{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:35:12Z","timestamp":1790724912826,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Taste changes are common during pregnancy and can have a significant impact on dietary habits. Objective: This study aimed to investigate the influence of the perception of sweet and fat taste on diet in pregnant diabetic women. Methods: This cross-sectional observational study included 66 pregnant women, 33 with gestational diabetes and 33 with pre-gestational type 2 diabetes. Taste perception tests were conducted to evaluate thresholds for detecting sweet and fatty tastes. Dietary surveys were used to assess daily nutrient intake, and various biochemical parameters, such as glycemia, HbA1c, and cholesterol, were analyzed. Results: The low-fat taster group (threshold &gt; 0.75 mmol\/L) included more patients with diabetes compared to those with gestational diabetes. All diabetic patients had low sucrose perception. Although pregnant women with gestational diabetes detected sweetness at high concentrations, pregnant women with diabetes detected it at lower concentrations (0.012 \u00b1 0.023 mmol\/L vs. 0.006 \u00b1 0.005 mmol\/L; p = 0.3). High-fat tasters exhibited elevated glycemia compared to low-fat tasters (6.04 \u00b1 1.88 mmol\/L vs. 7.47 \u00b1 3.4 mmol\/L; p = 0.03). They also had higher cholesterol (p = 0.04) and lower HDL-C levels (4.96 \u00b1 1.04 mmol\/L vs. 1.36 \u00b1 0.29 mmol\/L; p = 0.03). High-fat tasters showed more frequent daily consumption of oil, butter, cheese, and chocolate. The highly sweet tasters had higher cholesterol levels and lower LDL levels. Individuals who reported being highly sensitive to sweet taste consumed more daily oil, sweetened yogurt, or cream desserts, as well as white sugar. Conclusions: These findings indicate that altered sensitivity to fat and sweet tastes is associated with different dietary habits and metabolic profiles in pregnant women with diabetes. Specifically, reduced sensitivity to the taste of fat is associated with higher consumption of high-fat foods and poorer lipid profiles. In contrast, sensitivity to sweet taste correlates with an increased intake of sugary and fatty foods. Understanding these taste-related behaviors can help develop personalized nutritional strategies to improve metabolic control and maternal\u2013fetal outcomes in this high-risk group.<\/jats:p>","DOI":"10.3390\/nu17152515","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:51:41Z","timestamp":1754038301000},"page":"2515","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sweet and Fat Taste Perception: Impact on Dietary Intake in Diabetic Pregnant Women\u2014A Cross-Sectional Observational Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-6862","authenticated-orcid":false,"given":"Inchirah","family":"Karmous","sequence":"first","affiliation":[{"name":"Research Unit on Obesity UR18ES01, Faculty of Medicine, University of Tunis El Manar, Tunis 1007, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-9778","authenticated-orcid":false,"given":"Rym","family":"Ben Othman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis 1007, Tunisia"},{"name":"National Institute of Nutrition and Food Technology, Tunis 1007, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-1856","authenticated-orcid":false,"given":"Ismail","family":"Dergaa","sequence":"additional","affiliation":[{"name":"Higher Institute of Sport and Physical Education of Ksar Sa\u00efd, University of Manouba, Manouba 2010, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-5511","authenticated-orcid":false,"given":"Halil \u0130brahim","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Physical Education of Sports Teaching Department, Faculty of Sports Sciences, Atat\u00fcrk University, Erzurum 25030, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrine","family":"Bey","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-546X","authenticated-orcid":false,"given":"Wissem","family":"Dhahbi","sequence":"additional","affiliation":[{"name":"Research Unit \u201cSport Sciences, Health and Movement\u201d, High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef 7100, Tunisia"},{"name":"Training Department, Police College, Qatar Police Academy, Doha 7157, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira Sayed","family":"Khan","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Research Center U1231, Team Physiology of Nutrition & Toxicology, Faculty of Life Sciences, University Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8215-3718","authenticated-orcid":false,"given":"Henda","family":"Jamoussi","sequence":"additional","affiliation":[{"name":"National Institute of Nutrition and Food Technology, Tunis 1007, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4615-6687","authenticated-orcid":false,"given":"Raul Ioan","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty of Law and Social Sciences, University \u201c1 Decembrie 1918\u201d of Alba Iulia, 510009 Alba Iulia, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-9332","authenticated-orcid":false,"given":"Naim Akhtar","family":"Khan","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Research Center U1231, Team Physiology of Nutrition & Toxicology, Faculty of Life Sciences, University Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2337\/dc16-2397","article-title":"In Utero Exposure to Maternal Hyperglycemia Increases Childhood Cardiometabolic Risk in Offspring","volume":"40","author":"Tam","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"A41","DOI":"10.1016\/S1262-3636(14)72344-4","article-title":"P50 Le diab\u00e8te gestationnel: Profil clinique, modalit\u00e9s de d\u00e9pistage et de prise en charge","volume":"40","author":"Maaroufi","year":"2014","journal-title":"Diabetes Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/ajcn.70.2.277","article-title":"Sweet taste and intake of sweet foods in normal pregnancy and pregnancy complicated by gestational diabetes mellitus","volume":"70","author":"Tepper","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2337\/diacare.26.2.302","article-title":"Dietary fat intake as risk factor for the development of diabetes: Multinational, multicenter study of the Mediterranean Group for the Study of Diabetes (MGSD)","volume":"26","author":"Thanopoulou","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2337\/diacare.24.9.1528","article-title":"Dietary fat and incidence of type 2 diabetes in older Iowa women","volume":"24","author":"Meyer","year":"2001","journal-title":"Diabetes Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"113191","DOI":"10.1016\/j.physbeh.2020.113191","article-title":"Decrease in sweet taste response and T1R3 sweet taste receptor expression in pregnant mice highlights a potential mechanism for increased caloric consumption in pregnancy","volume":"228","author":"Choo","year":"2021","journal-title":"Physiol. Behav."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1098\/rstb.2006.1853","article-title":"Psychophysics of sweet and fat perception in obesity: Problems, solutions and new perspectives","volume":"361","author":"Bartoshuk","year":"2006","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00394-016-1334-6","article-title":"Differences in food intake and genetic variability in taste receptors between Czech pregnant women with and without gestational diabetes mellitus","volume":"57","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2019). Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes\u20142019. Diabetes Care, 42, S13\u2013S28.","DOI":"10.2337\/dc19-S002"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.clnu.2017.06.004","article-title":"Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38","volume":"37","author":"Karmous","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1080\/07420528.2021.1897609","article-title":"Does lunar cycle affect biological parameters in young healthy men?","volume":"38","author":"Dergaa","year":"2021","journal-title":"Chronobiol. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/chemse\/bjv080","article-title":"Reliability of a simple method for determining salt taste detection and recognition thresholds","volume":"41","author":"Gallani","year":"2016","journal-title":"Chem. Senses"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/187152511794182855","article-title":"CD36 as a multiple-ligand signaling receptor in atherothrombosis","volume":"9","author":"Rademakers","year":"2011","journal-title":"Cardiovasc. Hematol. Agents Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.lfs.2010.12.015","article-title":"Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet","volume":"88","author":"Lynes","year":"2011","journal-title":"Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0031-9384(97)00193-5","article-title":"Nontasters, tasters, and supertasters of 6-n-propylthiouracil (PROP) and hedonic response to sweet","volume":"62","author":"Drewnowski","year":"1997","journal-title":"Physiol. Behav."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ijo.2011.155","article-title":"Recent fat intake modulates fat taste sensitivity in lean and overweight subjects","volume":"36","author":"Stewart","year":"2012","journal-title":"Int. J. Obes."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1161\/ATVBAHA.113.302917","article-title":"Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen","volume":"34","author":"Kuijpers","year":"2014","journal-title":"Arteroscler. Thromb. Vasc. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/j.biocel.2007.03.012","article-title":"CD36: Implications in cardiovascular disease","volume":"39","author":"Febbraio","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1017\/S0007114517003269","article-title":"Fatty acid transport receptor soluble CD36 and dietary fatty acid pattern in type 2 diabetic patients: A comparative study","volume":"119","author":"Ekici","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.numecd.2020.08.025","article-title":"Differences in taste and smell perception between type 2 diabetes mellitus patients and healthy controls","volume":"31","author":"Catamo","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wasalathanthri, S., Hettiarachchi, P., and Prathapan, S. (2014). Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: A comparative cross sectional study. BMC Endocr. Disord., 14.","DOI":"10.1186\/1472-6823-14-67"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/chemse\/bjp041","article-title":"Changes in sweet taste across pregnancy in mild gestational diabetes mellitus: Relationship to endocrine factors","volume":"34","author":"Belzer","year":"2009","journal-title":"Chem. Senses"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/0031-9384(90)90374-D","article-title":"Variations in human taste bud density and taste intensity perception","volume":"47","author":"Miller","year":"1990","journal-title":"Physiol. Behav."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0165-3806(94)90170-8","article-title":"Topographical differences in sweetness sensitivity in the peripheral gustatory system of adults and children","volume":"82","author":"Stein","year":"1994","journal-title":"Dev. Brain Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3945\/ajcn.2010.29836","article-title":"Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations","volume":"92","author":"Eny","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Habberstad, C., Drake, I., and Sonestedt, E. (2017). Variation in the sweet taste receptor gene and dietary intake in a Swedish middle-aged population. Front. Endocrinol., 8.","DOI":"10.3389\/fendo.2017.00348"},{"key":"ref_27","first-page":"379","article-title":"Functional roles of the sweet taste receptor in oral and extraoral tissues","volume":"17","author":"Laffitte","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/omi.2008.0031","article-title":"Genetic variation in taste and its influence on food selection","volume":"13","author":"Toguri","year":"2009","journal-title":"OMICS J. Integr. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mezei, G.C., Ural, S.H., and Hajnal, A. (2020). Differential Effects of Maternal High Fat Diet During Pregnancy and Lactation on Taste Preferences in Rats. Nutrients, 12.","DOI":"10.3390\/nu12113553"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1017\/S0007114510000267","article-title":"Oral sensitivity to fatty acids, food consumption and BMI in human subjects","volume":"104","author":"Stewart","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.appet.2016.03.011","article-title":"The influence of a high-fat meal on fat taste thresholds","volume":"101","author":"Newman","year":"2016","journal-title":"Appetite"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1142S","DOI":"10.3945\/jn.111.149575","article-title":"Sweetness and food preference","volume":"142","author":"Drewnowski","year":"2012","journal-title":"J. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.diabres.2014.02.007","article-title":"Decreased sucrose preference in patients with type 2 diabetes mellitus","volume":"104","author":"Yu","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wilk, K., Korytek, W., Pelczy\u0144ska, M., Moszak, M., and Bogda\u0144ski, P. (2022). The Effect of Artificial Sweeteners Use on Sweet Taste Perception and Weight Loss Efficacy: A Review. Nutrients, 14.","DOI":"10.3390\/nu14061261"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2000472","DOI":"10.1002\/mnfr.202000472","article-title":"Sweetness Perception is not Involved in the Regulation of Blood Glucose after Oral Application of Sucrose and Glucose Solutions in Healthy Male Subjects","volume":"65","author":"Schweiger","year":"2021","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/15\/2515\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:19:38Z","timestamp":1760033978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/15\/2515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":35,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["nu17152515"],"URL":"https:\/\/doi.org\/10.3390\/nu17152515","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}