{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:57:05Z","timestamp":1792069025076,"version":"4.4.0"},"reference-count":91,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["NPRP 14S-0311-210033"],"award-info":[{"award-number":["NPRP 14S-0311-210033"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM) are two of the most rapidly rising chronic diseases globally. Despite appearing distinct, an emerging body of literature identifies shared etiopathogenic mechanisms mediated by gut microbiota. This review synthesizes 38 peer-reviewed studies to evaluate the compositional, metabolic, immune, and translational intersections of gut dysbiosis in the pathogenesis of T2DM-associated CRC. Methods: This narrative literature review examined 38 primary research articles (human and animal studies) retrieved from PubMed, Scopus, and Embase. Studies were selected based on relevance to the microbiota-mediated mechanisms linking T2DM and CRC, with a focus on compositional analysis, metabolomic shifts, immune activation, and therapeutic interventions. Results: The findings highlight a mechanistically rich overlap between T2DM and CRC through shared dysbiosis, characterized by depletion of SCFA-producing taxa (e.g., Faecalibacterium, Roseburia, Butyricicoccus), enrichment of pathobionts (e.g., Fusobacterium nucleatum, Peptostreptococcus), and the disruption of mucosal immunity and epithelial integrity. Metabolic shifts include reduced butyrate and increased toxic bile acids (e.g., deoxycholic acid), TMAO, and oxidative metabolites, while immune dysregulation features elevated LPS, IL-1\u03b2, CXCL3, and NF-\u03baB signaling. Therapeutically, microbiota modulation via diet, metformin, and probiotics shows promise. Conclusions: Gut microbiota lies at the nexus of T2DM and CRC, functioning as a modifiable mediator rather than a passive bystander. Future research should prioritize longitudinal, multi-omic, and intervention-driven studies to enable personalized prevention and treatment strategies.<\/jats:p>","DOI":"10.3390\/nu17233803","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T15:14:06Z","timestamp":1764861246000},"page":"3803","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Gut Nexus: Unraveling Microbiota-Mediated Links Between Type 2 Diabetes and Colorectal Cancer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0956-4377","authenticated-orcid":false,"given":"Anns","family":"Mahboob","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine-Qatar, Doha P.O. Box 24144, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9807-0535","authenticated-orcid":false,"given":"Chehbin","family":"Shin","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine-Qatar, Doha P.O. Box 24144, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6797-1752","authenticated-orcid":false,"given":"Shahd","family":"Almughanni","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine-Qatar, Doha P.O. Box 24144, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-0850","authenticated-orcid":false,"given":"Lubica","family":"Hornakova","sequence":"additional","affiliation":[{"name":"Center of Experimental and Clinical Regenerative Medicine, Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 041 81 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-5076","authenticated-orcid":false,"given":"Peter","family":"Kubatka","sequence":"additional","affiliation":[{"name":"Center of Experimental and Clinical Regenerative Medicine, Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 041 81 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-3366","authenticated-orcid":false,"given":"Dietrich","family":"B\u00fcsselberg","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine-Qatar, Doha P.O. 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Microbiota Food Health"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chong, S., Lin, M., Chong, D., Jensen, S., and Lau, N.S. (2024). A systematic review on gut microbiota in type 2 diabetes mellitus. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1486793"},{"key":"ref_5","unstructured":"IDF Diabetes Atlas (2021). IDF Diabetes Atlas, IDF Diabetes Atlas. [10th ed.]. Available online: www.diabetesatlas.org."},{"key":"ref_6","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2337\/dc14-1175","article-title":"The risk of colorectal cancer in patients with type 2 Diabetes: Associations with treatment stage and obesity","volume":"38","author":"Peeters","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Murray","year":"2020","journal-title":"Lancet"},{"key":"ref_9","first-page":"1095","article-title":"The impact of Vitamin D pathway genetic variation and circulating 25-hydroxyVitamin D on cancer outcome: Systematic review and meta-Analysis","volume":"116","author":"Farrington","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00592-011-0333-6","article-title":"Gut microbiota and diabetes: From pathogenesis to therapeutic perspective","volume":"48","author":"Burcelin","year":"2011","journal-title":"Acta Diabetol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41575-019-0209-8","article-title":"Gut microbiota in colorectal cancer: Mechanisms of action and clinical applications","volume":"16","author":"Wong","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1136\/gutjnl-2023-330291","article-title":"Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells","volume":"72","author":"Kang","year":"2023","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12672-024-01313-5","article-title":"Short-chain fatty acids play a positive role in colorectal cancer","volume":"15","author":"Liu","year":"2024","journal-title":"Discov. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Gasaly, N., Hermoso, M.A., and Gotteland, M. (2021). Butyrate and the fine-tuning of colonic homeostasis: Implication for inflammatory bowel diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063061"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2011.02.018","article-title":"The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon","volume":"13","author":"Donohoe","year":"2011","journal-title":"Cell Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jnutbio.2007.08.002","article-title":"Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon","volume":"19","author":"Waldecker","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.12998\/wjcc.v8.i24.6213","article-title":"Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes","volume":"8","author":"Huang","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1097\/CM9.0000000000002421","article-title":"Metagenomic and targeted metabolomic analyses reveal distinct phenotypes of the gut microbiota in patients with colorectal cancer and type 2 diabetes mellitus","volume":"136","author":"Yang","year":"2023","journal-title":"Chin. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s00394-023-03110-2","article-title":"Garlic consumption in relation to colorectal cancer risk and to alterations of blood bacterial DNA","volume":"62","author":"Speciani","year":"2023","journal-title":"Eur. J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.csbj.2023.02.022","article-title":"Short-chain fatty acids reprogram metabolic profiles with the induction of reactive oxygen species production in human colorectal adenocarcinoma cells","volume":"21","author":"Huang","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1158\/1055-9965.EPI-19-0326","article-title":"The Association between Prebiotic Fiber Supplement Use and Colorectal Cancer Risk and Mortality in the Women\u2019s Health Initiative","volume":"28","author":"Skiba","year":"2019","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11684-019-0695-7","article-title":"Altered intestinal microbiota associated with colorectal cancer","volume":"13","author":"Zhang","year":"2019","journal-title":"Front. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1007\/s00432-022-04477-1","article-title":"Relationship between obesity-related colorectal tumors and the intestinal microbiome: An animal-based trial","volume":"149","author":"Iwama","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e081379","DOI":"10.1136\/bmjopen-2023-081379","article-title":"Fibre-rich Foods to Treat Obesity and Prevent Colon Cancer trial study protocol: A randomised clinical trial of fibre-rich legumes targeting the gut microbiome, metabolome and gut transit time of overweight and obese patients with a history of noncancerous adenomatous polyps","volume":"14","author":"Hartman","year":"2024","journal-title":"BMJ Open"},{"key":"ref_25","first-page":"1133","article-title":"Impact of a high-fat diet on intestinal stem cells and epithelial barrier function in middle-aged female mice","volume":"21","author":"Xie","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11641","DOI":"10.1002\/cam4.5868","article-title":"Impacts of pre-existing diabetes mellitus on colorectal cancer in a mice model","volume":"12","author":"Lv","year":"2023","journal-title":"Cancer Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-024-48935-5","article-title":"Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils","volume":"15","author":"Shantaram","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ma, W., Chen, J., Meng, Y., Yang, J., Cui, Q., and Zhou, Y. (2018). Metformin Alters Gut Microbiota of Healthy Mice: Implication for Its Potential Role in Gut Microbiota Homeostasis. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01336"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101498","DOI":"10.1016\/j.molmet.2022.101498","article-title":"Metformin-induced reductions in tumor growth involves modulation of the gut microbiome","volume":"61","author":"Broadfield","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.5009\/gnl.2012.6.4.411","article-title":"Dietary Factors: Major Regulators of the Gut\u2019s Microbiota","volume":"6","author":"Moschen","year":"2012","journal-title":"Gut Liver"},{"key":"ref_31","first-page":"163","article-title":"Comparative study of effect of Akkermansia muciniphila and its extracellular vesicles on toll-like receptors and tight junction","volume":"12","author":"Ashrafian","year":"2019","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","article-title":"Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis","volume":"94","author":"Yang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4062\/biomolther.2019.071","article-title":"Involvement of estrogen receptor-\u03b1 in the activation of Nrf2-antioxidative signaling pathways by silibinin in pancreatic \u03b2-cells","volume":"28","author":"Chu","year":"2020","journal-title":"Biomol. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5110276","DOI":"10.1155\/2021\/5110276","article-title":"Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications","volume":"2021","author":"Zhang","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/gutjnl-2015-309595","article-title":"Tumour-associated and non-tumour-associated microbiota in colorectal cancer","volume":"66","author":"Flemer","year":"2017","journal-title":"Gut"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet Public Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"106029","DOI":"10.1016\/j.phrs.2021.106029","article-title":"Mulberry leaf (Morus alba L.): A review of its potential influences in mechanisms of action on metabolic diseases","volume":"175","author":"Zhang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhang, W., An, Y., Qin, X., Wu, X., Wang, X., Hou, H., Song, X., Liu, T., Wang, B., and Huang, X. (2021). Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.739648"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wu, Z., Zhang, B., Chen, F., Xia, R., Zhu, D., Chen, B., Lin, A., Zheng, C., Hou, D., and Li, X. (2023). Fecal microbiota transplantation reverses insulin resistance in type 2 diabetes: A randomized, controlled, prospective study. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1089991"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7633","DOI":"10.3748\/wjg.v26.i48.7633","article-title":"Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota","volume":"26","author":"Li","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1459497","DOI":"10.1155\/2017\/1459497","article-title":"The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity","volume":"2017","author":"Zhao","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1097\/CM9.0000000000001887","article-title":"Microbe-based management for colorectal cancer","volume":"134","author":"Gao","year":"2021","journal-title":"Chin. Med. J."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Luan, S., Cheng, W., Wang, C., Gong, J., and Zhou, J. (2022). Impact of glucagon-like peptide 1 analogs on cognitive function among patients with type 2 diabetes mellitus: A systematic review and meta\u2212analysis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1047883"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6713194","DOI":"10.1155\/2019\/6713194","article-title":"The bioprotective effects of polyphenols on metabolic syndrome against oxidative stress: Evidences and perspectives","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wu, J., Xia, C., Liu, C., Zhang, Q., and Xia, C. (2023). The role of gut microbiota and drug interactions in the development of colorectal cancer. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1265136"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/jcsm.12798","article-title":"Bile acid metabolism dysregulation associates with cancer cachexia: Roles of liver and gut microbiome","volume":"12","author":"Feng","year":"2021","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zhao, K., Zhou, G., Liu, Y., Zhang, J., Chen, Y., Liu, L., and Zhang, G. (2023). HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances. Biomolecules, 13.","DOI":"10.3390\/biom13040601"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Chen, G., Ren, Q., Zhong, Z., Li, Q., Huang, Z., Zhang, C., Yuan, H., Feng, Z., Chen, B., and Wang, N. (2024). Exploring the gut microbiome\u2019s role in colorectal cancer: Diagnostic and prognostic implications. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1431747"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrendo.2011.126","article-title":"Targeting gut microbiota in obesity: Effects of prebiotics and probiotics","volume":"7","author":"Delzenne","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_51","unstructured":"Gauthier, S., Webster, C., Servaes, S., Morais, J.A., and Rosa-Neto, P. (2022). World Alzheimer Report 2022\u2014Life After Diagnosis: Navigating Treatment, Care and Support, Alzheimer\u2019s Disease International."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1039\/C4FO00844H","article-title":"The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice","volume":"6","author":"Zang","year":"2015","journal-title":"Food Funct."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1001\/archinternmed.2012.3138","article-title":"A prospective study of weight training and risk of type 2 diabetes mellitus in men","volume":"172","author":"Rimm","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Zhao, S., Lu, Z., Zhao, F., Tang, S., Zhang, L., and Feng, C. (2025). Assessing the impact of probiotics on immunotherapy effectiveness and antibiotic-mediated resistance in cancer: A systematic review and meta-analysis. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1538969"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature18642","article-title":"The genetic architecture of type 2 diabetes","volume":"536","author":"Fuchsberger","year":"2016","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101478","DOI":"10.1016\/j.xcrm.2024.101478","article-title":"Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy","volume":"5","author":"Kang","year":"2024","journal-title":"Cell Rep. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1365-277X.2010.01078.x","article-title":"Green tea improves metabolic biomarkers, not weight or body composition: A pilot study in overweight breast cancer survivors","volume":"23","author":"Thomson","year":"2010","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1039\/C7MD00222J","article-title":"Discovery of human lactate dehydrogenase A (LDHA) inhibitors as anticancer agents to inhibit the proliferation of MG-63 osteosarcoma cells","volume":"8","author":"Fang","year":"2017","journal-title":"MedChemComm"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3109\/10715762.2011.580343","article-title":"Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells","volume":"45","author":"Liu","year":"2011","journal-title":"Free Radic. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1001\/jama.2013.168118","article-title":"Prevalence and control of diabetes in Chinese adults","volume":"310","author":"Xu","year":"2013","journal-title":"JAMA"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kent, B.A., Holman, C., Amoako, E., Antonietti, A., Azam, J.M., Ballhausen, H., Bediako, Y., Belasen, A.M., Carneiro, C.F.D., and Chen, Y.-C. (2022). Recommendations for empowering early career researchers to improve research culture and practice. PLoS Biol., 20.","DOI":"10.1371\/journal.pbio.3001680"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00384-024-04702-y","article-title":"Prediction of postoperative complications following transanal total mesorectal excision in middle and low rectal cancer: Development and internal validation of a clinical prediction model","volume":"39","author":"Zhu","year":"2024","journal-title":"Int. J. Color. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Solverson, P.M., Rumpler, W.V., Leger, J.L., Redan, B.W., Ferruzzi, M.G., Baer, D.J., Castonguay, T.W., and Novotny, J.A. (2018). Blackberry Feeding Increases Fat Oxidation and Improves Insulin Sensitivity in Overweight and Obese Males. Nutrients, 10.","DOI":"10.3390\/nu10081048"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e155101","DOI":"10.1172\/JCI155101","article-title":"Colorectal cancer: The facts in the case of the microbiota","volume":"132","author":"Clay","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1038\/ncomms7528","article-title":"Gut microbiome development along the colorectal adenoma-carcinoma sequence","volume":"6","author":"Feng","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.canlet.2014.11.046","article-title":"Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt-mTOR signaling pathway","volume":"358","author":"Zhao","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Wu, H., Ma, W., Wang, Y., Wang, Y., Sun, X., and Zheng, Q. (2024). Gut microbiome-metabolites axis: A friend or foe to colorectal cancer progression. Biomed. Pharmacother., 173.","DOI":"10.1016\/j.biopha.2024.116410"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1177\/0884533612452012","article-title":"The microbiota and its metabolites in colonic mucosal health and cancer risk","volume":"27","author":"Vipperla","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.biocel.2017.01.012","article-title":"Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic \u00df-cells: A potential beneficial effect in the pre-diabetic state?","volume":"88","author":"Pournourmohammadi","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1021\/jf802715t","article-title":"Phenolic compounds rutin and o-coumaric acid ameliorate obesity induced by high-fat diet in rats","volume":"57","author":"Hsu","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gastro\/gox031","article-title":"Dysbiosis of gut microbiota in promoting the development of colorectal cancer","volume":"6","author":"Zou","year":"2018","journal-title":"Gastroenterol. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zhang, C., Wang, Y., Cheng, L., Cao, X., and Liu, C. (2025). Gut microbiota in colorectal cancer: A review of its influence on tumor immune surveillance and therapeutic response. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1557959"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack Europe PMC Funders Group","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Kiriyama, Y., and Nochi, H. (2018). Role and cytotoxicity of amylin and protection of pancreatic islet \u03b2-cells from amylin cytotoxicity. Cells, 7.","DOI":"10.3390\/cells7080095"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/oby.22088","article-title":"Dysbiosis Signatures of Gut Microbiota Along the Sequence from Healthy, Young Patients to Those with Overweight and Obesity","volume":"26","author":"Gao","year":"2018","journal-title":"Obesity"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ismej.2011.109","article-title":"Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers","volume":"6","author":"Wang","year":"2012","journal-title":"ISME J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13073-015-0157-z","article-title":"The gut microbiome in cardio-metabolic health","volume":"7","author":"Hansen","year":"2015","journal-title":"Genome Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1001\/jama.298.22.2654","article-title":"Active Smoking and the Risk of Type 2 Diabetes A Systematic Review and Meta-Analysis","volume":"298","author":"Willi","year":"2007","journal-title":"JAMA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41591-018-0222-4","article-title":"Gut microbiota and intestinal FXR mediate the clinical benefits of metformin","volume":"24","author":"Sun","year":"2018","journal-title":"Nat. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clnu.2022.10.024","article-title":"Butyrate\u2019s role in human health and the current progress towards its clinical application to treat gastrointestinal disease","volume":"42","author":"Hodgkinson","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12934-020-01330-3","article-title":"Type 2 diabetes induced microbiome dysbiosis is associated with therapy resistance in pancreatic adenocarcinoma","volume":"19","author":"Kesh","year":"2020","journal-title":"Microb. Cell Factories"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1056\/NEJMra012240","article-title":"Genomic Medicine","volume":"347","author":"Guttmacher","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ana.25570","article-title":"Amylin as a potential link between type 2 diabetes and alzheimer disease","volume":"86","author":"Riverol","year":"2019","journal-title":"Ann. Neurol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e046986","DOI":"10.1136\/bmjopen-2020-046986","article-title":"Virtual reality in medical students\u2019 education: A scoping review protocol","volume":"11","author":"Haowen","year":"2021","journal-title":"BMJ Open"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Cruz Rivera, S., Kyte, D.G., Aiyegbusi, O.L., Keeley, T.J., and Calvert, M.J. (2017). Assessing the impact of healthcare research: A systematic review of methodological frameworks. PLoS Med., 14.","DOI":"10.1371\/journal.pmed.1002370"},{"key":"ref_90","first-page":"89","article-title":"Is protein metabolism changed with obesity?","volume":"14","author":"Guillet","year":"2011","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1021\/acschembio.8b01128","article-title":"Glycated Insulin Exacerbates the Cytotoxicity of Human Islet Amyloid Polypeptides: A Vicious Cycle in Type 2 Diabetes","volume":"14","author":"Ma","year":"2019","journal-title":"ACS Chem. Biol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/23\/3803\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T09:19:56Z","timestamp":1765185596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/23\/3803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":91,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["nu17233803"],"URL":"https:\/\/doi.org\/10.3390\/nu17233803","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,4]]}}}