{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:03:21Z","timestamp":1783422201679,"version":"3.54.6"},"reference-count":34,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013263","name":"Norwegian Health Association","doi-asserted-by":"publisher","award":["7330"],"award-info":[{"award-number":["7330"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Identifying compounds with neuroprotective properties that target the neurogenic process will have a considerable impact on dementia prevention. Methods: This is a secondary analysis of a 24-week randomised, double-blind, placebo-controlled anthocyanin supplementation trial in 181 participants. Using blood-derived serum collected during this trial, we treated hippocampal progenitor cells and analysed the ensuing cellular changes in the context of the participant\u2019s clinical and blood-based biomarker data. Results: We show that anthocyanin supplementation impacts hippocampal progenitor cells and that this can impact hippocampal-dependent cognition. We also show for the first time that blood-based dementia biomarkers correlate with human in vitro neurogenesis markers. Conclusions: Our data demonstrates moderator effects of BMI and ApoE4 carrier status and supports the need for more individualised trials. Further studies are warranted to explore the mechanism of action of anthocyanins and the use of blood-based biomarkers for clinical trial enrichment, trial individualization, and therapy development. Trial registration: NCT03419039; date first registered: 15\/01\/2018.<\/jats:p>","DOI":"10.3390\/nu17162680","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:41:41Z","timestamp":1755603701000},"page":"2680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Oral Anthocyanin Supplementation on In Vitro Neurogenesis, Hippocampus-Dependent Cognition, and Blood-Based Dementia Biomarkers: Results from a 24-Week Randomized Controlled Trial in Older Adults At Risk for Dementia (ACID)"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7541-2814","authenticated-orcid":false,"given":"Chiara","family":"de Lucia","sequence":"first","affiliation":[{"name":"Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway"},{"name":"Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, Memory Lane, London S5 9NU, UK"},{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, 125 Coldharbour Lane, London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-9899","authenticated-orcid":false,"given":"Diego Alejandro","family":"Tovar-Rios","sequence":"additional","affiliation":[{"name":"Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway"},{"name":"Doctoral School Biomedical Sciences, Katholieke Universiteit, Herestraat 49, P.O. Box 700, 3000 Leuven, Belgium"},{"name":"Grupo de Investigaci\u00f3n en Estad\u00edstica Aplicada\u2014INFERIR, Universidad del Valle, Cali 760032, Colombia"},{"name":"Prevenci\u00f3n y Control de la Enfermedad Cr\u00f3nica\u2014PRECEC, Universidad del Valle, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway"},{"name":"The Faculty of Health Sciences, University of Stavanger, Telegrafdirekt\u00f8r Heftyes vei 73, 4021 Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silje Meihack","family":"Kvernberg","sequence":"additional","affiliation":[{"name":"Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Pola","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Wallinsgatan 6, 431 39 M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7299-3383","authenticated-orcid":false,"given":"Anne Katrine","family":"Bergland","sequence":"additional","affiliation":[{"name":"Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Haukelandsveien 28, 5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Maple-Gr\u00f8dem","sequence":"additional","affiliation":[{"name":"The Centre for Movement Disorders, Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway"},{"name":"Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Kristine Bonnevies vei 22, 4021 Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-9763","authenticated-orcid":false,"given":"Richard","family":"Siow","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine and Sciences, King\u2019s BHF Centre of Research Excellence, Faculty of Life Sciences & Medicine, King\u2019s College London, 50 Stamford Street, London SE1 9NH, UK"},{"name":"Department of Physiology, Anatomy and Genetics, Medical Sciences Division, University of Oxford, Sherrington Building, Sherrington Road, Oxford OX1 3PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Wallinsgatan 6, 431 39 M\u00f6lndal, Sweden"},{"name":"Banner Alzheimer\u2019s Institute, 901 E Willetta St, Phoenix, AZ 85006, USA"},{"name":"Banner Sun Health Research Institute, 10515 W Santa Fe Drive, Sun City, AZ 85351, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Ballard","sequence":"additional","affiliation":[{"name":"Department of Health and Community Sciences, Faculty of Life Sciences, University of Exeter, Heavitree Road, Exeter EX1 12LU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-8083","authenticated-orcid":false,"given":"Sandrine","family":"Thuret","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, 125 Coldharbour Lane, London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway"},{"name":"Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, Memory Lane, London S5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: A new immune\u2013metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. 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