{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:58:53Z","timestamp":1782709133077,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi University of Chinese Medicine","award":["2024QN044"],"award-info":[{"award-number":["2024QN044"]}]},{"name":"University Engineering Research Center of Characteristic Traditional Chinese Medicine and Ethnomedicine, Guangxi","award":["GXGCZXKF06"],"award-info":[{"award-number":["GXGCZXKF06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Achyranthes bidentata (AB), recognized as a food and traditional Chinese medicine, exhibits notable biological activity. Our previous study showed the hypoglycemic effect of Achyrantha bidentata polysaccharide (ABP). The properties and digestion process of polysaccharides affect their pharmacological activities. The digestion characteristics of ABP are unclear. In this study, we aimed to explore the characteristics of ABP\u2019s simulated digestion and its prebiotic properties and hypoglycemic effects. Methods: We used simulated digestion methods to investigate the alterations in ABP levels in the process of digestion and fermentation. Animal experiments were used to compare the effects of the prebiotic properties of ABP on normal control (NC) and type 2 diabetes mellitus (T2DM) mice. Then, in order to further verify the hypoglycemic effect of ABP after fermentation (ABPF), \u03b1-glucosidase activity and glucose uptake in Caco-2 cells were examined. Results: The results showed that ABP was anti-digestive and mainly degraded by the intestinal flora. Moreover, ABP showed a stronger promoting advantage against beneficial bacteria and inhibited harmful bacteria in the T2DM mice. Compared with NC mice, after ABP treatment, T2DM mice showed a higher increase in levels of short-chain fatty acids (SCFAs). Additionally, the glucose uptake and \u03b1-glucosidase activity of Caco-2 cells were significantly decreased after treatment with ABPF. Conclusions: These results underscore the potential of ABP as a prebiotic candidate for gut health promotion and T2DM alleviation.<\/jats:p>","DOI":"10.3390\/nu17203249","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:17:02Z","timestamp":1760617022000},"page":"3249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Anti-Digestive Characteristics, Effects of Prebiotic Properties on NC and T2DM Mice of Achyranthes bidentata Polysaccharide, and the Hypoglycemic Effect of Its Fermentation Products"],"prefix":"10.3390","volume":"17","author":[{"given":"Ting","family":"Xia","sequence":"first","affiliation":[{"name":"Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Zhuang Yao Medical Research Institute of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"University Engineering Research Center of Characteristic Traditional Chinese Medicine and Ethnomedicine, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Guangxi Engineering Research Center for High-Value Utilization of Guangxi-Produced Authentic Medicinal Herbs, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6441-5382","authenticated-orcid":false,"given":"Zhenjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Zhuang Yao Medical Research Institute of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Ding","sequence":"additional","affiliation":[{"name":"University Engineering Research Center of Characteristic Traditional Chinese Medicine and Ethnomedicine, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Guangxi Engineering Research Center for High-Value Utilization of Guangxi-Produced Authentic Medicinal Herbs, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Zhuang Yao Medical Research Institute of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Ning","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Zhuang Yao Medical Research Institute of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfang","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Zhuang Yao Medical Research Institute of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113551","DOI":"10.1016\/j.biopha.2022.113551","article-title":"Achyranthes bidentata polysaccharides alleviate endoplasmic reticulum stress in osteoarthritis via lncRNA NEAT1\/miR-377-3p pathway","volume":"154","author":"Fu","year":"2022","journal-title":"Biomed. 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