{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T13:38:57Z","timestamp":1786282737849,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vitabio Inc.","award":["YUWCM 2024-71-0116"],"award-info":[{"award-number":["YUWCM 2024-71-0116"]}]},{"name":"Yonsei University Wonju College of Medicine","award":["YUWCM 2024-71-0116"],"award-info":[{"award-number":["YUWCM 2024-71-0116"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Modulating ethanol metabolism and attenuating alcohol-induced oxidative stress are promising therapeutic strategies for reducing the severity of hangovers and alleviating their associated physiological burden. Methods: A randomized, double-blind, placebo-controlled, crossover study was conducted to evaluate the effects of the probiotic strain Leuconostoc mesenteroides VITA-PB2 on ethanol metabolism, oxidative stress, and hangover-related symptoms in 28 healthy adults. The participants consumed either VITA-PB2 or a placebo before standardized alcohol intake, with a 7-day washout period and subsequent crossover. Primary outcomes included blood ethanol, acetaldehyde levels, and aldehyde dehydrogenase (ALDH) activity. Secondary outcomes measured hangover severity assessed by the Acute Hangover Scale (AHS), liver enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT), oxidative stress indicators reactive oxygen species (ROS) and nitric oxide (NO), and antioxidant responses measured by glutathione peroxidase (GPx), catalase, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging capacity. Results: VITA-PB2 supplementation led to a sustained reduction in blood ethanol concentrations beginning at 0.5 h post-ingestion compared with the placebo group, indicating more efficient ethanol clearance. Additionally, VITA-PB2 significantly reduced acetaldehyde levels at 1 h post-ingestion (p &lt; 0.05) and increased ALDH activity by 42.15% at 30 min (p &lt; 0.05). It also markedly reduced ROS levels at 1 h (p &lt; 0.05), enhanced glutathione peroxidase (GPx) activity at 2 h (p &lt; 0.01), and significantly improved the subjective hangover symptoms, particularly thirst (p &lt; 0.05). Conclusions: No adverse effects were reported during the trial, indicating that Leuconostoc mesenteroides VITA-PB2 is a safe probiotic. These findings suggest its efficacy in mitigating alcohol-induced oxidative stress and alleviating hangover-related symptoms.<\/jats:p>","DOI":"10.3390\/nu17142276","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:38:27Z","timestamp":1752140307000},"page":"2276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Probiotic VITA-PB2 from Fermented Foods on Alcohol Consumption and Hangover Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.3390","volume":"17","author":[{"given":"Chaodeng","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"},{"name":"Department of Global Medical Science, Yonsei University Graduate School, Wonju College of Medicine, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7228-8053","authenticated-orcid":false,"given":"Johny","family":"Bajgai","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"},{"name":"Department of Laboratory Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Habibur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6680-3075","authenticated-orcid":false,"given":"Sofian","family":"Abdul-Nasir","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"},{"name":"Department of Global Medical Science, Yonsei University Graduate School, Wonju College of Medicine, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2638-3789","authenticated-orcid":false,"given":"Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"},{"name":"Department of Global Medical Science, Yonsei University Graduate School, Wonju College of Medicine, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu Thao","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"},{"name":"Department of Global Medical Science, Yonsei University Graduate School, Wonju College of Medicine, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buchan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"},{"name":"Department of Global Medical Science, Yonsei University Graduate School, Wonju College of Medicine, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hoon","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongik","family":"Kim","sequence":"additional","affiliation":[{"name":"Vitabio Inc., Sejong 30141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyeong","family":"Seol","sequence":"additional","affiliation":[{"name":"Vitabio Inc., Sejong 30141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Geon","family":"Yu","sequence":"additional","affiliation":[{"name":"Essobiome Inc., Sejong 30141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-9990","authenticated-orcid":false,"given":"Cheol-Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-8122","authenticated-orcid":false,"given":"Kyu-Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"},{"name":"Department of Global Medical Science, Yonsei University Graduate School, Wonju College of Medicine, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Taek","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41575-022-00688-6","article-title":"Global epidemiology of alcohol-associated cirrhosis and HCC: Trends, projections and risk factors","volume":"20","author":"Huang","year":"2023","journal-title":"Nat. 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