{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:28:30Z","timestamp":1789756110599,"version":"4.0.1"},"reference-count":60,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["GR-2021-12375174"],"award-info":[{"award-number":["GR-2021-12375174"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["SG-2021\u201312375551"],"award-info":[{"award-number":["SG-2021\u201312375551"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PRIN 2022","award":["202273HF8"],"award-info":[{"award-number":["202273HF8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Fibromyalgia is a chronic condition characterized by widespread pain, fatigue, and localized tenderness. Its pathophysiology remains unclear, and treatment options are often limited and only partially effective. Recent studies suggest a potential link between vitamin D deficiency and symptom severity, as vitamin D may play a role in modulating pain and inflammation. Methods: This systematic review and meta-analysis assessed the efficacy of vitamin D supplementation in reducing pain and improving quality of life in fibromyalgia patients, focusing on studies up to 31 December 2024. Following PRISMA guidelines, a literature search in PubMed, Web of Science, and Scopus identified 2776 articles; 7 were included in the systematic review and 4 studies in each meta-analysis. Results: Results showed that vitamin D supplementation significantly reduced pain levels compared to the control group, with a statistically significant effect observed using the NRS or VAS (SMD = \u22120.85; 95% CI: \u22121.54 to \u22120.17; p = 0.0148), as well as the FIQ scale (SMD = \u22120.87; 95% CI: \u22121.56 to \u22120.20; p= 0.0115), resulting in an improvement in quality of life. Conclusions: These findings suggest that vitamin D may be a valuable adjunct in fibromyalgia management, particularly for pain. However, further high-quality trials are needed to confirm these effects and identify responsive patient subgroups.<\/jats:p>","DOI":"10.3390\/nu17203232","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:57:42Z","timestamp":1760529462000},"page":"3232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6756-6530","authenticated-orcid":false,"given":"Sara","family":"Ilari","sequence":"first","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma, 00166 Rome, Italy"},{"name":"Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Nucera","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1533-704X","authenticated-orcid":false,"given":"Valentina","family":"Malafoglia","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero 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Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Bonaddio","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-8987","authenticated-orcid":false,"given":"Francesca","family":"Oppedisano","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Maiuolo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8593-9495","authenticated-orcid":false,"given":"Daniela","family":"Caccamo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-810X","authenticated-orcid":false,"given":"Marco","family":"Tafani","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1823-2195","authenticated-orcid":false,"given":"Carlo","family":"Tomino","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-7173","authenticated-orcid":false,"given":"Vincenzo","family":"Mollace","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Raffaeli","sequence":"additional","affiliation":[{"name":"Istituto per la Ricerca sul Dolore, Fondazione ISAL, 47921 Rimini, 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