{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:00:23Z","timestamp":1790805623262,"version":"4.1.0"},"reference-count":253,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centre of Postgraduate Medical Education","award":["501-1-025-01-25"],"award-info":[{"award-number":["501-1-025-01-25"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Micronutrients and environmental factors are key exogenous agents influencing thyroid DNA integrity. Micronutrients act as cofactors in DNA replication, repair, and antioxidant defence, while environmental exposure, such as radiation, heavy metals, and endocrine-disrupting chemicals, can directly damage DNA, leading to genomic instability. Although many studies have confirmed the link between micronutrient status and thyroid health, the effects of nutrient imbalances and environmental stressors on thyroid DNA remain underexplored. This narrative review examines how these factors may compromise thyroid genome stability and contribute to disease development. The analysis focused on the roles of iodine, selenium, iron, zinc, copper and vitamins D, B9, and B12 as well as environmental exposures such as radiation, heavy metals, and endocrine-disrupting chemicals. The findings suggest that both micronutrient imbalance and environmental stress can impair DNA integrity in thyroid cells. Understanding these complex relationships is critical for developing effective strategies to maintain thyroid health and mitigate the risk of thyroid diseases associated with compromised genomic integrity. Methodology: This narrative review was based on 254 articles retrieved through a manual search of the PubMed and Google Scholar databases, covering the years 2000\u20132025 and focusing on the influence of micronutrients and environmental factors on thyroid DNA integrity and repair. Several seminal earlier publications, fundamental to a comprehensive understanding of the topic, were also included.<\/jats:p>","DOI":"10.3390\/nu17132065","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:39:26Z","timestamp":1750649966000},"page":"2065","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Influence of Micronutrients and Environmental Factors on Thyroid DNA Integrity"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-1585","authenticated-orcid":false,"given":"Katarzyna D.","family":"Arczewska","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Centre of Translational Research, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Piekie\u0142ko-Witkowska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Centre of Translational Research, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1172\/JCI60047","article-title":"Mechanisms of Thyroid Hormone Action","volume":"122","author":"Brent","year":"2012","journal-title":"J. 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