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China","award":["20242BAB20322"],"award-info":[{"award-number":["20242BAB20322"]}]},{"name":"High-level Scientific Research and Innovation Team of Biology and Medicine of Jingdezhen University of China","award":["32302073"],"award-info":[{"award-number":["32302073"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objectives: In response to the high prevalence of global obesity and associated metabolic diseases, this study aimed to investigate the effects of Pickering emulsions stabilized by cellulase-hydrolyzed pomelo peel insoluble dietary fiber (IDF), namely EPI and its octenyl succinic anhydride (OSA)-modified form (OSA-EPI), on alleviating high-fat diet (HFD)-induced metabolic disorders in mice. Methods: Male C57BL\/6J mice were subjected to an HFD-induced obesity model. Biochemical index determination, histopathological examination, gut microbiota analysis, and short-chain fatty acids (SCFAs) analysis were used to study the potential efficacy of pomelo peel IDF-based emulsion (EPI and OSA-EPI) in alleviating obesity and related metabolic diseases. Results: The findings demonstrated that both emulsions effectively mitigated HFD-induced health impairments: reduced weight gain, improved blood glucose and lipid profiles, attenuated tissue steatosis and inflammation, and lowered oxidative stress. Furthermore, both EPI and OSA-EPI restored gut microbiota diversity, promoted the proliferation of beneficial bacterial taxa (e.g., Akkermansia), and inhibited the growth of harmful genera (e.g., Muribaculum, Faecalibaculum). These changes were accompanied by increased production of SCFAs. Conclusions: This study confirms that modified pomelo peel IDF can effectively exert the health intervention effect of IDF on obesity when used as an emulsion stabilizer, providing a robust scientific foundation for the application of emulsified dietary fibers in combating obesity and related metabolic disorders.<\/jats:p>","DOI":"10.3390\/nu17193036","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T15:54:54Z","timestamp":1758642894000},"page":"3036","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-Obesity Potential of Modified Pomelo-Peel Dietary Fiber-Based Pickering Emulsion"],"prefix":"10.3390","volume":"17","author":[{"given":"Kaitao","family":"Peng","sequence":"first","affiliation":[{"name":"School of Food and Health, Beijing Technology & Business University, Beijing 100048, China"},{"name":"State Key Laboratory of Food Science and Resources, Engineering Research Center for Biomass Conversion, Ministry of Education, Nanchang University, Nanchang 330047, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyi","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1896-1171","authenticated-orcid":false,"given":"Shuang","family":"Bi","sequence":"additional","affiliation":[{"name":"School of Food and Health, Beijing Technology & Business University, Beijing 100048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Engineering Research Center for Biomass Conversion, Ministry of Education, Nanchang University, Nanchang 330047, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaili","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Biological and Environmental Engineering, Jingdezhen University, Jingdezhen 334000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0435-2572","authenticated-orcid":false,"given":"Yuhuan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Engineering Research Center for Biomass Conversion, Ministry of Education, Nanchang University, Nanchang 330047, China"},{"name":"Chongqing Research Institute of Nanchang University, Chongqing 402660, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tang, C., Wang, Y., Xu, Z., Chen, D., Xu, J., Yang, D., Zhang, L., Liu, J., and Kan, J. 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