{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:24:47Z","timestamp":1790011487431,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["434159\/2018-2"],"award-info":[{"award-number":["434159\/2018-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["n.01\/2022"],"award-info":[{"award-number":["n.01\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa (FUNAPE\/UFG)","award":["434159\/2018-2"],"award-info":[{"award-number":["434159\/2018-2"]}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa (FUNAPE\/UFG)","award":["n.01\/2022"],"award-info":[{"award-number":["n.01\/2022"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s","award":["434159\/2018-2"],"award-info":[{"award-number":["434159\/2018-2"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s","award":["n.01\/2022"],"award-info":[{"award-number":["n.01\/2022"]}]},{"name":"Funda\u00e7\u00e3o Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["434159\/2018-2"],"award-info":[{"award-number":["434159\/2018-2"]}]},{"name":"Funda\u00e7\u00e3o Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["n.01\/2022"],"award-info":[{"award-number":["n.01\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Gastrointestinal symptoms, including reflux, bloating, dyspepsia, stomach pain, and altered bowel patterns, are commonly reported in individuals with severe obesity and may significantly impact quality of life. Background\/Objectives: Curcumin, a bioactive compound found in turmeric (Curcuma longa L.), possesses anti-inflammatory and antioxidant properties and has been investigated for its potential role in gastrointestinal health. However, its effects in individuals with severe obesity remain unclear. Methods: This double-blind, placebo-controlled clinical trial aimed to evaluate the effect of curcumin supplementation on gastrointestinal symptoms in women with severe obesity. Thirty-one women with a body mass index (BMI) \u2265 40 kg\/m2 undergoing bariatric surgery were randomized to receive either 1500 mg of curcumin (98.75%) or a placebo (1500 mg corn starch) daily for 13 weeks. Gastrointestinal symptoms were assessed using the Gastrointestinal Symptom Rating Scale (GSRS), and stool consistency was assessed using the Bristol Stool Scale. Anthropometric measurements were also collected. Results: Participants had an average age of 33.1 \u00b1 8 years and a BMI of 45.6 \u00b1 3.31 kg\/m2. No differences were observed between groups at baseline. At the end of the study, the curcumin group showed a significant reduction in the GSRS\u2019s total score compared to the placebo group (p = 0.002), with improvements in eructation (p = 0.011) and constipation (p = 0.007). Additionally, the curcumin group showed reduced BMI (p = 0.019) and neck circumference (p = 0.042). Conclusions: These findings suggest that curcumin supplementation may alleviate some gastrointestinal symptoms and improve anthropometric measures in women with severe obesity, providing a potential dietary strategy.<\/jats:p>","DOI":"10.3390\/nu17132064","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T13:13:04Z","timestamp":1750425184000},"page":"2064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial\u2014A Pilot Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8945-9333","authenticated-orcid":false,"given":"Fabiana Martins","family":"Kattah","sequence":"first","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-3543","authenticated-orcid":false,"given":"Nayra","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla Kenned","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5869-2562","authenticated-orcid":false,"given":"Emilly Santos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinara Costa de","family":"Melo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislene Batista","family":"Lima","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joc\u00e9lia Paula Rocha","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Bacheschi do Carmo","family":"Benetti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia Carielo","family":"Lima","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-7616","authenticated-orcid":false,"given":"Jo\u00e3o Felipe","family":"Mota","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"},{"name":"Faculty of Medicine, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Campos","family":"Corgosinho","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"},{"name":"Faculty of Medicine, Federal University of Goi\u00e1s, Goi\u00e2nia 74605-080, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S2213-8587(24)00316-4","article-title":"Definition and diagnostic criteria of clinical obesity","volume":"13","author":"Rubino","year":"2025","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e14758","DOI":"10.1111\/nmo.14758","article-title":"Understanding the gastrointestinal tract in obesity: From gut motility patterns to enzyme secretion","volume":"36","author":"Steenackers","year":"2024","journal-title":"Neurogastroenterol. 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