{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:11:41Z","timestamp":1792789901968,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LILT-Lega Italiana per la lotta contro i Tumori, Naples, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Several studies have reported the association between malnutrition risk and survival outcomes in surgically treated lung cancer patients; in contrast, limited data are available on patients undergoing medical therapies. The aim of this study was to evaluate malnutrition risk (using the CONUT score) and its relationships with treatment response and survival in patients with an advanced stage of non-small cell lung cancer (NSCLC). Methods: We retrospectively evaluated 109 patients with a diagnosis of locally advanced and advanced NSCLC. Patients were assessed at baseline (before any therapy), after four cycles of therapy, and during a follow-up period of 4 years. Results: Thirty-two (29.4%) NSCLC patients had a CONUT score \u2265 2. Patients with a higher CONUT score were more likely to have brain metastases while patients with a CONUT score &lt; 2 had a significantly better response to therapy in terms of partial response\/stable disease. In addition, The Kaplan\u2013Meier curves revealed a significantly worse prognosis for the high CONUT than the low CONUT group regarding both OS and PFS. Cox regression analysis indicated that the CONUT score (\u22652) was as a significant determinant of OS and PFS in the patients studied even after considering other possible predictors. Conclusion: This study suggests that malnutrition risk assessment with CONUT score may be valuable in the prognosis assessment of advanced-stage NSCLC patients.<\/jats:p>","DOI":"10.3390\/nu17213416","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:33:07Z","timestamp":1761881587000},"page":"3416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Controlling Nutritional Status (CONUT) Score as a Predictor of Prognosis in Non-Small Cell Lung Cancer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2902-3558","authenticated-orcid":false,"given":"Raffaella","family":"Pagliaro","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cL.Vanvitelli\u201d, 80131 Naples, Italy"},{"name":"Clinic of Respiratory Diseases \u201cL. Vanvitelli\u201d, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Scalfi","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Di Fiore","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cL.Vanvitelli\u201d, 80131 Naples, Italy"},{"name":"Clinic of Respiratory Diseases \u201cL. Vanvitelli\u201d, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Leoni","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cL.Vanvitelli\u201d, 80131 Naples, Italy"},{"name":"Clinic of Respiratory Diseases \u201cL. Vanvitelli\u201d, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Masi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cL.Vanvitelli\u201d, 80131 Naples, Italy"},{"name":"Clinic of Respiratory Diseases \u201cL. Vanvitelli\u201d, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"D\u2019Agnano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cL.Vanvitelli\u201d, 80131 Naples, Italy"},{"name":"Clinic of Respiratory Diseases \u201cL. Vanvitelli\u201d, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Picone","sequence":"additional","affiliation":[{"name":"Division of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Napoli, Italy"},{"name":"Department of Medicine and Health Science, Vincenzo Tiberio University of Molise, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-7315","authenticated-orcid":false,"given":"Filippo","family":"Scial\u00f2","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"},{"name":"CEINGE-Biotecnologie Avanzate Franco Salvatore, Via G. Salvatore 486, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-7037","authenticated-orcid":false,"given":"Fabio","family":"Perrotta","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cL.Vanvitelli\u201d, 80131 Naples, Italy"},{"name":"Clinic of Respiratory Diseases \u201cL. Vanvitelli\u201d, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-5901","authenticated-orcid":false,"given":"Andrea","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cL.Vanvitelli\u201d, 80131 Naples, Italy"},{"name":"Clinic of Respiratory Diseases \u201cL. Vanvitelli\u201d, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.clnu.2008.07.009","article-title":"A rational approach to nutritional assessment","volume":"27","author":"Soeters","year":"2008","journal-title":"Clin. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1080\/01635581.2024.2381271","article-title":"Cancer-Related Malnutrition and the Role of Parenteral Nutrition in Cancer; A Narrative Review","volume":"76","author":"Firouzabadi","year":"2024","journal-title":"Nutr. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.ejon.2005.09.006","article-title":"Cancer-associated malnutrition","volume":"9","year":"2005","journal-title":"Eur. J. Oncol. 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Surg."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/21\/3416\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:33:49Z","timestamp":1761896029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/21\/3416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":52,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["nu17213416"],"URL":"https:\/\/doi.org\/10.3390\/nu17213416","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]}}}