{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:05:53Z","timestamp":1792026353650,"version":"4.4.0"},"reference-count":122,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diet influences brain health through many connected metabolic and molecular pathways, and these effects are stronger in obesity. This review links diet quality with cognitive decline and dementia risk. Ultra-processed, high-fat, high-sugar diets drive weight gain, insulin resistance, and chronic inflammation. These changes trigger brain oxidative stress, reduce DNA repair, deplete NAD+, disturb sirtuin\/PARP balance, and alter epigenetic marks. Gut dysbiosis and leaky gut add inflammatory signals, weaken the blood\u2013brain barrier, and disrupt microglia. Mediterranean and MIND diets, rich in plants, fiber, polyphenols, and omega-3 fats, slow cognitive decline and lower dementia risk. Trials show extra benefit when diet improves alongside exercise and vascular risk control. Specific nutrients can help in certain settings. DHA and EPA support brain health in people with low omega-3 status or early disease. B-vitamins slow brain shrinkage in mild cognitive impairment when homocysteine is high. Vitamin D correction is beneficial when levels are low. A practical plan emphasizes healthy eating and good metabolic control. It includes screening for deficiencies and supporting the microbiome with fiber and fermented foods. Mechanism-based add-ons, such as NAD+ boosters, deserve testing in lifestyle-focused trials. Together, these measures may reduce diet-related brain risk across the life span. At the same time, artificial intelligence can integrate diet exposures, adiposity, metabolic markers, multi-omics, neuroimaging, and digital phenotyping. This can identify high-risk phenotypes, refine causal links along the diet\u2013obesity\u2013brain axis, and personalize nutrition-plus-lifestyle interventions. It can also highlight safety, equity, and privacy considerations. Translationally, a pattern-first strategy can support early screening and personalized risk reduction by integrating diet quality, adiposity, vascular risk, micronutrient status, and microbiome-responsive behaviors. AI can aid measurement and risk stratification when developed with privacy, equity, and interpretability safeguards, but clinical decisions should remain mechanism-aligned and trial-anchored.<\/jats:p>","DOI":"10.3390\/nu17213493","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:51:43Z","timestamp":1762451503000},"page":"3493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Diet\u2013Obesity\u2013Brain Axis: Metabolic, Epigenetic, and DNA-Repair Pathways Linking Eating Patterns to Cognitive Aging, with an AI-Enabled Translational Perspective"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3200-0713","authenticated-orcid":false,"given":"Manish","family":"Loomba","sequence":"first","affiliation":[{"name":"Amity University Uttar Pradesh, Sector 125, Noida 201303, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Bansal","sequence":"additional","affiliation":[{"name":"Amity University Uttar Pradesh, Sector 125, Noida 201303, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3849-5945","authenticated-orcid":false,"given":"Krishna Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Symbiosis Centre for Information Technology, Symbiosis International (Deemed University), Rajiv Gandhi InfoTech Park, Hinjawadi, Pune 411057, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"TCG Centres of Research and Education in Science and Technology, Bengal Eco Intelligent Park, Sector-V, Salt Lake, Kolkata 700091, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3252-7216","authenticated-orcid":false,"given":"Shampa","family":"Ghosh","sequence":"additional","affiliation":[{"name":"GloNeuro, Sector 107, Vishwakarma Road, Noida 201301, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manchala","family":"Raghunath","sequence":"additional","affiliation":[{"name":"ICMR\u2014National Institute of Nutrition (NIN), Tarnaka 500007, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-3264","authenticated-orcid":false,"given":"Awdhesh Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-6932","authenticated-orcid":false,"given":"Jitendra Kumar","family":"Sinha","sequence":"additional","affiliation":[{"name":"GloNeuro, Sector 107, Vishwakarma Road, Noida 201301, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nrn2421","article-title":"Brain Foods: The Effects of Nutrients on Brain Function","volume":"9","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2014.04.001","article-title":"Obesity and Neuroinflammation: A Pathway to Cognitive Impairment","volume":"42","author":"Miller","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tins.2017.02.005","article-title":"Obesity-Induced Neuroinflammation: Beyond the Hypothalamus","volume":"40","author":"Muccioli","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How Mitochondria Produce Reactive Oxygen Species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102667","DOI":"10.1016\/j.arr.2025.102667","article-title":"Oxidative Stress and Mitochondrial Impairment: Key Drivers in Neurodegenerative Disorders","volume":"104","author":"Wen","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neurobiolaging.2021.07.014","article-title":"Emerging Roles of Oxidative Stress in Brain Aging and Alzheimer\u2019s Disease","volume":"107","author":"Cotman","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1007\/s12035-024-04474-0","article-title":"The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging","volume":"62","author":"Sinha","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuroscience.2014.03.040","article-title":"Increased Macromolecular Damage Due to Oxidative Stress in the Neocortex and Hippocampus of WNIN\/Ob, a Novel Rat Model of Premature Aging","volume":"269","author":"Sinha","year":"2014","journal-title":"Neuroscience"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"a025130","DOI":"10.1101\/cshperspect.a025130","article-title":"DNA Damage, DNA Repair, Aging, and Neurodegeneration","volume":"5","author":"Maynard","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_10","first-page":"1019","article-title":"SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular Lifespan","volume":"19","author":"Mishra","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1089\/rej.2015.1767","article-title":"NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair, Longevity, and Health Span","volume":"19","author":"Poljsak","year":"2016","journal-title":"Rejuvenation Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.aac4854","article-title":"NAD+ in Aging, Metabolism, and Neurodegeneration","volume":"350","author":"Verdin","year":"2015","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e3182190d09","article-title":"Midlife Overweight and Obesity Increase Late-Life Dementia Risk: A Population-Based Twin Study","volume":"76","author":"Xu","year":"2011","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jalz.2017.09.016","article-title":"Body Mass Index and Risk of Dementia: Analysis of Individual-Level Data from 1.3 Million Individuals","volume":"14","author":"Luukkonen","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3233\/JAD-130830","article-title":"Association of Mediterranean Diet with Mild Cognitive Impairment and Alzheimer\u2019s Disease: A Systematic Review and Meta-Analysis","volume":"39","author":"Singh","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/jnnp-2012-304792","article-title":"Mediterranean Diet Improves Cognition: The PREDIMED-NAVARRA Randomised Trial","volume":"84","author":"Clavero","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jalz.2014.11.009","article-title":"MIND Diet Associated with Reduced Incidence of Alzheimer\u2019s Disease","volume":"11","author":"Morris","year":"2015","journal-title":"Alzheimers Dement."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Shannon, O.M., Ranson, J.M., Gregory, S., Macpherson, H., Milte, C., Lentjes, M., Mulligan, A., McEvoy, C., Griffiths, A., and Matu, J. (2023). Mediterranean Diet Adherence Is Associated with Lower Dementia Risk, Independent of Genetic Predisposition: Findings from the UK Biobank Prospective Cohort Study. BMC Med., 21.","DOI":"10.1186\/s12916-023-02772-3"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jalouli, M., Rahman, M.A., Biswas, P., Rahman, H., Harrath, A.H., Lee, I.-S., Kang, S., Choi, J., Park, M.N., and Kim, B. (2025). Targeting Natural Antioxidant Polyphenols to Protect Neuroinflammation and Neurodegenerative Diseases: A Comprehensive Review. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1492517"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ojo, O., Ojo, O.O., Zand, N., and Wang, X. (2021). The Effect of Dietary Fibre on Gut Microbiota, Lipid Profile, and Inflammatory Markers in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Nutrients, 13.","DOI":"10.3390\/nu13061805"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.18632\/aging.101168","article-title":"Epigenetic Clock Analysis of Diet, Exercise, Education, and Lifestyle Factors","volume":"9","author":"Quach","year":"2017","journal-title":"Aging"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.18632\/aging.202913","article-title":"Potential Reversal of Epigenetic Age Using a Diet and Lifestyle Intervention: A Pilot Randomized Clinical Trial","volume":"13","author":"Fitzgerald","year":"2021","journal-title":"Aging"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Marcos, J.L., Olivares-Barraza, R., Ceballo, K., Wastavino, M., Ortiz, V., Riquelme, J., Mart\u00ednez-Pinto, J., Mu\u00f1oz, P., Cruz, G., and Sotomayor-Z\u00e1rate, R. (2023). Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021468"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/iub.1532","article-title":"Epigenomic Maintenance through Dietary Intervention Can Facilitate DNA Repair Process to Slow down the Progress of Premature Aging","volume":"68","author":"Ghosh","year":"2016","journal-title":"IUBMB Life"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Fad\u00f3, R., Molins, A., Rojas, R., and Casals, N. (2022). Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors. Nutrients, 14.","DOI":"10.3390\/nu14194137"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Maniam, J., Antoniadis, C.P., Youngson, N.A., Sinha, J.K., and Morris, M.J. (2015). Sugar Consumption Produces Effects Similar to Early Life Stress Exposure on Hippocampal Markers of Neurogenesis and Stress Response. Front. Mol. Neurosci., 8.","DOI":"10.3389\/fnmol.2015.00086"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 Reasons Why the Brain Is Susceptible to Oxidative Stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"eadf9382","DOI":"10.1126\/scitranslmed.adf9382","article-title":"Metaflammation in Obesity and Its Therapeutic Targeting","volume":"15","author":"Schleh","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and Metabolic Disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory Mechanisms in Obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","article-title":"NAD+ Metabolism: Pathophysiologic Mechanisms and Therapeutic Potential","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2011.03.004","article-title":"PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation","volume":"13","author":"Bai","year":"2011","journal-title":"Cell Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.1202723","article-title":"SIRT6 Promotes DNA Repair under Stress by Activating PARP1","volume":"332","author":"Mao","year":"2011","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Khan, R.I., Nirzhor, S.S.R., and Akter, R. (2018). A Review of the Recent Advances Made with SIRT6 and Its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets. Biomolecules, 8.","DOI":"10.20944\/preprints201806.0163.v2"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"12948","DOI":"10.1038\/ncomms12948","article-title":"Nicotinamide Riboside Is Uniquely and Orally Bioavailable in Mice and Humans","volume":"7","author":"Trammell","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11357-022-00705-1","article-title":"The Efficacy and Safety of \u03b2-Nicotinamide Mononucleotide (NMN) Supplementation in Healthy Middle-Aged Adults: A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Dependent Clinical Trial","volume":"45","author":"Yi","year":"2023","journal-title":"Geroscience"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Mahajan, A., Sapehia, D., Thakur, S., Mohanraj, P.S., Bagga, R., and Kaur, J. (2019). Effect of Imbalance in Folate and Vitamin B12 in Maternal\/Parental Diet on Global Methylation and Regulatory miRNAs. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-54070-9"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"597","DOI":"10.4162\/nrp.2023.17.4.597","article-title":"Modulation of DNA Methylation by One-Carbon Metabolism: A Milestone for Healthy Aging","volume":"17","author":"Choi","year":"2023","journal-title":"Nutr. Res. Pract."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Shinagawa, A., Yamazaki, T., Minematsu, A., Serizawa, N., Hosoi, Y., Ninomiya, Y., Miyakoshi, Y., Yano, T., and Ota, M. (2023). Changes in Homocysteine and Non-Mercaptoalbumin Levels after Acute Exercise: A Crossover Study. BMC Sports Sci. Med. Rehabil., 15.","DOI":"10.1186\/s13102-023-00656-w"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00125-007-0793-y","article-title":"Vitamin B12 and Folate Concentrations during Pregnancy and Insulin Resistance in the Offspring: The Pune Maternal Nutrition Study","volume":"51","author":"Yajnik","year":"2008","journal-title":"Diabetologia"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sachdeva, P., Ghosh, S., Ghosh, S., Han, S., Banerjee, J., Bhaskar, R., and Sinha, J.K. (2022). Childhood Obesity: A Potential Key Factor in the Development of Glioblastoma Multiforme. Life, 12.","DOI":"10.3390\/life12101673"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Konopka, A., and Atkin, J.D. (2022). The Role of DNA Damage in Neural Plasticity in Physiology and Neurodegeneration. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.836885"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ribeiro, J.H., Altinisik, N., Rajan, N., Verslegers, M., Baatout, S., Gopalakrishnan, J., and Quintens, R. (2023). DNA Damage and Repair: Underlying Mechanisms Leading to Microcephaly. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1268565"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ghosh, S., Dhungel, S., Shaikh, M.F., and Sinha, J.K. (2024). World Digestive Health Day: Investigating the Link between Neurodegenerative Disease and Gut Microbiota. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1351855"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"263ra158","DOI":"10.1126\/scitranslmed.3009759","article-title":"The Gut Microbiota Influences Blood-Brain Barrier Permeability in Mice","volume":"6","author":"Braniste","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ibarra, I.L., Ratnu, V.S., Gordillo, L., Hwang, I.-Y., Mariani, L., Weinand, K., Hammar\u00e9n, H.M., Heck, J., Bulyk, M.L., and Savitski, M.M. (2022). Comparative Chromatin Accessibility upon BDNF Stimulation Delineates Neuronal Regulatory Elements. Mol. Syst. Biol., 18.","DOI":"10.15252\/msb.202110473"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e161498","DOI":"10.1172\/jci.insight.161498","article-title":"Exercise Restores Brain Insulin Sensitivity in Sedentary Adults Who Are Overweight and Obese","volume":"7","author":"Kullmann","year":"2022","journal-title":"JCI Insight"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Polom, J., and Boccardi, V. (2025). Employing Nutrition to Delay Aging: A Plant-Based Telomere-Friendly Dietary Revolution. Nutrients, 17.","DOI":"10.3390\/nu17122004"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/ana.20854","article-title":"Mediterranean Diet and Risk for Alzheimer\u2019s Disease","volume":"59","author":"Scarmeas","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jalz.2015.04.011","article-title":"MIND Diet Slows Cognitive Decline with Aging","volume":"11","author":"Morris","year":"2015","journal-title":"Alzheimers Dement."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 Year Multidomain Intervention of Diet, Exercise, Cognitive Training, and Vascular Risk Monitoring versus Control to Prevent Cognitive Decline in at-Risk Elderly People (FINGER): A Randomised Controlled Trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jalz.2018.10.001","article-title":"Dietary Changes and Cognition over 2 Years within a Multidomain Intervention Trial-The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)","volume":"15","author":"Lehtisalo","year":"2019","journal-title":"Alzheimers Dement."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1001\/jamainternmed.2015.1668","article-title":"Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial","volume":"175","author":"Corella","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3945\/ajcn.110.007369","article-title":"Adherence to a Mediterranean-Type Dietary Pattern and Cognitive Decline in a Community Population","volume":"93","author":"Tangney","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1056\/NEJM199704173361601","article-title":"A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure. DASH Collaborative Research Group","volume":"336","author":"Appel","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/joim.12044","article-title":"Effects of an Isocaloric Healthy Nordic Diet on Insulin Sensitivity, Lipid Profile and Inflammation Markers in Metabolic Syndrome\u2014A Randomized Study (SYSDIET)","volume":"274","author":"Uusitupa","year":"2013","journal-title":"J. Intern. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/EDE.0000000000000338","article-title":"Dietary Patterns and Cognitive Decline Among Chinese Older Adults","volume":"26","author":"Qin","year":"2015","journal-title":"Epidemiology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3945\/ajcn.112.045575","article-title":"Dietary Patterns and Risk of Dementia in an Elderly Japanese Population: The Hisayama Study","volume":"97","author":"Ozawa","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Arjmand, G., Abbas-Zadeh, M., and Eftekhari, M.H. (2022). Effect of MIND Diet Intervention on Cognitive Performance and Brain Structure in Healthy Obese Women: A Randomized Controlled Trial. Sci. Rep., 12.","DOI":"10.1038\/s41598-021-04258-9"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Chew, H., Solomon, V.A., and Fonteh, A.N. (2020). Involvement of Lipids in Alzheimer\u2019s Disease Pathology and Potential Therapies. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00598"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13024-025-00803-6","article-title":"Lipidome Disruption in Alzheimer\u2019s Disease Brain: Detection, Pathological Mechanisms, and Therapeutic Implications","volume":"20","author":"He","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Suh, S.W., Lim, E., Burm, S.-Y., Lee, H., Bae, J.B., Han, J.W., and Kim, K.W. (2024). The Influence of N-3 Polyunsaturated Fatty Acids on Cognitive Function in Individuals without Dementia: A Systematic Review and Dose-Response Meta-Analysis. BMC Med., 22.","DOI":"10.1186\/s12916-024-03296-0"},{"key":"ref_64","first-page":"e73390","article-title":"The Role of Omega-3 Fatty Acid Supplementation in Slowing Cognitive Decline Among Elderly Patients with Alzheimer\u2019s Disease: A Systematic Review of Randomized Controlled Trials","volume":"16","author":"Deshmukh","year":"2024","journal-title":"Cureus"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zhu, D., Bungart, B.L., Yang, X., Zhumadilov, Z., Lee, J.C.-M., and Askarova, S. (2015). Role of Membrane Biophysics in Alzheimer\u2019s-Related Cell Pathways. Front. Neurosci., 9.","DOI":"10.3389\/fnins.2015.00186"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.ajcnut.2023.04.001","article-title":"The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers","volume":"117","author":"Wei","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.apsb.2014.09.001","article-title":"Pharmacokinetic Aspects and in Vitro-in Vivo Correlation Potential for Lipid-Based Formulations","volume":"4","author":"Kollipara","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1021\/acs.molpharmaceut.8b00172","article-title":"Preclinical Bioavailability Strategy for Decisions on Clinical Drug Formulation Development: An In Depth Analysis","volume":"15","author":"Bevernage","year":"2018","journal-title":"Mol. Pharm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/nn.3850","article-title":"Enhancing Dentate Gyrus Function with Dietary Flavanols Improves Cognition in Older Adults","volume":"17","author":"Brickman","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"329","DOI":"10.14283\/jpad.2021.7","article-title":"Elevated Blood Homocysteine and Risk of Alzheimer\u2019s Dementia: An Updated Systematic Review and Meta-Analysis Based on Prospective Studies","volume":"8","author":"Zuin","year":"2021","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Hama, Y., Hamano, T., Shirafuji, N., Hayashi, K., Ueno, A., Enomoto, S., Nagata, M., Kimura, H., Matsunaga, A., and Ikawa, M. (2020). Influences of Folate Supplementation on Homocysteine and Cognition in Patients with Folate Deficiency and Cognitive Impairment. Nutrients, 12.","DOI":"10.3390\/nu12103138"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Smith, A.D., Smith, S.M., de Jager, C.A., Whitbread, P., Johnston, C., Agacinski, G., Oulhaj, A., Bradley, K.M., Jacoby, R., and Refsum, H. (2010). Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012244"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2165\/11593080-000000000-00000","article-title":"Vitamin D, Cognitive Dysfunction and Dementia in Older Adults","volume":"25","author":"Dickens","year":"2011","journal-title":"CNS Drugs"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12937-015-0063-7","article-title":"Vitamin D Deficiency Is Associated with Increased Risk of Alzheimer\u2019s Disease and Dementia: Evidence from Meta-Analysis","volume":"14","author":"Shen","year":"2015","journal-title":"Nutr. J."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Skoczek-Rubi\u0144ska, A., Cisek-Wo\u017aniak, A., Molska, M., Heyser, M., Trocholepsza, M., Pietrzak, S., and Mruczyk, K. (2025). Impact of Vitamin D Status and Supplementation on Brain-Derived Neurotrophic Factor and Mood-Cognitive Outcomes: A Structured Narrative Review. Nutrients, 17.","DOI":"10.3390\/nu17162655"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/WNL.0000000000000755","article-title":"Vitamin D and the Risk of Dementia and Alzheimer Disease","volume":"83","author":"Littlejohns","year":"2014","journal-title":"Neurology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.physbeh.2010.12.003","article-title":"Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity","volume":"103","author":"Kanoski","year":"2011","journal-title":"Physiol. Behav."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/jamaneurol.2022.4397","article-title":"Association Between Consumption of Ultraprocessed Foods and Cognitive Decline","volume":"80","author":"Khandpur","year":"2023","journal-title":"JAMA Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Mota, B., Ramos, M., Marques, S.I., Silva, A., Pereira, P.A., Madeira, M.D., Mateus, N., and Cardoso, A. (2023). Effects of High-Fat and High-Fat High-Sugar Diets in the Anxiety, Learning and Memory, and in the Hippocampus Neurogenesis and Neuroinflammation of Aged Rats. Nutrients, 15.","DOI":"10.3390\/nu15061370"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(18)30338-7","article-title":"Nutrition and Prevention of Cognitive Impairment","volume":"17","author":"Scarmeas","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"112110","DOI":"10.1016\/j.exger.2023.112110","article-title":"The Role of Nutrition and the Mediterranean Diet on the Trajectories of Cognitive Decline","volume":"173","author":"Maggi","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Noble, E.E., Hsu, T.M., and Kanoski, S.E. (2017). Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment. Front. Behav. Neurosci., 11.","DOI":"10.3389\/fnbeh.2017.00009"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.apsb.2024.10.004","article-title":"Oxidative Stress and Inflammation in the Pathogenesis of Neurological Disorders: Mechanisms and Implications","volume":"15","author":"Dash","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Fock, E., and Parnova, R. (2023). Mechanisms of Blood-Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids. Cells, 12.","DOI":"10.3390\/cells12040657"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1208\/s12248-017-0079-3","article-title":"Blood-Brain Barriers in Obesity","volume":"19","author":"Rhea","year":"2017","journal-title":"AAPS J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4062\/biomolther.2024.009","article-title":"Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction","volume":"32","author":"Lee","year":"2024","journal-title":"Biomol. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/s41467-020-18262-6","article-title":"Intestinal Microbiota-Derived Short-Chain Fatty Acids Regulation of Immune Cell IL-22 Production and Gut Immunity","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/j.cmet.2021.10.010","article-title":"Microbiota-Derived Acetate Enables the Metabolic Fitness of the Brain Innate Immune System during Health and Disease","volume":"33","author":"Erny","year":"2021","journal-title":"Cell Metab."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e59826","DOI":"10.7554\/eLife.59826","article-title":"Microbiota-Derived Short Chain Fatty Acids Modulate Microglia and Promote A\u03b2 Plaque Deposition","volume":"10","author":"Colombo","year":"2021","journal-title":"Elife"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12974-023-02712-1","article-title":"Endothelial Toll-like Receptor 4 Is Required for Microglia Activation in the Murine Retina after Systemic Lipopolysaccharide Exposure","volume":"20","author":"Tsioti","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/s41423-025-01333-3","article-title":"Beyond the Gut: Decoding the Gut-Immune-Brain Axis in Health and Disease","volume":"22","author":"Park","year":"2025","journal-title":"Cell Mol. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1136\/gutjnl-2019-319654","article-title":"Mediterranean Diet Intervention Alters the Gut Microbiome in Older People Reducing Frailty and Improving Health Status: The NU-AGE 1-Year Dietary Intervention across Five European Countries","volume":"69","author":"Ghosh","year":"2020","journal-title":"Gut"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Fu, J., Zheng, Y., Gao, Y., and Xu, W. (2022). Dietary Fiber Intake and Gut Microbiota in Human Health. Microorganisms, 10.","DOI":"10.3390\/microorganisms10122507"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"103687","DOI":"10.1016\/j.jpet.2025.103687","article-title":"\u03b3-Secretase Modulation and Plaque Regression in Alzheimer\u2019s Disease","volume":"392","author":"Ghosh","year":"2025","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kumar, S., Mukherjee, R., Gaur, P., Leal, \u00c9., Lyu, X., Ahmad, S., Puri, P., Chang, C.-M., Raj, V.S., and Pandey, R.P. (2025). Unveiling Roles of Beneficial Gut Bacteria and Optimal Diets for Health. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1527755"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S2213-8587(19)30291-8","article-title":"High Sugar Content in Baby Food: An Indian Perspective","volume":"7","author":"Ghosh","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Ezkurdia, A., Ram\u00edrez, M.J., and Solas, M. (2023). Metabolic Syndrome as a Risk Factor for Alzheimer\u2019s Disease: A Focus on Insulin Resistance. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054354"},{"key":"ref_98","first-page":"240","article-title":"Expanding the Clinical Implications of Biomarkers and Physiological Indicators in Geriatric Institutionalization","volume":"7","author":"Ghosh","year":"2025","journal-title":"Aging Pathobiol. Ther."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41392-025-02145-7","article-title":"Antiageing Strategy for Neurodegenerative Diseases: From Mechanisms to Clinical Advances","volume":"10","author":"Jiang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Wang, X., Sun, Z., Xue, H., and An, R. (2025). Artificial Intelligence Applications to Personalized Dietary Recommendations: A Systematic Review. Healthcare, 13.","DOI":"10.3390\/healthcare13121417"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/s41467-023-37457-1","article-title":"Machine Learning Prediction of the Degree of Food Processing","volume":"14","author":"Menichetti","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e51432","DOI":"10.2196\/51432","article-title":"Advancements in Using AI for Dietary Assessment Based on Food Images: Scoping Review","volume":"26","author":"Chotwanvirat","year":"2024","journal-title":"J. Med. Internet Res."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Rouhafzay, A., Rouhafzay, G., and Jbilou, J. (2025). Image-Based Food Monitoring and Dietary Management for Patients Living with Diabetes: A Scoping Review of Calorie Counting Applications. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1501946"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41746-024-01346-8","article-title":"AI-Enabled Wearable Cameras for Assisting Dietary Assessment in African Populations","volume":"7","author":"Lo","year":"2024","journal-title":"NPJ Digit. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41746-023-00985-7","article-title":"Multimodal Digital Phenotyping of Diet, Physical Activity, and Glycemia in Hispanic\/Latino Adults with or at Risk of Type 2 Diabetes","volume":"7","author":"Pai","year":"2024","journal-title":"NPJ Digit. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/09727531241275347","article-title":"Sleep and Immune System Crosstalk: Implications for Inflammatory Homeostasis and Disease Pathogenesis","volume":"32","author":"Singh","year":"2025","journal-title":"Ann. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e71006","DOI":"10.1002\/fsn3.71006","article-title":"Personalized Nutrition in the Era of Digital Health: A New Frontier for Managing Diabetes and Obesity","volume":"13","author":"Arshad","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Tsolakidis, D., Gymnopoulos, L.P., and Dimitropoulos, K. (2024). Artificial Intelligence and Machine Learning Technologies for Personalized Nutrition: A Review. Informatics, 11.","DOI":"10.3390\/informatics11030062"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/s41380-023-02025-y","article-title":"Brain Functional and Structural Magnetic Resonance Imaging of Obesity and Weight Loss Interventions","volume":"28","author":"Li","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"K\u00e9ri, S. (2025). Diffusion Basis Restricted Fraction as a Putative Magnetic Resonance Imaging Marker of Neuroinflammation: Histological Evidence, Diagnostic Accuracy, and Translational Potential. Life, 15.","DOI":"10.3390\/life15101599"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Woo, A., Botta, A., Shi, S.S.W., Paus, T., and Pausova, Z. (2022). Obesity-Related Neuroinflammation: Magnetic Resonance and Microscopy Imaging of the Brain. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158790"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1210\/clinem\/dgae014","article-title":"Quantitative MRI Biomarkers Measure Changes in Targeted Brain Areas in Patients with Obesity","volume":"109","author":"Baynat","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Liu, D., Zuo, E., Wang, D., He, L., Dong, L., and Lu, X. (2025). Deep Learning in Food Image Recognition: A Comprehensive Review. Appl. Sci., 15.","DOI":"10.3390\/app15147626"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41551-023-01056-8","article-title":"Algorithmic Fairness in Artificial Intelligence for Medicine and Healthcare","volume":"7","author":"Chen","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Kassem, H., Beevi, A.A., Basheer, S., Lutfi, G., Cheikh Ismail, L., and Papandreou, D. (2025). Investigation and Assessment of AI\u2019s Role in Nutrition-An Updated Narrative Review of the Evidence. Nutrients, 17.","DOI":"10.3390\/nu17010190"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.nutos.2023.07.001","article-title":"Artificial Intelligence, Nutrition, and Ethical Issues: A Mini-Review","volume":"50","author":"Detopoulou","year":"2023","journal-title":"Clin. Nutr. Open Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"56","DOI":"10.21037\/jmai-24-415","article-title":"Disability and Algorithmic Fairness in Healthcare: A Narrative Review","volume":"8","author":"Vogt","year":"2025","journal-title":"J. Med. Artif. Intell."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia Prevention, Intervention, and Care: 2020 Report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"9523","DOI":"10.1073\/pnas.1301816110","article-title":"Preventing Alzheimer\u2019s Disease-Related Gray Matter Atrophy by B-Vitamin Treatment","volume":"110","author":"Douaud","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Zhang, L., Chen, X., Chen, Y., Yan, J., Huang, G., and Li, W. (2024). A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 16.","DOI":"10.3390\/nu16142199"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ypmed.2004.02.030","article-title":"The Omega-3 Index: A New Risk Factor for Death from Coronary Heart Disease?","volume":"39","author":"Harris","year":"2004","journal-title":"Prev. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1016\/j.cell.2021.06.019","article-title":"Gut-Microbiota-Targeted Diets Modulate Human Immune Status","volume":"184","author":"Wastyk","year":"2021","journal-title":"Cell"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/21\/3493\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:57:27Z","timestamp":1762451847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/21\/3493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":122,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["nu17213493"],"URL":"https:\/\/doi.org\/10.3390\/nu17213493","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]}}}