{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:43:21Z","timestamp":1780044201485,"version":"3.53.1"},"reference-count":38,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004881","name":"Fondo de Investigaci\u00f3n en Salud, Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["FIS\/IMSS\/PROT\/PRIO\/19\/127"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/PRIO\/19\/127"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objective: In patients with acute lymphoblastic leukemia (ALL), it has been demonstrated that the treatment has a negative effect on bone health. The n-3 polyunsaturated fatty acids (LCPUFAs-\u03c93) may attenuate bone resorption. We evaluated the effects of LCPUFAs-\u03c93, vitamin D, and calcium supplementation on bone turnover markers and changes in vitamin D concentrations during 6 weeks of supplementation and during 6 weeks of post-intervention follow-up in pediatric patients with ALL. Methods: Thirty-six pediatric patients with ALL were randomly assigned to the \u03c9-3VDCa group (100 mg\/kg\/d LCPUFAs-\u03c93 + 4000 IU vitamin D + 1000 mg calcium) or the VDCa group (4000 IU vitamin D + 1000 mg calcium) for 6 weeks. Blood samples were collected to determine 25(OH)D, PTH, ICTP, and TRAP-5b (biomarkers of bone resorption) and osteocalcin (OC, a biomarker of bone production) levels at baseline, 6 weeks, and 12 weeks after supplementation. The 25(OH)D analysis was performed using ultra-high-performance liquid chromatography coupled to a mass spectrometer, and PTH and bone turnover markers were measured by ELISA. Results: The 25(OH)D concentration increased in both groups (\u03c93VDCa group: 19.4 ng\/mL vs. 44.0 ng\/mL, p &lt; 0.0001; VDCa group: 15.3 ng\/mL vs. 42.8 ng\/mL, p = 0.018) and remained significantly higher at 12 weeks. At 12 weeks, ICTP showed lower concentrations in the \u03c9-3VDCa group than in the VDCa group (0.74 ng\/mL vs. 1.05 ng\/mL, p = 0.024). Conclusions: Combined omega-3 and 4000 IU vitamin D supplementation for 6 weeks had a positive effect on bone health, as indicated by serum ICTP, with no effect on serum 25(OH)D levels over vitamin D supplementation alone.<\/jats:p>","DOI":"10.3390\/nu17152526","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:51:41Z","timestamp":1754038301000},"page":"2526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Omega-3 and Vitamin D Supplementation on Bone Turnover Markers in Children with Leukemia: Follow-Up During and After Supplementation"],"prefix":"10.3390","volume":"17","author":[{"given":"Lourdes","family":"Barbosa-Cort\u00e9s","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon B.","family":"Morales-Montes","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"},{"name":"Secci\u00f3n de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Maldonado-Alvarado","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Martin-Trejo","sequence":"additional","affiliation":[{"name":"Departamento Cl\u00ednico de Hematolog\u00eda, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Atilano-Miguel","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Jim\u00e9nez-Aguayo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabi\u00e1n I.","family":"Mart\u00ednez-Becerril","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"},{"name":"Facultad de Ciencias de la Salud, Universidad An\u00e1huac, Ciudad de M\u00e9xico 52786, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7318-580X","authenticated-orcid":false,"given":"V\u00edctor M.","family":"Cort\u00e9s-Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atzin V.","family":"Hern\u00e1ndez-Barbosa","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina A.","family":"Sol\u00eds-Labastida","sequence":"additional","affiliation":[{"name":"Departamento Cl\u00ednico de Hematolog\u00eda, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Maldonado-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito A.","family":"Bautista-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento Cl\u00ednico de Hematolog\u00eda, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azalia","family":"Ju\u00e1rez-Moya","sequence":"additional","affiliation":[{"name":"Departamento Cl\u00ednico de Hematolog\u00eda, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-7508","authenticated-orcid":false,"given":"Zayra","family":"Hern\u00e1ndez-Pi\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento Cl\u00ednico de Hematolog\u00eda, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Dom\u00ednguez-Salgado","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Villa-Morales","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Dom\u00ednguez-Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta 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