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00387"],"award-info":[{"award-number":["2023 FISDU 00387"]}]},{"name":"Autonomous Government of Catalunya","award":["FI23\/00268"],"award-info":[{"award-number":["FI23\/00268"]}]},{"name":"Autonomous Government of Catalunya","award":["2024PMF-PIPF-01"],"award-info":[{"award-number":["2024PMF-PIPF-01"]}]},{"name":"Autonomous Government of Catalunya","award":["2021 SGR 00213"],"award-info":[{"award-number":["2021 SGR 00213"]}]},{"name":"Autonomous Government of Catalunya","award":["PV15110S"],"award-info":[{"award-number":["PV15110S"]}]},{"name":"Department de Recerca i Universitats de la Generalitat de Catalunya to the Nutrition and Metabolic Health Research Group","award":["2023 FISDU 00387"],"award-info":[{"award-number":["2023 FISDU 00387"]}]},{"name":"Department de Recerca i Universitats de la Generalitat de Catalunya to the Nutrition and Metabolic Health Research Group","award":["FI23\/00268"],"award-info":[{"award-number":["FI23\/00268"]}]},{"name":"Department de Recerca i Universitats de la Generalitat de Catalunya to the Nutrition and Metabolic Health Research Group","award":["2024PMF-PIPF-01"],"award-info":[{"award-number":["2024PMF-PIPF-01"]}]},{"name":"Department de Recerca i Universitats de la Generalitat de Catalunya to the Nutrition and Metabolic Health Research Group","award":["2021 SGR 00213"],"award-info":[{"award-number":["2021 SGR 00213"]}]},{"name":"Department de Recerca i Universitats de la Generalitat de Catalunya to the Nutrition and Metabolic Health Research Group","award":["PV15110S"],"award-info":[{"award-number":["PV15110S"]}]},{"name":"International Nut and Dried Fruit Council (INC)","award":["2023 FISDU 00387"],"award-info":[{"award-number":["2023 FISDU 00387"]}]},{"name":"International Nut and Dried Fruit Council (INC)","award":["FI23\/00268"],"award-info":[{"award-number":["FI23\/00268"]}]},{"name":"International Nut and Dried Fruit Council (INC)","award":["2024PMF-PIPF-01"],"award-info":[{"award-number":["2024PMF-PIPF-01"]}]},{"name":"International Nut and Dried Fruit Council (INC)","award":["2021 SGR 00213"],"award-info":[{"award-number":["2021 SGR 00213"]}]},{"name":"International Nut and Dried Fruit Council (INC)","award":["PV15110S"],"award-info":[{"award-number":["PV15110S"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Low semen quality and male infertility are critical global health issues. Emerging research highlights that nutritional factors could play a significant role in determining reproductive outcomes. Understanding and optimizing these dietary influences, including the role of polyphenols, is crucial for developing targeted strategies to improve male fertility. We aimed to explore the relationship between the intake of different classes of polyphenols and semen quality indicators in a cohort of healthy young males. Methods: This is a secondary analysis involving 106 male individuals, aged 18\u201335 years, from the FERTINUTS trial. Dietary intake was assessed using 3-day dietary records, and semen quality parameters were analyzed. Multivariable linear regression analysis was employed to evaluate the associations between dietary polyphenol consumption and semen quality indicators. Results: Our findings revealed both positive and negative associations between polyphenol consumption and sperm morphology parameters. A higher intake of total polyphenols was associated with a lower percentage of abnormalities in sperm heads but a higher rate of abnormalities in the principal piece. Similar results were observed for lignan and flavonoid intake. Additionally, a higher intake of flavonoids was also associated with a greater percentage of normal sperm forms. In contrast, a higher dietary intake of stilbenes was associated with a higher percentage of combined abnormalities. Conclusions: Higher intake of polyphenols, particularly flavonoids and lignans, was associated with improved sperm head morphology but also with increased tail abnormalities, although no associations with motility or vitality were observed. These results suggest that specific polyphenol classes may have both beneficial and adverse effects on sperm structure, warranting consideration of compound type and dosage in dietary recommendations. Further studies are needed to determine whether these morphological changes impact fertilization outcomes and reproductive potential.<\/jats:p>","DOI":"10.3390\/nu17172785","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:49:34Z","timestamp":1756309774000},"page":"2785","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Dietary Polyphenol Intake and Semen Quality: Insights from the FERTINUTS Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-9542","authenticated-orcid":false,"given":"Hamza","family":"Mostafa","sequence":"first","affiliation":[{"name":"Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV), 43201 Reus, Spain"},{"name":"Institute of Health Pere Virgili (IISPV), 43201 Reus, Spain"},{"name":"Center of Environmental, Food and Toxicological Technology (TecnATox), Rovira i Virgili University, 43201 Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1628-0118","authenticated-orcid":false,"given":"Javier","family":"Mateu-Fabregat","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV), 43201 Reus, Spain"},{"name":"Institute of Health Pere Virgili (IISPV), 43201 Reus, Spain"},{"name":"Center of Environmental, Food and Toxicological Technology (TecnATox), Rovira i Virgili University, 43201 Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-9429","authenticated-orcid":false,"given":"Asmae","family":"Benchohra","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV), 43201 Reus, Spain"},{"name":"Institute of Health Pere Virgili (IISPV), 43201 Reus, Spain"},{"name":"Center of Environmental, Food and Toxicological Technology (TecnATox), Rovira i Virgili University, 43201 Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7229-7540","authenticated-orcid":false,"given":"Nil","family":"Novau-Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV), 43201 Reus, Spain"},{"name":"Institute of Health Pere Virgili (IISPV), 43201 Reus, Spain"},{"name":"Center of Environmental, Food and Toxicological Technology (TecnATox), Rovira i Virgili University, 43201 Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2943-3450","authenticated-orcid":false,"given":"Laura","family":"Panisello","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV), 43201 Reus, Spain"},{"name":"Institute of Health Pere Virgili (IISPV), 43201 Reus, Spain"},{"name":"Center of Environmental, Food and Toxicological Technology (TecnATox), Rovira i Virgili University, 43201 Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-7046","authenticated-orcid":false,"given":"M\u00f2nica","family":"Bull\u00f3","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV), 43201 Reus, Spain"},{"name":"Institute of Health Pere Virgili (IISPV), 43201 Reus, Spain"},{"name":"Center of Environmental, Food and Toxicological Technology (TecnATox), Rovira i Virgili University, 43201 Reus, Spain"},{"name":"CIBER Physiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). Infertility Prevalence Estimates, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Caroppo, E., and Colpi, G.M. (2023). Male Infertility: A Review of Key Papers Appearing in the Reproductive Medicine and Andrology Section of the Journal of Clinical Medicine. J. Clin. Med., 12.","DOI":"10.3390\/jcm12062366"},{"key":"ref_3","first-page":"563","article-title":"The Impact of Selected Modifiable Lifestyle Factors on Male Fertility in the Modern World","volume":"73","author":"Balawender","year":"2020","journal-title":"Cent. Eur. J. Urol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kami\u0144ski, P., Baszy\u0144ski, J., Jerzak, I., Kavanagh, B.P., Nowacka-Chiari, E., Polanin, M., Szyma\u0144ski, M., Wo\u017aniak, A., and Kozera, W. (2020). External and Genetic Conditions Determining Male Infertility. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155274"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Tesarik, J. (2025). Lifestyle and Environmental Factors Affecting Male Fertility, Individual Predisposition, Prevention, and Intervention. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202503.1302.v1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4103\/aja202252","article-title":"The Effect of Healthy Dietary Patterns on Male Semen Quality: A Systematic Review and Meta-Analysis","volume":"24","author":"Cao","year":"2022","journal-title":"Asian J. Androl."},{"key":"ref_7","first-page":"215","article-title":"Association Between Adherence to the Mediterranean Diet and Semen Quality Parameters in Male Partners of Couples Attempting Fertility","volume":"32","author":"Karayiannis","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Petre, G.C., Francini-Pesenti, F., Di Nisio, A., De Toni, L., Grande, G., Mingardi, A., Cusmano, A., Spinella, P., Ferlin, A., and Garolla, A. (2023). Observational Cross-Sectional Study on Mediterranean Diet and Sperm Parameters. Nutrients, 15.","DOI":"10.3390\/nu15234989"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhang, L., Han, Z., and Granato, D. (2021). Polyphenols in Foods: Classification, Methods of Identification, and Nutritional Aspects in Human Health, Elsevier Inc.. [1st ed.].","DOI":"10.1016\/bs.afnr.2021.02.004"},{"key":"ref_10","first-page":"E36","article-title":"Modern Vision of the Mediterranean Diet","volume":"63","author":"Kiani","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.advnut.2023.01.002","article-title":"Efficacy of Dietary Polyphenols from Whole Foods and Purified Food Polyphenol Extracts in Optimizing Cardiometabolic Health: A Meta-Analysis of Randomized Controlled Trials","volume":"14","author":"Kiyimba","year":"2023","journal-title":"Adv. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zupo, R., Castellana, F., Lisco, G., Corbo, F., Crupi, P., Sardone, R., Panza, F., Lozupone, M., Rondanelli, M., and Clodoveo, M.L. (2024). Dietary Intake of Polyphenols and All-Cause Mortality: A Systematic Review with Meta-Analysis. Metabolites, 14.","DOI":"10.3390\/metabo14080404"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pot\u00ec, F., Santi, D., Spaggiari, G., Zimetti, F., and Zanotti, I. (2019). Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020351"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zubair, M., Partyka, A., and Martyniuk, C.J. (2025). Polyphenols as a Strategy for Improving Male Reproductive System. Mol. Biol. Rep., 52.","DOI":"10.1007\/s11033-025-10240-9"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8926075","DOI":"10.1155\/2019\/8926075","article-title":"Antioxidant Effect of the Castanea Sativa Mill. Leaf Extract on Oxidative Stress Induced upon Human Spermatozoa","volume":"2019","author":"Biagi","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100153","DOI":"10.1016\/j.advnut.2023.100153","article-title":"Nut Consumption and Fertility: A Systematic Review and Meta-Analysis","volume":"15","author":"Cardoso","year":"2024","journal-title":"Adv. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ferramosca, A., and Zara, V. (2022). Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052542"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/ptr.4799","article-title":"A New Perspective on the Quercetin Paradox in Male Reproductive Dysfunction","volume":"27","author":"Ranawat","year":"2013","journal-title":"Phytother. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Di Lorenzo, C., Colombo, F., Biella, S., Stockley, C., and Restani, P. (2021). Polyphenols and Human Health: The Role of Bioavailability. Nutrients, 13.","DOI":"10.3390\/nu13010273"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-food-060721-023817","article-title":"Bioavailability of Food Polyphenols: Current State of Knowledge","volume":"16","author":"Williamson","year":"2025","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/ajcn\/nqy181","article-title":"Effect of Nut Consumption on Semen Quality and Functionality in Healthy Men Consuming a Western-Style Diet: A Randomized Controlled Trial","volume":"108","author":"Moraleda","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","unstructured":"Mataix, J. (2003). Tabla de Composici\u00f3n de Alimentos 4a Edici\u00f3n Corregida y Aumentada, Editorial Universidad de Granada. [4th ed.]."},{"key":"ref_23","unstructured":"WHO World Health Organization (2024). WHO Laboratory Manual for the Examination and Processing of Human Semen, World Health Organization. [5th ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/rda.12891","article-title":"Epigallocatechin-3-Gallate (EGCG) and Green Tea Polyphenols Do Not Improve Stallion Semen Parameters during Cooling at 4 \u00b0C","volume":"52","author":"Bucci","year":"2017","journal-title":"Reprod. Domest. Anim."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Akomolafe, S.F., Oyeleye, S.I., and Oboh, G. (2022). Effect of Cashew (Anacardium occidentale L.) Nut-Supplemented Diet on Steroidogenic Enzymes, Hormonal and Oxidative Imbalances, and Sperm Parameters in Cisplatin-Induced Reproductive Toxicity in Male Rats. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14100"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.sjbs.2020.11.043","article-title":"Effects of Dietary Plant Polyphenols and Seaweed Extract Mixture on Male-Rabbit Semen: Quality Traits and Antioxidant Markers","volume":"28","author":"Vizzari","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Illiano, E., Trama, F., Zucchi, A., Iannitti, R.G., Fioretti, B., and Costantini, E. (2020). Resveratrol-Based Multivitamin Supplement Increases Sperm Concentration and Motility in Idiopathic Male Infertility: A Pilot Clinical Study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9124017"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"nzz039.P18-042-19","DOI":"10.1093\/cdn\/nzz039.P18-042-19","article-title":"Randomized Clinical Trial: Effect of Walnuts on Semen Parameters and Male Fertility (P18-042-19)","volume":"3","author":"Robbins","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.envint.2019.04.076","article-title":"Associations between Semen Phytoestrogens Concentrations and Semen Quality in Chinese Men","volume":"129","author":"Yuan","year":"2019","journal-title":"Environ. Int."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mongio\u00ec, L.M., Perelli, S., Condorelli, R.A., Barbagallo, F., Crafa, A., Cannarella, R., La Vignera, S., and Calogero, A.E. (2021). The Role of Resveratrol in Human Male Fertility. Molecules, 26.","DOI":"10.3390\/molecules26092495"},{"key":"ref_31","first-page":"1122","article-title":"Resveratrol and Male Infertility: A Systematic Review of the Literature","volume":"4","author":"Cannarella","year":"2024","journal-title":"Minerva Endocrinol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1615\/JEnvironPatholToxicolOncol.2016015298","article-title":"Resveratrol Alleviates Cadmium-Induced Damage and Overexpression of Epidermal Growth Factor Receptor and Its Downstream Signaling Proteins in the Reproductive System of Male Swiss Albino Mice","volume":"35","author":"Mitra","year":"2016","journal-title":"J. Environ. Pathol. Toxicol. Oncol. Off. Organ. Int. Soc. Environ. Toxicol. 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