{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:36:41Z","timestamp":1790221001201,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"American Heart Association","award":["17SFRN33490004"],"award-info":[{"award-number":["17SFRN33490004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: The aim of this secondary analysis is to determine the baseline characteristics that are associated with a higher likelihood of weight-loss success in a personalized nutrition intervention. Methods: Data were analyzed in adults with abnormal glucose metabolism and obesity from a 6-month behavioral counseling randomized clinical trial. Participants were randomized to two calorie-restricted diets: a low-fat diet (Standardized) or a personalized nutrition diet leveraging a machine learning algorithm (Personalized). The gradient boosting machine method was used to determine the baseline variables (i.e., age, weight-loss self-efficacy) that predicted successful weight loss (\u22655%) at 6 months in each study arm separately, using repeated five-fold cross-validation with 100 repetitions. Results: A total of 155 participants (Personalized: n = 84 vs. Standardized: n = 71) contributed data (mean [standard deviation]: age, 59 [10] y; 66.5% female; 56.1% White; body mass index (BMI), 33.4 [4.6] kg\/m2). In both arms, higher baseline self-efficacy for weight loss was a predictor of weight-loss success. Participants with a higher BMI (p &lt; 0.0001) in the Standardized arm and those who were older (p &lt; 0.0001) in the Personalized arm were more likely to achieve successful weight loss. Conclusions: Future weight-loss interventions may consider providing tailored behavioral support for individuals based on weight-loss self-efficacy, BMI, and age.<\/jats:p>","DOI":"10.3390\/nu17132178","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T10:03:48Z","timestamp":1751277828000},"page":"2178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Baseline Characteristics of Weight-Loss Success in a Personalized Nutrition Intervention: A Secondary Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-8784","authenticated-orcid":false,"given":"Collin J.","family":"Popp","sequence":"first","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Berube","sequence":"additional","affiliation":[{"name":"Public Health Nutrition Program, Department of Epidemiology, NYU School of Global Public Health, 708 Broadway, New York, NY 10003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Curran","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8847-802X","authenticated-orcid":false,"given":"Mary Lou","family":"Pompeii","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souptik","family":"Barua","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University Langone Health, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-7068","authenticated-orcid":false,"given":"Huilin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-3016","authenticated-orcid":false,"given":"David E.","family":"St-Jules","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Nevada, Reno, 1664 N. Virginia Street, Reno, NV 89557, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Schoenthaler","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-2976","authenticated-orcid":false,"given":"Michael","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"},{"name":"Department of Medicine, New York University Langone Health, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Sevick","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Langone Health, 180 Madison Ave, New York, NY 10016, USA"},{"name":"Department of Medicine, New York University Langone Health, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1152\/physiol.00014.2022","article-title":"Precision Nutrition: Recent Advances in Obesity","volume":"38","author":"Voruganti","year":"2023","journal-title":"Physiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/s41591-024-02951-6","article-title":"Effects of a personalized nutrition program on cardiometabolic health: A randomized controlled trial","volume":"30","author":"Bermingham","year":"2024","journal-title":"Nat. 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