{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:39:37Z","timestamp":1791956377634,"version":"4.3.4"},"reference-count":223,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Neurodegenerative diseases (NDs) encompass a group of chronic conditions, characterized by neuronal losses in large areas of the brain, leading to cognitive and behavioral impairments. Alzheimer\u2019s Disease (AD), the most common form of dementia, is a progressive ND, characterized by the accumulation of amyloid \u03b2 and tau protein, entails cognitive decline, neuroinflammation, mitochondrial dysfunction, and blood\u2013brain barrier impairment, with oxidative stress playing a critical role in its pathogenesis. To date, the available pharmacotherapy has shown limited efficacy, and multitarget activity of plant-derived neuroprotective bioactive compounds is currently in focus. This review synthesizes experimental evidence regarding Ocimum species with neuroprotective potential in AD, particularly Ocimum sanctum and Ocimum basilicum. These plants are rich in bioactive compounds including polyphenols, flavonoids, essential oils, and triterpenoids that synergistically scavenge reactive oxygen\/nitrogen species, upregulate endogenous antioxidant enzymes (SOD, CAT, and GPx), and reduce lipid peroxidation. Furthermore, these extracts have demonstrated the ability to decrease \u03b2-amyloid accumulation and tau protein levels, key pathological features of AD. Even though additional research is required to fully assess their potential as therapeutic agents for NDs, by diving into the specific mechanisms through which they improve neurodegenerative processes, important steps can be made towards this endpoint.<\/jats:p>","DOI":"10.3390\/nu17172877","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T12:18:18Z","timestamp":1757074698000},"page":"2877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Neuroprotective Potential of Ocimum Plant Species: Seasoning the Mind with Sweet and Holy Basil"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-6496","authenticated-orcid":false,"given":"Alexandru","family":"Vasincu","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-325X","authenticated-orcid":false,"given":"R\u0103zvan-Nicolae","family":"Rusu","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5568-2123","authenticated-orcid":false,"given":"Daniela-Carmen","family":"Ababei","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Bulea","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana Dana","family":"Arcan","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-2789","authenticated-orcid":false,"given":"Ioana Mirela","family":"Vasincu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Be\u0219chea Chiriac","sequence":"additional","affiliation":[{"name":"Department of Veterinary Toxicology, \u201cIon Ionescu de la Brad\u201d University of Life Sciences, 8 M. Sadoveanu Alley, 700489 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4260-9565","authenticated-orcid":false,"given":"Ionu\u021b-R\u0103ducu","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-8020","authenticated-orcid":false,"given":"Walther","family":"Bild","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"\u201cOlga Necrasov\u201d Center of Anthropological and Biomedical Research, Romanian Academy, Iasi Branch, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-0345","authenticated-orcid":false,"given":"Veronica","family":"Bild","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"\u201cOlga Necrasov\u201d Center of Anthropological and Biomedical Research, Romanian Academy, Iasi Branch, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dugger, B.N., and Dickson, D.W. 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