{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T13:18:17Z","timestamp":1780838297158,"version":"3.54.1"},"reference-count":56,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre (NCN) in Poland","doi-asserted-by":"publisher","award":["2022\/47\/B\/NZ9\/03123"],"award-info":[{"award-number":["2022\/47\/B\/NZ9\/03123"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Inflammatory bowel diseases include Crohn\u2019s disease (CD) and ulcerative colitis (UC). These diseases are characterized by periods of exacerbated inflammation of the gastrointestinal mucosa, interspersed with periods of remission. Current pharmacological interventions are only partially effective. There is a need for effective dietary therapies and interventions involving plant substances that can alleviate the course of this disease. Objectives: This study aimed to determine the effects of a 28-day dietary intervention involving a 3% solution of chemically pure, low-molar-mass oat beta-glucan (OBG) in patients diagnosed with de novo UC. Similar-aged men and women were compared. Methods: The OBG was isolated and prepared for consumption as a sterile aqueous suspension. This solution had previously been evaluated for in vitro toxicity using 3D intestinal co-cultures comprising Caco-2, HT29-MTX and THP-1 cells. Before and after the dietary intervention, endoscopic colon examinations were performed and blood hematological, biochemical and immunological parameters, as well as stool calprotectin concentrations, were analyzed. The Disease Activity Index (DAI), endoscopic Mayo score, the Lichtiger Colitis Activity Index (LCAI) and the neutrophil-to-lymphocyte ratio (NLR) were also determined. Following dietary intervention, the Mayo score, DAI, fecal calprotectin levels, and indices of peripheral blood white cells, CRP, and pro-inflammatory cytokine concentrations were decreased. Results\/Conclusions: The obtained results demonstrated the beneficial effect of dietary intervention with OBG in accelerating the achievement of clinical remission in patients with UC.<\/jats:p>","DOI":"10.3390\/nu17243812","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T13:17:07Z","timestamp":1764940627000},"page":"3812","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Outcomes of Oat Beta-Glucan Nutritional Intervention in Ulcerative Colitis: Case Reports of a Female and a Male Patient"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-1123","authenticated-orcid":false,"given":"Alicja","family":"Zaleci\u0144ska","sequence":"first","affiliation":[{"name":"Doctoral School, Warsaw University of Life Sciences, 02-797 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-7106","authenticated-orcid":false,"given":"Joanna","family":"Harasym","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Analysis, Faculty of Production Engineering, Wroclaw University of Economics and Business, 53-345 Wroc\u0142aw, Poland"},{"name":"Adaptive Food Systems Accelerator, Research Centre, Wroclaw University of Economics and Business, 53-345 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8069-6356","authenticated-orcid":false,"given":"Katarzyna","family":"Dziendzikowska","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition, Warsaw University of Life Sciences, 02-797 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-7722","authenticated-orcid":false,"given":"Katarzyna","family":"Sikorska","sequence":"additional","affiliation":[{"name":"Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9529-3744","authenticated-orcid":false,"given":"Joanna","family":"Gromadzka-Ostrowska","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition, Warsaw University of Life Sciences, 02-797 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"391787","DOI":"10.1155\/2011\/391787","article-title":"Cytokine Networks in Ulcerative Colitis","volume":"2011","author":"Roda","year":"2011","journal-title":"Ulcers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.tips.2024.08.003","article-title":"Ulcerative Colitis: Clinical Biomarkers, Therapeutic Targets, and Emerging Treatments","volume":"45","author":"Wangchuk","year":"2024","journal-title":"Trends Pharmacol. 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