{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:48:18Z","timestamp":1792291698993,"version":"4.4.0"},"reference-count":116,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Statutory Subsidy Funds of the Department of Molecular and Cellular Biology","award":["SUBZ.D260.25.027"],"award-info":[{"award-number":["SUBZ.D260.25.027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Herbs from the Gentianaceae family are widely known for their medicinal and pharmacological properties. They were used centuries ago as a part of traditional medicine in China and Tibet. This review aims to draw attention to the potential uses of gentian herbs in treating various diseases, including skin conditions, gastrointestinal and liver disorders, wound healing, rheumatoid arthritis, and diabetes. The aim of our study was to systematically summarize current knowledge about key bioactive compounds present in both roots and aerial parts\u2014such as xanthones, iridoids, and flavonoids\u2014and highlight their pharmacological significance. We also focused on the Gentianaceae family\u2019s usage in complementary and alternative medicine, as well as their anti-inflammatory, anti-melanogenic, anti-ischemic, anti-fibrotic, and antioxidant properties, which can be utilized in the treatment and prevention of dermatological diseases, such as skin cancers. Here, we involve ethnomedicinal knowledge with modern pharmacological data; we also highlight the scientific relevance of gentian-derived compounds in drug development. This review concludes that these species represent a promising source of natural agents, while also underlining the need for further research and conservation strategies to preserve threatened species.<\/jats:p>","DOI":"10.3390\/nu17162619","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:30:38Z","timestamp":1755091838000},"page":"2619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gentianaceae Family\u2014Derived Bioactive Compounds\u2014Therapeutic Values and Supporting Role in Inflammation and Detoxification"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1827-6387","authenticated-orcid":false,"given":"Wiktoria","family":"Andryszkiewicz","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland"},{"name":"Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Chmielewska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland"},{"name":"Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3782-1468","authenticated-orcid":false,"given":"Julia","family":"Ciecierska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland"},{"name":"Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Lenkiewicz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland"},{"name":"Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktoria","family":"Marciniak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland"},{"name":"Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4544-1501","authenticated-orcid":false,"given":"Wiktoria","family":"Raczycka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland"},{"name":"Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Wojno","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland"},{"name":"Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8272-5440","authenticated-orcid":false,"given":"Julita","family":"Kulbacka","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"},{"name":"Department of Immunology and Bioelectrochemistry, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw","family":"Niewi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Bie\u017cu\u0144ska-Kusiak","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Barone, R.P., Knittel, D.K., Ooka, J.K., Porter, L.N., Smith, N.T., and Owens, D.K. 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