{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:47:21Z","timestamp":1761094041490,"version":"build-2065373602"},"reference-count":61,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Severe radiation-induced mucositis (RIM) is the most distressing acute side effect experienced by oropharyngeal squamous cell carcinoma (OPSCC) patients during chemo-radiotherapy (CRT), with a prevalence between 40 and 68%. RIM severity exhibits a multifactorial etiology that remains unclear. We aimed to analyze nutritional and morphofunctional predictive factors for severe RIM in OPSCC patients undergoing CRT. Methods: A prospective cohort study was conducted. Global Leadership Initiative on Malnutrition (GLIM) criteria, bioelectrical impedance vector analysis (BIVA), functional assessment and dosimetric analysis were performed prior to radiotherapy. Results: Eighty-two patients were analyzed. Severe RIM affected 46.3% of patients. Severe malnutrition according to GLIM (p = 0.011), prolonged Timed Up and Go (TUG) test (p = 0.025) and larger PTV54 volume (p = 0.049) were independent predictive factors for severe RIM, while higher fat-free mass (FFM) (p = 0.006) showed a protective effect. Conclusions: These findings highlight the importance of a comprehensive early nutritional assessment for accurately identifying patients at a higher risk of severe RIM.<\/jats:p>","DOI":"10.3390\/nu17203301","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:24:02Z","timestamp":1761056642000},"page":"3301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Nutritional Status on Severe Radiation-Induced Mucositis in Oropharyngeal Cancer Patients Undergoing Chemo-Radiotherapy"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-0866","authenticated-orcid":false,"given":"\u00c1frica","family":"Fern\u00e1ndez-Forn\u00e9","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain"},{"name":"Department of Radiation Oncology, Comprehensive Cancer Unit, Quir\u00f3nsalud M\u00e1laga Hospital, 29004 Malaga, Spain"},{"name":"School of Medicine, University of Malaga, 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-5488","authenticated-orcid":false,"given":"Roc\u00edo","family":"Fern\u00e1ndez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, Spain"},{"name":"M\u00e1laga Biomedical Research Institute and BIONAND Platform (IBIMA), 29010 Malaga, Spain"},{"name":"Department of Endocrinology and Nutrition, Quir\u00f3nSalud M\u00e1laga Hospital, 29004 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Dolores","family":"Toledo-Serrano","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain"},{"name":"M\u00e1laga Biomedical Research Institute and BIONAND Platform (IBIMA), 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herminda","family":"Jim\u00e9nez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain"},{"name":"M\u00e1laga Biomedical Research Institute and BIONAND Platform (IBIMA), 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7340-7394","authenticated-orcid":false,"given":"Marina","family":"Mu\u00f1oz-Lupi\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain"},{"name":"M\u00e1laga Biomedical Research Institute and BIONAND Platform (IBIMA), 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9911-159X","authenticated-orcid":false,"given":"Mar\u00eda Asunci\u00f3n","family":"Ruiz-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain"},{"name":"M\u00e1laga Biomedical Research Institute and BIONAND Platform (IBIMA), 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8570-184X","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Garc\u00eda-Almeida","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, Spain"},{"name":"M\u00e1laga Biomedical Research Institute and BIONAND Platform (IBIMA), 29010 Malaga, Spain"},{"name":"Department of Endocrinology and Nutrition, Quir\u00f3nSalud M\u00e1laga Hospital, 29004 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"De la Pe\u00f1a-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Radiology and Physical Medicine, School of Medicine, University of M\u00e1laga, 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-0845","authenticated-orcid":false,"given":"Mar\u00eda Isabel","family":"Queipo-Ortu\u00f1o","sequence":"additional","affiliation":[{"name":"M\u00e1laga Biomedical Research Institute and BIONAND Platform (IBIMA), 29010 Malaga, Spain"},{"name":"Department of Surgical Specialties, Biochemical and Immunology, School of Medicine, University of M\u00e1laga, 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-1148","authenticated-orcid":false,"given":"Jaime","family":"G\u00f3mez-Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain"},{"name":"M\u00e1laga Biomedical Research Institute and BIONAND Platform (IBIMA), 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/jnci\/djad169","article-title":"Global epidemiologic patterns of oropharyngeal cancer incidence trends","volume":"115","author":"Zumsteg","year":"2023","journal-title":"J. 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