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project from the Education Ministry of China","award":["22JCZXJC00020"],"award-info":[{"award-number":["22JCZXJC00020"]}]},{"name":"National Innovation Demonstration Zone (Zaozhuang) for Sustainable Development of China","award":["2022YFD2101003"],"award-info":[{"award-number":["2022YFD2101003"]}]},{"name":"National Innovation Demonstration Zone (Zaozhuang) for Sustainable Development of China","award":["32172772"],"award-info":[{"award-number":["32172772"]}]},{"name":"National Innovation Demonstration Zone (Zaozhuang) for Sustainable Development of China","award":["B18053"],"award-info":[{"award-number":["B18053"]}]},{"name":"National Innovation Demonstration Zone (Zaozhuang) for Sustainable Development of China","award":["2024SFQZX014"],"award-info":[{"award-number":["2024SFQZX014"]}]},{"name":"National Innovation Demonstration Zone (Zaozhuang) for Sustainable Development of 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disease (MASLD) is one of the most prevalent chronic diseases in the world, lacking specific pharmacological interventions or well-established treatments. MASLD involves intricate pathological mechanisms characterized by oxidative stress and robust inflammatory responses. Selenium, an essential trace element, plays a critical role in antioxidation, regulation of inflammation, anticancer activity, and so on. Recent studies have reported that supplementation with selenium could alleviate MASLD and associated hepatic disorders, while excessive consumption may result in insulin resistance or even selenosis. Therefore, supranutritional selenium supplementation can be more suitable for the therapy and prevention of MASLD. This paper comprehensively reviews research about selenium and MASLD to highlight the potential applications and risks of supranutritional selenium supplementation in MASLD, following three steps: conducting a search, reviewing research articles and reviews, and discussing results. The keywords for the search include but are not limited to selenium, MASLD, supranutritional, hepatic diseases, selenoproteions, and selenium nanoparticles (SeNPs). We have reached the following conclusions: supranutritional selenium supplementation exhibits promising potential as a strategy to treat MASLD, but there are still some risks, depending on the dose and form of selenium; evaluating MASLD severity and selenium nutritional status accurately, as well as supplementing with superior forms of selenium (e.g., organic selenium and SeNPs), can further ensure the safety and efficacy of selenium supplementation. However, relationships between selenium homeostasis disorders and the occurrence and development of MASLD have not been fully elucidated. Methods for comprehensively assessing selenium status and mechanisms of selenosis require further investigation and research.<\/jats:p>","DOI":"10.3390\/nu17152484","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:37:23Z","timestamp":1753861043000},"page":"2484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Critical Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3502-7432","authenticated-orcid":false,"given":"Chuanming","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"},{"name":"Beijing Laboratory of Food Quality and Safety, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"},{"name":"Beijing Laboratory of Food Quality and Safety, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianshun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2803-3579","authenticated-orcid":false,"given":"Yinhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"},{"name":"Beijing Laboratory of Food Quality and Safety, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengquan","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Biological Sciences, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Agricultural Products Preservation and Processing Technology (National Engineering and Technology Research Center for Preservation of Agricultural Products), Tianjin Academy of Agricultural Sciences, Key Laboratory of Storage and Preservation of Agricultural Products, Ministry of Agriculture and Rural Affairs, Tianjin 300384, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-3086","authenticated-orcid":false,"given":"Jiaqiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"},{"name":"Beijing Laboratory of Food Quality and Safety, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jhep.2024.01.014","article-title":"Clinical Profiles and Mortality Rates Are Similar for Metabolic Dysfunction-Associated Steatotic Liver Disease and Non-Alcoholic Fatty Liver Disease","volume":"80","author":"Younossi","year":"2024","journal-title":"J. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.gastro.2018.06.031","article-title":"Bioactive lipid species and metabolic pathways in progression and resolution of nonalcoholic steatohepatitis","volume":"155","author":"Musso","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mcna.2017.08.010","article-title":"Obesity Pharmacotherapy","volume":"102","author":"Saunders","year":"2018","journal-title":"Med. Clin. North Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.freeradbiomed.2018.06.002","article-title":"Selenium at the redox interface of the genome, metabolome and exposome","volume":"127","author":"Fernandes","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Tang, C., Li, S., Zhang, K., Li, J., Han, Y., Zhan, T., Zhao, Q., Guo, X., and Zhang, J. (2020). Selenium deficiency-induced redox imbalance leads to metabolic reprogramming and inflammation in the liver. Redox Biol., 36.","DOI":"10.1016\/j.redox.2020.101519"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/mnfr.200700330","article-title":"The influence of selenium on immune responses","volume":"52","author":"Hoffmann","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_11","first-page":"61","article-title":"Selenium and selenoprotein P in nonalcoholic fatty liver disease","volume":"19","author":"Polyzos","year":"2020","journal-title":"Horm.-Int. J. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7009863","DOI":"10.1155\/2022\/7009863","article-title":"Selenium status and its antioxidant role in metabolic diseases","volume":"2022","author":"Huang","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15458","DOI":"10.1021\/acs.jafc.1c04992","article-title":"Selenium in wheat from farming to food","volume":"69","author":"Wang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wu, Z., Ba\u00f1uelos, G.S., Lin, Z.-Q., Liu, Y., Yuan, L., Yin, X., and Li, M. (2015). Biofortification and Phytoremediation of Selenium in China. Front. Plant Sci., 6.","DOI":"10.3389\/fpls.2015.00136"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7478523","DOI":"10.1155\/2017\/7478523","article-title":"Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in Human Health and Disease","volume":"14","author":"Bao","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.1073\/pnas.0308096101","article-title":"Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase","volume":"101","author":"McClung","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3945\/an.115.010785","article-title":"Selenium","volume":"7","author":"Prabhu","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Steinbrenner, H., Duntas, L.H., and Rayman, M.P. (2022). The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities. Redox Biol., 50.","DOI":"10.1016\/j.redox.2022.102236"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Han, F., Liu, Y., Wang, Q., and Huang, Z. (J. Nutr., 2025). Dietary Reference Intakes of Selenium for Chinese Residents, J. Nutr., in press.","DOI":"10.1016\/j.tjnut.2025.01.008"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2014). Scientific Opinion on Dietary Reference Values for Selenium. EFSA J., 12, 3846.","DOI":"10.2903\/j.efsa.2014.3846"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck, D., Bohn, T., Castenmiller, J., de Henauw, S., Hirsch-Ernst, K.-I., Knutsen, H.K., Maciuk, A., Mangelsdorf, I., and McArdle, H.J. (2023). Scientific Opinion on the Tolerable Upper Intake Level for Selenium. EFSA J., 21, e07704.","DOI":"10.2903\/j.efsa.2023.7704"},{"key":"ref_23","first-page":"420","article-title":"Dietary Reference Intakes (DRIs) in Japan","volume":"17","author":"Sasaki","year":"2008","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4163\/jnh.2022.55.4.430","article-title":"2020 korean dietary reference intakes of selenium and a review of selenium database of foods by evaluating of selenium contents of the recommended menus","volume":"55","author":"Choi","year":"2022","journal-title":"J. Nutr. Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and Nonalcoholic Fatty Liver Disease: From Pathophysiology to Therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.metabol.2015.10.032","article-title":"Exercise and diet in the management of nonalcoholic fatty liver disease","volume":"65","author":"Mahady","year":"2016","journal-title":"Metabolism"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.fshw.2022.10.026","article-title":"High-starchy carbohydrate diet aggravates NAFLD by increasing fatty acids influx mediated by NOX2","volume":"12","author":"Gao","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.metabol.2016.02.014","article-title":"Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease","volume":"65","author":"Mota","year":"2016","journal-title":"Metabolism"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.metabol.2015.11.006","article-title":"Adipokines in nonalcoholic fatty liver disease","volume":"65","author":"Polyzos","year":"2016","journal-title":"Metab.-Clin. Exp."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/156652412798376161","article-title":"The emerging role of endocrine disruptors in pathogenesis of insulin resistance: A concept implicating nonalcoholic fatty liver disease","volume":"12","author":"Polyzos","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jhep.2017.09.003","article-title":"Genetics and epigenetics of NAFLD and NASH: Clinical impact","volume":"68","author":"Eslam","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: A tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1055\/s-0035-1562942","article-title":"Diagnosis and assessment of NAFLD: Definitions and histopathological classification","volume":"35","author":"Burt","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00125-016-3930-7","article-title":"EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease: Disease mongering or call to action?","volume":"59","author":"Bugianesi","year":"2016","journal-title":"Diabetologia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.metabol.2014.10.017","article-title":"Leptin in health and disease: Facts and expectations at its twentieth anniversary","volume":"64","author":"Polyzos","year":"2015","journal-title":"Metabolism"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wang, P., Lu, Z., He, M., Shi, B., Lei, X., and Shan, A. (2020). The Effects of Endoplasmic-Reticulum-Resident Selenoproteins in a Nonalcoholic Fatty Liver Disease Pig Model Induced by a High-Fat Diet. Nutrients, 12.","DOI":"10.3390\/nu12030692"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11154-016-9339-2","article-title":"The role of immune cells in metabolism-related liver inflammation and development of non-alcoholic steatohepatitis (NASH)","volume":"17","author":"Nati","year":"2016","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/hep.28948","article-title":"The origin of fibrogenic myofibroblasts in fibrotic liver","volume":"65","author":"Kisseleva","year":"2017","journal-title":"Hepatology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev-nutr-062320-121834","article-title":"Dietary selenium across species","volume":"42","author":"Lei","year":"2022","journal-title":"Annu. Rev. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00018-022-04385-0","article-title":"The protective effect of selenoprotein M on non-alcoholic fatty liver disease: The role of the AMPK\u03b11\u2013MFN2 pathway and Parkin mitophagy","volume":"79","author":"Cai","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e2404073","DOI":"10.1002\/advs.202404073","article-title":"SELENOI Functions as a Key Modulator of Ferroptosis Pathway in Colitis and Colorectal Cancer","volume":"11","author":"Huang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Miyata, M., Matsushita, K., Shindo, R., Shimokawa, Y., Sugiura, Y., and Yamashita, M. (2020). Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD. Nutrients, 12.","DOI":"10.3390\/nu12061898"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wang, C., Yang, S., Zhang, N., Mu, Y., Ren, H., Wang, Y., and Li, K. (2014). Long-term supranutritional supplementation with selenate decreases hyperglycemia and promotes fatty liver degeneration by inducing hyperinsulinemia in diabetic db\/db mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101315"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10534-014-9819-3","article-title":"Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Selenium Deficiency-Induced Apoptosis in Chicken Liver","volume":"28","author":"Yao","year":"2015","journal-title":"Biometals"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/jn\/nxz317","article-title":"Targeted Metabolomics Analysis Reveals That Dietary Supranutritional Selenium Regulates Sugar and Acylcarnitine Metabolism Homeostasis in Pig Liver","volume":"150","author":"Zhang","year":"2020","journal-title":"J. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105596","DOI":"10.1016\/j.jff.2023.105596","article-title":"Organic selenium ameliorates non-alcoholic fatty liver disease through 5-hydroxytryptamine\/bile acid enterohepatic circulation in mice","volume":"106","author":"Zhang","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wang, Y., Liu, B., Wu, P., Chu, Y., Gui, S., Zheng, Y., and Chen, X. (2022). Dietary selenium alleviated mouse liver oxidative stress and NAFLD induced by obesity by regulating the KEAP1\/NRF2 pathway. Antioxidants, 11.","DOI":"10.3390\/antiox11020349"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1039\/C5FO00557D","article-title":"Selenium-containing polysaccharides from Ziyang green tea ameliorate high-fructose diet induced insulin resistance and hepatic oxidative stress in mice","volume":"6","author":"Ren","year":"2015","journal-title":"Food Funct."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jnutbio.2016.12.012","article-title":"Supranutritional selenium intake from enriched milk casein impairs hepatic insulin sensitivity via attenuated IRS\/PI3K\/AKT signaling and decreased PGC-1\u03b1 expression in male Sprague\u2013Dawley rats","volume":"41","author":"Stahel","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3945\/jn.116.229955","article-title":"High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs","volume":"146","author":"Zhao","year":"2016","journal-title":"J. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1002\/fsn3.2980","article-title":"Ameliorative Effects of Supranutritional Selenium on TLR-4-NF-\u03baB-TNF-\u03b1-Mediated Hepatic Oxidative Injury and Inflammation in Goats Fed High Concentrate Diet","volume":"10","author":"Shah","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1007\/s12011-021-02601-9","article-title":"Effects of supranutritional selenium nanoparticles on immune and antioxidant capacity in Sprague-Dawley rats","volume":"199","author":"Jin","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Qiao, L., Guo, Z., Liu, H., Liu, J., Lin, X., Deng, H., Liu, X., Zhao, Y., Xiao, X., and Lei, J. (2022). Protective effect of mitophagy regulated by mTOR signaling pathway in liver fibrosis associated with selenium. Nutrients, 14.","DOI":"10.3390\/nu14122410"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"175235","DOI":"10.1016\/j.ejphar.2022.175235","article-title":"Amorphous selenium nanodots alleviate non-alcoholic fatty liver disease via activating VEGF receptor 1 to further inhibit phosphorylation of JNK\/p38 MAPK pathways","volume":"932","author":"Zhu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"115850","DOI":"10.1016\/j.ecoenv.2023.115850","article-title":"Microplastic-induced NAFLD: Hepatoprotective effects of nanosized selenium","volume":"272","author":"Shen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Evenson, J.K., and Sunde, R.A. (2021). Metabolism of tracer 75Se selenium from inorganic and organic selenocompounds into selenoproteins in rats, and the missing 75Se metabolites. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.699652"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"mfad066","DOI":"10.1093\/mtomcs\/mfad066","article-title":"Effect of Graded Levels of Selenium Supplementation as Selenite on Expression of Selenosugars, Selenocysteine, and Other Selenometabolites in Rat Liver","volume":"15","author":"Bierla","year":"2023","journal-title":"Metallomics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"9547613","DOI":"10.1155\/2018\/9547613","article-title":"Role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease","volume":"2018","author":"Masarone","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"20704","DOI":"10.3390\/ijms141020704","article-title":"Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)","volume":"14","author":"Takaki","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis","volume":"52","author":"Rolo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Xu, L., Lu, Y., Wang, N., and Feng, Y. (2022). The role and mechanisms of selenium supplementation on fatty liver-associated disorder. Antioxidants, 11.","DOI":"10.3390\/antiox11050922"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/ars.2007.1528","article-title":"From selenium to selenoproteins: Synthesis, identity, and their role in human health","volume":"9","author":"Papp","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ng1655","article-title":"Genetic variation in selenoprotein S influences inflammatory response","volume":"37","author":"Curran","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cyto.2006.02.005","article-title":"Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells","volume":"33","author":"Gao","year":"2006","journal-title":"Cytokine"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/ars.2018.7594","article-title":"Selenoprotein M promotes hypothalamic leptin signaling and thioredoxin antioxidant activity","volume":"35","author":"Gong","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/s41467-017-01863-z","article-title":"Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models","volume":"8","author":"Mita","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cmet.2010.09.015","article-title":"A liver-derived secretory protein, selenoprotein P, causes insulin resistance","volume":"12","author":"Misu","year":"2010","journal-title":"Cell Metab."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"You, M., Wu, F., Gao, M., Chen, M., Zeng, S., Zhang, Y., Zhao, W., Li, D., Wei, L., and Ruan, X.Z. (2022). Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis. Redox Biol., 57.","DOI":"10.1016\/j.redox.2022.102500"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Miao, Z., Wang, W., Miao, Z., Cao, Q., and Xu, S. (2024). Role of Selenoprotein W in Participating in the Progression of Non-Alcoholic Fatty Liver Disease. Redox Biol., 71.","DOI":"10.1016\/j.redox.2024.103114"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jnutbio.2019.03.020","article-title":"Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice","volume":"69","author":"Akahoshi","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/carcin\/20.9.1657","article-title":"Selenium metabolism, selenoproteins and mechanisms of cancer prevention: Complexities with thioredoxin reductase","volume":"20","author":"Ganther","year":"1999","journal-title":"Carcinogenesis"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s12011-014-0002-z","article-title":"Effects on Liver Hydrogen Peroxide Metabolism Induced by Dietary Selenium Deficiency or Excess in Chickens","volume":"159","author":"Xu","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s12011-023-03705-0","article-title":"Comparison of sodium selenite and selenium-enriched spirulina supplementation effects after selenium deficiency on growth, tissue selenium concentrations, antioxidant activities, and selenoprotein expression in rats","volume":"202","author":"Castel","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s12011-016-0781-5","article-title":"Long-term selenium-deficient diet induces liver damage by altering hepatocyte ultrastructure and MMP1\/3 and TIMP1\/3 expression in growing rats","volume":"175","author":"Han","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1007\/s12011-022-03453-7","article-title":"Short-term dietary selenium deficiency induced liver fibrosis by inhibiting the Akt\/mTOR signaling pathway in rats","volume":"201","author":"Qiao","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Raines, A.M., and Sunde, R.A. (2011). Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents. BMC Genom., 12.","DOI":"10.1186\/1471-2164-12-26"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/biof.5520150103","article-title":"Biological effects of a nano red elemental selenium","volume":"15","author":"Zhang","year":"2001","journal-title":"BioFactors"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.lfs.2004.09.026","article-title":"A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats","volume":"76","author":"Jia","year":"2005","journal-title":"Life Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"53034","DOI":"10.1007\/s11356-021-14400-9","article-title":"Dose-dependent hepatic toxicity and oxidative stress on exposure to nano and bulk selenium in mice","volume":"28","author":"Kondaparthi","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"18134","DOI":"10.1074\/jbc.C110.106377","article-title":"Identification of a novel selenium-containing compound, selenoneine, as the predominant chemical form of organic selenium in the blood of bluefin tuna","volume":"285","author":"Yamashita","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.lfs.2004.08.015","article-title":"Comparison of Short-Term Toxicity between Nano-Se and Selenite in Mice","volume":"76","author":"Zhang","year":"2005","journal-title":"Life Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.freeradbiomed.2007.02.013","article-title":"Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: Comparison with selenomethionine in mice","volume":"42","author":"Wang","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/toxsci\/kfm221","article-title":"Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: Comparison with se-methylselenocysteine in mice","volume":"101","author":"Zhang","year":"2008","journal-title":"Toxicol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/13880209.2012.710241","article-title":"Acute and subacute toxicity of novel biogenic selenium nanoparticles in mice","volume":"51","author":"Shakibaie","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1002\/etc.1995","article-title":"Subacute Toxicity of Nano-Selenium Compared to Other Selenium Species in Mice","volume":"31","author":"Benko","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.lfs.2014.08.023","article-title":"Toxicity of selenium nanoparticles in male Sprague\u2013Dawley rats at supranutritional and nonlethal levels","volume":"115","author":"He","year":"2014","journal-title":"Life Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e2500467","DOI":"10.1002\/adhm.202500467","article-title":"Biomimetic Selenium-Nanocomposites Alleviate MASH by Modulating Lipid and Iron Homeostasis","volume":"14","author":"Zhang","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"10789","DOI":"10.1073\/pnas.2001387117","article-title":"Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity","volume":"117","author":"Jedrychowski","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Fujii, H., Kawada, N., and Japan Study Group of NAFLD (JSG-NAFLD) (2020). The role of insulin resistance and diabetes in nonalcoholic fatty liver disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113863"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tjnut.2024.10.041","article-title":"Possible Metabolic Remodeling Based on de Novo Biosynthesis of L-Serine in Se-Subtoxic or -Deficient Mammals","volume":"155","author":"Wang","year":"2025","journal-title":"J. Nutr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1001\/archinte.1979.03630440082028","article-title":"Long-term selenium exposure","volume":"139","author":"Diskin","year":"1979","journal-title":"Arch. Intern. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/bmc-2017-0007","article-title":"Recent Advances in the Mechanism of Selenoamino Acids Toxicity in Eukaryotic Cells","volume":"8","author":"Lazard","year":"2017","journal-title":"Biomol. Concepts"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"mfad067","DOI":"10.1093\/mtomcs\/mfad067","article-title":"Selenomethionine Supplementation and Expression of Selenosugars, Selenocysteine, and Other Selenometabolites in Rat Liver","volume":"15","author":"Bierla","year":"2023","journal-title":"Metallomics"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"114589","DOI":"10.1016\/j.ecoenv.2023.114589","article-title":"L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos","volume":"252","author":"Zhu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"739572","DOI":"10.1016\/j.aquaculture.2023.739572","article-title":"Dietary selenium requirement for on-growing grass carp, Ctenopharyngodon idellus","volume":"573","author":"Chen","year":"2023","journal-title":"Aquaculture"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/jn\/nxaa333","article-title":"Gene set enrichment analysis of selenium-deficient and high-selenium rat liver transcript expression and comparison with turkey liver expression","volume":"151","author":"Sunde","year":"2021","journal-title":"J. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Day, K., Seale, L.A., Graham, R.M., and Cardoso, B.R. (2021). Selenotranscriptome network in non-alcoholic fatty liver disease. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.744825"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"117677","DOI":"10.1016\/j.ecoenv.2025.117677","article-title":"High-Selenium Exposure Is Associated with Modulation of Serum Lipid Metabolism","volume":"289","author":"Tan","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12011-015-0237-3","article-title":"Study of trace elements in liver cirrhosis patients and their role in prognosis of disease","volume":"165","author":"Nangliya","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Shih, C.-W., Chen, Y.-J., and Chen, W.-L. (2022). Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study. Nutrients, 14.","DOI":"10.3390\/nu14173625"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3945\/ajcn.116.131672","article-title":"Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort","volume":"104","author":"Hughes","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/hep.24808","article-title":"Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma","volume":"55","author":"Sieghart","year":"2012","journal-title":"Hepatology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3945\/ajcn.115.110932","article-title":"Selenium deficiency occurs in some patients with moderate-to-severe cirrhosis and can be corrected by administration of selenate but not selenomethionine: A randomized controlled trial","volume":"102","author":"Burk","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"111190","DOI":"10.1016\/j.envres.2021.111190","article-title":"Serum selenium and non-alcoholic fatty liver disease (NAFLD) in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2011\u20132016","volume":"197","author":"Wang","year":"2021","journal-title":"Environ. Res."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Urbano, T., Filippini, T., Lasagni, D., De Luca, T., Grill, P., Sucato, S., Polledri, E., Djeukeu Noumbi, G., Malavolti, M., and Santachiara, A. (2021). Association of urinary and dietary selenium and of serum selenium species with serum alanine aminotransferase in a healthy Italian population. Antioxidants, 10.","DOI":"10.3390\/antiox10101516"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Yang, Z., Yan, C., Liu, G., Niu, Y., Zhang, W., Lu, S., Li, X., Zhang, H., Ning, G., and Fan, J. (2016). Plasma selenium levels and nonalcoholic fatty liver disease in Chinese adults: A cross-sectional analysis. Sci. Rep., 6.","DOI":"10.1038\/srep37288"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1080\/07853890.2022.2110277","article-title":"The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017\u20132018","volume":"54","author":"Liu","year":"2022","journal-title":"Ann. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.29219\/fnr.v64.4548","article-title":"Cross-Sectional Analysis of the Health Profile and Dietary Intake of a Sample of Canadian Adults Diagnosed with Non-Alcoholic Fatty Liver Disease","volume":"64","author":"Aktary","year":"2020","journal-title":"Food Nutr. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/07315724.2019.1613271","article-title":"Association between dietary selenium intake and the prevalence of nonalcoholic fatty liver disease: A cross-sectional study","volume":"39","author":"Wu","year":"2020","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Zarghani, S.S., Kashkooli, N.R., Bagheri, Z., Tabatabaei, M., Fattahi, M.R., and Safarpour, A.R. (2023). Dietary selenium intake in relation to non-alcoholic fatty liver disease assessed by fatty liver index and hepatic steatosis index; a cross-sectional study on the baseline data of prospective PERSIAN Kavar cohort study. BMC Endocr. Disord., 23.","DOI":"10.1186\/s12902-023-01307-4"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Lin, Y., He, F., Lian, S., Xie, B., Liu, T., He, J., and Liu, C. (2022). Selenium Status in Patients with Chronic Liver Disease: A Systematic Review and Meta-Analysis. Nutrients, 14.","DOI":"10.3390\/nu14050952"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1158\/1055-9965.EPI-05-0950","article-title":"Effects of Chemical Form of Selenium on Plasma Biomarkers in a High-Dose Human Supplementation Trial","volume":"15","author":"Burk","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2018.02.015","article-title":"Effect of Long-Term Selenium Supplementation on Mortality: Results from a Multiple-Dose, Randomised Controlled Trial","volume":"127","author":"Rayman","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s13311-018-0662-z","article-title":"Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer\u2019s Disease","volume":"16","author":"Cardoso","year":"2019","journal-title":"Neurotherapeutics"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Demircan, K., Bengtsson, Y., Sun, Q., Brange, A., Vallon-Christersson, J., Rijntjes, E., Malmberg, M., Saal, L.H., Ryd\u00e9n, L., and Borg, \u00c5. (2021). Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study. Redox Biol., 47.","DOI":"10.1016\/j.redox.2021.102145"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev.nutr.24.012003.132120","article-title":"Selenoprotein P: An extracellular protein with unique physical characteristics and a role in selenium homeostasis","volume":"25","author":"Burk","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.freeradbiomed.2022.08.022","article-title":"Selenoprotein P\u2014Selenium transport protein, enzyme and biomarker of selenium status","volume":"191","author":"Schomburg","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Brodin, O., Hackler, J., Misra, S., Wendt, S., Sun, Q., Laaf, E., Stoppe, C., Bj\u00f6rnstedt, M., and Schomburg, L. (2020). Selenoprotein P as biomarker of selenium status in clinical trials with therapeutic dosages of selenite. Nutrients, 12.","DOI":"10.3390\/nu12041067"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3945\/ajcn.2010.29642","article-title":"Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: A placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects","volume":"92","author":"Xia","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Sun, Q., Mehl, S., Renko, K., Seemann, P., G\u00f6rlich, C.L., Hackler, J., Minich, W.B., Kahaly, G.J., and Schomburg, L. (2021). Natural autoimmunity to selenoprotein P impairs selenium transport in Hashimoto\u2019s thyroiditis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222313088"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"15932","DOI":"10.1073\/pnas.252610699","article-title":"Selenosugars Are Key and Urinary Metabolites for Selenium Excretion within the Required to Low-Toxic Range","volume":"99","author":"Kobayashi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00216-005-0007-8","article-title":"Selenium Metabolites in Human Urine after Ingestion of Selenite, L-Selenomethionine, or DL-Selenomethionine: A Quantitative Case Study by HPLC\/ICPMS","volume":"383","author":"Kuehnelt","year":"2005","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1039\/d0mt00040j","article-title":"Identification and Determination of Selenocysteine, Selenosugar, and Other Selenometabolites in Turkey Liver","volume":"12","author":"Katarzyna","year":"2020","journal-title":"Metallomics"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Zambonino, M.C., Quizhpe, E.M., Mouheb, L., Rahman, A., Agathos, S.N., and Dahoumane, S.A. (2023). Biogenic selenium nanoparticles in biomedical sciences: Properties, current trends, novel opportunities and emerging challenges in theranostic nanomedicine. Nanomaterials, 13.","DOI":"10.3390\/nano13030424"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"133287","DOI":"10.1016\/j.jhazmat.2023.133287","article-title":"Amorphous Structure and Crystal Stability Determine the Bioavailability of Selenium Nanoparticles","volume":"465","author":"Li","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Yang, X., Fu, Y., Zhang, J., Liu, J., Liu, X., Peng, Y., Kyin, S.L., Zhang, M., and Zhou, D. (2023). Preparation, characterization, and antioxidant and antiapoptotic activities of biosynthesized nano-selenium by yak-derived Bacillus cereus and chitosan-encapsulated chemically synthesized nano-selenium. Int. J. Biol. Macromol., 242.","DOI":"10.1016\/j.ijbiomac.2023.124708"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.carbpol.2018.04.110","article-title":"Preparation, characteristics and antioxidant activity of polysaccharides and proteins-capped selenium nanoparticles synthesized by Lactobacillus casei ATCC 393","volume":"195","author":"Xu","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1039\/D0FO03141K","article-title":"Biogenic selenium nanoparticles by Lactobacillus casei ATCC 393 alleviate the intestinal permeability, mitochondrial dysfunction and mitophagy induced by oxidative stress","volume":"12","author":"Yan","year":"2021","journal-title":"Food Funct."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"153593","DOI":"10.1016\/j.tox.2023.153593","article-title":"Selenium nanoparticles alleviate deoxynivalenol-induced intestinal epithelial barrier dysfunction by regulating endoplasmic reticulum stress in IPEC-J2 cells","volume":"494","author":"Song","year":"2023","journal-title":"Toxicology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"114276","DOI":"10.1016\/j.ecoenv.2022.114276","article-title":"Dietary supplementation with selenium nanoparticles-enriched Lactobacillus casei ATCC 393 alleviates intestinal barrier dysfunction of mice exposed to deoxynivalenol by regulating endoplasmic reticulum stress and gut microbiota","volume":"248","author":"Song","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lei, X., Peng, Y., Li, Y., Chen, Q., Shen, Z., Yin, W., Lemiasheuski, V., Xu, S., and He, J. (2024). Effects of selenium nanoparticles produced by Lactobacillus acidophilus HN23 on lipid deposition in WRL68 cells. Bioorganic Chem., 145.","DOI":"10.1016\/j.bioorg.2024.107165"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"13439","DOI":"10.1021\/acsami.3c16340","article-title":"Stabilization by chaperone GroEL in biogenic selenium nanoparticles produced from Bifidobacterium animalis H15 for the treatment of DSS-induced colitis","volume":"16","author":"Li","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"EL-Sayed, A.I.M., El-Sheekh, M.M., and Abo-Neima, S.E. (2024). Mycosynthesis of selenium nanoparticles using Penicillium tardochrysogenum as a therapeutic agent and their combination with infrared irradiation against Ehrlich carcinoma. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-52982-9"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Hassan, M.G., Hawwa, M.T., Baraka, D.M., El-Shora, H.M., and Hamed, A.A. (2024). Biogenic selenium nanoparticles and selenium\/chitosan-Nanoconjugate biosynthesized by Streptomyces parvulus MAR4 with antimicrobial and anticancer potential. BMC Microbiol., 24.","DOI":"10.1186\/s12866-023-03171-7"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Li, K., Zhu, Y., Zhang, S., Xu, Q., and Guo, Y. (2024). Nitrate reductase involves in selenite reduction in Rahnella aquatilis HX2 and the characterization and anticancer activity of the biogenic selenium nanoparticles. J. Trace Elem. Med. Biol., 83.","DOI":"10.1016\/j.jtemb.2024.127387"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1039\/D0NA00984A","article-title":"Biogenic selenium nanoparticles produced by Lactobacillus casei ATCC 393 inhibit colon cancer cell growth in vitro and in vivo","volume":"3","author":"Spyridopoulou","year":"2021","journal-title":"Nanoscale Adv."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"119062","DOI":"10.1016\/j.envpol.2022.119062","article-title":"Potentials of orally supplemented selenium-enriched Lacticaseibacillus rhamnosus to mitigate the lead induced liver and intestinal tract injury","volume":"302","author":"Jin","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Liu, R., Sun, W., Sun, T., Zhang, W., Nan, Y., Zhang, Z., Xiang, K., Yang, H., Wang, F., and Ge, J. (2023). Nano selenium-enriched probiotic Lactobacillus enhances alum adjuvanticity and promotes antigen-specific systemic and mucosal immunity. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1116223"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijbiomac.2021.09.178","article-title":"Apoptosis of hepatocellular carcinoma HepG2 cells induced by seleno-ovalbumin (Se-OVA) via mitochondrial pathway","volume":"192","author":"Sun","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.foodchem.2016.01.016","article-title":"Selenium modification of \u03b2-lactoglobulin (\u03b2-Lg) and its biological activity","volume":"204","author":"Zheng","year":"2016","journal-title":"Food Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jff.2018.09.011","article-title":"Apoptosis and autophagy induction of Seleno-\u03b2-lactoglobulin (Se-\u03b2-Lg) on hepatocellular carcinoma cells lines","volume":"49","author":"Zhao","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ijbiomac.2017.12.152","article-title":"Characterization of Se-enriched Pleurotus ostreatus polysaccharides and their antioxidant effects in vitro","volume":"111","author":"Ma","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.carbpol.2016.12.041","article-title":"Structural elucidation and antioxidant activity a novel Se-polysaccharide from Se-enriched Grifola frondosa","volume":"161","author":"Li","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.apsb.2019.02.006","article-title":"Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway","volume":"9","author":"Liu","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Zhou, J., Zhang, N., Aldhahrani, A., Soliman, M.M., Zhang, L., and Zhou, F. (2022). Puerarin ameliorates nonalcoholic fatty liver in rats by regulating hepatic lipid accumulation, oxidative stress, and inflammation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.956688"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12944-018-0815-4","article-title":"Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet","volume":"17","author":"Zhang","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12011-017-1059-2","article-title":"Zinc and selenium co-supplementation reduces some lipid peroxidation and angiogenesis markers in a rat model of NAFLD-fed high fat diet","volume":"181","author":"Mousavi","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/iub.1991","article-title":"Role of vitamin E in nonalcoholic fatty liver disease","volume":"71","author":"Nagashimada","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"EFSA Scientific Committee (2012). Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured data. EFSA J., 10, 2579.","DOI":"10.2903\/j.efsa.2012.2579"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/15\/2484\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:18:33Z","timestamp":1760033913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/15\/2484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":151,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["nu17152484"],"URL":"https:\/\/doi.org\/10.3390\/nu17152484","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]}}}