{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T08:40:24Z","timestamp":1760431224136,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["23K08003"],"award-info":[{"award-number":["23K08003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Dyslipidemia is one of the major problems of long-term management in people living with human immunodeficiency virus (HIV) (PLH) as a risk factor for cardiovascular diseases. Lipoprotein lipase (LPL) is anchored on the surface of the capillary endothelial cells and plays a pivotal role in triglyceride metabolism by catabolizing dietary chylomicrons and very low-density lipoprotein synthesized in the liver. However, the details of the mechanisms in the era of integrase strand transfer inhibitor-based antiretroviral therapy have not yet been clarified. Methods: This study was a cross-sectional, single-center, non-interventional study evaluating the underlying factors associated with dyslipidemia, insulin resistance or secretion, and changes in the body composition of PLH. Results: Among PLH (n = 48), lower LPL (&lt;60.8 ng\/mL) and older age independently predicted antilipemic drug (ALD) necessity. A comparison of ALD-na\u00efve PLH (n = 33) and age- and sex-matched non-HIV controls (n = 33) showed that PLH were significantly associated with lower high-density lipoprotein cholesterol (HDL-C) and higher HOMA-\u03b2. LPL was also the independent predictor of HDL-C &lt; 40 mg\/dL in PLH (adjusted odds ratio = 0.901, p = 0.044). Furthermore, LPL &lt; 65.3 ng\/mL predicted HDL-C &lt; 40 mg\/dL with 100% sensitivity and 60.9% specificity. Low levels of HIV-RNA were detected in the high HOMA-\u03b2 group. Conclusions: In Japanese individuals, compared to non-HIV controls, PLH has low HDL-C and LPL. The measurement of LPL may confer the risk assessment and decision-making with relevance to ALD in PLH. Additionally, the effectiveness of HIV antiviral therapy and glucose tolerance may interact with each other.<\/jats:p>","DOI":"10.3390\/nu17203207","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:51:28Z","timestamp":1760428288000},"page":"3207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance of Lipoprotein Lipase (LPL) in People Living with HIV: A Comprehensive Assessment Including Lipidemia, Body Composition, Insulin Secretion, and Insulin Resistance"],"prefix":"10.3390","volume":"17","author":[{"given":"Akira","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Hematology, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Fukaya Red Cross Hospital, Kamishiba-cho-nishi 5-8-1, Fukaya 366-0052, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Blood Transfusion Service, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0872-5399","authenticated-orcid":false,"given":"Takumi","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Clinical Laboratory Center, Gunma University Hospital, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Centre for Health Control, Hidaka Hospital, Nakao-Machi-886, Takasaki 370-0001, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-6550","authenticated-orcid":false,"given":"Akihiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Medical Education and Development, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Graduate School of Food and Population Health Science, Gunma University, Aramaki-Machi 4-2, Maebashi 371-8510, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Graduate School of Food and Population Health Science, Gunma University, Aramaki-Machi 4-2, Maebashi 371-8510, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-4158","authenticated-orcid":false,"given":"Katsuhiko","family":"Tsunekawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Clinical Laboratory Center, Gunma University Hospital, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Graduate School of Food and Population Health Science, Gunma University, Aramaki-Machi 4-2, Maebashi 371-8510, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-9862","authenticated-orcid":false,"given":"Hiroshi","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-2525","authenticated-orcid":false,"given":"Takao","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Clinical Laboratory Center, Gunma University Hospital, Showa-Machi 3-39-22, Maebashi 371-8511, Gunma, Japan"},{"name":"Graduate School of Food and Population Health Science, Gunma University, Aramaki-Machi 4-2, Maebashi 371-8510, Gunma, Japan"},{"name":"General Health Support Center, Gunma University, Aramaki-Machi 4-2, Maebashi 371-8510, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Obel, N., Omland, L.H., Kronborg, G., Larsen, C.S., Pedersen, C., Pedersen, G., S\u00f8rensen, H.T., and Gerstoft, J. 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