{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:56:35Z","timestamp":1785419795026,"version":"3.56.0"},"reference-count":38,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012415","name":"Agency for Science, Technology and Research (A*STAR) Biomedical Research Council","doi-asserted-by":"publisher","award":["BMRC\/08\/1\/21\/19\/567"],"award-info":[{"award-number":["BMRC\/08\/1\/21\/19\/567"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Agency for Science, Technology and Research (A*STAR) Biomedical Research Council","doi-asserted-by":"publisher","award":["NMRC\/1108\/2007"],"award-info":[{"award-number":["NMRC\/1108\/2007"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Agency for Science, Technology and Research (A*STAR) Biomedical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CIRG\/1409\/2014"],"award-info":[{"award-number":["NMRC\/CIRG\/1409\/2014"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["BMRC\/08\/1\/21\/19\/567"],"award-info":[{"award-number":["BMRC\/08\/1\/21\/19\/567"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/1108\/2007"],"award-info":[{"award-number":["NMRC\/1108\/2007"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CIRG\/1409\/2014"],"award-info":[{"award-number":["NMRC\/CIRG\/1409\/2014"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: We studied the possible protective effect of dietary curcumin in curry meals against cognitive decline and mild cognitive impairment (MCI) and dementia in a population-based Singapore Longitudinal Ageing cohort study. Methods: Baseline curry consumption frequency was categorized as five categories ranging from \u2018never or rarely\u2019 to \u2018daily\u2019. Among 2920 participants (mean age 65.5 \u00b1 SD 7.1 years) free of stroke, Parkinson\u2019s disease, or traumatic brain injury at baseline, cognitive decline (MMSE drop \u22652) was assessed at 3\u20135 years (mean 4.5) follow-up. Occurrence of incident MCI-dementia was assessed at follow-up among 2446 participants without neurocognitive disorder at baseline. Results: A decreasing linear trend was observed between higher levels of curry consumption and cognitive decline (p = 0.037). The cumulative incidence of MCI-dementia decreased from 13.1% in those who never or rarely consumed curry to 3.6% in those who consumed curry daily (linear p &lt; 0.001). The adjusted OR across levels of curry consumption exhibited a linear trend (p = 0.021) from OR = 0.61 (p &lt; 0.05) for occasional consumption to OR = 0.21 (p &lt; 0.001) for daily consumption. Conclusions: The intake of dietary curcumin through curry shows a dose-dependent reduction in incidence of cognitive decline and MCI-dementia in this Asian population of community-based elders.<\/jats:p>","DOI":"10.3390\/nu17152488","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:37:23Z","timestamp":1753861043000},"page":"2488","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Curcumin-Rich Curry Consumption Is Associated with Lower Risk of Cognitive Decline and Incidence of Mild Cognitive Impairment or Dementia: An Asian Population-Based Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-7525","authenticated-orcid":false,"given":"Yanxia","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Medical Psychology and Ethics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tih Shih","family":"Lee","sequence":"additional","affiliation":[{"name":"Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3975-7230","authenticated-orcid":false,"given":"Wee Shiong","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics and Active Aging, Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore 308433, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9465-5937","authenticated-orcid":false,"given":"Philip","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Yee","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Rawtaer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Sengkang General Hospital, Singapore 544886, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-7752","authenticated-orcid":false,"given":"Tau Ming","family":"Liew","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Gwee","sequence":"additional","affiliation":[{"name":"Gerontological Research Programme (GRP), Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore 308433, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng Bee","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ng Teng Fong General Hospital, Singapore 609606, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Pin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore 768828, Singapore"},{"name":"Geriatric Education and Research Institute, Singapore 768024, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejmech.2018.12.016","article-title":"The therapeutic potential of curcumin: A review of clinical trials","volume":"163","author":"Salehi","year":"2019","journal-title":"Eur. 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