{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:02:20Z","timestamp":1773720140042,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Neurodegenerative diseases, including spastic paraplegia type 11 (SPG11), are complex disorders characterized by progressive neurological decline and significant metabolic disturbances. Spatacsin, the protein encoded by the SPG11 gene, plays a critical role in autophagy and lysosomal homeostasis, which are essential for neuronal health. Its impairment leads to defective cellular clearance and neurodegeneration. Recently, personalized and precision nutrition have emerged as promising approaches to enhance clinical outcomes by tailoring dietary interventions to individual genetic, metabolic, and phenotypic profiles. Objectives: This mini scoping review aimed to synthesize current evidence on the application of personalized and precision nutrition in SPG11 and to explore how insights from related neurodegenerative diseases could inform the development of future dietary and metabolic interventions for this rare disorder. Methods: Following PRISMA-ScR guidelines, a scoping review was conducted using PubMed, Scopus, and Web of Science databases (2020\u20132024). Eligible studies included investigations addressing nutritional, genomic, or metabolic interventions in neurodegenerative diseases. Of 30 screened papers, nine met the inclusion criteria, primarily focusing on nutritional and metabolic interventions related to neurodegenerative and neuromuscular conditions. Results: To date, no dietary intervention trials have been conducted specifically for SPG11. However, evidence from studies on related neurodegenerative diseases suggests that antioxidant, mitochondrial-supportive, and microbiota-targeted dietary approaches may beneficially influence key pathological processes such as oxidative stress, lipid dysregulation, and autophagy\u2014core mechanisms that are also central to SPG11 pathophysiology. Conclusions: Although current evidence remains preliminary, personalized nutrition is a promising supplementary strategy for managing neurodegenerative diseases, including SPG11. Future research should incorporate systems-based approaches that combine dietary, metabolic, and neuroimaging assessments, with sex and comorbidity-stratified analyses, multi-omics profiling, and predictive modeling. These frameworks could help design safe, effective, and personalized nutritional interventions aimed at enhancing metabolic resilience and slowing disease progression in SPG11.<\/jats:p>","DOI":"10.3390\/nu17213344","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:31:58Z","timestamp":1761550318000},"page":"3344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nutritional Approaches in Neurodegenerative Disorders: A Mini Scoping Review with Emphasis on SPG11-Related Conditions"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-5903","authenticated-orcid":false,"given":"Paulo Renato","family":"Ribeiro","sequence":"first","affiliation":[{"name":"ESAV, Polytechnic University of Viseu, 3500-606 Viseu, Portugal"},{"name":"CERNAS-IPV Research Centre, Polytechnic University of Viseu, 3500-606 Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3088-7760","authenticated-orcid":false,"given":"Carmen","family":"Ferreira","sequence":"additional","affiliation":[{"name":"ESAS, Polytechnic University of Santar\u00e9m, 2001-904 Santar\u00e9m, Portugal"},{"name":"CERNAS-IPC Research Centre, Polytechnic of Coimbra, 3045-601 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-7446","authenticated-orcid":false,"given":"Carlos","family":"Antunes","sequence":"additional","affiliation":[{"name":"CERNAS-IPC Research Centre, Polytechnic of Coimbra, 3045-601 Coimbra, Portugal"},{"name":"ESACB, Polytechnic University of Castelo Branco, 6001-909 Castelo Branco, Portugal"},{"name":"APROSER, Association of Producers from Sert\u00e3, 6100-601 Sert\u00e3, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7030-5642","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Dias","sequence":"additional","affiliation":[{"name":"CERNAS-IPC Research Centre, Polytechnic of Coimbra, 3045-601 Coimbra, Portugal"},{"name":"ESAC, Polytechnic University of Coimbra, 3045-601 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-7892","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Lima","sequence":"additional","affiliation":[{"name":"CERNAS-IPV Research Centre, Polytechnic University of Viseu, 3500-606 Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-6805","authenticated-orcid":false,"given":"Raquel","family":"Guin\u00e9","sequence":"additional","affiliation":[{"name":"CERNAS-IPV Research Centre, Polytechnic University of Viseu, 3500-606 Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-8319","authenticated-orcid":false,"given":"Edite","family":"Teixeira-Lemos","sequence":"additional","affiliation":[{"name":"CERNAS-IPV Research Centre, Polytechnic University of Viseu, 3500-606 Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Singar, S., Nagpal, R., Arjmandi, B.H., and Akhavan, N.S. 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