{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:01:38Z","timestamp":1791594098556,"version":"4.3.4"},"reference-count":59,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder characterized by excess body weight, hyperandrogenism, hyperglycemia, and insulin resistance often resulting in hirsutism and infertility. Dietary strategies have been shown to ameliorate metabolic disturbances, hormonal imbalances, and inflammation associated with PCOS. Recent evidence indicates that intermittent fasting (IF) could effectively enhance health outcomes and regulate circadian rhythm; however, its impact on PCOS remain unclear. Objective: Therefore, this systematic review and meta-analysis aims to examine the effect of IF on women diagnosed with PCOS. Methods: Comprehensive research was conducted across three major databases including PubMed, Scopus, and Web of Science without date restrictions. Meta-analysis was performed using Cochrane Review Manager Version 5.4 software. Results: Five studies fulfilled the inclusion criteria. IF significantly reduced body weight (MD = \u22124.25 kg, 95% CI: \u22127.71, \u22120.79; p = 0.02), BMI (MD = \u22122.05 kg\/m2, 95% CI: \u22123.26, \u22120.85; p = 0.0008), fasting blood glucose (FBG; MD = \u22122.86 mg\/dL, 95% CI: \u22124.83, \u22120.89; p = 0.004), fasting blood insulin (FBI; MD = \u22123.17 \u03bcU\/mL, 95% CI: \u22125.18, \u22121.16; p = 0.002), insulin resistance (HOMA-IR; MD = \u22120.94, 95% CI: \u22121.39, \u22120.50; p &lt; 0.0001), triglycerides (TG; MD = \u221240.71 mg\/dL, 95% CI: \u221261.53, \u221219.90; p = 0.0001), dehydroepiandrosterone sulfate (DHEA-S; MD = \u221233.21 \u03bcg\/dL, 95% CI: \u221257.29, \u22129.13; p = 0.007), free androgen index (FAI; MD = \u22121.61%, 95% CI: \u22122.76, \u22120.45; p = 0.006), and C-reactive protein (CRP; MD = \u22122.00 mg\/L, 95% CI: \u22123.15, \u22120.85; p = 0.006), while increasing sex hormone-binding globulin (SHBG; SMD = 0.50, 95% CI: 0.22, 0.77; p = 0.004). No significant changes were observed in waist-to-hip ratio (WHR), total cholesterol (TC), LDL, HDL, total testosterone (TT), or anti-Mullerian hormone (AMH). Conclusions: IF represents a promising strategy for improving weight and metabolic, hormonal, and inflammatory profiles in women with PCOS. However, the existing evidence remains preliminary, necessitating further robust studies to substantiate these findings.<\/jats:p>","DOI":"10.3390\/nu17152436","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T12:56:43Z","timestamp":1753448203000},"page":"2436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Intermittent Fasting on Anthropometric Measurements, Metabolic Profile, and Hormones in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-8468","authenticated-orcid":false,"given":"Yazan","family":"Ranneh","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, College of Pharmacy, Al-Ain University, Abu-Dhabi P.O. Box 64141, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0408-3485","authenticated-orcid":false,"given":"Mohammed","family":"Hamsho","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Science, Istanbul Yeni Y\u00fczy\u0131l University, Istanbul 34010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3757-9617","authenticated-orcid":false,"given":"Wijdan","family":"Shkorfu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Bah\u00e7e\u015fehir University, Istanbul 34349, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-9692","authenticated-orcid":false,"given":"Merve","family":"Terzi","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Science, Istanbul Yeni Y\u00fczy\u0131l University, Istanbul 34010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-8939","authenticated-orcid":false,"given":"Abdulmannan","family":"Fadel","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 1555, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2018.04.008","article-title":"Polycystic Ovary Syndrome (PCOS), an Inflammatory, Systemic, Lifestyle Endocrinopathy","volume":"182","author":"Patel","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jozkowiak, M., Piotrowska-Kempisty, H., Kobylarek, D., Gorska, N., Mozdziak, P., Kempisty, B., Rachon, D., and Spaczynski, R.Z. (2023). Endocrine Disrupting Chemicals in Polycystic Ovary Syndrome: The Relevant Role of the Theca and Granulosa Cells in the Pathogenesis of the Ovarian Dysfunction. Cells, 12.","DOI":"10.3390\/cells12010174"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.23736\/S0026-4784.19.04404-6","article-title":"Criteria, Phenotypes and Prevalence of Polycystic Ovary Syndrome","volume":"71","author":"Belenkaia","year":"2019","journal-title":"Minerva Ginecol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Teede, H., Deeks, A., and Moran, L. (2010). Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive and Metabolic Manifestations That Impacts on Health across the Lifespan. BMC Med., 8.","DOI":"10.1186\/1741-7015-8-41"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e11010","DOI":"10.1016\/j.heliyon.2022.e11010","article-title":"An Update of Polycystic Ovary Syndrome: Causes and Therapeutics Options","volume":"8","author":"Matani","year":"2022","journal-title":"Heliyon"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s10815-022-02625-7","article-title":"A Brief Insight into the Etiology, Genetics, and Immunology of Polycystic Ovarian Syndrome (PCOS)","volume":"39","author":"Siddiqui","year":"2022","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4274\/jtgga.galenos.2019.2018.0142","article-title":"Polycystic Ovarian Syndrome: Environmental\/ Occupational, Lifestyle Factors; an Overview","volume":"20","author":"Kshetrimayum","year":"2019","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1179558119874042","DOI":"10.1177\/1179558119874042","article-title":"Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies","volume":"13","author":"Barber","year":"2019","journal-title":"Clin. Med. Insights Reprod. Heal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/cen.14421","article-title":"Obesity and Polycystic Ovary Syndrome","volume":"95","author":"Barber","year":"2021","journal-title":"Clin. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Herman, R., Sikonja, J., Jensterle, M., Janez, A., and Dolzan, V. (2023). Insulin Metabolism in Polycystic Ovary Syndrome: Secretion, Signaling, and Clearance. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043140"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Jurczewska, J., Ostrowska, J., Che\u0142chowska, M., Panczyk, M., Rudnicka, E., Kucharski, M., Smolarczyk, R., and Szostak-W\u0119gierek, D. (2023). Abdominal Obesity in Women with Polycystic Ovary Syndrome and Its Relationship with Diet, Physical Activity and Insulin Resistance: A Pilot Study. Nutrients, 15.","DOI":"10.3390\/nu15163652"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/a-2386-9281","article-title":"Fat Distribution and Its Correlation with Insulin Resistance, Androgen Markers, and Proinflammatory Cytokines in Polycystic Ovary Syndrome","volume":"57","author":"Tavares","year":"2025","journal-title":"Horm. Metab. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9240569","DOI":"10.1155\/2022\/9240569","article-title":"Association of Insulin Resistance and Elevated Androgen Levels with Polycystic Ovarian Syndrome (PCOS): A Review of Literature","volume":"2022","author":"Xu","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Xu, Y., Zhang, Z., Wang, R., Xue, S., Ying, Q., and Jin, L. (2024). Roles of Estrogen and Its Receptors in Polycystic Ovary Syndrome. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1395331"},{"key":"ref_15","first-page":"682","article-title":"Abdominal Obesity May Play a Significant Role in Exacerbation of Inflammation in Polycystic Ovary Syndrome Patients","volume":"27","author":"Shirvanizadeh","year":"2023","journal-title":"JBRA Assist. Reprod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"139239","DOI":"10.1155\/2013\/139239","article-title":"Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines","volume":"2013","author":"Makki","year":"2013","journal-title":"ISRN Inflamm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome","volume":"19","author":"Fauser","year":"2004","journal-title":"Hum. Reprod."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Barrea, L., Arnone, A., Annunziata, G., Muscogiuri, G., Laudisio, D., Salzano, C., Pugliese, G., Colao, A., and Savastano, S. (2019). Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS). Nutrients, 11.","DOI":"10.3390\/nu11102278"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kim, C.H., and Lee, S.H. (2022). Effectiveness of Lifestyle Modification in Polycystic Ovary Syndrome Patients with Obesity: A Systematic Review and Meta-Analysis. Life, 12.","DOI":"10.3390\/life12020308"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12978-024-01758-5","article-title":"Ranking the Dietary Interventions by Their Effectiveness in the Management of Polycystic Ovary Syndrome: A Systematic Review and Network Meta-Analysis","volume":"21","author":"Stubnya","year":"2024","journal-title":"Reprod. Health"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Vasim, I., Majeed, C.N., and DeBoer, M.D. (2022). Intermittent Fasting and Metabolic Health. Nutrients, 14.","DOI":"10.3390\/nu14030631"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mulas, A., Cienfuegos, S., Ezpeleta, M., Lin, S., Pavlou, V., and Varady, K.A. (2023). Effect of Intermittent Fasting on Circulating Inflammatory Markers in Obesity: A Review of Human Trials. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1146924"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Naous, E., Achkar, A., and Mitri, J. (2023). Intermittent Fasting and Its Effects on Weight, Glycemia, Lipids, and Blood Pressure: A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15163661"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.cmet.2016.06.001","article-title":"Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan","volume":"23","author":"Longo","year":"2016","journal-title":"Cell Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/humrep\/deae066","article-title":"Epigenetic\/circadian Clocks and PCOS","volume":"39","author":"Vatier","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kalsekar, A.S., Abdelrahim, D.N., and Faris, M.E. (2024). Effect of Calorie Restriction and Intermittent Fasting on Glucose Homeostasis, Lipid Profile, Inflammatory, and Hormonal Markers in Patients with Polycystic Ovary Syndrome: A Systematic Review. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1362226"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100341","DOI":"10.1016\/j.metop.2024.100341","article-title":"The Impact of Intermittent Fasting on Fertility: A Focus on Polycystic Ovary Syndrome and Reproductive Outcomes in Women-A Systematic Review","volume":"25","author":"Velissariou","year":"2025","journal-title":"Metab. Open"},{"key":"ref_28","first-page":"790","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"ref_29","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2021). Cochrane Handbook for Systematic Reviews of Interventions, Version 6.2 [Updated February 2021], John Wiley & Sons."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s Tool for Assessing Risk of Bias in Randomised Trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A Tool for Assessing Risk of Bias in Non-Randomised Studies of Interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wan, X., Wang, W., Liu, J., and Tong, T. (2014). Estimating the Sample Mean and Standard Deviation from the Sample Size, Median, Range And\/or Interquartile Range. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-135"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13098-023-01155-1","article-title":"Effect of C-Reactive Protein Deficiency on Insulin Resistance Reversal in Rats with Polycystic Ovary Syndrome through Augmented Leptin Action","volume":"15","author":"Li","year":"2023","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Feyzioglu, B.S., G\u00fcven, C.M., and Avul, Z. (2023). Eight-Hour Time-Restricted Feeding: A Strong Candidate Diet Protocol for First-Line Therapy in Polycystic Ovary Syndrome. Nutrients, 15.","DOI":"10.3390\/nu15102260"},{"key":"ref_35","first-page":"122","article-title":"Effect of Intermittent Fasting on Improve Body Composition and Anthropometric Measurements of Women with Polycystic Ovarian Syndrome","volume":"44","author":"Thekrallah","year":"2024","journal-title":"Nutr. Clin. Diet. Hosp."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1111\/dom.15801","article-title":"The Effects of Time-restricted Eating Alone or in Combination with Probiotic Supplementation in Comparison with a Calorie-restricted Diet on Endocrine and Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Randomized Clinical Trial","volume":"26","author":"Talebi","year":"2024","journal-title":"Diabetes Obes. Metab."},{"key":"ref_37","first-page":"5","article-title":"Comparison of the Impact of Intermittent Fasting Diet Alone or in Conjunction with Probiotic Supplementation versus Calorie-Restricted Diet on Inflammatory, Oxidative Stress, and Antioxidant Capacity Biomarkers in Women with Polycystic Ovary Syndrome: A randomized placebo-controlled trial","volume":"30","author":"Talebi","year":"2025","journal-title":"J. Res. Med. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sadeghi, H.M., Adeli, I., Calina, D., Docea, A.O., Mousavi, T., Daniali, M., Nikfar, S., Tsatsakis, A., and Abdollahi, M. (2022). Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020583"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"100162","DOI":"10.1016\/j.endmts.2024.100162","article-title":"A Review on Critical Appraisal and Pathogenesis of Polycystic Ovarian Syndrome","volume":"14","author":"Hajam","year":"2024","journal-title":"Endocr. Metab. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/cen.14726","article-title":"How to Manage Weight Loss in Women with Obesity and PCOS Seeking Fertility?","volume":"97","author":"Hazlehurst","year":"2022","journal-title":"Clin. Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2830545","DOI":"10.1155\/2022\/2830545","article-title":"The Effect of Time-Restricted Eating on Insulin Levels and Insulin Sensitivity in Patients with Polycystic Ovarian Syndrome: A Systematic Review","volume":"2022","author":"Floyd","year":"2022","journal-title":"Int. J. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Mazza, E., Troiano, E., Ferro, Y., Lisso, F., Tosi, M., Turco, E., Pujia, R., and Montalcini, T. (2024). Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts. Nutrients, 16.","DOI":"10.3390\/nu16111629"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.7326\/M23-3179","article-title":"Effect of Weight Loss Interventions on the Symptomatic Burden and Biomarkers of Polycystic Ovary Syndrome","volume":"177","author":"Scragg","year":"2024","journal-title":"Ann. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4386401","DOI":"10.1155\/2019\/4386401","article-title":"The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials","volume":"2019","author":"Zhang","year":"2019","journal-title":"Int. J. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Alenezi, S.A., Elkmeshi, N., Alanazi, A., Alanazi, S.T., Khan, R., and Amer, S. (2024). The Impact of Diet-Induced Weight Loss on Inflammatory Status and Hyperandrogenism in Women with Polycystic Ovarian Syndrome (PCOS)\u2014A Systematic Review and Meta-Analysis. J. Clin. Med., 13.","DOI":"10.20944\/preprints202407.2141.v1"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cho, Y., Hong, N., Kim, K.W., Cho, S.J., Lee, M., Lee, Y.H., Lee, Y.H., Kang, E.S., Cha, B.S., and Lee, B.W. (2019). The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101645"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6999907","DOI":"10.1155\/2022\/6999907","article-title":"Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis","volume":"2022","author":"Yuan","year":"2022","journal-title":"Int. J. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"102519","DOI":"10.1016\/j.eclinm.2024.102519","article-title":"Intermittent Fasting and Health Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomised Controlled Trials","volume":"70","author":"Sun","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1210\/endrev\/bnab027","article-title":"Time-Restricted Eating for the Prevention and Management of Metabolic Diseases","volume":"43","author":"Manoogian","year":"2022","journal-title":"Endocr. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Bao, R., Sun, Y., Jiang, Y., Ye, L., Hong, J., and Wang, W. (2022). Effects of Time-Restricted Feeding on Energy Balance: A Cross-Over Trial in Healthy Subjects. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.870054"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Szczuko, M., Kikut, J., Szczuko, U., Szyd\u0142owska, I., Nawrocka-Rutkowska, J., Zi\u0119tek, M., Verbanac, D., and Saso, L. (2021). Nutrition Strategy and Life Style in Polycystic Ovary Syndrome\u2014Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13072452"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Hamsho, M., Shkorfu, W., Ranneh, Y., and Fadel, A. (2025). Nourishing the Evidence: Exposing Bias and Filling Gaps in Isocaloric Intermittent Fasting research\u2014An Opinion. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1563017"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"103805","DOI":"10.1016\/j.numecd.2024.103805","article-title":"Is Isocaloric Intermittent Fasting Superior to Calorie Restriction? A Systematic Review and Meta-Analysis of RCTs","volume":"35","author":"Hamsho","year":"2025","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cmet.2016.02.005","article-title":"Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity","volume":"23","author":"Magkos","year":"2016","journal-title":"Cell Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s13679-017-0262-y","article-title":"Weight Loss and Improvement in Comorbidity: Differences at 5%, 10%, 15%, and Over","volume":"6","author":"Ryan","year":"2017","journal-title":"Curr. Obes. Rep."},{"key":"ref_56","first-page":"419","article-title":"Quantitative Assessment of Nutrition in Patients with Polycystic Ovary Syndrome (PCOS)","volume":"67","author":"Szczuko","year":"2016","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"ref_57","unstructured":"Hamsho, M., Ranneh, Y., and Fadel, A. Therapeutic Effects of Chromium Supplementation on Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis, Endocrinol. Diabetes Nutr., in press."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Liu, H., Shangguan, F., Liu, F., Guo, Y., Yu, H., Li, H., Su, Y., and Li, Z. (2025). Evaluating the effects of time-restricted eating on overweight and obese women with polycystic ovary syndrome: A randomized controlled trial study protocol. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0316333"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Talebi, S., Shab-Bidar, S., Mohammadi, H., Moini, A., and Djafarian, K. (2023). The effects of intermittent fasting diet alone or in combination with probiotic supplementation in comparison with calorie-restricted diet on metabolic and hormonal profile in patients with polycystic ovary syndrome: Study protocol for a randomized clinical trial. Trials, 24.","DOI":"10.1186\/s13063-023-07691-5"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/15\/2436\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:16:08Z","timestamp":1760033768000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/15\/2436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":59,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["nu17152436"],"URL":"https:\/\/doi.org\/10.3390\/nu17152436","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]}}}