{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:33:30Z","timestamp":1760060010322,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Malnutrition and unintended weight loss are frequent in cancer patients and linked to poorer outcomes. However, data on long-term weight trajectories, particularly comparing different cancer entities, remain limited. Methods: In this retrospective, multicenter study, we analyzed 145 patients diagnosed with either head and neck cancer (HNC; n = 48) or high-grade B-cell lymphoma (HGBCL; n = 97). Body weight, C-reactive protein (CrP), albumin, and modified Glasgow Prognostic Score (mGPS) were assessed at diagnosis and at 3, 6, 9, and 12 months. Clinically relevant weight loss was defined as &gt;5% from baseline. Survival analyses were performed for HGBCL patients. Results: Weight loss was common in both cohorts, affecting 32.2% at 3 months and persisting in 42.3% at 12 months. Nearly half of HNC patients had sustained &gt;5% weight loss at one year, whereas HGBCL patients were more likely to regain weight, with significantly higher rates of weight gain at 6 and 12 months (p = 0.04 and p = 0.02). At baseline, HGBCL patients showed elevated CrP and lower albumin compared to HNC (both p &lt; 0.001). Weight loss at 6 months was significantly associated with reduced overall survival in HGBCL (p &lt; 0.01). Both \u0394weight at 6 months and mGPS emerged as useful prognostic indicators. Conclusions: This study reveals distinct patterns of weight change and systemic inflammation between HNC and HGBCL patients during the first year after diagnosis. These findings highlight the need for entity-specific nutritional monitoring and tailored supportive care strategies extending into survivorship. Prospective studies integrating body composition analyses are warranted to better guide long-term management.<\/jats:p>","DOI":"10.3390\/nu17152530","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:51:41Z","timestamp":1754038301000},"page":"2530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Not All Weight Loss Is Equal: Divergent Patterns and Prognostic Roles in Head and Neck Cancer Versus High-Grade B-Cell Lymphoma"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9531-7910","authenticated-orcid":false,"given":"Judith","family":"B\u00fcntzel","sequence":"first","affiliation":[{"name":"Department of Hematology and Medical Oncology, University Hospital, Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Westhofen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, University Hospital, Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilken","family":"Harms","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, University Hospital, Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7585-8956","authenticated-orcid":false,"given":"Markus","family":"Maulhardt","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, University Hospital, Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Casimir","family":"Angleitner","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, University Hospital, Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7242-5727","authenticated-orcid":false,"given":"Jens","family":"B\u00fcntzel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head Neck Surgery, S\u00fcdharz Hospital, 99734 Nordhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.3390\/curroncol31120565","article-title":"Symptom Burden and Dietary Changes Among Older Adults with Cancer: A Cross-Sectional Study","volume":"31","author":"Westhofen","year":"2024","journal-title":"Curr. 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