{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:43:03Z","timestamp":1762522983561,"version":"build-2065373602"},"reference-count":75,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32402120","2023J05029"],"award-info":[{"award-number":["32402120","2023J05029"]}]},{"name":"Natural Science Foundation of Fujian Province, China","award":["32402120","2023J05029"],"award-info":[{"award-number":["32402120","2023J05029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Marine-derived oils rich in long-chain polyunsaturated fats have long been associated with positive effects on plasma lipid levels and anti-inflammatory responses. Abalone viscera are rich in oils that are rarely extracted and made available. Methods: Abalone viscera oil (AVO) was extracted by multistage countercurrent extraction using ethanol as a solvent, and its oil quality, fatty acid composition, and in vitro antioxidant activity were determined. Meanwhile, the anti-hyperlipidemic effect of AVO on HFD-induced hyperlipidemia mice was evaluated. Results: The abalone viscera were extracted at a solid\u2013liquid ratio of 1:3 with an oscillation frequency of 300 rpm for 40 min, and the extraction rate was 81.18% after four-stage countercurrent extraction. The acid value, iodine value, peroxide value, vitamin E, and astaxanthin of AVO were 1.26 mg KOH\/g, 140.9 g\/100 g, 3.6 meq\/kg, 105 mg\/kg, and 533.8 mg\/kg, respectively. The unsaturated fatty acids of AVO account for 56.60%, with eicosapentaenoic acid (C20:5n3) and arachidonic acid (C20:4n6) the two predominant PUFAs, and oleic acid (C18:1n9) the most dominant MUFA. The DPPH, ABTS, and \u00b7OH radicals scavenging capacities of AVO increased with concentration, and the IC50 values were 6.30 mg\/mL, 0.45 mg\/mL, and 8.95 mg\/mL, respectively. Moreover, the administration of AVO significantly alleviated HFD-induced weight gain, liver fat accumulation, lipid disorder, and oxidative stress in mice. Conclusions: Collectively, our study provides a theoretical basis for the application of AVO and the comprehensive utilization of abalone viscera, which helps increase the additional value of abalone.<\/jats:p>","DOI":"10.3390\/nu17193062","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:48:05Z","timestamp":1758808085000},"page":"3062","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multistage Countercurrent Extraction of Abalone Viscera Oil and Its Hypolipidemic Action on High-Fat Diet-Induced Hyperlipidemia Mice"],"prefix":"10.3390","volume":"17","author":[{"given":"Meiling","family":"Tian","sequence":"first","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"National R&D Center for Vegetable Processing, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjiang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahui","family":"Xiang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Agro-Products Quality & Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changcheng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"National R&D Center for Vegetable Processing, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5207-8553","authenticated-orcid":false,"given":"Binxiong","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"National R&D Center for Vegetable Processing, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"National R&D Center for Vegetable Processing, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"The potential of marine oils as functional foods: Nutritional composition, health benefits, applications, and future perspectives","volume":"1","author":"Wei","year":"2025","journal-title":"Food Rev. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S2213-8587(20)30148-0","article-title":"Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: Nutritional implications for cardiometabolic diseases","volume":"8","author":"Schulze","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.jacc.2011.06.063","article-title":"Omega-3 fatty acids and cardiovascular disease: Effects on risk factors, molecular pathways, and clinical events","volume":"58","author":"Mozaffarian","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s11886-019-1175-z","article-title":"Optimizing Dyslipidemia Management for the Prevention of Cardiovascular Disease: A Focus on Risk Assessment and Therapeutic Options","volume":"21","author":"Berman","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kim, O.K., Yun, J.M., Kim, D., Park, S.J., Lee, C., Go, E.B., Kim, J.S., Park, S.Y., and Lee, J. (2022). Krill Oil Inhibits Cholesterol Synthesis and Stimulated Cholesterol Excretion in Hypercholesterolemic Rats. Mar. Drugs, 20.","DOI":"10.3390\/md20100609"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1089\/jmf.2020.0114","article-title":"Influence of omega-3 fatty acid-rich fish oils on hyperlipidemia: Effect of eel, sardine, trout, and cod oils on hyperlipidemic mice","volume":"24","author":"Kontostathi","year":"2021","journal-title":"J. Med. Food"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41387-017-0007-8","article-title":"Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: A randomized, open-labeled trial","volume":"7","author":"Zibaeenezhad","year":"2017","journal-title":"Nutr. Diabetes"},{"key":"ref_8","first-page":"645","article-title":"Methods of extraction, refining and concentration of fish oil as a source of omega-3 fatty acids","volume":"19","year":"2018","journal-title":"Cienc. Tecnol. Agropecu."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Aitta, E., Marsol-Vall, A., Damerau, A., and Yang, B. (2021). Enzyme-assisted extraction of fish oil from whole fish and by-products of Baltic herring (Clupea harengus membras). Foods, 10.","DOI":"10.3390\/foods10081811"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jfoodeng.2017.01.019","article-title":"Simulation and process design of continuous countercurrent ethanolic extraction of rice bran oil","volume":"202","author":"Bessa","year":"2017","journal-title":"J. Food Eng."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bej.2004.06.002","article-title":"Development of multi-stage countercurrent extraction technology for the extraction of glycyrrhizic acid (GA) from licorice (Glycyrrhiza uralensis Fisch)","volume":"21","author":"Wang","year":"2004","journal-title":"Biochem. Eng. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fbp.2011.05.003","article-title":"Optimization of multi-stage countercurrent extraction of antioxidants from Ginkgo biloba L. leaves","volume":"90","author":"Yu","year":"2012","journal-title":"Food Bioprod. Process"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bej.2010.02.011","article-title":"Improving Jatropha curcas seed protein recovery by using counter current multistage extraction","volume":"50","author":"Lestari","year":"2010","journal-title":"Biochem. Eng. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"108659","DOI":"10.1016\/j.cep.2021.108659","article-title":"Soybean oil extraction with ethanol from multiple-batch assays to reproduce a continuous, countercurrent, and multistage equipment","volume":"170","author":"Ferreira","year":"2022","journal-title":"Chem. Eng. Process"},{"key":"ref_15","unstructured":"The People\u2019s Republic of China Ministry of Agriculture, Fisheries Bureau (2024). China Fishery Statistical Yearbook. 2023. Production (Chapter 2), China Agriculture Press."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"137398","DOI":"10.1016\/j.foodchem.2023.137398","article-title":"Structure characterization and antioxidant activity of abalone visceral peptides-selenium in vitro","volume":"433","author":"Jia","year":"2024","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Liu, B., Liu, L., Li, C., Guo, T., Li, C., Tian, M., and Fang, T. (2025). The alleviating effect of abalone viscera collagen peptide in DSS-induced colitis mice: Effect on inflammatory cytokines, oxidative stress, and gut microbiota. Nutrients, 17.","DOI":"10.3390\/nu17111926"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ijbiomac.2017.08.055","article-title":"Effects of polysaccharides from abalone viscera (Haliotis discus hannai Ino) on MGC 803 cells proliferation","volume":"106","author":"Zhang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1002\/fsn3.1548","article-title":"Hypolipidemic and anti-atherogenic activities of crude polysaccharides from abalone viscera","volume":"8","author":"Liu","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Heo, J.H., Kim, E.A., Kang, N., Heo, S.Y., Ahn, G., and Heo, S.J. (2024). The Antioxidant Effects of Trypsin-Hydrolysate Derived from Abalone Viscera and Fishery By-Products, and the Angiotensin-I Converting Enzyme (ACE) Inhibitory Activity of Its Purified Bioactive Peptides. Mar. Drugs, 22.","DOI":"10.3390\/md22100461"},{"key":"ref_21","unstructured":"Lin, Y. (2015). Studies on Extraction of Abalone Viscera Oil. [Master\u2019s thesis, Fujian Agriculture and Forestry University]."},{"key":"ref_22","unstructured":"(2016). National Food Safety Standard. Determination of Acid Value in Food (Standard No. GB 5009.229-2016)."},{"key":"ref_23","unstructured":"(2022). National Standard of the People\u2019s Republic of China. Animal and Vegetable Fats and Oils\u2014Determination of Iodine Value (Standard No. GB\/T 5532-2022)."},{"key":"ref_24","unstructured":"(2023). National Food Safety Standard. Determination of Peroxide Value in Food (Standard No. GB 5009.227-2023)."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.foodchem.2016.03.089","article-title":"Simultaneous analysis of eight vitamin E isomers in Moringa oleifera Lam. leaves by ultra performance convergence chromatography","volume":"207","author":"Qi","year":"2016","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1900443","DOI":"10.1002\/ejlt.201900443","article-title":"Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice","volume":"122","author":"Han","year":"2020","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_27","unstructured":"(2016). Aquaculture Industry Standard of China. Fish Oil (Standard No. SC\/T 3502-2016)."},{"key":"ref_28","unstructured":"(2017). Standard for Fish Oils Codex Stan 329-2017 (Standard No. CXS 329-2017)."},{"key":"ref_29","first-page":"13","article-title":"Chemical characterization and evaluation of anti-inflammatory and antioxidant properties of fish oil from Coregonus peled","volume":"42","author":"Song","year":"2023","journal-title":"J. Dalian Polytech. Univ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00217-022-04193-7","article-title":"Quantitative analysis of fatty acids and vitamin E and total lipid profiling of dietary supplements from the German market","volume":"249","author":"Zartmann","year":"2023","journal-title":"Eur. Food Res. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/md12010128","article-title":"Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications\u2014A review","volume":"12","author":"Ambati","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jfda.2017.05.006","article-title":"Modifications of Atlantic salmon by-product oil for obtaining different \u03c9-3 polyunsaturated fatty acids concentrates: An approach to comparative analysis","volume":"26","author":"Haq","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/fsn3.914","article-title":"The comparison of krill oil extracted through ethanol-hexane method and subcritical method","volume":"7","author":"Sun","year":"2019","journal-title":"Food Sci. Nutr."},{"key":"ref_34","unstructured":"Guo, Y.X. (2014). Three-Liquid-Phase Salting-Out Extraction and Component Analysis of Lipids in the Abalone Viscera. [Master\u2019s thesis, Dalian University of Technology]."},{"key":"ref_35","first-page":"3872","article-title":"Free radical scavenging activity of fish oil-an in-vitro study","volume":"8","author":"Akmal","year":"2017","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1039\/D0FO00133C","article-title":"Tomato seed oil attenuates hyperlipidemia and modulates gut microbiota in C57BL\/6J mice","volume":"11","author":"He","year":"2020","journal-title":"Food Funct."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Su, Y., Choi, H.S., Choi, J.H., Kim, H.S., Lee, G.Y., Cho, H.W., Choi, H., Jang, Y.S., and Seo, J.W. (2023). Effects of fish oil, lipid mediators, derived from docosahexaenoic acid, and their co-treatment against lipid metabolism dysfunction and inflammation in HFD Mice and HepG2 cells. Nutrients, 15.","DOI":"10.3390\/nu15020427"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Haneishi, Y., Furuya, Y., Hasegawa, M., Takemae, H., Tanioka, Y., Mizutani, T., Rossi, M., and Miyamoto, J. (2023). Polyunsaturated fatty acids-rich dietary lipid prevents high fat diet-induced obesity in mice. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-32851-7"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Jin, W., Li, C., Yang, S., Song, S., Hou, W., Song, Y., and Du, Q. (2023). Hypolipidemic effect and molecular mechanism of ginsenosides: A review based on oxidative stress. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1166898"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.foodchem.2009.10.055","article-title":"Fatty acid compositions of fish oil extracted from different parts of Indian mackerel (Rastrelliger kanagurta) using various techniques of supercritical CO2 extraction","volume":"120","author":"Sahena","year":"2010","journal-title":"Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e15088","DOI":"10.1016\/j.heliyon.2023.e15088","article-title":"Iodine values, peroxide values and acid values of Bohai algae oil compared with other oils during the cooking","volume":"9","author":"Geng","year":"2023","journal-title":"Heliyon"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.renene.2017.12.071","article-title":"A novel approach for extraction of algal oil from marine macroalgae Ulva fasciata","volume":"127","author":"Veeranan","year":"2018","journal-title":"Renew. Energ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.profoo.2015.01.019","article-title":"Amino acid and fatty acid of abalone haliotis squamata cultured in different aquaculture systems","volume":"3","author":"Latuihamallo","year":"2015","journal-title":"Procedia Food Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09637480410001666469","article-title":"Comparison of n-3 polyunsaturated fatty acid contents of wild and cultured Australian abalone","volume":"55","author":"Su","year":"2004","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1745-4514.2011.00631.x","article-title":"Lipid and fatty acid composition of two species of abalone, haliotis discus hannai ino and haliotis diversicolor reeve","volume":"37","author":"Lou","year":"2013","journal-title":"J. Food Biochem."},{"key":"ref_46","first-page":"454","article-title":"Fish oil for human health: Omega-3 fatty acid profiles of marine seafood species","volume":"39","year":"2018","journal-title":"Food Sci. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Sonnweber, T., Pizzini, A., Nairz, M., Weiss, G., and Tancevski, I. (2018). Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113285"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/00325481.2019.1607414","article-title":"The eicosapentaenoic acid: Arachidonic acid ratio and its clinical utility in cardiovascular disease","volume":"131","author":"Nelson","year":"2019","journal-title":"Postgrad. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cmet.2014.09.004","article-title":"The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism","volume":"20","author":"Demetz","year":"2014","journal-title":"Cell Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.phrs.2009.10.007","article-title":"Health effects of oleic acid and long chain omega-3 fatty acids (EPA and DHA) enriched milks. A review of intervention studies","volume":"61","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_51","first-page":"1","article-title":"Vitamins A, D3 and E in Nova Scotian cod liver oils","volume":"37","author":"Ackman","year":"1987","journal-title":"Proc. NS Inst. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bj\u00f8rklund, G., Gasmi, A., Lenchyk, L., Shanaida, M., Zafar, S., Mujawdiya, P.K., Lysiuk, R., Antonyak, H., Noor, S., and Akram, M. (2022). The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions. Molecules, 27.","DOI":"10.3390\/molecules27217167"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.18295\/2075-0528.1566","article-title":"The Role of Vitamin E in Human Health and Some Diseases","volume":"14","author":"Rizvi","year":"2014","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.rvsc.2021.05.023","article-title":"Beneficial effects and health benefits of Astaxanthin molecules on animal production: A review","volume":"138","author":"Raza","year":"2021","journal-title":"Res. Vet. Sci."},{"key":"ref_55","first-page":"57","article-title":"Antioxidant activities of Muntingia calabura, Syzygium cumini, Ocimum basilicum, and Eleutherine bulbosa using DPPH Method","volume":"1","author":"Haerani","year":"2019","journal-title":"Indones. J. Pharm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"62","DOI":"10.56557\/upjoz\/2022\/v43i93027","article-title":"Antioxidant properties of trash fish Odonus niger liver oil in comparison with cod liver oil","volume":"43","author":"Giruba","year":"2022","journal-title":"Uttar Pradesh J. Zool."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.lwt.2016.12.029","article-title":"Quality, composition, and antioxidant activity of virgin olive oil from introduced varieties at Liangshan","volume":"78","author":"Xiang","year":"2017","journal-title":"LWT"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Cuffaro, D., Bertini, S., Macchia, M., and Digiacomo, M. (2023). Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment. Nutrients, 15.","DOI":"10.3390\/nu15051073"},{"key":"ref_59","first-page":"833","article-title":"Fatty acid profiles of fish oil derived by different techniques from by-products of cultured Black Sea salmon, Oncorhynchus mykiss","volume":"29","author":"Duyar","year":"2023","journal-title":"J. Agric. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s42269-021-00557-3","article-title":"Quality characteristics of extracted oil from the head and gills of Catfish and Titus fish","volume":"45","author":"Abiona","year":"2021","journal-title":"Bull. Natl. Res. Cent."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.plefa.2017.12.003","article-title":"Arachidonic acid supplementation modulates blood and skeletal muscle lipid profile with no effect on basal inflammation in resistance exercise trained men","volume":"128","author":"Markworth","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cbi.2006.08.005","article-title":"Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices","volume":"163","author":"Wang","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"M\u00e9ndez, L., and Medina, I. (2021). Polyphenols and Fish Oils for Improving Metabolic Health: A Revision of the Recent Evidence for Their Combined Nutraceutical Effects. Molecules, 26.","DOI":"10.3390\/molecules26092438"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11130-011-0258-9","article-title":"Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects","volume":"66","author":"Choi","year":"2011","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.freeradbiomed.2007.06.019","article-title":"The relationship between dose of vitamin E and suppression of oxidative stress in humans","volume":"43","author":"Roberts","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3164\/jcbn.2008044","article-title":"Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index","volume":"43","author":"Yang","year":"2008","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"129651","DOI":"10.1155\/2014\/129651","article-title":"Nitric Oxide-Related Oxidative Stress and Redox Status in Health and Disease","volume":"2014","author":"Modun","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Jeong, H.D., Song, M.J., Lee, D.H., Chung, J.H., and Lee, S.T. (2022). SOD3 suppresses the expression of mmp-1 and increases the integrity of extracellular matrix in fibroblasts. Antioxidants, 11.","DOI":"10.3390\/antiox11050928"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"114440","DOI":"10.1016\/j.ecoenv.2022.114440","article-title":"The involvement of oxidative stress mediated endoplasmic reticulum pathway in apoptosis of Golden Pompano (Trachinotus blochii) liver under PS-MPs stress","volume":"249","author":"Yao","year":"2023","journal-title":"Ecotox Environ. Safe"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zhao, M., Zhang, D., Zhang, Q., Lin, Y., and Cao, H. (2024). Association between composite dietary antioxidant index and hyperlipidemia: A cross-sectional study from NHANES (2005\u20132020). Sci. Rep., 14.","DOI":"10.1038\/s41598-024-66922-0"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5937\/jomb0-24652","article-title":"The role of oxidative stress in the development of obesity and obesity-related metabolic disorders","volume":"40","author":"Pap","year":"2021","journal-title":"J. Med. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Berardo, C., Di Pasqua, L.G., Cagna, M., Richelmi, P., Vairetti, M., and Ferrigno, A. (2020). Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: Current Issues and Future Perspectives in Preclinical and Clinical Research. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249646"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.advnut.2023.03.014","article-title":"The Potential Cardiometabolic Effects of Long-Chain \u03c9-3 Polyunsaturated Fatty Acids: Recent Updates and Controversies","volume":"14","author":"Bae","year":"2023","journal-title":"Adv. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"105937","DOI":"10.1016\/j.jff.2023.105937","article-title":"Astaxanthin as a metabolic regulator of glucose and lipid homeostasis","volume":"112","author":"Medoro","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3904\/kjim.2015.30.5.571","article-title":"Evidence for beneficial effects of vitamin E","volume":"30","author":"Niki","year":"2015","journal-title":"Korean J. Intern. 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