{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:37:55Z","timestamp":1775745475150,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The mechanisms underlying the disruption of bone balance are well known. To date, several possible treatments exist for osteoporosis, mostly based on inhibition of bone resorption. However, as osteoporosis is a disease that causes significant fragility, it merits a proactive prevention-based approach, which identifies risk factors, such as nutritional deficiencies, during the preosteoporotic stage. In this context, nutraceuticals may find application in delaying the onset of osteoporosis and prior to the need for pharmaceutical invention. The beneficial effects of inositol supplementation have been extensively studied in endocrinology and gynecology; herein, we discuss the potential of inositols in the prevention of osteoporosis, highlighting the link with bone metabolism and possible future applications.<\/jats:p>","DOI":"10.3390\/nu17121999","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T04:06:24Z","timestamp":1750046784000},"page":"1999","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inositols and Bone Health: Potential Therapeutic Applications in Osteoporosis Prevention and Treatment"],"prefix":"10.3390","volume":"17","author":[{"given":"Fiammetta","family":"Cipriani","sequence":"first","affiliation":[{"name":"Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8217-2372","authenticated-orcid":false,"given":"Lucio","family":"Gnessi","sequence":"additional","affiliation":[{"name":"Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Baldelli","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Oncology and Medical Specialties, A.O. San Camillo-Forlanini, 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref_1","first-page":"e43031","article-title":"Osteoporosis: A narrative review","volume":"15","year":"2023","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2147\/TCRM.S138000","article-title":"A comprehensive overview on osteoporosis and its risk factors","volume":"14","author":"Pouresmaeili","year":"2018","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/jbmr.3699","article-title":"Cost-effectiveness of osteoporosis interventions to improve quality of care after upper extremity fracture: Results from a randomized trial (c-stop trial)","volume":"34","author":"Majumdar","year":"2019","journal-title":"J. Bone Miner. 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