{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:25:00Z","timestamp":1791908700156,"version":"4.3.4"},"reference-count":94,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lodz","award":["503\/3-045-02\/503-31-001-19-00"],"award-info":[{"award-number":["503\/3-045-02\/503-31-001-19-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Thiamine (vitamin B1) is key in maintaining cellular health and energy metabolism. Thiamine is required for proper functioning of enzymes involved in glucose metabolism, which is critical for providing energy to cells. This energy is essential for various cellular processes, including DNA repair mechanisms. In addition, it is a prerequisite for the functioning of key enzymes in the biosynthesis of pentose sugars, which are essential in the synthesis of nucleic acids. Additionally, thiamine has antioxidant properties that help reduce oxidative stress in cells; thus, by relieving this stress, thiamine indirectly supports the maintenance of DNA integrity. Ensuring adequate thiamine intake through diet or supplements can support overall cellular health and potentially aid in DNA repair processes. This review aims to highlight the essential role of vitamin B1 in supporting metabolic health, especially given that deficiencies can develop in patients with disease-related malnutrition as well as in those with an inadequate diet.<\/jats:p>","DOI":"10.3390\/nu17132206","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:07:17Z","timestamp":1751515637000},"page":"2206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Thiamine (Vitamin B1)\u2014An Essential Health Regulator"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-5727","authenticated-orcid":false,"given":"Julia","family":"Ka\u017amierczak-Bara\u0144ska","sequence":"first","affiliation":[{"name":"DNA Damage Laboratory, Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Halczuk","sequence":"additional","affiliation":[{"name":"DNA Damage Laboratory, Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-7834","authenticated-orcid":false,"given":"Boles\u0142aw T.","family":"Karwowski","sequence":"additional","affiliation":[{"name":"DNA Damage Laboratory, Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e7681","DOI":"10.1002\/ccr3.7681","article-title":"Thiamine deficiency unrelated to alcohol consumption presented with urinary retention and Wernicke\u2019s encephalopathy: A case report","volume":"11","author":"Uchi","year":"2023","journal-title":"Clin. Case Rep."},{"key":"ref_2","first-page":"4653","article-title":"Dietary reference values for thiamin","volume":"14","author":"Turck","year":"2016","journal-title":"EFSA J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Combs, G.F. (2012). Thiamin. 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