{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:21:08Z","timestamp":1788366068428,"version":"build-2803163510"},"reference-count":39,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico","award":["815084"],"award-info":[{"award-number":["815084"]}]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","award":["815084"],"award-info":[{"award-number":["815084"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: MicroRNAs (miRNAs) have emerged as molecular mediators involved in the pathogenesis of rheumatoid arthritis (RA). Given the influence of diet on gene expression and inflammation, plant-based diets represent a potential non-pharmacological strategy for modulating disease activity. This study aimed to explore and validate, through a bioinformatic-guided pilot approach, the regulation of miRNAs associated with RA in response to a 14-day plant-based dietary intervention. Methods: Candidate miRNAs were identified through differential expression analysis of the GSE124373 dataset using GEO2R and were further supported by a literature review. Target gene prediction and functional enrichment analyses were conducted to assess the biological relevance of these findings. Twenty-three RA patients followed a plant-based diet for 14 days. The clinical activity (DAS28-CRP), biochemical markers, and plasma expression of five selected miRNAs (miR-26a-5p, miR-125a-5p, miR-125b-5p, miR-146a-5p, and miR-155-5p) were evaluated before and after the intervention using RT-qPCR. Results: Significant reductions were observed in DAS28-CRP scores, C-reactive protein, glucose, and lipid levels after 14 days of intervention. Three of the five miRNAs (miR-26a-5p, miR-125a-5p, and miR-155-5p) were significantly downregulated post-intervention. Bioinformatic analyses indicated that these miRNAs regulate immune\u2013inflammatory pathways relevant to RA pathogenesis. Conclusions: This pilot study suggests that a short-term plant-based dietary intervention may modulate circulating miRNAs and improve clinical and biochemical parameters in RA patients. These findings support further research into dietary strategies as complementary approaches for RA management.<\/jats:p>","DOI":"10.3390\/nu17132222","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T11:20:11Z","timestamp":1751628011000},"page":"2222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A 14-Day Plant-Based Dietary Intervention Modulates the Plasma Levels of Rheumatoid Arthritis-Associated MicroRNAs: A Bioinformatics-Guided Pilot Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-0028","authenticated-orcid":false,"given":"Mario","family":"Pe\u00f1a-Pe\u00f1a","sequence":"first","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"},{"name":"Departamento de Fisiolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyzabeth","family":"Berm\u00fadez-Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Departamento de Reumatolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"S\u00e1nchez-Gloria","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-431X","authenticated-orcid":false,"given":"Karla M.","family":"Rada","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"},{"name":"Departamento de Fisiolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Mora-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Torre M\u00e9dica (Grupo Dalinde), Centro M\u00e9dico Dalinde, Tuxpan No. 29, Roma Sur, Cuauht\u00e9moc, Mexico City 06760, Mexico"},{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana Xochimilco, Mexico City 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-5732","authenticated-orcid":false,"given":"Luis M.","family":"Amezcua-Guerra","sequence":"additional","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana Xochimilco, Mexico City 04960, Mexico"},{"name":"Departamento de Inmunolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha A.","family":"Ballinas-Verdugo","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"},{"name":"Departamento de Bioqu\u00edmica, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tavera-Alonso","sequence":"additional","affiliation":[{"name":"Laboratorio Central, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-9023","authenticated-orcid":false,"given":"Carlos A.","family":"Guzm\u00e1n-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"},{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Mexico City 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-8108","authenticated-orcid":false,"given":"Leonor","family":"Jacobo-Albavera","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica de Enfermedades Cardiovasculares, Instituto Nacional de Medicina Gen\u00f3mica, Mexico City 14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-6600","authenticated-orcid":false,"given":"Aar\u00f3n","family":"Dom\u00ednguez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3976-4759","authenticated-orcid":false,"given":"Rogelio F.","family":"Jim\u00e9nez-Ortega","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica, Instituto Nacional de Rehabilitaci\u00f3n (INR), Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis H.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Departamento de Reumatolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-2615","authenticated-orcid":false,"given":"Laura A.","family":"Mart\u00ednez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Reumatolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-1632","authenticated-orcid":false,"given":"Fausto","family":"S\u00e1nchez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"},{"name":"Departamento de Inmunolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Yang, M., Xie, H., Hong, F., and Yang, S. (2023). Role of MiRNAs in Rheumatoid Arthritis Therapy. Cells, 12.","DOI":"10.3390\/cells12131749"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00296-020-04731-0","article-title":"The Global Prevalence of Rheumatoid Arthritis: A Meta-Analysis Based on a Systematic Review","volume":"41","author":"Almutairi","year":"2021","journal-title":"Rheumatol. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid Arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/ajcn\/nqaa019","article-title":"Anti-Inflammatory Diet In Rheumatoid Arthritis (ADIRA)\u2014A Randomized, Controlled Crossover Trial Indicating Effects on Disease Activity","volume":"111","author":"Vadell","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hartmann, A.M., Dell\u2019Oro, M., Spoo, M., Fischer, J.M., Steckhan, N., Jeitler, M., H\u00e4upl, T., Kandil, F.I., Michalsen, A., and Koppold-Liebscher, D.A. (2022). To Eat or Not to Eat\u2014An Exploratory Randomized Controlled Trial on Fasting and Plant-Based Diet in Rheumatoid Arthritis (NutriFast-Study). Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1030380"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/rheumatology\/keac693","article-title":"A Multidisciplinary Lifestyle Program for Rheumatoid Arthritis: The \u2018Plants for Joints\u2019 Randomized Controlled Trial","volume":"62","author":"Walrabenstein","year":"2023","journal-title":"Rheumatology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1093\/jn\/nxab313","article-title":"Proposed Anti-Inflammatory Diet Reduces Inflammation in Compliant, Weight-Stable Patients with Rheumatoid Arthritis in a Randomized Controlled Crossover Trial","volume":"151","author":"Hulander","year":"2021","journal-title":"J. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12937-018-0354-x","article-title":"A Randomized Controlled Cross-over Trial Investigating the Effect of Anti-Inflammatory Diet on Disease Activity and Quality of Life in Rheumatoid Arthritis: The Anti-Inflammatory Diet In Rheumatoid Arthritis (ADIRA) Study Protocol","volume":"17","author":"Winkvist","year":"2018","journal-title":"Nutr. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Craig, W.J., Mangels, A.R., Fres\u00e1n, U., Marsh, K., Miles, F.L., Saunders, A.V., Haddad, E.H., Heskey, C.E., Johnston, P., and Larson-meyer, E. (2021). The Safe and Effective Use of Plant-Based Diets with Guidelines for Health Professionals. Nutrients, 13.","DOI":"10.3390\/nu13114144"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pe\u00f1a-Pe\u00f1a, M., Gonz\u00e1lez-Ram\u00edrez, J., Berm\u00fadez-Ben\u00edtez, E., S\u00e1nchez-Gloria, J.L., Amezcua-Guerra, L.M., Tavera-Alonso, C., Guzm\u00e1n-Mart\u00edn, C.A., Jacobo-Albavera, L., Silveira-Torre, L.H., and Mart\u00ednez-Mart\u00ednez, L.A. (2025). Regulation of LncRNA NUTM2A-AS1 and CCR3 in the Clinical Response to a Plant-Based Diet in Rheumatoid Arthritis: A Pilot Study. Nutrients, 17.","DOI":"10.3390\/nu17111752"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1017\/S0029665121003839","article-title":"Plant-Based Diets: A Review of the Definitions and Nutritional Role in the Adult Diet","volume":"81","author":"Kent","year":"2022","journal-title":"Proc. Nutr. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jand.2021.10.024","article-title":"Plant-Based Foods for Skin Health: A Narrative Review","volume":"122","author":"Fam","year":"2022","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Alwarith, J., Kahleova, H., Rembert, E., Yonas, W., Dort, S., Calcagno, M., Burgess, N., Crosby, L., and Barnard, N.D. (2019). Nutrition Interventions in Rheumatoid Arthritis: The Potential Use of Plant-Based Diets. A Review. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00141"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Khanna, S., Jaiswal, K.S., and Gupta, B. (2017). Managing Rheumatoid Arthritis with Dietary Interventions. Front. Nutr., 4.","DOI":"10.3389\/fnut.2017.00052"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sala-Climent, M., L\u00f3pez de Coca, T., Guerrero, M.D., Mu\u00f1oz, F.J., L\u00f3pez-Ru\u00edz, M.A., Moreno, L., Alacreu, M., and Dea-Ayuela, M.A. (2023). The Effect of an Anti-Inflammatory Diet on Chronic Pain: A Pilot Study. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1205526"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12937-022-00805-w","article-title":"Association between Dietary Inflammatory Index Scores and the Increased Disease Activity of Rheumatoid Arthritis: A Cross-Sectional Study","volume":"21","author":"Nayebi","year":"2022","journal-title":"Nutr. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00296-021-04864-w","article-title":"MiR-19b-3p and MiR-20a-5p Are Associated with the Levels of Antiphospholipid Antibodies in Patients with Antiphospholipid Syndrome","volume":"41","author":"Gamboa","year":"2021","journal-title":"Rheumatol. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/pcmedi\/pbaa037","article-title":"Vegetarian Diets, Circulating MiRNA Expression and Healthspan in Subjects Living in the Blue Zone","volume":"3","author":"Liu","year":"2020","journal-title":"Precis. Clin. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41413-023-00244-1","article-title":"Comprehensive Overview of MicroRNA Function in Rheumatoid Arthritis","volume":"11","author":"Peng","year":"2023","journal-title":"Bone Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Guzm\u00e1n-Mart\u00edn, C.A., Jim\u00e9nez-Ortega, R.F., Ortega-Springall, M.F., Pe\u00f1a-Pe\u00f1a, M., Guerrero-Ponce, A.E., Vega-Memije, M.E., Amezcua-Guerra, L.M., S\u00e1nchez-Mu\u00f1oz, F., and Springall, R. (2025). MiR-16-5p, MiR-21-5p, and MiR-155-5p in Circulating Vesicles as Psoriasis Biomarkers. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-91532-9"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"vi5","DOI":"10.1093\/rheumatology\/kes279","article-title":"ACR\/EULAR 2010 Rheumatoid Arthritis Classification Criteria","volume":"51","author":"Kay","year":"2012","journal-title":"Rheumatology"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Paradowska-Gorycka, A., and Stypi\u0144ska, B. (2017). MicroRNAs in Rheumatoid Arthritis: From Pathogenesis to Clinical Utility. New Developments in the Pathogenesis of Rheumatoid Arthritis, InTech.","DOI":"10.5772\/67320"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/annrheumdis-2021-eular.98","article-title":"POS0191| THE VALUE OF MIR-20B, MIR-22, MIR-26A, MIR-125B AND MIR-221 IN RHEUMATOID ARTHRITIS","volume":"80","author":"Singh","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kmio\u0142ek, T., and Paradowska-Gorycka, A. (2022). MiRNAs as Biomarkers and Possible Therapeutic Strategies in Rheumatoid Arthritis. Cells, 11.","DOI":"10.3390\/cells11030452"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/annrheumdis-2015-eular.6041","article-title":"SAT0125| Utility of Select Plasma Mirnas for Diagnosis of Rheumatoid Arthritis and Monitoring of Disease Activity and Cardiovascular Risk","volume":"74","author":"Ormseth","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_26","first-page":"1936","article-title":"MiR-146a and MiR-155 as Potential Biomarkers for Rheumatoid Arthritis and Disease Activity","volume":"9","author":"Sun","year":"2018","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1007\/s00394-021-02594-0","article-title":"Mediterranean Diet Enriched in Extra-Virgin Olive Oil or Nuts Modulates Circulating Exosomal Non-Coding RNAs","volume":"60","author":"Crespo","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jnutbio.2015.05.001","article-title":"Circulating Profiling Reveals the Effect of a Polyunsaturated Fatty Acid-Enriched Diet on Common MicroRNAs","volume":"26","author":"Ortega","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.nut.2015.06.008","article-title":"Expression of Inflammation-Related MiRNAs in White Blood Cells from Subjects with Metabolic Syndrome after 8 Wk of Following a Mediterranean Diet\u2013Based Weight Loss Program","volume":"32","author":"Milagro","year":"2016","journal-title":"Nutrition"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/cvr\/cvp121","article-title":"MicroRNA-125a-5p Partly Regulates the Inflammatory Response, Lipid Uptake, and ORP9 Expression in OxLDL-Stimulated Monocyte\/Macrophages","volume":"83","author":"Chen","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.abb.2014.04.009","article-title":"Identification of MicroRNAs Involved in the Modulation of Pro-Angiogenic Factors in Atherosclerosis by a Polyphenol-Rich Extract from Propolis","volume":"557","author":"Cuevas","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/ATVBAHA.113.302701","article-title":"MicroRNA-155 Deficiency Results in Decreased Macrophage Inflammation and Attenuated Atherogenesis in Apolipoprotein E-Deficient Mice","volume":"34","author":"Du","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Huang, Z., Xing, S., Liu, M., Deng, W., Wang, Y., Huang, Z., Huang, Y., Huang, X., Wu, C., and Guo, X. (2019). MiR-26a-5p Enhances Cells Proliferation, Invasion, and Apoptosis Resistance of Fibroblast-like Synoviocytes in Rheumatoid Arthritis by Regulating PTEN\/PI3K\/AKT Pathway. Biosci. Rep., 39.","DOI":"10.1042\/BSR20182192"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/jcp.29013","article-title":"Role of MicroRNA-26a in Cartilage Injury and Chondrocyte Proliferation and Apoptosis in Rheumatoid Arthritis Rats by Regulating Expression of CTGF","volume":"235","author":"Jiang","year":"2020","journal-title":"J. Cell Physiol."},{"key":"ref_35","first-page":"2474529","article-title":"Rheumatoid Arthritis and miRNAs: A Critical Review through a Functional View","volume":"2018","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.thromres.2023.09.008","article-title":"Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy","volume":"231","author":"Senthilkumar","year":"2023","journal-title":"Thromb. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Liu, K., Zhang, Y., Liu, L., and Yuan, Q. (2019). miR-125 regulates PI3K\/Akt\/mTOR signaling pathway in rheumatoid arthritis rats via PARP2. Biosci. Rep., 39.","DOI":"10.1042\/BSR20180890"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1089\/gtmb.2011.0026","article-title":"MicroRNA 146a expression in rheumatoid arthritis: Association with tumor necrosis factor-alpha and disease activity","volume":"15","author":"Saad","year":"2011","journal-title":"Genet. Test. Mol. Biomark."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3892\/ijmm.2024.5415","article-title":"miR 155 promotes an inflammatory response in HaCaT cells via the IRF2BP2\/KLF2\/NF \u03baB pathway in psoriasis","volume":"54","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Med."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/13\/2222\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:04:34Z","timestamp":1760033074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/13\/2222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":39,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["nu17132222"],"URL":"https:\/\/doi.org\/10.3390\/nu17132222","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]}}}