{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:01:06Z","timestamp":1792008066492,"version":"4.4.0"},"reference-count":122,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bezos Earth Foundation","award":["A-8003360-14-00"],"award-info":[{"award-number":["A-8003360-14-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Arabinoxylan (AX) has shown potential benefits in glycemic control; however, findings remain inconclusive. This systematic review and meta-analysis aimed to assess the impact of AX intake on glycemic control in preclinical and clinical studies. Methods: A database search was conducted in PubMed, Embase, Cochrane Library, and CINAHL. A total of 133 studies were included for systematic review and extracted data from 46 clinical studies and 25 preclinical studies were further analyzed for meta-analysis. Results: The AX consumption improved overall postprandial glycemic control in clinical studies, as evidenced by reductions in glucose iAUC (SMD: \u22120.41; 95% CI: [\u22120.57, \u22120.25]), insulin iAUC (SMD: \u22120.28; 95% CI: [\u22120.44, \u22120.12]), glucose iPeak (SMD: \u22120.52; 95% CI: [\u22120.80, \u22120.25]), and insulin iPeak (SMD: \u22120.24; 95% CI: [\u22120.41, \u22120.06]) compared to the control. For chronic glycemic control, fasting glucose (Hedges\u2019 g: \u22121.18; 95% CI: [\u22121.56, \u22120.80]), insulin (Hedges\u2019 g: \u22121.07; 95% CI: [\u22121.92, \u22120.23]), HbA1c (Hedges\u2019 g: \u22122.93; 95% CI: [\u22125.48, \u22120.38]), and HOMA-IR (Hedges\u2019 g: \u22122.44; 95% CI: [\u22123.66, \u22121.22]) reduced in preclinical studies, while improvements were limited to fasting glucose (MD: \u22120.10; 95% CI: [\u22120.16, \u22120.03]) in clinical studies. Subgroup analyses revealed that AX exerted a greater glycemic-lowering effect in metabolically impaired animals and individuals compared to healthy counterparts. Furthermore, extracted AX was found to be more effective than intrinsic AX in optimizing glycemic control. Conclusions: The consumption of AX improves glycemic control, particularly in metabolically impaired animals and human participants. Moreover, the benefit appears more pronounced with extract AX interventions.<\/jats:p>","DOI":"10.3390\/nu17172840","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T14:02:46Z","timestamp":1756735366000},"page":"2840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Arabinoxylan Consumption on Glycemic Control: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies"],"prefix":"10.3390","volume":"17","author":[{"given":"Yujing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology, National University of Singapore, Singapore 117543, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, National University of Singapore, Singapore 117543, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3912-9042","authenticated-orcid":false,"given":"Jung Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, National University of Singapore, Singapore 117543, Singapore"},{"name":"Bezos Centre for Sustainable Protein, National University of Singapore, Singapore 117542, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41572-024-00563-5","article-title":"Metabolic syndrome","volume":"10","author":"Neeland","year":"2024","journal-title":"Nat. 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