","year":"2010","journal-title":"Magn. Reson. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1519\/JSC.0000000000003524","article-title":"Progressive resistance training volume: Effects on muscle thickness, mass, and strength adaptations in resistance-trained individuals","volume":"36","author":"Aube","year":"2022","journal-title":"J. Strength Cond. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3806\/ijktr.4.1","article-title":"Increased muscle volume and strength following six days of low-intensity resistance training with restricted muscle blood flow","volume":"4","author":"Fujita","year":"2008","journal-title":"Int. J. KAATSU Train. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/gerona\/glt107","article-title":"Markers of human skeletal muscle mitochondrial biogenesis and quality control: Effects of age and aerobic exercise training","volume":"69","author":"Konopka","year":"2014","journal-title":"J. Gerontol. Ser. A Biomed. Sci. Med. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e22500","DOI":"10.1096\/fj.202200398RR","article-title":"Short-term aerobic conditioning prior to resistance training augments muscle hypertrophy and satellite cell content in healthy young men and women","volume":"36","author":"Thomas","year":"2022","journal-title":"FASEB J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.advnut.2023.04.001","article-title":"Nutrition and exercise interventions to improve body composition for persons with overweight or obesity near retirement age: A systematic review and network meta-analysis of randomized controlled trials","volume":"14","author":"Eglseer","year":"2023","journal-title":"Adv. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Jeong, W., Moon, J.Y., and Kim, J.-H. (2023). Association of absolute and relative hand grip strength with all-cause mortality among middle-aged and old-aged people. BMC Geriatr., 23.","DOI":"10.1186\/s12877-023-04008-8"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.pulmoe.2022.09.007","article-title":"Handgrip strength and respiratory disease mortality: Longitudinal analyses from SHARE","volume":"30","author":"Mey","year":"2024","journal-title":"Pulmonology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/nutrit\/nuad155","article-title":"Effects of intermittent fasting combined with physical exercise on cardiometabolic outcomes: Systematic review and meta-analysis of clinical studies","volume":"82","author":"Kazeminasab","year":"2024","journal-title":"Nutr. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1017\/S0029665118002574","article-title":"Is exercise best served on an empty stomach?","volume":"78","author":"Wallis","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.21315\/mjms2023.30.3.6","article-title":"The controversial relationship between body mass index and handgrip strength in the elderly: An overview","volume":"30","author":"Soraya","year":"2023","journal-title":"Malays. J. Med. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Palacio, A.C., D\u00edaz-Torrente, X., and Quintiliano-Scarpelli, D. (2022). Higher abdominal adiposity is associated with lower muscle strength in Chilean adults. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.812928"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40279-017-0694-2","article-title":"Periodized nutrition for athletes","volume":"47","author":"Jeukendrup","year":"2017","journal-title":"Sports Med."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Keenan, S., Cooke, M.B., and Belski, R. (2020). The effects of intermittent fasting combined with resistance training on lean body mass: A systematic review of human studies. Nutrients, 12.","DOI":"10.3390\/nu12082349"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1017\/S0007114516003160","article-title":"Effects of aerobic exercise performed in fasted v. fed state on fat and carbohydrate metabolism in adults: A systematic review and meta-analysis","volume":"116","author":"Vieira","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"E84","DOI":"10.1152\/ajpendo.00006.2017","article-title":"Feeding influences adipose tissue responses to exercise in overweight men","volume":"313","author":"Chen","year":"2017","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"E1023","DOI":"10.1152\/ajpendo.00193.2005","article-title":"Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes","volume":"289","author":"Civitarese","year":"2005","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1152\/japplphysiol.00907.2010","article-title":"Beneficial metabolic adaptations due to endurance exercise training in the fasted state","volume":"110","author":"Szlufcik","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.clnesp.2018.01.002","article-title":"Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss","volume":"24","author":"Santos","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Liu, M.-Y., and Chen, S.-Q. (2022). Effects of low\/medium-intensity exercise on fat metabolism after a 6-h fast. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192315502"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"110801","DOI":"10.1016\/j.nut.2020.110801","article-title":"Effects of intermittent fasting and energy-restricted diets on lipid profile: A systematic review and meta-analysis","volume":"77","author":"Meng","year":"2020","journal-title":"Nutrition"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.clnu.2020.10.034","article-title":"The influence of fasting and energy-restricted diets on leptin and adiponectin levels in humans: A systematic review and meta-analysis","volume":"40","author":"Kord","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"111847","DOI":"10.1016\/j.nut.2022.111847","article-title":"Effects of time-restricted feeding (16\/8) combined with a low-sugar diet on the management of non-alcoholic fatty liver disease: A randomized controlled trial","volume":"105","author":"Tinsley","year":"2023","journal-title":"Nutrition"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.clnesp.2023.11.009","article-title":"Effects of intermittent fasting regimens on glycemic, hepatic, anthropometric, and clinical markers in patients with non-alcoholic fatty liver disease: Systematic review and meta-analysis of randomized controlled trials","volume":"59","author":"Saleh","year":"2024","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Kord Varkaneh, H., Salehi sahlabadi, A., G\u0103man, M.A., Rajabnia, M., Sedanur Macit-\u00c7elebi, M., Santos, H.O., and Hekmatdoost, A. (2022). Effects of the 5, 2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.948655"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/nutrit\/nuad132","article-title":"Intermittent fasting in the management of diabetes: A review of glycemic control and safety","volume":"82","author":"Santos","year":"2024","journal-title":"Nutr. Rev."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/12\/1992\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:51:21Z","timestamp":1760032281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/12\/1992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":115,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["nu17121992"],"URL":"https:\/\/doi.org\/10.3390\/nu17121992","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,13]]}}}