{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:35:33Z","timestamp":1760060133309,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PT Sarihusada Generasi Mahardika, Jakarta, Indonesia","award":["025\/Legal\/SHJO-FKUI\/V\/12-287\/PKS\/FK\/UI\/2012","14.002\/INA-WNJ\/V\/2012"],"award-info":[{"award-number":["025\/Legal\/SHJO-FKUI\/V\/12-287\/PKS\/FK\/UI\/2012","14.002\/INA-WNJ\/V\/2012"]}]},{"name":"Indonesian Nutrition Association","award":["025\/Legal\/SHJO-FKUI\/V\/12-287\/PKS\/FK\/UI\/2012","14.002\/INA-WNJ\/V\/2012"],"award-info":[{"award-number":["025\/Legal\/SHJO-FKUI\/V\/12-287\/PKS\/FK\/UI\/2012","14.002\/INA-WNJ\/V\/2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and Objectives: Anemia and stunting are major public health concerns for young Indonesian children. Limited information is available from studies on multi-micronutrient supplements in Indonesia. The objective of this study was to investigate the effect of 12-month multi-micronutrient powder (MNP) supplementation on serum hemoglobin levels, anemia, and growth. Methods: A randomized double-blinded placebo-controlled study was performed, including 232 eligible children aged 8\u201310 months old. Children with severe anemia or stunting\/those classed as underweight were not included as subjects. The study was performed in a low-socioeconomic-status community in Jakarta. With an active-to-placebo ratio of 60:40, 139 subjects received MNP sachets twice\/day, and 93 subjects received placebo sachets, mixed with complementary food. The outcome parameters were hemoglobin level, anemia, and growth indicators. Per-protocol analysis was performed for 179 (intervention: 110; control: 69) subjects. Results: There were no differences at baseline between the groups, except for the weight-for-length z-scores (WLZ). Upon intervention, the serum hemoglobin level and anemia proportion did not change significantly within the group, and no significant differences were found between the groups (p &gt; 0.05). However, subgroup analysis of non-anemic children at baseline showed a significant increase in hemoglobin levels in the youngest age group (8.0\u20138.9 months old) receiving MNP compared to placebo (0.13 vs. \u22120.79, p = 0.031). Iron deficiency anemia proportion showed a similar upward trend upon intervention in both groups. No significant differences in growth were found between both groups. Conclusions: This study failed to find a significant effect of 12-month MNP supplementation on serum hemoglobin level, anemia, and growth.<\/jats:p>","DOI":"10.3390\/nu17152520","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:51:41Z","timestamp":1754038301000},"page":"2520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Hemoglobin Level, Anemia, and Growth Were Unaffected by a 12-Month Multiple-Micronutrient Powder Intervention Among Children Aged 8\u201310 Months in a Low-Socioeconomic-Status Community of Jakarta"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-0792","authenticated-orcid":false,"given":"Dian","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia"},{"name":"Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saptawati","family":"Bardosono","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-661X","authenticated-orcid":false,"given":"Tonny","family":"Sundjaya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Faculty of Public Health, Universitas Indonesia, Depok 16424, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-5868","authenticated-orcid":false,"given":"Tjhin","family":"Wiguna","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-5468","authenticated-orcid":false,"given":"Rini","family":"Sekartini","sequence":"additional","affiliation":[{"name":"Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2016). 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