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Methods: Biomarkers, such as antioxidant activity (glutathione peroxidase, glutathione reductase, MDA), immune response (IgA, IgG, IgM, IL-6, TNF-\u03b1), and purine metabolism (uric acid, xanthine oxidase, 5\u2032-nucleotidase) were selected for evaluation and their influence change. The model was white outbred rats (n = 45), randomly distributed into three groups: control (basic product), experimental group 1 (supplements of collagen-containing concentrate and extract of the composition of sea buckthorn and rosehips), and experimental group 2 (supplements of collagen-containing concentrate and extract of the composition of yarrow and sage). Results: In both experimental groups, a reliable increase in the enzymatic activity of the antioxidant system, a decrease in lipid peroxidation and the level of proinflammatory cytokines, an increase in immunoglobulins, and activation of 5\u2032-nucleotidase were observed. The most pronounced effects were observed with the introduction of a curd product containing collagen-containing concentrate and sea buckthorn and rosehip extract. Conclusions: The scientific novelty of the study lies in the first comprehensive in vivo evaluation of the combined enrichment of a dairy product with collagen and plant extracts for a set of biomarkers. The data obtained confirm the physiological activity and functional properties of the developed product, which can be considered as a promising means of specialized and sports nutrition with proven biological action.<\/jats:p>","DOI":"10.3390\/nu17213373","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:59:36Z","timestamp":1761659976000},"page":"3373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional Properties of Enriched Curd with Collagen and Plant Phytochemicals for Athletes and Physiological Benefits: Evidence Data from Preclinical Trials In Vivo"],"prefix":"10.3390","volume":"17","author":[{"given":"Klara","family":"Zharykbasova","sequence":"first","affiliation":[{"name":"Department of Applied Biology, Alikhan Bokeikhan University, Semey 070000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitbek","family":"Kakimov","sequence":"additional","affiliation":[{"name":"Department of Technological Equipment, Shakarim University, Semey 071412, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerlan","family":"Zharykbasov","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Shakarim University, Semey 071412, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhainagul","family":"Kakimova","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Shakarim University, Semey 071412, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimkhanova","family":"Guldana","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Shakarim University, Semey 071412, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozykenova","family":"Zhanna","sequence":"additional","affiliation":[{"name":"Department of Physiological Disciplines Named After T.A. 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