{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:00:05Z","timestamp":1776286805375,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Post-colonoscopy syndrome is an emerging clinical entity characterised by the onset of gastrointestinal symptoms following a colonoscopy. The current management of this syndrome has not yet been established, although probiotics have been proposed. The therapeutic potential of a combination nutraceutical compound based on HBQ-Complex\u00ae, butyrate, and probiotics (Lactobacillus acidophilus, Bifidobacterium animalis, and Lactiplantibacillus plantarum) in this setting remains unknown. Methods: A retrospective, multicentre, observational study was conducted in adult patients undergoing colonoscopy in the absence of known gastrointestinal diseases, assessing the onset of upper and lower gastrointestinal symptoms post-colonoscopy immediately after the procedure (T0), at 2 weeks (T1), and 4 weeks (T2) thereafter, using a VAS (0\u201310). Two groups were analysed, one undergoing nutraceutical supplementation and a control group. Results: A total of 599 patients were included (64.9% receiving nutraceutical supplementation and 35% in the control group). Several variations were observed involving the treated group compared to the control for abdominal pain (59.9% vs. 33.3%), meteorism (64.9% vs. 35.1%), diarrhoea (46.9% vs. 19.5%), and bloating (59.3% vs. 26.7%) (p &lt; 0.001 for all). Logistic regression analysis showed a reduction in constipation (OR: 3.344) and bloating (OR: 3.791) scores. Conclusions: Nutraceutical supplementation based on this combinational compound was associated with a reduction in gastrointestinal symptoms arising after colonoscopy, suggesting potential benefit in this setting. These findings pose a rationale for controlled prospective studies to confirm such evidence in broader clinical settings.<\/jats:p>","DOI":"10.3390\/nu17193152","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:07:48Z","timestamp":1759417668000},"page":"3152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management of Post-Colonoscopy Syndrome with a Nutraceutical Intervention Based on Hericium erinaceus: A Retrospective Two-Arm Multicentre Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-5541","authenticated-orcid":false,"given":"Antonio","family":"Tursi","sequence":"first","affiliation":[{"name":"Territorial Gastroenterology Service, Barletta-Andria-Trani Local Health Agency, Via Fornaci, 76123 Andria, Italy"},{"name":"Department of Medical and Surgical Sciences, Catholic University of Rome, Largo A. Gemelli, 00168 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"D\u2019Avino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, IRCCS Istituto Dermopatico dell\u2019Immacolata, 00167 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Brandimarte","sequence":"additional","affiliation":[{"name":"Consorzio Universitario Humanitas, Via della Conciliazione, 00193 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-7409","authenticated-orcid":false,"given":"Giammarco","family":"Mocci","sequence":"additional","affiliation":[{"name":"SC Gastroenterologia, ARNAS Brotzu, Piazzale Alessandro Ricchi, 09047 Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-230X","authenticated-orcid":false,"given":"Raffaele","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 80138 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0885-0793","authenticated-orcid":false,"given":"Alessandro","family":"Federico","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 80138 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":false,"given":"Edoardo Vincenzo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, Via VIII Febbraio, 35121 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-0115","authenticated-orcid":false,"given":"Antonietta Gerarda","family":"Gravina","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 80138 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the HERICIUM-COLON Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.gastro.2019.06.043","article-title":"Strategies for Colorectal Cancer Screening","volume":"158","author":"Ladabaum","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1055\/a-0959-0505","article-title":"Bowel Preparation for Colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline\u2014Update 2019","volume":"51","author":"Hassan","year":"2019","journal-title":"Endoscopy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4253\/wjge.v15.i3.133","article-title":"Quality of Bowel Preparation in Patients with Inflammatory Bowel Disease Undergoing Colonoscopy: What Factors to Consider?","volume":"15","author":"Gravina","year":"2023","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.dld.2022.08.025","article-title":"Incidence, Risk and Protective Factors of Symptoms after Colonoscopy","volume":"54","author":"Collatuzzo","year":"2022","journal-title":"Dig. Liver Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1080\/0284186X.2019.1574979","article-title":"Patient-Reported Minor Adverse Events after Colonoscopy: A Systematic Review","volume":"58","author":"Steffenssen","year":"2019","journal-title":"Acta Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jopan.2024.08.023","article-title":"Examination of Core Clinical Symptoms of Postoperative Fatigue Syndrome Following Colonoscopy With Sedation","volume":"40","author":"Liu","year":"2025","journal-title":"J. Perianesth. Nurs."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/ajg.2016.234","article-title":"Post-Colonoscopy Complications: A Systematic Review, Time Trends, and Meta-Analysis of Population-Based Studies","volume":"111","author":"Reumkens","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/CEG.S285573","article-title":"Characteristics of Patients with Post-Colonoscopy Unplanned Hospital Visit: A Retrospective Single-Center Observational Study","volume":"14","author":"Makker","year":"2021","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_9","first-page":"22","article-title":"Bacterial Network Community in Fecal and Endoluminal Microbiota after Colonoscopy","volume":"43","author":"Meroni","year":"2020","journal-title":"New Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/MEG.0000000000000581","article-title":"Persisting Changes of Intestinal Microbiota after Bowel Lavage and Colonoscopy","volume":"28","author":"Drago","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e1305","DOI":"10.1016\/j.cgh.2021.08.049","article-title":"Risk for Post-Colonoscopy Irritable Bowel Syndrome in Patients With and Without Antibiotic Exposure: A Retrospective Cohort Study","volume":"20","author":"Vajravelu","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1111\/j.1440-1746.2006.04145.x","article-title":"Factors Determining Post-Colonoscopy Abdominal Pain: Prospective Study of Screening Colonoscopy in 1000 Subjects","volume":"21","author":"Lee","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert Consensus Document. The International Scientific Association for Probiotics and Prebiotics Consensus Statement on the Scope and Appropriate Use of the Term Probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_14","first-page":"387","article-title":"Utilization of Probiotics in Relieving Post-Colonoscopy Gastrointestinal Symptoms: A Systematic Review and Meta-Analysis","volume":"62","author":"Muzellina","year":"2024","journal-title":"Rom. J. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert Consensus Document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1208\/ps050325","article-title":"Nutraceutical\u2014Definition and Introduction","volume":"5","author":"Kalra","year":"2003","journal-title":"AAPS PharmSci"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.3748\/wjg.v29.i20.3048","article-title":"Hericium erinaceus, a Medicinal Fungus with a Centuries-Old History: Evidence in Gastrointestinal Diseases","volume":"29","author":"Gravina","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.23736\/S2724-5985.22.03132-1","article-title":"Performance of a Multicompounds Nutraceutical Formulation in Patients with Symptomatic Uncomplicated Diverticular Disease","volume":"68","author":"Brandimarte","year":"2022","journal-title":"Minerva Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Tursi, A., D\u2019Avino, A., Brandimarte, G., Mocci, G., Pellegrino, R., Savarino, E.V., Gravina, A.G., and The Hericium-Uc Study Group (2024). null Enhancing Oral 5-ASA Effectiveness in Mild-to-Moderate Ulcerative Colitis through an H. Erinaceus-Based Nutraceutical Add-on Multi-Compound: The \u201cHERICIUM-UC\u201d Two-Arm Multicentre Retrospective Study. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16091133"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gravina, A.G., Pellegrino, R., Palladino, G., Coppola, A., Brandimarte, G., Tuccillo, C., Ciardiello, F., Romano, M., and Federico, A. (2023). Hericium erinaceus, in Combination with Natural Flavonoid\/Alkaloid and B3\/B8 Vitamins, Can Improve Inflammatory Burden in Inflammatory Bowel Diseases Tissue: An Ex Vivo Study. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1215329"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/bmj.39339.610000.BE","article-title":"The Declaration of Helsinki","volume":"335","author":"Goodyear","year":"2007","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S2468-1253(20)30217-X","article-title":"Global Prevalence of Irritable Bowel Syndrome According to Rome III or IV Criteria: A Systematic Review and Meta-Analysis","volume":"5","author":"Oka","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.gie.2008.05.057","article-title":"The Boston Bowel Preparation Scale: A Valid and Reliable Instrument for Colonoscopy-Oriented Research","volume":"69","author":"Lai","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15403\/jgld.2014.1121.281.dic","article-title":"The \u201cDICA\u201d Endoscopic Classification for Diverticular Disease of the Colon Shows a Significant Interobserver Agreement among Community Endoscopists","volume":"28","author":"Tursi","year":"2019","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.sjpain.2016.06.012","article-title":"How to Analyze the Visual Analogue Scale: Myths, Truths and Clinical Relevance","volume":"13","author":"Heller","year":"2016","journal-title":"Scand. J. Pain."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3748\/wjg.v25.i2.190","article-title":"Adverse Events Related to Colonoscopy: Global Trends and Future Challenges","volume":"25","author":"Kim","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/aid2.13186","article-title":"Influence of Probiotics on Gastrointestinal Symptoms in Patients Undergoing Colonoscopy","volume":"8","author":"Hung","year":"2021","journal-title":"Adv. Dig. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1080\/00365521.2024.2406537","article-title":"Correlation of Gastrointestinal Symptom Rating Scale and Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease with Endoscopic Findings","volume":"59","author":"Uchiyama","year":"2024","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_29","first-page":"13","article-title":"Lactobacillus plantarum LP01, Lactobacillus Lactis Subspecies Cremoris LLC02, and Lactobacillus delbrueckii LDD01 in Patients Undergoing Bowel Preparation","volume":"90","author":"Bonavina","year":"2019","journal-title":"Acta Biomed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3920\/BM2020.0191","article-title":"Lactiplantibacillus plantarum 299v (LP299V\u00ae): Three Decades of Research","volume":"12","author":"Teixeira","year":"2021","journal-title":"Benef. Microbes"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s12602-022-09987-5","article-title":"Lactiplantibacillus plantarum Regulated Intestinal Microbial Community and Cytokines to Inhibit Salmonella yyphimurium Infection","volume":"15","author":"Liu","year":"2023","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Shi, C., and Kn\u00f8chel, S. (2023). Bioprotection Potential of Lacticaseibacillus rhamnosus LRH01 and Lactiplantibacillus plantarum LP01 against Spoilage-Associated Penicillium Strains in Yoghurt. Molecules, 28.","DOI":"10.3390\/molecules28217397"},{"key":"ref_33","first-page":"18","article-title":"Post-Surgical Intestinal Dysbiosis: Use of an Innovative Mixture (Lactobacillus plantarum LP01, Lactobacillus lactis Subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01)","volume":"90","author":"Bonavina","year":"2019","journal-title":"Acta Biomed."},{"key":"ref_34","first-page":"8","article-title":"Abincol\u00ae (Lactobacillus plantarum LP01, Lactobacillus lactis Subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01), an Oral Nutraceutical, Pragmatic Use in Patients with Chronic Intestinal Disorders","volume":"90","author":"Bonavina","year":"2019","journal-title":"Acta Biomed."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"de Jesus, L.C.L., Freitas, A.D.S., Dutra, J.d.C.F., Campos, G.M., Am\u00e9rico, M.F., Laguna, J.G., Dornelas, E.G., Carvalho, R.D.d.O., Vital, K.D., and Fernandes, S.O.A. (2024). Lactobacillus Delbrueckii CIDCA 133 Fermented Milk Modulates Inflammation and Gut Microbiota to Alleviate Acute Colitis. Food Res. Int., 186.","DOI":"10.1016\/j.foodres.2024.114322"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1097\/MCG.0b013e318267b55d","article-title":"The Innovative Potential of Lactobacillus rhamnosus LR06, Lactobacillus pentosus LPS01, Lactobacillus plantarum LP01, and Lactobacillus delbrueckii Subsp. delbrueckii LDD01 to Restore the \u201cGastric Barrier Effect\u201d in Patients Chronically Treated with PPI: A Pilot Study","volume":"46","author":"Anderloni","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1038\/s41598-023-29404-3","article-title":"Subspecies-Level Genome Comparison of Lactobacillus Delbrueckii","volume":"13","author":"Baek","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.1097\/MCG.0000000000000680","article-title":"In Vitro Inhibition of Klebsiella pneumoniae by Lactobacillus delbrueckii Subsp. delbrueckii LDD01 (DSM 22106): An Innovative Strategy to Possibly Counteract Such Infections in Humans?","volume":"50","author":"Mogna","year":"2016","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0029665120006916","article-title":"SCFA: Mechanisms and Functional Importance in the Gut","volume":"80","author":"Marinelli","year":"2021","journal-title":"Proc. Nutr. Soc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12602-017-9264-z","article-title":"Lactobacillus plantarum and Its Probiotic and Food Potentialities","volume":"9","author":"Seddik","year":"2017","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"790561","DOI":"10.3389\/fnut.2021.790561","article-title":"Bifidobacterium animalis Subsp. lactis HN019 Effects on Gut Health: A Review","volume":"8","author":"Cheng","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.4014\/jmb.2205.05041","article-title":"The Functional Roles of Lactobacillus acidophilus in Different Physiological and Pathological Processes","volume":"32","author":"Gao","year":"2022","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Xie, X.-Q., Geng, Y., Guan, Q., Ren, Y., Guo, L., Lv, Q., Lu, Z.-M., Shi, J.-S., and Xu, Z.-H. (2021). Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study. Nutrients, 13.","DOI":"10.3390\/nu13031008"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Karunaratne, T.B., Okereke, C., Seamon, M., Purohit, S., Wakade, C., and Sharma, A. (2020). Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson\u2019s Disease. Nutrients, 13.","DOI":"10.3390\/nu13010028"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"104722","DOI":"10.1016\/j.phrs.2020.104722","article-title":"Berberine Pharmacology and the Gut Microbiota: A Hidden Therapeutic Link","volume":"155","author":"Habtemariam","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102433","DOI":"10.1016\/j.psj.2022.102433","article-title":"Quercetin Alleviates Intestinal Inflammation and Improves Intestinal Functions via Modulating Gut Microbiota Composition in LPS-Challenged Laying Hens","volume":"102","author":"Feng","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pupt.2014.01.005","article-title":"Randomized Controlled Trials and Real Life Studies. Approaches and Methodologies: A Clinical Point of View","volume":"27","author":"Saturni","year":"2014","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Liu, F., and Panagiotakos, D. (2022). Real-World Data: A Brief Review of the Methods, Applications, Challenges and Opportunities. BMC Med. Res. Methodol., 22.","DOI":"10.1186\/s12874-022-01768-6"},{"key":"ref_49","first-page":"25","article-title":"Real-World Evidence: A Primer","volume":"37","author":"Dang","year":"2023","journal-title":"Pharmaceut. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e674","DOI":"10.1016\/S2666-7568(22)00186-6","article-title":"Comparing Clinical Trial Population Representativeness to Real-World Populations: An External Validity Analysis Encompassing 43\u2008895 Trials and 5\u2008685\u2008738 Individuals across 989 Unique Drugs and 286 Conditions in England","volume":"3","author":"Tan","year":"2022","journal-title":"Lancet Healthy Longev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"102915","DOI":"10.1016\/j.eclinm.2024.102915","article-title":"Real-World Data: Bridging the Gap between Clinical Trials and Practice","volume":"78","author":"Wilson","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"579","DOI":"10.5217\/ir.2018.00021","article-title":"Patient Self-Reported Symptoms Using Visual Analog Scales Are Useful to Estimate Endoscopic Activity in Ulcerative Colitis","volume":"16","author":"Tsuda","year":"2018","journal-title":"Intest. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1016\/j.ejim.2013.05.013","article-title":"The Brief Visual Analogue Scale for Irritable Bowel Syndrome Questionnaire Can Be Used to Evaluate Psychological Well-Being in Patients with Irritable Bowel Syndrome","volume":"24","author":"Bengtsson","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/SGA.0b013e3182945881","article-title":"Further Validation of the Visual Analogue Scale for Irritable Bowel Syndrome after Use in Clinical Practice","volume":"36","author":"Bengtsson","year":"2013","journal-title":"Gastroenterol. Nurs."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.14309\/ajg.0000000000003499","article-title":"Validation of Esophageal Global Symptom Severity as a Patient-Reported Outcome for Evaluation of Reflux Symptoms","volume":"120","author":"Chan","year":"2025","journal-title":"Am. J. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"17562848221115319","DOI":"10.1177\/17562848221115319","article-title":"Pharmacologic Treatment of GERD in Adolescents: Is Esophageal Mucosal Protection an Option?","volume":"15","author":"Romano","year":"2022","journal-title":"Ther. Adv. Gastroenterol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/19\/3152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:09:35Z","timestamp":1759997375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/19\/3152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":56,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["nu17193152"],"URL":"https:\/\/doi.org\/10.3390\/nu17193152","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]}}}