{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:12:52Z","timestamp":1790871172615,"version":"4.1.0"},"reference-count":141,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vascular health relies on the proper function of endothelial cells, which regulate vascular tone, blood fluidity, and barrier integrity. Endothelial dysfunction, often aggravated by inadequate vitamin absorption, contributes to a spectrum of clinical disorders, including cardiovascular disease, cerebrovascular disease, peripheral artery disease, age-related macular degeneration, lymphedema, and chronic venous insufficiency. B-group vitamins (especially folate, or vitamin B9), along with vitamins B12, B6, C, D, and E, are essential in maintaining endothelial function, supporting DNA synthesis, regulating methylation, enhancing cellular repair, mitigating oxidative stress and inflammatory signaling, and curtailing vascular damage. Folate is noted for its central function in one-carbon metabolism and in converting homocysteine to methionine, thereby reducing vascular toxicity. We cover natural dietary sources of folate, synthetic folic acid, and the biologically active forms 5-methyl-(6S)-tetrahydrofolate (L-5-MTHF, L-methylfolate) and 5-formyl-(6S)-tetrahydrofolate (levoleucovorin). Therapeutic strategies to address vascular health and prevent hyperhomocysteinemia in order to preclude follow-on disorders include targeted vitamin supplementation, dietary improvements to ensure a sufficient intake of bioavailable nutrient forms, and, in certain clinical contexts, the use of active L-methylfolate or levoleucovorin (a drug product) to bypass metabolic conversion issues. These evidence-based interventions aim to restore endothelial homeostasis, slow disease progression, and improve patient outcomes across a variety of disorders linked to poor vascular health.<\/jats:p>","DOI":"10.3390\/nu17182955","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T09:43:41Z","timestamp":1757929421000},"page":"2955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Vitamins, Vascular Health and Disease"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-8983","authenticated-orcid":false,"given":"George","family":"Ayoub","sequence":"first","affiliation":[{"name":"Psychology Department, Santa Barbara City College, Santa Barbara, CA 93109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.aopr.2025.03.001","article-title":"The Effect of a Specific Vitamin Supplement Containing L-Methylfolate (Ocufolin Forte) in Patients with Neovascular Age-Related Macular Degeneration","volume":"5","author":"Josifova","year":"2025","journal-title":"Adv. Ophthalmol. Pract. Res."},{"key":"ref_2","first-page":"10","article-title":"Treatment of Primary Lymphedema Following Lessons from Endothelin-Driven Retinal Edema, a Case Report","volume":"14","author":"Ayoub","year":"2024","journal-title":"Heal. TIMES Schweiz. \u00c4rztejournal J. M\u00e9decins Suisses"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/nutrit\/nuw053","article-title":"Role of Folic Acid in Nitric Oxide Bioavailability and Vascular Endothelial Function","volume":"75","author":"Stanhewicz","year":"2017","journal-title":"Nutr. Rev."},{"key":"ref_4","unstructured":"Baddam, S., Khan, K.M., and Jialal, I. (2025). Folic Acid Deficiency. StatPearls, StatPearls Publishing."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1636S","DOI":"10.3945\/jn.114.206599","article-title":"Biomarkers of Nutrition for Development\u2014Folate Review","volume":"145","author":"Bailey","year":"2015","journal-title":"J. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1161\/hq0701.092000","article-title":"Folate Improves Endothelial Function in Coronary Artery Disease","volume":"21","author":"Doshi","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ayoub, G., and Luo, Y. (2023). Ischemia from Retinal Vascular Hypertension in Normal Tension Glaucoma: Neuroprotective Role of Folate. Am. J. Biomed. Sci. Res., 20.","DOI":"10.34297\/AJBSR.2023.20.002786"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Raghubeer, S., and Matsha, T.E. (2021). Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks. Nutrients, 13.","DOI":"10.3390\/nu13124562"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.18103\/mra.v11i5.3824","article-title":"Folate and Folic Acid Metabolism: A Significant Nutrient-Gene-Environment Interaction","volume":"11","author":"Smith","year":"2023","journal-title":"Med. Res. Arch."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.20181965","article-title":"Toward a Better Understanding of Folate Metabolism in Health and Disease","volume":"216","author":"Zheng","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.3390\/nu5093481","article-title":"The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway","volume":"5","author":"Obeid","year":"2013","journal-title":"Nutrients"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12937-023-00843-y","article-title":"The Effects of Folic Acid Supplementation on Endothelial Function in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials","volume":"22","author":"Zamani","year":"2023","journal-title":"Nutr. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3945\/jn.111.153056","article-title":"Plasma Pyridoxal-5-Phosphate Is Inversely Associated with Systemic Markers of Inflammation in a Population of U.S. Adults","volume":"142","author":"Sakakeeny","year":"2012","journal-title":"J. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/bs.vh.2022.02.003","article-title":"Vitamin B12 Deficiency","volume":"119","author":"Green","year":"2022","journal-title":"Vitam. Horm."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Julian, T., Syeed, R., Glascow, N., Angelopoulou, E., and Zis, P. (2020). B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review. Nutrients, 12.","DOI":"10.3390\/nu12082221"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1017\/S0029665108007076","article-title":"Homocysteine, B-Vitamins and CVD","volume":"67","author":"McNulty","year":"2008","journal-title":"Proc. Nutr. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41538-025-00460-5","article-title":"Vitamin D: Recent Advances, Associated Factors, and Its Role in Combating Non-Communicable Diseases","volume":"9","author":"Deepika","year":"2025","journal-title":"NPJ Sci. Food"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.31083\/j.rcm2311381","article-title":"Current Evidence and Future Perspectives of the Best Supplements for Cardioprotection: Have We Reached the Final Chapter for Vitamins?","volume":"23","author":"Yasmin","year":"2022","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Grant, W.B., Boucher, B.J., Cheng, R.Z., Pludowski, P., and Wimalawansa, S.J. (2025). Vitamin D and Cardiovascular Health: A Narrative Review of Risk Reduction Evidence. Nutrients, 17.","DOI":"10.3390\/nu17132102"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"103871","DOI":"10.1016\/j.numecd.2025.103871","article-title":"The Effect of Vitamin D Supplementation on Endothelial Function: An Umbrella Review of Interventional Meta-Analyses","volume":"35","author":"Chen","year":"2025","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"US Preventive Services Task Force (2022). Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement. JAMA, 327, 2326\u20132333.","DOI":"10.1001\/jama.2022.8970"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jacc.2011.02.051","article-title":"Vitamin D Status Is Associated with Arterial Stiffness and Vascular Dysfunction in Healthy Humans","volume":"58","author":"Patel","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e001715","DOI":"10.1136\/openhrt-2021-001715","article-title":"Vitamin K2\u2014A Neglected Player in Cardiovascular Health: A Narrative Review","volume":"8","author":"Hariri","year":"2021","journal-title":"Open Heart"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ryu, T., Chae, S.Y., Lee, J., Han, J.W., Yang, H., Chung, B.S., and Yang, K. (2025). Multivitamin Supplementation and Its Impact in Metabolic Dysfunction-Associated Steatotic Liver Disease. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-92858-0"},{"key":"ref_25","unstructured":"(2025, August 04). Folate (Folic Acid)\u2014Vitamin B9 \u2022 The Nutrition Source. Available online: https:\/\/nutritionsource.hsph.harvard.edu\/folic-acid\/."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2174\/1570161121666230911115725","article-title":"Role of Vitamins in Cardiovascular Health: Know Your Facts-Part 2","volume":"21","author":"Manolis","year":"2023","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_27","unstructured":"Institute for Natural Medicine Staff (2024). Fact Sheet: Folate (Vitamin B9) & Folic Acid, Institute for Natural Medicine."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1200\/JCO.2016.71.7587","article-title":"Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report from the Children\u2019s Oncology Group","volume":"35","author":"Hardy","year":"2017","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1455S","DOI":"10.3945\/ajcn.2010.28674E","article-title":"Folate Bioavailability: Implications for Establishing Dietary Recommendations and Optimizing Status","volume":"91","author":"Caudill","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_30","unstructured":"(2025, August 04). Office of Dietary Supplements\u2014Folate, Available online: https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zheng, J., Wang, X., Wu, B., Qiao, L., Zhao, J., Pourkheirandish, M., Wang, J., and Zheng, X. (2022). Folate (Vitamin B9) Content Analysis in Bread Wheat (Triticum aestivum L.). Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.933358"},{"key":"ref_32","unstructured":"Merrell, B.J., and McMurry, J.P. (2025). Folic Acid. StatPearls, StatPearls Publishing."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"124570","DOI":"10.52504\/001c.124570","article-title":"The Critical Role of Folate in Prenatal Health and a Proposed Shift from Folic Acid to 5-Methyltetrahydrofolate Supplementation","volume":"8","author":"Tate","year":"2024","journal-title":"Georget. Med. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/mp.2016.168","article-title":"Folinic Acid Improves Verbal Communication in Children with Autism and Language Impairment: A Randomized Double-Blind Placebo-Controlled Trial","volume":"23","author":"Frye","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_35","first-page":"10258","article-title":"Folate\u2014A Scoping Review for Nordic Nutrition Recommendations 2023","volume":"67","author":"Ueland","year":"2023","journal-title":"Food Nutr. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/jn\/121.4.445","article-title":"Bioavailability of Food Folates and Evaluation of Food Matrix Effects with a Rat Bioassay","volume":"121","author":"Clifford","year":"1991","journal-title":"J. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"McKay, J.A., Groom, A., Potter, C., Coneyworth, L.J., Ford, D., Mathers, J.C., and Relton, C.L. (2012). Genetic and Non-Genetic Influences during Pregnancy on Infant Global and Site Specific DNA Methylation: Role for Folate Gene Variants and Vitamin B12. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033290"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Copped\u00e8, F. (2015). The Genetics of Folate Metabolism and Maternal Risk of Birth of a Child with Down Syndrome and Associated Congenital Heart Defects. Front. Genet., 6.","DOI":"10.3389\/fgene.2015.00223"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1079\/PNS2006495","article-title":"Genetic Variation in Genes of Folate Metabolism and Neural-Tube Defect Risk","volume":"65","author":"Afman","year":"2006","journal-title":"Proc. Nutr. Soc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1002\/ajmg.a.38478","article-title":"Finding the Genetic Mechanisms of Folate Deficiency and Neural Tube Defects\u2014Leaving No Stone Unturned","volume":"173","author":"Au","year":"2017","journal-title":"Am. J. Med. Genet. A."},{"key":"ref_41","first-page":"54","article-title":"The Effects of Vitamin Supplementation Containing L-Methylfolate (Ocufolin\u00ae Forte) on Retinal Venous Pressure and Homocysteine Plasma Levels in Patients with Glaucoma","volume":"3","author":"Devogelaere","year":"2021","journal-title":"Heakthbook TIMES"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lee, I., Piao, S., Kim, S., Nagar, H., Choi, S.-J., Jeon, B.H., Oh, S.-H., Irani, K., and Kim, C.-S. (2021). CRIF1 Deficiency Increased Homocysteine Production by Disrupting Dihydrofolate Reductase Expression in Vascular Endothelial Cells. Antioxidants, 10.","DOI":"10.3390\/antiox10111645"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, Q., Yang, J., Yu, C., Deng, Y., Wen, Q., Yang, H., Liu, H., and Luo, R. (2024). Case Report: Cerebral Folate Deficiency Caused by FOLR1 Variant. Front. Pediatr., 12.","DOI":"10.3389\/fped.2024.1434209"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"201399","DOI":"10.1016\/j.humgen.2025.201399","article-title":"RFC and VDR -Mediated Genetic Regulation of Brain Folate Transport in Patients with Multiple Sclerosis","volume":"44","author":"Skavinska","year":"2025","journal-title":"Hum. Gene"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12031-025-02338-3","article-title":"Analysis of the Association Between the SLC19A1 Genetic Variant (Rs1051266) and Autism Spectrum Disorders, Cerebral Folate Deficiency, and Clinical and Laboratory Parameters","volume":"75","author":"Stefanyshyn","year":"2025","journal-title":"J. Mol. Neurosci. MN"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ayoub, G. (2025). Autism Spectrum Disorder as a Multifactorial Disorder: The Interplay of Genetic Factors and Inflammation. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202506.1224.v1"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"369S","DOI":"10.1093\/jn\/130.2.369S","article-title":"Homocysteine and Endothelial Dysfunction: A Link with Cardiovascular Disease","volume":"130","author":"McDowell","year":"2000","journal-title":"J. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jnutbio.2003.08.010","article-title":"Folate, Homocysteine, Endothelial Function and Cardiovascular Disease","volume":"15","author":"Moat","year":"2004","journal-title":"J. Nutr. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/hq0102.102190","article-title":"Folates and Cardiovascular Disease","volume":"22","author":"Verhaar","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Clarke, R., Bennett, D.A., Parish, S., Verhoef, P., D\u00f6tsch-Klerk, M., Lathrop, M., Xu, P., Nordestgaard, B.G., Holm, H., and Hopewell, J.C. (2012). Homocysteine and Coronary Heart Disease: Meta-Analysis of MTHFR Case-Control Studies, Avoiding Publication Bias. PLoS Med., 9.","DOI":"10.1371\/journal.pmed.1001177"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jcm.2008.09.001","article-title":"High-Dose Folic Acid Supplementation Effects on Endothelial Function and Blood Pressure in Hypertensive Patients: A Meta-Analysis of Randomized Controlled Clinical Trials","volume":"8","author":"McRae","year":"2009","journal-title":"J. Chiropr. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Varadharaj, S., Kelly, O.J., Khayat, R.N., Kumar, P.S., Ahmed, N., and Zweier, J.L. (2017). Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease. Front. Cardiovasc. Med., 4.","DOI":"10.3389\/fcvm.2017.00064"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e003768","DOI":"10.1161\/JAHA.116.003768","article-title":"Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials","volume":"5","author":"Li","year":"2016","journal-title":"J. Am. Heart Assoc. Cardiovasc. Cerebrovasc. Dis."},{"key":"ref_54","first-page":"246","article-title":"Association of Folate Intake with Cardiovascular-Disease Mortality and All-Cause Mortality among People at High Risk of Cardiovascular-Disease","volume":"41","author":"Xu","year":"2022","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1038\/s41440-023-01307-w","article-title":"Folate and Cardiovascular Disease","volume":"46","author":"Otsu","year":"2023","journal-title":"Hypertens. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1001\/archinte.160.21.3258","article-title":"Serum Folate and Cardiovascular Disease Mortality Among US Men and Women","volume":"160","author":"Loria","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15424","DOI":"10.1073\/pnas.0902072106","article-title":"The Extremely Slow and Variable Activity of Dihydrofolate Reductase in Human Liver and Its Implications for High Folic Acid Intake","volume":"106","author":"Bailey","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Fardous, A.M., and Heydari, A.R. (2023). Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15214699"},{"key":"ref_59","unstructured":"(2025, August 05). Folate\u2014Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline\u2014NCBI Bookshelf, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK114318\/."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Reynolds, E.H., Sobczy\u0144ska-Malefora, A., and Green, R. (2025). Fortification, Folate and Vitamin B12 Balance, and the Nervous System. Is Folic Acid Excess Potentially Harmful?. Eur. J. Clin. Nutr.","DOI":"10.1038\/s41430-025-01652-8"},{"key":"ref_61","unstructured":"(2025, September 11). Study Details|NCT00317005|Uremic Hyperhomocysteinemia\u2014A Folate Trial for Possible Prevention of Cardio-Vascular Events|ClinicalTrials.Gov, Available online: https:\/\/clinicaltrials.gov\/study\/NCT00317005."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.jacc.2005.02.038","article-title":"High-Dose Folic Acid Acutely Improves Coronary Vasodilator Function in Patients with Coronary Artery Disease","volume":"45","author":"Tawakol","year":"2005","journal-title":"JACC"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/hc3501.095358","article-title":"Folic Acid Prevents Nitroglycerin-Induced Nitric Oxide Synthase Dysfunction and Nitrate Tolerance","volume":"104","author":"Gori","year":"2001","journal-title":"Circulation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/S0735-1097(99)00469-6","article-title":"Folic Acid Improves Arterial Endothelial Function in Adults with Hyperhomocystinemia","volume":"34","author":"Woo","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jacbts.2021.10.003","article-title":"Targeting the Lymphatic System for Interstitial Decongestion","volume":"6","author":"Martens","year":"2021","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12609-023-00491-5","article-title":"The Future of Lymphedema: Potential Therapeutic Targets for Treatment","volume":"5","author":"Brown","year":"2023","journal-title":"Curr. Breast Cancer Rep."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Brown, S., Dayan, J.H., Coriddi, M., Campbell, A., Kuonqui, K., Shin, J., Park, H.J., Mehrara, B.J., and Kataru, R.P. (2022). Pharmacological Treatment of Secondary Lymphedema. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.828513"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1523\/JNEUROSCI.0619-21.2021","article-title":"The Glymphatic System: A Novel Component of Fundamental Neurobiology","volume":"41","author":"Hablitz","year":"2021","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Gao, Y., Liu, K., and Zhu, J. (2023). Glymphatic System: An Emerging Therapeutic Approach for Neurological Disorders. Front. Mol. Neurosci., 16.","DOI":"10.3389\/fnmol.2023.1138769"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic System\u2014A Beginner\u2019s Guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/B978-0-443-19104-6.00006-1","article-title":"The Glymphatic System","volume":"209","author":"Ghanizada","year":"2025","journal-title":"Handb. Clin. Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/WCO.0000000000001252","article-title":"Glymphatic System Dysfunction in Neurodegenerative Diseases","volume":"37","author":"Beschorner","year":"2024","journal-title":"Curr. Opin. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Corbali, O., and Levey, A.I. (2025). Glymphatic System in Neurological Disorders and Implications for Brain Health. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1543725"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e2407246121","DOI":"10.1073\/pnas.2407246121","article-title":"The Perivascular Space Is a Conduit for Cerebrospinal Fluid Flow in Humans: A Proof-of-Principle Report","volume":"121","author":"Yamamoto","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","first-page":"25158414241240687","article-title":"Case Series of Retinal Vein Occlusions Showing Early Recovery Using Oral L-Methylfolate","volume":"16","author":"Baker","year":"2024","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Gu, J., Lei, C., and Zhang, M. (2023). Folate and Retinal Vascular Diseases. BMC Ophthalmol., 23.","DOI":"10.1186\/s12886-023-03149-z"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Mohamed, R., Sharma, I., Ibrahim, A.S., Saleh, H., Elsherbiny, N.M., Fulzele, S., Elmasry, K., Smith, S.B., Al-Shabrawey, M., and Tawfik, A. (2017). Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-09731-y"},{"key":"ref_78","first-page":"633","article-title":"Effects of Folate Supplementation on Homocysteine-Induced Retinopathy in Cbs Mice","volume":"48","author":"Mysona","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13167-015-0043-1","article-title":"Retinal Venous Pressure: The Role of Endothelin","volume":"6","author":"Flammer","year":"2015","journal-title":"EPMA J."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Elsherbiny, N.M., Sharma, I., Kira, D., Alhusban, S., Samra, Y.A., Jadeja, R., Martin, P., Al-Shabrawey, M., and Tawfik, A. (2020). Homocysteine Induces Inflammation in Retina and Brain. Biomolecules, 10.","DOI":"10.3390\/biom10030393"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"017","DOI":"10.17352\/2455-1414.000106","article-title":"Managing Normal Tension Glaucoma with Dietary Folate","volume":"11","author":"George","year":"2024","journal-title":"J. Clin. Res. Ophthalmol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.exer.2018.03.022","article-title":"Excess Homocysteine Upregulates the NRF2-Antioxidant Pathway in Retinal M\u00fcller Glial Cells","volume":"178","author":"Navneet","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1136\/bjophthalmol-2011-301370","article-title":"Homocysteine Induces Oxidative Stress in Young Adult Central Retinal Vein Occlusion","volume":"96","author":"Devi","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"B\u00f6hm, E.W., Buonfiglio, F., Voigt, A.M., Bachmann, P., Safi, T., Pfeiffer, N., and Gericke, A. (2023). Oxidative Stress in the Eye and Its Role in the Pathophysiology of Ocular Diseases. Redox Biol., 68.","DOI":"10.1016\/j.redox.2023.102967"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Tawfik, A., Samra, Y.A., Elsherbiny, N.M., and Al-Shabrawey, M. (2020). Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction. Biomolecules, 10.","DOI":"10.3390\/biom10081119"},{"key":"ref_86","first-page":"895","article-title":"Homocysteine Reduction for Stroke Prevention: Regarding the Recent AHA\/ASA 2021 Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack","volume":"16","author":"Brown","year":"2023","journal-title":"Pharmacogenomics Pers. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3233\/JAD-171042","article-title":"Homocysteine and Dementia: An International Consensus Statement","volume":"62","author":"Smith","year":"2018","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1523\/JNEUROSCI.0940-08.2008","article-title":"Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase","volume":"28","author":"Kronenberg","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/ebmental-2021-300309","article-title":"Serum Folate Deficiency and the Risks of Dementia and All-Cause Mortality: A National Study of Old Age","volume":"25","author":"Rotstein","year":"2022","journal-title":"Evid. Based Ment. Health"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-nutr-071715-050947","article-title":"Homocysteine, B Vitamins, and Cognitive Impairment","volume":"36","author":"Smith","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Ma, F., Wu, T., Zhao, J., Song, A., Liu, H., Xu, W., and Huang, G. (2016). Folic Acid Supplementation Improves Cognitive Function by Reducing the Levels of Peripheral Inflammatory Cytokines in Elderly Chinese Subjects with MCI. Sci. Rep., 6.","DOI":"10.1038\/srep37486"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41430-021-01057-3","article-title":"Low Folate Predicts Accelerated Cognitive Decline: 8-Year Follow-up of 3140 Older Adults in Ireland","volume":"76","author":"Scarlett","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1093\/ajcn\/82.6.1346","article-title":"Low Folate Status Is Associated with Impaired Cognitive Function and Dementia in the Sacramento Area Latino Study on Aging","volume":"82","author":"Ramos","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"532","DOI":"10.30773\/pi.2019.05.29","article-title":"Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment","volume":"16","author":"Jang","year":"2019","journal-title":"Psychiatry Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1136\/bmj.324.7352.1512","article-title":"Folic Acid, Ageing, Depression, and Dementia","volume":"324","author":"Reynolds","year":"2002","journal-title":"BMJ"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Zhang, J., Yue, D., and Zhang, H. (2025). Cardiovascular Disease Attenuates the Protective Effect of Folate on Global Cognitive Function in an Elderly Population: A Cross-Sectional Study. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-87129-x"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3177\/jnsv.47.181","article-title":"Folic Acid-Responsive Neurological Diseases in Japan","volume":"47","author":"Yukawa","year":"2001","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Puga, A.M., Ruperto, M., Samaniego-Vaesken, M.d.L., Montero-Bravo, A., Partearroyo, T., and Varela-Moreiras, G. (2021). Effects of Supplementation with Folic Acid and Its Combinations with Other Nutrients on Cognitive Impairment and Alzheimer\u2019s Disease: A Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13092966"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"105540","DOI":"10.1016\/j.archger.2024.105540","article-title":"Effects of Folic Acid Supplementation on Cognitive Function and Inflammation in Elderly Patients with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"126","author":"Wang","year":"2024","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zhang, L., Chen, X., Chen, Y., Yan, J., Huang, G., and Li, W. (2024). A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 16.","DOI":"10.3390\/nu16142199"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1093\/gerona\/glv183","article-title":"Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China","volume":"71","author":"Ma","year":"2016","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/joim.13279","article-title":"Homocysteine\u2014From Disease Biomarker to Disease Prevention","volume":"290","author":"Smith","year":"2021","journal-title":"J. Intern. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/hmg\/ddab246","article-title":"The Dihydrofolate Reductase 19-Bp Deletion Modifies the Beneficial Effect of B-Vitamin Therapy in Mild Cognitive Impairment: Pooled Study of Two Randomized Placebo-Controlled Trials","volume":"31","author":"Wu","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"glad266","DOI":"10.1093\/gerona\/glad266","article-title":"Associations of Folate\/Folic Acid Supplementation Alone and in Combination with Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants","volume":"79","author":"Ling","year":"2024","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Chen, S.-J., Chen, H., You, J., Chen, S.-D., Fu, Y., Zhang, W., Huang, L., Feng, J.-F., Gao, X., and Cheng, W. (2025). Machine Learning-Assisted Optimization of Dietary Intervention against Dementia Risk. Nat. Hum. Behav.","DOI":"10.1038\/s41562-025-02255-w"},{"key":"ref_106","first-page":"30","article-title":"Too Much Folate\u2014A Risk Factor for Cancer and Cardiovascular Disease?","volume":"12","author":"Sauer","year":"2009","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e801","DOI":"10.1093\/nutrit\/nuae077","article-title":"Folate Biomarkers, Folate Intake, and Risk of Death from All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies","volume":"83","author":"Fallah","year":"2025","journal-title":"Nutr. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/j.jacc.2022.09.048","article-title":"Micronutrient Supplementation to Reduce Cardiovascular Risk","volume":"80","author":"An","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Chen, P., Tang, L., Song, Y., Wang, B., Qin, X., Zhang, N., Wei, Y., Xu, X., Zhou, Z., and He, Q. (2023). Association of Folic Acid Dosage with Circulating Unmetabolized Folic Acid in Chinese Adults with H-Type Hypertension: A Multicenter, Double-Blind, Randomized Controlled Trial. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1191610"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1093\/ajcn\/nqab436","article-title":"Plasma Unmetabolized Folic Acid in Pregnancy and Risk of Autistic Traits and Language Impairment in Antiseizure Medication-Exposed Children of Women with Epilepsy","volume":"115","author":"Husebye","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Cochrane, K.M., Elango, R., Devlin, A.M., Hutcheon, J.A., and Karakochuk, C.D. (2023). Human Milk Unmetabolized Folic Acid Is Increased Following Supplementation with Synthetic Folic Acid as Compared to (6S)-5-Methyltetrahydrofolic Acid. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-38224-4"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Jankovic-Karasoulos, T., Smith, M.D., Leemaqz, S., Mittinty, M., Williamson, J., McCullough, D., Arthurs, A.L., Dekker, G.A., and Roberts, C.T. (2025). Maternal Folate Excess, Placental Hormones, and Gestational Diabetes Mellitus: Findings from Prospective Cohorts Before and After Mandatory Folic Acid Food Fortification. Nutrients, 17.","DOI":"10.3390\/nu17172863"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1002\/1097-0142(19931001)72:7<2242::AID-CNCR2820720730>3.0.CO;2-E","article-title":"Cardiotoxicity of 5-Fluorouracil in Combination with Folinic Acid in Patients with Gastrointestinal Cancer","volume":"72","author":"Papageorgiou","year":"1993","journal-title":"Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Ayoub, G. (2024). Neurodevelopment of Autism: Critical Periods, Stress and Nutrition. Cells, 13.","DOI":"10.3390\/cells13231968"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biochi.2020.04.019","article-title":"Folinic Acid Improves the Score of Autism in the EFFET Placebo-Controlled Randomized Trial","volume":"173","author":"Renard","year":"2020","journal-title":"Biochimie"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1007\/s00431-024-05762-6","article-title":"Efficacy of Oral Folinic Acid Supplementation in Children with Autism Spectrum Disorder: A Randomized Double-Blind, Placebo-Controlled Trial","volume":"183","author":"Panda","year":"2024","journal-title":"Eur. J. Pediatr."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zhang, C., Chen, Y., Hou, F., Li, Y., Wang, W., Guo, L., Zhang, C., Li, L., and Lu, C. (2025). Safety and Efficacy of High-Dose Folinic Acid in Children with Autism: The Impact of Folate Metabolism Gene Polymorphisms. Nutrients, 17.","DOI":"10.3390\/nu17091602"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"i110","DOI":"10.1093\/ije\/dyq028","article-title":"Folic Acid to Reduce Neonatal Mortality from Neural Tube Disorders","volume":"39","author":"Blencowe","year":"2010","journal-title":"Int. J. Epidemiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/advances\/nmy120","article-title":"The Importance of Maternal Folate Status for Brain Development and Function of Offspring","volume":"10","author":"Naninck","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Barua, S., Chadman, K.K., Kuizon, S., Buenaventura, D., Stapley, N.W., Ruocco, F., Begum, U., Guariglia, S.R., Brown, W.T., and Junaid, M.A. (2014). Increasing Maternal or Post-Weaning Folic Acid Alters Gene Expression and Moderately Changes Behavior in the Offspring. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101674"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1001\/jama.2012.155925","article-title":"Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children","volume":"309","author":"Roth","year":"2013","journal-title":"JAMA"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13229-017-0170-8","article-title":"The Association between Maternal Use of Folic Acid Supplements during Pregnancy and Risk of Autism Spectrum Disorders in Children: A Meta-Analysis","volume":"8","author":"Wang","year":"2017","journal-title":"Mol. Autism"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/ajcn\/80.6.1611","article-title":"Metabolic Biomarkers of Increased Oxidative Stress and Impaired Methylation Capacity in Children with Autism","volume":"80","author":"James","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/mp.2011.175","article-title":"Cerebral Folate Receptor Autoantibodies in Autism Spectrum Disorder","volume":"18","author":"Frye","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/ppe.12414","article-title":"Maternal Multivitamin Intake, Plasma Folate and Vitamin B12 Levels and Autism Spectrum Disorder Risk in Offspring","volume":"32","author":"Raghavan","year":"2018","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2217\/epi-2021-0494","article-title":"Correlation among Maternal Risk Factors, Gene Methylation and Disease Severity in Females with Autism Spectrum Disorder","volume":"14","author":"Gallo","year":"2022","journal-title":"Epigenomics"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.2023.9864","article-title":"Folic Acid Supplementation to Prevent Neural Tube Defects: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force","volume":"330","author":"Viswanathan","year":"2023","journal-title":"JAMA"},{"key":"ref_128","first-page":"888","article-title":"High Dietary Folate in Pregnant Mice Leads to Pseudo-MTHFR Deficiency and Altered Methyl Metabolism, with Embryonic Growth Delay and Short-Term Memory Impairment in Offspring","volume":"26","author":"Bahous","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Jennings, L., and Basiri, R. (2022). Amino Acids, B Vitamins, and Choline May Independently and Collaboratively Influence the Incidence and Core Symptoms of Autism Spectrum Disorder. Nutrients, 14.","DOI":"10.3390\/nu14142896"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Usui, N., Kobayashi, H., and Shimada, S. (2023). Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065487"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1469-8749.2008.02053.x","article-title":"A Milk-Free Diet Downregulates Folate Receptor Autoimmunity in Cerebral Folate Deficiency Syndrome","volume":"50","author":"Ramaekers","year":"2008","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Hoxha, B., Hoxha, M., Domi, E., Gervasoni, J., Persichilli, S., Malaj, V., and Zappacosta, B. (2021). Folic Acid and Autism: A Systematic Review of the Current State of Knowledge. Cells, 10.","DOI":"10.3390\/cells10081976"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Guo, C., Kuang, M., Lin, L., Xu, G., Pan, N., Weng, X., Jing, J., Shi, L., and Yi, Q. (2024). Examining Associations of Folic Acid Supplements Administered to Mothers during Pre-Conceptional and Prenatal Periods with Autism Spectrum Disorders in Their Offspring: Insights from a Multi-Center Study in China. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1321046"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3945\/ajcn.110.004416","article-title":"Maternal Periconceptional Folic Acid Intake and Risk of Autism Spectrum Disorders and Developmental Delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) Case-Control Study","volume":"96","author":"Schmidt","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Giorlandino, C., Margiotti, K., Fabiani, M., and Mesoraca, A. (2025). Folinic Acid Supplementation During Pregnancy in Two Women with Folate Receptor Alpha Autoantibodies: Potential Prevention of Autism Spectrum Disorder in Offspring. Clin. Transl. Neurosci., 9.","DOI":"10.3390\/ctn9030030"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1017\/S0029665118002689","article-title":"Maternal Folate Nutrition and Offspring Health: Evidence and Current Controversies","volume":"78","author":"Caffrey","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Irvine, N., England-Mason, G., Field, C.J., Dewey, D., and Aghajafari, F. (2022). Prenatal Folate and Choline Levels and Brain and Cognitive Development in Children: A Critical Narrative Review. Nutrients, 14.","DOI":"10.3390\/nu14020364"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Virdi, S., and Jadavji, N.M. (2022). The Impact of Maternal Folates on Brain Development and Function after Birth. Metabolites, 12.","DOI":"10.3390\/metabo12090876"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1080\/10408398.2021.1993781","article-title":"Neurodevelopmental Effects of Maternal Folic Acid Supplementation: A Systematic Review and Meta-Analysis","volume":"63","author":"Chen","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s10578-020-01072-8","article-title":"Folinic Acid as Adjunctive Therapy in Treatment of Inappropriate Speech in Children with Autism: A Double-Blind and Placebo-Controlled Randomized Trial","volume":"52","author":"Batebi","year":"2021","journal-title":"Child. Psychiatry Hum. Dev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-nutr-043020-091647","article-title":"Folic Acid and the Prevention of Birth Defects: 30 Years of Opportunity and Controversies","volume":"42","author":"Crider","year":"2022","journal-title":"Annu. Rev. 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