{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:53:18Z","timestamp":1788299598367,"version":"build-2803163510"},"reference-count":80,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Metabolic dysfunction-associated steatosis liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver related morbidity and mortality affecting 38% of the adult global population. As of now, there is no clear consensus on a standardized pharmacological treatment for MASLD; therefore, lifestyle interventions particularly diet and exercise remain the first-line approach for both prevention and management. Extra virgin olive oil (EVOO), the primary source of fat in the Mediterranean diet. (MD) is widely recognized as a key contributor to its well-documented health benefits. As a central component of this dietary pattern, EVOO has demonstrated promising therapeutic potential due to its high phenolic content. The primary aim of this review is to synthesize existing human studies examining the effects of olive oil primarily EVOO on key pathological features of MASLD. Methods: A systematic search of human clinical and observational studies was conducted across major databases. Key outcomes assessed include hepatic steatosis, inflammation, oxidative stress, fibrosis, liver enzymes, and anthropometric measures. Study quality was evaluated using the Academy of Nutrition and Dietetics Quality Criteria Checklist. Results: This review included 25 high-quality studies, 12 of which assessed olive oil alone and 13 evaluated the MD emphasizing extra virgin olive oil (EVOO). EVOO-rich interventions consistently improved hepatic steatosis, liver enzyme levels (ALT, AST), and inflammatory markers in MASLD patients, particularly when paired with calorie-restricted or MD patterns. Benefits were dose- and type-dependent, with EVOO showing superior effects compared to refined olive oils. Modest improvements in lipid profiles and insulin resistance were observed. Longer study durations and higher EVOO intake (&gt;30\u201350 g\/day) yielded greater improvements. Findings suggest EVOO may exert beneficial effects on liver health through its anti-inflammatory and antioxidant properties. Future studies on EVOO\u2019s role in MASLD should use well-characterized oils with known polyphenol and bioactive compound levels and include clear biomarkers of oxidative stress, inflammation, and liver health outcomes on humans. Overall, EVOO represents a promising, non-pharmacological strategy for MASLD prevention and management. Conclusions: Current evidence suggests that EVOO, particularly when rich in phenolic compounds, is a promising dietary strategy for managing MASLD due to its hepato-protective effects, especially within a Mediterranean diet framework. However, findings are limited by study heterogeneity and a lack of high-quality randomized controlled trials, highlighting the need for future research to refine optimal dosing, assess long-term outcomes, and clarify underlying mechanisms.<\/jats:p>","DOI":"10.3390\/nu17182932","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:23:50Z","timestamp":1757600630000},"page":"2932","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploring the Role of Extra Virgin Olive Oil (EVOO) in MASLD: Evidence from Human Consumption"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3625-6775","authenticated-orcid":false,"given":"Melvin","family":"Bernardino","sequence":"first","affiliation":[{"name":"MASLD Unit, Fondazione Italiana Fegato, 34149 Trieste, Italy"},{"name":"Department of Life Sciences, University of Trieste, 34100 Trieste, Italy"},{"name":"Philippine Council for Health Research and Development, Department of Science and Technology, Taguig City 1631, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-7595","authenticated-orcid":false,"given":"Claudio","family":"Tiribelli","sequence":"additional","affiliation":[{"name":"MASLD Unit, Fondazione Italiana Fegato, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-3547","authenticated-orcid":false,"given":"Natalia","family":"Rosso","sequence":"additional","affiliation":[{"name":"MASLD Unit, Fondazione Italiana Fegato, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: A systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction-associated steatotic liver disease","volume":"31","author":"Younossi","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"EASL\u2013EASD\u2013EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"81","author":"Tacke","year":"2024","journal-title":"J. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e70225","DOI":"10.1111\/liv.70225","article-title":"Metabolic Dysfunction\u2013Associated Steatohepatitis Diagnosis and Management in Germany: Insights from an Expert Consensus Panel","volume":"45","author":"Kim","year":"2025","journal-title":"Liver Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"156028","DOI":"10.1016\/j.metabol.2024.156028","article-title":"The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus","volume":"161","author":"Zeng","year":"2024","journal-title":"Metabolism"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/gerona\/glx227","article-title":"Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms","volume":"73","author":"Tosti","year":"2018","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bucciantini, M., Leri, M., Nardiello, P., Casamenti, F., and Stefani, M. (2021). Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants, 10.","DOI":"10.3390\/antiox10071044"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Reyes-Goya, C., Santana-Garrido, \u00c1., Espinosa-Mart\u00edn, P., V\u00e1zquez, C.M., and Mate, A. (2024). Wild and cultivated olive trees: Nutraceutical insights of extra virgin olive oils in cardiovascular and ocular diseases. Biochim. Biophys. Acta BBA Mol. Basis Dis., 1870.","DOI":"10.1016\/j.bbadis.2023.166904"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Jimenez-Lopez, C., Carpena, M., Louren\u00e7o-Lopes, C., Gallardo-Gomez, M., Lorenzo, J.M., Barba, F.J., Prieto, M.A., and Simal-Gandara, J. (2020). Bioactive Compounds and Quality of Extra Virgin Olive Oil. Foods, 9.","DOI":"10.3390\/foods9081014"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.3748\/wjg.15.1809","article-title":"Olive oil consumption and non-alcoholic fatty liver disease","volume":"15","author":"Assy","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.maturitas.2018.10.013","article-title":"Olive oil consumption and human health: A narrative review","volume":"118","author":"Foscolou","year":"2018","journal-title":"Maturitas"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jand.2015.11.008","article-title":"Academy of Nutrition and Dietetics Methodology for Conducting Systematic Reviews for the Evidence Analysis Library","volume":"116","author":"Handu","year":"2016","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Myers, E., Parrott, J., Cummins, D., and Splett, P. (2011). Funding Source and Research Report Quality in Nutrition Practice-Related Research. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028437"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mondon, C., Tan, P.Y., Chan, C.L., Tran, T.N., and Gong, Y.Y. (2024). Prevalence, determinants, intervention strategies and current gaps in addressing childhood malnutrition in Vietnam: A systematic review. BMC Public Health, 24.","DOI":"10.1186\/s12889-024-18419-8"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e000139","DOI":"10.1136\/bmjgast-2017-000139","article-title":"Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease: A systematic review","volume":"4","author":"Kenneally","year":"2017","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1097\/HEP.0000000000000670","article-title":"Metabolic dysfunction\u2013associated steatotic liver disease: Update and impact of new nomenclature on the American Association for the Study of Liver Diseases practice guidance on nonalcoholic fatty liver disease","volume":"79","author":"Kanwal","year":"2024","journal-title":"Hepatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s42255-024-00985-1","article-title":"From NAFLD to MASLD: Implications of the new nomenclature for preclinical and clinical research","volume":"6","author":"Hsu","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nut.2018.02.021","article-title":"Olive oil lessened fatty liver severity independent of cardiometabolic correction in patients with non-alcoholic fatty liver disease: A randomized clinical trial","volume":"57","author":"Rezaei","year":"2019","journal-title":"Nutrition"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3109\/09637486.2010.487480","article-title":"Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: A preliminary study","volume":"61","author":"Sofi","year":"2010","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Patti, A.M., Carruba, G., Cicero, A.F.G., Banach, M., Nikolic, D., Giglio, R.V., Terranova, A., Soresi, M., Giannitrapani, L., and Montalto, G. (2020). Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study. Metabolites, 10.","DOI":"10.3390\/metabo10100392"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1093\/jn\/nxz147","article-title":"A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk","volume":"149","author":"Corbella","year":"2019","journal-title":"J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1089\/dia.2013.0178","article-title":"Effect of a 6-Month Intervention with Cooking Oils Containing a High Concentration of Monounsaturated Fatty Acids (Olive and Canola Oils) Compared with Control Oil in Male Asian Indians with Nonalcoholic Fatty Liver Disease","volume":"16","author":"Nigam","year":"2014","journal-title":"Diabetes Technol. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2000419","DOI":"10.1002\/mnfr.202000419","article-title":"Dietary Rapeseed Oil Supplementation Reduces Hepatic Steatosis in Obese Men\u2014A Randomized Controlled Trial","volume":"64","author":"Kruse","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Tobin, D., Brevik-Andersen, M., Qin, Y., Innes, J.K., and Calder, P.C. (2018). Evaluation of a High Concentrate Omega-3 for Correcting the Omega-3 Fatty Acid Nutritional Deficiency in Non-Alcoholic Fatty Liver Disease (CONDIN). Nutrients, 10.","DOI":"10.20944\/preprints201807.0240.v1"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1053710","DOI":"10.1155\/2018\/1053710","article-title":"The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients Undergoing Low Calorie Diet","volume":"2018","author":"Shidfar","year":"2018","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_29","first-page":"435","article-title":"Changes in fatty liver index after consuming a Mediterranean diet: 6-Year follow-up of the PREDIMED-Malaga trial","volume":"148","author":"Valdivielso","year":"2017","journal-title":"Med. Cl\u00edn. Engl. Ed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12944-021-01433-9","article-title":"The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: A randomized controlled trial","volume":"20","author":"Yahay","year":"2021","journal-title":"Lipids Health Dis."},{"key":"ref_31","first-page":"57","article-title":"The Effect of a Hypocaloric Diet Containing Olive Oil on Hepatic Steatosis Grading Using Tissue Elastography: A Randomized Controlled Trial","volume":"12","author":"Keshk","year":"2022","journal-title":"Afro-Egypt. J. Infect. Endem. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/hep.27289","article-title":"Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study","volume":"60","author":"Scorletti","year":"2014","journal-title":"Hepatology"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Quetglas-Llabr\u00e9s, M.M., Monserrat-Mesquida, M., Bouzas, C., Garc\u00eda, S., Argelich, E., Casares, M., Ugarriza, L., Llompart, I., Tur, J.A., and Sureda, A. (2024). Impact of Adherence to the Mediterranean Diet on Antioxidant Status and Metabolic Parameters in NAFLD Patients: A 24-Month Lifestyle Intervention Study. Antioxidants, 13.","DOI":"10.3390\/antiox13040480"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/liv.15264","article-title":"Impact of a Mediterranean diet on hepatic and metabolic outcomes in non-alcoholic fatty liver disease: The MEDINA randomised controlled trial","volume":"42","author":"George","year":"2022","journal-title":"Liver Int."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ristic-Medic, D., Kovacic, M., Takic, M., Arsic, A., Petrovic, S., Paunovic, M., Jovicic, M., and Vucic, V. (2021). Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease. Nutrients, 13.","DOI":"10.3390\/nu13010015"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Marin-Alejandre, B.A., Abete, I., Cantero, I., Monreal, J.I., Elorz, M., Herrero, J.I., Benito-Boillos, A., Quiroga, J., Martinez-Echeverria, A., and Uriz-Otano, J.I. (2019). The Metabolic and Hepatic Impact of Two Personalized Dietary Strategies in Subjects with Obesity and Nonalcoholic Fatty Liver Disease: The Fatty Liver in Obesity (FLiO) Randomized Controlled Trial. Nutrients, 11.","DOI":"10.3390\/nu11102543"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1089\/jmf.2018.0020","article-title":"The Effectiveness of Mediterranean Diet in Nonalcoholic Fatty Liver Disease Clinical Course: An Intervention Study","volume":"22","author":"Kaliora","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Barrea, L., Verde, L., Savastano, S., Colao, A., and Muscogiuri, G. (2023). Adherence to Mediterranean Diet: Any Association with NAFLD?. Antioxidants, 12.","DOI":"10.3390\/antiox12071318"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Montemayor, S., Mascar\u00f3, C.M., Ugarriza, L., Casares, M., Llompart, I., Abete, I., Zulet, M.\u00c1., Mart\u00ednez, J.A., Tur, J.A., and Bouzas, C. (2022). Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study. Nutrients, 14.","DOI":"10.3390\/nu14153186"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/hep.30076","article-title":"Ad Libitum Mediterranean and Low-Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial","volume":"68","author":"Properzi","year":"2018","journal-title":"Hepatology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1017\/S000711451800137X","article-title":"Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle: A randomised controlled clinical trial","volume":"120","author":"Katsagoni","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.3748\/wjg.v23.i17.3150","article-title":"Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease","volume":"23","author":"Gelli","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Abbate, M., Mascar\u00f3, C.M., Montemayor, S., Barber\u00eda-Latasa, M., Casares, M., G\u00f3mez, C., Angullo-Martinez, E., Tejada, S., Abete, I., and Zulet, M.A. (2021). Energy Expenditure Improved Risk Factors Associated with Renal Function Loss in NAFLD and MetS Patients. Nutrients, 13.","DOI":"10.3390\/nu13020629"},{"key":"ref_44","first-page":"2518","article-title":"Mediterranean Diet Is Associated With Liver Histology In Patients With Non Alcoholic Fatty Liver Disease","volume":"32","author":"Aller","year":"2015","journal-title":"Nutr. Hosp."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/ajg.2017.371","article-title":"Adherence to Mediterranean Diet and Non-Alcoholic Fatty Liver Disease: Effect on Insulin Resistance","volume":"112","author":"Baratta","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.3390\/nu4121989","article-title":"Monounsaturated Fatty Acids and Risk of Cardiovascular Disease: Synopsis of the Evidence Available from Systematic Reviews and Meta-Analyses","volume":"4","author":"Schwingshackl","year":"2012","journal-title":"Nutrients"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Mancebo-Campos, V., Salvador, M.D., and Fregapane, G. (2023). EFSA Health Claims-Based Virgin Olive Oil Shelf-Life. Antioxidants, 12.","DOI":"10.3390\/antiox12081563"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1080\/10408398.2018.1470491","article-title":"The effect of high-polyphenol extra virgin olive oil on cardiovascular risk factors: A systematic review and meta-analysis","volume":"59","author":"George","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Shabalala, S.C., Dludla, P.V., Mabasa, L., Kappo, A.P., Basson, A.K., Pheiffer, C., and Johnson, R. (2020). The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling. Biomed. Pharmacother., 131.","DOI":"10.1016\/j.biopha.2020.110785"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Bouzas, C., Bibiloni, M.M., Julibert, A., Ruiz-Canela, M., Salas-Salvad\u00f3, J., Corella, D., Zome\u00f1o, M.D., Romaguera, D., Vioque, J., and Alonso-G\u00f3mez, \u00c1.M. (2020). Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study. Nutrients, 12.","DOI":"10.3390\/nu12072114"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Gonz\u00e1lez, M.A., Garc\u00eda-Arellano, A., Toledo, E., Salas-Salvad\u00f3, J., Buil-Cosiales, P., Corella, D., Covas, M.I., Schr\u00f6der, H., Ar\u00f3s, F., and G\u00f3mez-Gracia, E. (2012). A 14-Item Mediterranean Diet Assessment Tool and Obesity Indexes among High-Risk Subjects: The PREDIMED Trial. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043134"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ypmed.2006.12.009","article-title":"Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore","volume":"44","author":"Panagiotakos","year":"2007","journal-title":"Prev. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3945\/jn.110.135566","article-title":"A short screener is valid for assessing Mediterranean diet adherence among older Spanish men and women","volume":"141","author":"Estruch","year":"2011","journal-title":"J. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/joim.13333","article-title":"The Mediterranean diet and health: A comprehensive overview","volume":"290","author":"Willett","year":"2021","journal-title":"J. Intern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1080\/10408398.2019.1565281","article-title":"Mediterranean diet, cardiovascular disease and mortality in diabetes: A systematic review and meta-analysis of prospective cohort studies and randomized clinical trials","volume":"60","author":"Viguiliouk","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"102509","DOI":"10.1016\/j.cpcardiol.2024.102509","article-title":"Long-term impact of mediterranean diet on cardiovascular disease prevention: A systematic review and meta-analysis of randomized controlled trials","volume":"49","author":"Sebastian","year":"2024","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/wvn.12608","article-title":"The effectiveness of lifestyle interventions for diabetes remission on patients with type 2 diabetes mellitus: A systematic review and meta-analysis","volume":"20","author":"Zhang","year":"2023","journal-title":"Worldviews Evid. Based Nurs."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11154-013-9253-9","article-title":"Mediterranean diet and metabolic syndrome: An updated systematic review","volume":"14","author":"Esposito","year":"2013","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/nep.13778","article-title":"Mediterranean diet and the risk of chronic kidney disease: A systematic review and meta-analysis","volume":"25","author":"Hansrivijit","year":"2020","journal-title":"Nephrol. Carlton Vic"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/clinpract13010004","article-title":"Effects of Mediterranean Diet, DASH Diet, and Plant-Based Diet on Outcomes among End Stage Kidney Disease Patients: A Systematic Review and Meta-Analysis","volume":"13","author":"Charkviani","year":"2022","journal-title":"Clin. Pract."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1024\/0300-9831\/a000647","article-title":"Adherence to healthy dietary pattern and risk of kidney disease: A systematic review and meta-analysis of observational studies","volume":"92","author":"Soltani","year":"2022","journal-title":"Int. J. Vitam. Nutr. Res. Int. Z. Vitam.-Ernahrungsforschung J. Int. Vitaminol. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s40520-024-02718-6","article-title":"Association between Mediterranean diet and dementia and Alzheimer disease: A systematic review with meta-analysis","volume":"36","author":"Nucci","year":"2024","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/advances\/nmz054","article-title":"The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer\u2019s Disease-A Review","volume":"10","author":"Berendsen","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"120166","DOI":"10.1016\/j.jns.2022.120166","article-title":"Mediterranean diet adherence, gut microbiota, and Alzheimer\u2019s or Parkinson\u2019s disease risk: A systematic review","volume":"434","author":"Solch","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s00394-020-02346-6","article-title":"An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer","volume":"60","author":"Morze","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_66","first-page":"600","article-title":"Mediterranean diet and risk of breast cancer: An umbrella review","volume":"42","author":"Toledo","year":"2023","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1186\/s12967-023-04618-1","article-title":"Scientific evidence supporting the newly developed one-health labeling tool \u201cMed-Index\u201d: An umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective","volume":"21","author":"Zupo","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Rajewski, P., Cie\u015bci\u0144ski, J., Rajewski, P., Suwa\u0142a, S., Rajewska, A., and Potasz, M. (2025). Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease. Biomedicines, 13.","DOI":"10.3390\/biomedicines13010217"},{"key":"ref_69","unstructured":"(2025, July 15). WHO Updates Guidelines on Fats and Carbohydrates. Available online: https:\/\/www.who.int\/news\/item\/17-07-2023-who-updates-guidelines-on-fats-and-carbohydrates."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.3390\/nu6115018","article-title":"The Influence of Dietary Fat on Liver Fat Accumulation","volume":"6","author":"Green","year":"2014","journal-title":"Nutrients"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Tedesco, C.C., Bonfiglio, C., Notarnicola, M., Rendina, M., Castellaneta, A., Di Leo, A., Giannelli, G., and Fontana, L. (2023). High Extra Virgin Olive Oil Consumption Is Linked to a Lower Prevalence of NAFLD with a Prominent Effect in Obese Subjects: Results from the MICOL Study. Nutrients, 15.","DOI":"10.3390\/nu15214673"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Bonfiglio, C., Cuccaro, F., Campanella, A., Rosso, N., Tatoli, R., Giannelli, G., and Donghia, R. (2023). Effect of Intake of Extra Virgin Olive Oil on Mortality in a South Italian Cohort with and without NAFLD. Nutrients, 15.","DOI":"10.3390\/nu15214593"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Donghia, R., Tatoli, R., Campanella, A., Losurdo, G., Di Leo, A., De Pergola, G., Bonfiglio, C., and Giannelli, G. (2024). Extra Virgin Olive Oil Reduces the Risk of Non-Alcoholic Fatty Liver Disease in Females but Not in Males: Results from the NUTRIHEP Cohort. Nutrients, 16.","DOI":"10.3390\/nu16193234"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Flynn, M., Tierney, A., and Itsiopoulos, C. (2023). Is Extra Virgin Olive Oil the Critical Ingredient Driving the Health Benefits of a Mediterranean Diet? A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15132916"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Seidita, A., Soresi, M., Giannitrapani, L., Di Stefano, V., Citarrella, R., Mirarchi, L., Cusimano, A., Augello, G., Carroccio, A., and Iovanna, J.L. (2022). The clinical impact of an extra virgin olive oil enriched mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.980429"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"754","DOI":"10.2174\/138161211795428911","article-title":"Molecular mechanisms of inflammation. Anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal","volume":"17","author":"Lucas","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/jn\/137.8.1908","article-title":"Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats","volume":"137","author":"Sato","year":"2007","journal-title":"J. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2337\/dc06-2220","article-title":"Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects","volume":"30","author":"Paniagua","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_79","first-page":"e71451","article-title":"Diagnosis and Management of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Systematic Review","volume":"16","author":"Njei","year":"2024","journal-title":"Cureus"},{"key":"ref_80","first-page":"452","article-title":"Update in lean metabolic dysfunction-associated steatotic liver disease","volume":"16","author":"Chotiprasidhi","year":"2024","journal-title":"World J. Hepatol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/18\/2932\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:44:21Z","timestamp":1759146261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/18\/2932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":80,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["nu17182932"],"URL":"https:\/\/doi.org\/10.3390\/nu17182932","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,11]]}}}