{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:46:06Z","timestamp":1790102766367,"version":"4.0.1"},"reference-count":232,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006013","name":"United Arab Emirates University","doi-asserted-by":"publisher","award":["12R169"],"award-info":[{"award-number":["12R169"]}],"id":[{"id":"10.13039\/501100006013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Pancreatitis, encompassing acute (AP), severe acute (SAP), and chronic (CP) forms, is a life-threatening inflammatory disorder with limited therapeutic options. Current management is largely supportive, highlighting the urgent need for novel interventions targeting underlying molecular pathways. Aim: This review summarizes recent advances in the pathogenesis of pancreatitis, focusing on calcium dysregulation, ferroptosis, and microRNA-mediated mechanisms while exploring the therapeutic potential of phytochemicals as disease-modifying agents. Summary: Aberrant calcium signaling, iron-dependent lipid peroxidation, and microRNA imbalance drive acinar cell injury, inflammatory cascades, and pancreatic fibrosis. Phytochemicals, including flavonoids, terpenoids, alkaloids, and phenolics, have shown protective effects in preclinical models through multi-targeted mechanisms. These include suppression of NF-\u03baB-driven inflammation, activation of the Nrf2\/HO-1 antioxidant pathway, modulation of ferroptosis via GPX4 and iron efflux, regulation of calcium signaling, and modulation of microRNA expression. Importantly, several phytochemicals attenuate acinar cell death, reduce cytokine release, and limit fibrosis, thereby improving outcomes in experimental pancreatitis. However, poor solubility, bioavailability, and pharmacokinetic limitations remain significant barriers. Emerging strategies such as nanotechnology-based formulations, prodrug design, and pharmacokinetic profiling, as well as bioavailability studies, may enhance their clinical applicability. Conclusions: Phytochemicals represent a promising reservoir of multitarget therapeutic agents for pancreatitis. Their ability to modulate oxidative stress, inflammatory and calcium signaling, ferroptosis, and microRNA networks highlights their translational potential. Future studies should focus on clinical validation, bioavailability optimization, and advanced delivery platforms to bridge the gap from bench to bedside.<\/jats:p>","DOI":"10.3390\/nu17243841","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:41:41Z","timestamp":1765212101000},"page":"3841","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic Potentials of Phytochemicals in Pancreatitis: Targeting Calcium Signaling, Ferroptosis, microRNAs, and Inflammation with Drug-Likeness Evaluation"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-8216","authenticated-orcid":false,"given":"Fatma","family":"Farhat","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"},{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Ein Helwan 11795, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6561-2399","authenticated-orcid":false,"given":"Balaji","family":"Venkataraman","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4057-7125","authenticated-orcid":false,"given":"Bhoomendra A.","family":"Bhongade","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, RAK College of Pharmaceutical Chemistry, RAK Medical & Health Sciences University, Ras Al Khaimah P.O. Box 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-6795","authenticated-orcid":false,"given":"Mauro","family":"Pessia","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-2966","authenticated-orcid":false,"given":"Shreesh","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-500X","authenticated-orcid":false,"given":"Sandeep B.","family":"Subramanya","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1148\/rg.2016150097","article-title":"Revised Atlanta classification for acute pancreatitis: A pictorial essay","volume":"36","author":"Foster","year":"2016","journal-title":"Radiographics"},{"key":"ref_2","first-page":"19","article-title":"Classification of an acute pancreatitis: Revision by international consensus in 2012 of classification, adopted in Atlanta","volume":"9","author":"Kryvoruchko","year":"2014","journal-title":"Klin. Khirurhiia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: A review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2468-1253(16)30004-8","article-title":"Global incidence and mortality of pancreatic diseases: A systematic review, meta-analysis, and meta-regression of population-based cohort studies","volume":"1","author":"Xiao","year":"2016","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tips.2005.12.006","article-title":"Ca2+ signalling and pancreatitis: Effects of alcohol, bile and coffee","volume":"27","author":"Petersen","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1113\/jphysiol.2013.261784","article-title":"The role of Ca2+ in the pathophysiology of pancreatitis","volume":"592","author":"Gerasimenko","year":"2014","journal-title":"J. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wang, H., Gao, J., Wen, L., Huang, K., Liu, H., Zeng, L., Zeng, Z., Liu, Y., and Mo, Z. (2024). Ion channels in acinar cells in acute pancreatitis: Crosstalk of calcium, iron, and copper signals. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1444272"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"C683","DOI":"10.1152\/ajpcell.00360.2007","article-title":"Role of PKC-\u03b4 on substance P-induced chemokine synthesis in pancreatic acinar cells","volume":"294","author":"Ramnath","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"G1190","DOI":"10.1152\/ajpgi.90452.2008","article-title":"Protein kinase D1 mediates NF-\u03baB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells","volume":"295","author":"Yuan","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1007\/s10753-025-02256-x","article-title":"4-octyl Itaconate Attenuates Acute Pancreatitis and Associated Lung Injury by Suppressing Ferroptosis in Mice","volume":"48","author":"Lu","year":"2025","journal-title":"Inflammation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/01478885.2023.2261093","article-title":"The role of iron and ferroptosis in the pathogenesis of acute pancreatitis","volume":"46","author":"Tao","year":"2023","journal-title":"J. Histotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41419-023-06216-x","article-title":"Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1\u03b1\/HO-1 mediated ferroptosis","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrg2936","article-title":"Gene silencing by microRNAs: Contributions of translational repression and mRNA decay","volume":"12","author":"Huntzinger","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nsmb.2931","article-title":"From guide to target: Molecular insights into eukaryotic RNA-interference machinery","volume":"22","author":"Ipsaro","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Dharap, A., Pokrzywa, C., Murali, S., Pandi, G., and Vemuganti, R. (2013). MicroRNA miR-324-3p induces promoter-mediated expression of RelA gene. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079467"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ali, B.M., Al-Mokaddem, A.K., Selim, H.M.R.M., Alherz, F.A., Saleh, A., Hamdan, A.M.E., Ousman, M.S., and El-Emam, S.Z. (2024). Pinocembrin\u2019s protective effect against acute pancreatitis in a rat model: The correlation between TLR4\/NF-\u03baB\/NLRP3 and miR-34a-5p\/SIRT1\/Nrf2\/HO-1 pathways. Biomed. Pharmacother., 176.","DOI":"10.1016\/j.biopha.2024.116854"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10787-020-00767-7","article-title":"Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1","volume":"29","author":"Sheng","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ueg2.12743","article-title":"Acute Pancreatitis: An Update of Evidence-Based Management and Recent Trends in Treatment Strategies","volume":"13","author":"Beij","year":"2025","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"T\u0142ustochowicz, K., Krajewska, A., Kowalik, A., and Ma\u0142ecka-Wojciesko, E. (2025). Treatment Strategies for Chronic Pancreatitis (CP). Pharmaceuticals, 18.","DOI":"10.3390\/ph18030311"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00423-020-01944-6","article-title":"Severe acute pancreatitis: Surgical indications and treatment","volume":"406","author":"Heckler","year":"2021","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bachheti, A., Sharma, A., Bachheti, R., Husen, A., and Pandey, D. (2019). Plant allelochemicals and their various applications. Co-Evolution of Secondary Metabolites, Springer.","DOI":"10.1007\/978-3-319-76887-8_14-1"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Asmamaw, D., and Achamyeleh, H. (2018). Assessment of medicinal plants and their conservation status in case of Daligaw Kebela, Gozamen Werda, East Gojjam Zone. J. Biodivers. Bioprospect. Dev., 5.","DOI":"10.4172\/2376-0214.1000170"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.fitote.2018.11.012","article-title":"Polyphenols in the prevention and treatment of periodontal disease: A systematic review of in vivo, ex vivo and in vitro studies","volume":"132","author":"Kaymaz","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Roy, M., and Datta, A. (2019). Fundamentals of phytochemicals. Cancer Genetics and Therapeutics: Focus on Phytochemicals, Springer.","DOI":"10.1007\/978-981-13-9471-3"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3892\/mmr.2025.13501","article-title":"Curcumin ameliorates cerulein-induced chronic pancreatitis through Nrf-2\/HO-1 signaling","volume":"31","author":"Kim","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Pasari, L.P., Khurana, A., Anchi, P., Saifi, M.A., Annaldas, S., and Godugu, C. (2019). Visnagin attenuates acute pancreatitis via Nrf2\/NF\u03baB pathway and abrogates associated multiple organ dysfunction. Biomed. Pharmacother., 112.","DOI":"10.1016\/j.biopha.2019.108629"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jcmgh.2017.05.007","article-title":"Do animal models of acute pancreatitis reproduce human disease?","volume":"4","author":"Gorelick","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5009\/gnl.2008.2.2.74","article-title":"Cerulein pancreatitis: Oxidative stress, inflammation, and apoptosis","volume":"2","author":"Kim","year":"2008","journal-title":"Gut Liver"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/MPA.0000000000001082","article-title":"Melatonin attenuates endoplasmic reticulum stress in acute pancreatitis","volume":"47","author":"Zhao","year":"2018","journal-title":"Pancreas"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1053\/j.gastro.2017.10.018","article-title":"Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice","volume":"154","author":"Sendler","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1053\/j.gastro.2005.12.031","article-title":"Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis","volume":"130","author":"Criddle","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Yang, X., Yao, L., Fu, X., Mukherjee, R., Xia, Q., Jakubowska, M.A., Ferdek, P.E., and Huang, W. (2020). Experimental acute pancreatitis models: History, current status, and role in translational research. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.614591"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ning, W., Wang, Y., Zhang, F., Wang, H., Wang, F., Wang, X., Tang, H., Liang, S., Shi, X., and Liu, Z. (2013). Beneficial effects of trypsin inhibitors derived from a spider venom peptide in L-arginine-induced severe acute pancreatitis in mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061049"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s13105-025-01091-w","article-title":"Acute pancreatitis experimental models, advantages and disadvantages","volume":"81","year":"2025","journal-title":"J. Physiol. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yang, J., Tang, X., Wu, Q., Ren, P., and Yan, Y. (2022). A severe acute pancreatitis mouse model transited from mild symptoms induced by a \u201ctwo-hit\u201d strategy with L-arginine. Life, 12.","DOI":"10.3390\/life12010126"},{"key":"ref_37","first-page":"34251363","article-title":"Sodium taurocholate induced severe acute pancreatitis in c57bl\/6 mice","volume":"28","author":"Serra","year":"2021","journal-title":"J. Vis. Exp."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"212","DOI":"10.5946\/ce.2014.47.3.212","article-title":"Experimental models of pancreatitis","volume":"47","author":"Hyun","year":"2014","journal-title":"Clin. Endosc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"G700","DOI":"10.1152\/ajpgi.00502.2005","article-title":"A new model of chronic pancreatitis in rats","volume":"291","author":"Yamamoto","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1053\/j.gastro.2007.06.062","article-title":"Bacterial endotoxin: A trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model","volume":"133","author":"Vonlaufen","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1152\/physrev.00003.2021","article-title":"The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas","volume":"101","author":"Petersen","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/ncb3245","article-title":"STIMATE reveals a STIM1 transitional state","volume":"17","author":"Soboloff","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1113\/JP277856","article-title":"The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis","volume":"597","author":"Waldron","year":"2019","journal-title":"J. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1083\/jcb.201301148","article-title":"The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function","volume":"202","author":"Jha","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1038\/ncomms6843","article-title":"Translocation between PI (4, 5) P2-poor and PI (4, 5) P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating","volume":"5","author":"Choi","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102740","DOI":"10.1016\/j.ceca.2023.102740","article-title":"The role of Ca2+ signalling in the pathology of exocrine pancreas","volume":"112","author":"Gerasimenko","year":"2023","journal-title":"Cell Calcium"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/MPA.0000000000001793","article-title":"Auxora for the treatment of patients with acute pancreatitis and accompanying systemic inflammatory response syndrome: Clinical development of a calcium release-activated calcium channel inhibitor","volume":"50","author":"Bruen","year":"2021","journal-title":"Pancreas"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/emboj\/17.2.435","article-title":"Termination of cytosolic Ca2+ signals: Ca2+ reuptake into intracellular stores is regulated by the free Ca2+ concentration in the store lumen","volume":"17","author":"Mogami","year":"1998","journal-title":"EMBO J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0092-8674(00)81857-7","article-title":"Ca2+ flow via tunnels in polarized cells: Recharging of apical Ca2+ stores by focal Ca2+ entry through basal membrane patch","volume":"88","author":"Mogami","year":"1997","journal-title":"Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.molimm.2019.09.002","article-title":"8\u03b1-Hydroxypinoresinol isolated from Nardostachys jatamansi ameliorates cerulein-induced acute pancreatitis through inhibition of NF-\u03baB activation","volume":"114","author":"Choi","year":"2019","journal-title":"Mol. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2174\/1566524011313040007","article-title":"NFAT gene family in inflammation and cancer","volume":"13","author":"Pan","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1053\/j.gastro.2018.06.036","article-title":"Transient high pressure in pancreatic ducts promotes inflammation and alters tight junctions via calcineurin signaling in mice","volume":"155","author":"Wen","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41419-017-0073-9","article-title":"SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation","volume":"9","author":"Zhu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1053\/j.gastro.2018.11.082","article-title":"Acute pancreatitis: A multifaceted set of organelle and cellular interactions","volume":"156","author":"Habtezion","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/JLB.3RU0719-241R","article-title":"Calcium signaling and regulation of neutrophil functions: Still a long way to go","volume":"107","author":"Hann","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"24403","DOI":"10.1073\/pnas.2008032117","article-title":"ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense","volume":"117","author":"Grimes","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"zqad061","DOI":"10.1093\/function\/zqad061","article-title":"Neutrophil-specific ORAI1 calcium channel inhibition reduces pancreatitis-associated acute lung injury","volume":"5","author":"Niu","year":"2024","journal-title":"Function"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Kong, L., Zhang, H., Lu, C., Shi, K., Huang, H., Zheng, Y., Wang, Y., Wang, D., Wang, H., and Huang, W. (2021). AICAR, an AMP-activated protein kinase activator, ameliorates acute pancreatitis-associated liver injury partially through Nrf2-mediated antioxidant effects and inhibition of NLRP3 inflammasome activation. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.724514"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13885","DOI":"10.1021\/acsnano.4c03044","article-title":"Urolithin A\u2019s Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation","volume":"18","author":"Kang","year":"2024","journal-title":"ACS Nano"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1136\/gutjnl-2014-308553","article-title":"Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: Inhibition prevents acute pancreatitis by protecting production of ATP","volume":"65","author":"Mukherjee","year":"2016","journal-title":"Gut"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: Mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting ferroptosis to iron out cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1002\/mco2.298","article-title":"Iron homeostasis imbalance and ferroptosis in brain diseases","volume":"4","author":"Long","year":"2023","journal-title":"MedComm"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","article-title":"Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer","volume":"38","author":"Koppula","year":"2018","journal-title":"Cancer Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41419-025-07715-9","article-title":"Mechanistic insights into the role of FAT10 in modulating NCOA4-mediated ferroptosis in pancreatic acinar cells during acute pancreatitis","volume":"16","author":"Liu","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Xiang, X., Xu, M., Liu, L., Meng, N., Lei, Y., Feng, Y., and Tang, G. (2024). Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-60159-7"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"109981","DOI":"10.1016\/j.intimp.2023.109981","article-title":"Matrine alleviates oxidative stress and ferroptosis in severe acute pancreatitis-induced acute lung injury by activating the UCP2\/SIRT3\/PGC1\u03b1 pathway","volume":"117","author":"Jin","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3892\/ijmm.2024.5358","article-title":"Elimination of intracellular Ca2+ overload by BAPTA-AM liposome nanoparticles: A promising treatment for acute pancreatitis","volume":"53","author":"Fu","year":"2024","journal-title":"Int. J. Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Zhang, T., Huang, X., Feng, S., and Shao, H. (2025). Lactate-Dependent HIF1A Transcriptional Activation Exacerbates Severe Acute Pancreatitis Through the ACSL4\/LPCAT3\/ALOX15 Pathway Induced Ferroptosis. J. Cell. Biochem., 126.","DOI":"10.1002\/jcb.30687"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jcmgh.2021.09.008","article-title":"Trypsin-mediated sensitization to ferroptosis increases the severity of pancreatitis in mice","volume":"13","author":"Liu","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3892\/ijmm.2022.5212","article-title":"Secondary iron overload induces chronic pancreatitis and ferroptosis of acinar cells in mice","volume":"51","author":"Tian","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"16817","DOI":"10.1074\/jbc.R117.800169","article-title":"Stress-sensing mechanisms and the physiological roles of the Keap1\u2013Nrf2 system during cellular stress","volume":"292","author":"Suzuki","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Sykiotis, G.P. (2021). Keap1\/Nrf2 signaling pathway. Antioxidants, 10.","DOI":"10.3390\/antiox10060828"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5390482","DOI":"10.1155\/2020\/5390482","article-title":"Tanshinone IIA protects against acute pancreatitis in mice by inhibiting oxidative stress via the Nrf2\/ROS pathway","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI25790","article-title":"Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis","volume":"116","author":"Thimmulappa","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.2147\/DDDT.S247103","article-title":"Emodin protects against acute pancreatitis-associated lung injury by inhibiting NLPR3 inflammasome activation via Nrf2\/HO-1 signaling","volume":"14","author":"Gao","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"176646","DOI":"10.1016\/j.ejphar.2024.176646","article-title":"Melatonin ameliorates multiorgan injuries induced by severe acute pancreatitis in mice by regulating the Nrf2 signaling pathway","volume":"975","author":"Zhao","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Matzinger, M., Fischhuber, K., P\u00f6l\u00f6ske, D., Mechtler, K., and Heiss, E.H. (2020). AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes. Redox Biol., 29.","DOI":"10.1016\/j.redox.2019.101393"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"852","DOI":"10.21037\/atm-19-4552","article-title":"High-dose vitamin C alleviates pancreatic injury via the NRF2\/NQO1\/HO-1 pathway in a rat model of severe acute pancreatitis","volume":"8","author":"Xu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Song, Y.-D., Liu, Y.-Y., Li, D.-J., Yang, S.-J., Wang, Q.-F., Liu, Y.-N., Li, M.-K., Mei, C.-P., Cui, H.-N., and Chen, S.-Y. (2021). Galangin ameliorates severe acute pancreatitis in mice by activating the nuclear factor E2-related factor 2\/heme oxygenase 1 pathway. Biomed. Pharmacother., 144.","DOI":"10.1016\/j.biopha.2021.112293"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"112450","DOI":"10.1016\/j.intimp.2024.112450","article-title":"Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2\/HO-1 pathways","volume":"137","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6181754","DOI":"10.1155\/2019\/6181754","article-title":"DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling","volume":"2019","author":"Zhou","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"113490","DOI":"10.1016\/j.intimp.2024.113490","article-title":"Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects","volume":"143","author":"Wu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"113113","DOI":"10.1016\/j.intimp.2024.113113","article-title":"Bufalin alleviates inflammatory response and oxidative stress in experimental severe acute pancreatitis through activating Keap1-Nrf2\/HO-1 and inhibiting NF-\u03baB pathways","volume":"142","author":"Niu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/gut.2007.124115","article-title":"The role of NF-\u03baB activation in the pathogenesis of acute pancreatitis","volume":"57","author":"Rakonczay","year":"2008","journal-title":"Gut"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pan.2016.05.001","article-title":"NF-\u03baB in acute pancreatitis: Mechanisms and therapeutic potential","volume":"16","author":"Jakkampudi","year":"2016","journal-title":"Pancreatology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"21065","DOI":"10.1074\/jbc.M113.471425","article-title":"Pancreatic acinar cell nuclear factor \u03baB activation because of bile acid exposure is dependent on calcineurin","volume":"288","author":"Muili","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"112284","DOI":"10.1016\/j.intimp.2024.112284","article-title":"Myricetin ameliorates the severity of pancreatitis in mice by regulating cathepsin B activity and inflammatory cytokine production","volume":"136","author":"Choi","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.gassur.2006.04.007","article-title":"Bile-pancreatic juice exclusion promotes Akt\/NF-k B activation and chemokine production in ligation-induced acute pancreatitis","volume":"10","author":"Samuel","year":"2006","journal-title":"J. Gastrointest. Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-\u03baB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/01.mpa.0000160959.21580.41","article-title":"Toll-like receptor 4 detected in exocrine pancreas and the change of expression in cerulein-induced pancreatitis","volume":"30","author":"Li","year":"2005","journal-title":"Pancreas"},{"key":"ref_98","first-page":"138","article-title":"The protective effect of nano-curcumin in experimental model of acute pancreatitis: The involvement of TLR4\/NF-kB pathway","volume":"5","author":"Rashidian","year":"2018","journal-title":"Nanomed. J."},{"key":"ref_99","first-page":"2379","article-title":"Two-layer regulation of TRAF6 mediated by both TLR4\/NF-kB signaling and miR-589-5p increases proinflammatory cytokines in the pathology of severe acute pancreatitis","volume":"12","author":"Chen","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/ijmm.2015.2410","article-title":"TLR4-mediated NF-\u03baB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis","volume":"37","author":"Li","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.intimp.2019.02.053","article-title":"Indirubin-3\u2032-monoxime prevents aberrant activation of GSK-3\u03b2\/NF-\u03baB and alleviates high fat-high fructose induced A\u03b2-aggregation, gliosis and apoptosis in mice brain","volume":"70","author":"Priya","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.3892\/mmr.2014.2650","article-title":"Inhibition of glycogen synthase kinase-3\u03b2 attenuates acute kidney injury in sodium taurocholate-induced severe acute pancreatitis in rats","volume":"10","author":"Zhao","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bbrc.2018.04.176","article-title":"Respective roles of the mitogen-activated protein kinase (MAPK) family members in pancreatic stellate cell activation induced by transforming growth factor-\u03b21 (TGF-\u03b21)","volume":"501","author":"Xu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1111\/jcmm.16213","article-title":"The effects of nuclear factor-kappa B in pancreatic stellate cells on inflammation and fibrosis of chronic pancreatitis","volume":"25","author":"Wu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1053\/j.gastro.2013.01.041","article-title":"Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice","volume":"144","author":"Sah","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.gassur.2006.09.003","article-title":"In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production","volume":"10","author":"Samuel","year":"2006","journal-title":"J. Gastrointest. Surg."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.1039\/c3an01076g","article-title":"The role of p38 MAPK in neutrophil functions: Single cell chemotaxis and surface marker expression","volume":"138","author":"Kim","year":"2013","journal-title":"Analyst"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Asih, P.R., Prikas, E., Stefanoska, K., Tan, A.R.P., Ahel, H.I., and Ittner, A. (2020). Functions of p38 MAP kinases in the central nervous system. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.570586"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"745","DOI":"10.32604\/biocell.2024.049140","article-title":"Anemarsaponin B mitigates acute pancreatitis damage in mice through apoptosis reduction and MAPK pathway modulation","volume":"48","author":"Hu","year":"2024","journal-title":"Biocell"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.amjsurg.2009.12.004","article-title":"Nuclear factor kappa B\u2013dependent gene transcription in cholecystokinin-and tumor necrosis factor-\u03b1\u2013stimulated isolated acinar cells is regulated by p38 mitogen-activated protein kinase","volume":"200","author":"Williard","year":"2010","journal-title":"Am. J. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.3748\/wjg.v27.i18.2141","article-title":"Alleviation of acute pancreatitis-associated lung injury by inhibiting the p38 mitogen-activated protein kinase pathway in pulmonary microvascular endothelial cells","volume":"27","author":"Zhang","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12026-021-09195-3","article-title":"Inhibition of the p38 MAPK pathway attenuates renal injury in pregnant rats with acute necrotizing pancreatitis","volume":"69","author":"Zhang","year":"2021","journal-title":"Immunol. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2694","article-title":"Signal integration by JNK and p38 MAPK pathways in cancer development","volume":"9","author":"Wagner","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/j.freeradbiomed.2012.03.010","article-title":"p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression","volume":"52","author":"Park","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"686992","DOI":"10.3389\/fphar.2021.686992","article-title":"Puerarin ameliorates caerulein-induced chronic pancreatitis via inhibition of MAPK signaling pathway","volume":"12","author":"Zeng","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"111135","DOI":"10.1016\/j.cellsig.2024.111135","article-title":"COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK\/AKT signaling pathways","volume":"118","author":"Wang","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","article-title":"An overview of microRNAs","volume":"87","author":"Hammond","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11596-014-1263-7","article-title":"Expressions of miR-22 and miR-135a in acute pancreatitis","volume":"34","author":"Qin","year":"2014","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.pan.2016.03.004","article-title":"Regulation of autophagy by systemic admission of microRNA-141 to target HMGB1 in l-arginine-induced acute pancreatitis in vivo","volume":"16","author":"Zhu","year":"2016","journal-title":"Pancreatology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1038\/ncomms8151","article-title":"The oncogenic microRNA miR-21 promotes regulated necrosis in mice","volume":"6","author":"Ma","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ncb1897","article-title":"TGF-\u03b2 activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN","volume":"11","author":"Kato","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10620-014-3261-9","article-title":"Transforming growth factor (TGF)-\u03b2-induced microRNA-216a promotes acute pancreatitis via Akt and TGF-\u03b2 pathway in mice","volume":"60","author":"Zhang","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_123","first-page":"5647","article-title":"miR-148a-3p exhaustion inhibits necrosis by regulating PTEN in acute pancreatitis","volume":"11","author":"Cai","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/hep.26369","article-title":"MicroRNA-216a\/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer","volume":"58","author":"Xia","year":"2013","journal-title":"Hepatology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.ymthe.2022.01.033","article-title":"A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis","volume":"30","author":"Du","year":"2022","journal-title":"Mol. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","article-title":"Acute pancreatitis","volume":"386","author":"Lankisch","year":"2015","journal-title":"Lancet"},{"key":"ref_127","first-page":"3204","article-title":"Steroid receptor coactivator-interacting protein (sip) suppresses myocardial injury caused by acute pancreatitis","volume":"24","author":"Chen","year":"2018","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"119189","DOI":"10.1016\/j.lfs.2021.119189","article-title":"miR-29a-3p transferred by mesenchymal stem cells-derived extracellular vesicles protects against myocardial injury after severe acute pancreatitis","volume":"272","author":"Ren","year":"2021","journal-title":"Life Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"8282","DOI":"10.3748\/wjg.v19.i45.8282","article-title":"Overexpressed miRNA-155 dysregulates intestinal epithelial apical junctional complex in severe acute pancreatitis","volume":"19","author":"Tian","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.asjsur.2022.04.032","article-title":"Identification of key microRNAs in exosomes derived from patients with the severe acute pancreatitis","volume":"46","author":"Qu","year":"2023","journal-title":"Asian J. Surg."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Ge, P., Luo, Y., Okoye, C.S., Chen, H., Liu, J., Zhang, G., Xu, C., and Chen, H. (2020). Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis. Biomed. Pharmacother., 132.","DOI":"10.1016\/j.biopha.2020.110770"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.2147\/IJN.S428924","article-title":"Emodin ameliorates severe acute pancreatitis-associated acute lung injury in rats by modulating exosome-specific miRNA expression profiles","volume":"18","author":"Yang","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1166\/jbt.2023.3190","article-title":"miR-141-Modified Bone Marrow Mesenchymal Stem Cells (BMSCs) Inhibits the Progression of Severe Acute Pancreatitis","volume":"13","author":"Su","year":"2023","journal-title":"J. Biomater. Tissue Eng."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.cgh.2009.07.038","article-title":"Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis","volume":"7","author":"Masamune","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pan.2012.02.008","article-title":"miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro","volume":"12","author":"Shen","year":"2012","journal-title":"Pancreatology"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12079-014-0220-3","article-title":"Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes","volume":"8","author":"Charrier","year":"2014","journal-title":"J. Cell Commun. Signal."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11596-016-1570-2","article-title":"Functional role of MicroRNA-19b in acinar cell necrosis in acute necrotizing pancreatitis","volume":"36","author":"Hu","year":"2016","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e6668","DOI":"10.1097\/MD.0000000000006668","article-title":"Identifying miRNA-mRNA regulation network of chronic pancreatitis based on the significant functional expression","volume":"96","author":"Wang","year":"2017","journal-title":"Medicine"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pan.2015.10.009","article-title":"Association between microRNA polymorphisms and chronic pancreatitis","volume":"16","author":"Wang","year":"2016","journal-title":"Pancreatology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/gutjnl-2015-309363","article-title":"Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ release","volume":"66","author":"Huang","year":"2017","journal-title":"Gut"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Xia, K., Hei, Z., Li, S., Song, H., Huang, R., Ji, X., Zhang, F., Shen, J., Zhang, S., and Peng, S. (2024). Berberine inhibits intracellular Ca2+ signals in mouse pancreatic acinar cells through M3 muscarinic receptors: Novel target, mechanism, and implication. Biochem. Pharmacol., 225.","DOI":"10.1016\/j.bcp.2024.116279"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1074\/jbc.M111.318733","article-title":"Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation","volume":"287","author":"Kliem","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2412311","DOI":"10.1002\/advs.202412311","article-title":"Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU-EMRE Assembly","volume":"12","author":"Zhao","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1007\/s00394-024-03504-w","article-title":"EGCG suppressed activation of hepatic stellate cells by regulating the PLCE1\/IP3\/Ca2+ pathway","volume":"63","author":"Lin","year":"2024","journal-title":"Eur. J. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Akyuva, Y., and Naz\u0131ro\u011flu, M. (2020). Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-63577-5"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s12640-020-00314-w","article-title":"Curcumin attenuates hypoxia-Induced oxidative neurotoxicity, apoptosis, calcium, and zinc ion influxes in a neuronal cell line: Involvement of TRPM2 channel","volume":"39","year":"2021","journal-title":"Neurotox. Res."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Dost\u00e1l, Z., Zholobenko, A., P\u0159ichystalov\u00e1, H., Gottschalk, B., Valentov\u00e1, K., Malli, R., and Modriansk\u00fd, M. (2024). Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular Ca2+ elevations and mitochondrial depolarisation. Biochem. Pharmacol., 222.","DOI":"10.1016\/j.bcp.2024.116094"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhao, Y., Zhu, Y., Wang, Y., Liu, X., Nie, X., Zhao, J., Wang, W., and Cheng, J. (2022). Rhynchophylline regulates calcium homeostasis by antagonizing ryanodine receptor 2 phosphorylation to improve diabetic cardiomyopathy. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.882198"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/vms3.318","article-title":"Baicalin prevents the up-regulation of TRPV1 in dorsal root ganglion and attenuates chronic neuropathic pain","volume":"6","author":"Wang","year":"2020","journal-title":"Vet. Med. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"113869","DOI":"10.1016\/j.fct.2023.113869","article-title":"Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKC\u03b4 activation in the hippocampus of mice: Involvement of antioxidant potential","volume":"178","author":"Tran","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2021.07.009","article-title":"Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis","volume":"173","author":"Fan","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wang, K., Jiang, W., Ding, P., Wang, W., Zhao, K., and Chen, C. (2025). Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis. Int. J. Biol. Sci., 21.","DOI":"10.7150\/ijbs.112888"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-kappaB in biology and targeted therapy: New insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jpha.2021.07.002","article-title":"Phytochemicals targeting NF-kappaB signaling: Potential anti-cancer interventions","volume":"12","author":"Chauhan","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Glaubitz, J., Asgarbeik, S., Lange, R., Mazloum, H., Elsheikh, H., Weiss, F.U., and Sendler, M. (2023). Immune response mechanisms in acute and chronic pancreatitis: Strategies for therapeutic intervention. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1279539"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1499-3872(15)60327-7","article-title":"p38 MAPK inhibition alleviates experimental acute pancreatitis in mice","volume":"14","author":"Cao","year":"2015","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Zhu, M., Xu, Y., Zhang, W., Gu, T., and Wang, D. (2019). Inhibition of PAK1 alleviates cerulein-induced acute pancreatitis via p38 and NF-\u03baB pathways. Biosci. Rep., 39.","DOI":"10.1042\/BSR20182221"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Hou, X., Wang, C., Chen, C., Liu, H., Wang, L., Yi, Y., Jiang, S., Qi, X., Wei, Z., and Cheng, Y. (2025). Galangin protects against acute pancreatitis by inhibiting ROS-induced acinar cell apoptosis and M1-type macrophage polarization. Biochim. Biophys. Acta BBA Mol. Basis Dis., 1871.","DOI":"10.1016\/j.bbadis.2025.167887"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1142\/S0192415X21500087","article-title":"Baicalin protects against acute pancreatitis involving JNK signaling pathway via regulating miR-15a","volume":"49","author":"Zhen","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"118340","DOI":"10.1016\/j.lfs.2020.118340","article-title":"Dihydrokaempferol (DHK) ameliorates severe acute pancreatitis (SAP) via Keap1\/Nrf2 pathway","volume":"261","author":"Liang","year":"2020","journal-title":"Life Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.phrs.2015.03.011","article-title":"Thymoquinone and its therapeutic potentials","volume":"95\u201396","author":"Darakhshan","year":"2015","journal-title":"Pharmacol. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/mnfr.201000221","article-title":"Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: Relevance for anti-aging intervention","volume":"55","author":"Lima","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Tang, J.-Y., Chuang, Y.-T., Shiau, J.-P., Yen, C.-Y., Chang, F.-R., Tsai, Y.-H., Farooqi, A.A., and Chang, H.-W. (2023). Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512449"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Hsu, Y.-C., Chang, P.-J., Lin, S.-J., Liaw, C.-C., Shih, Y.-H., Chen, L.-W., and Lin, C.-L. (2021). Curcumin Reinforces MiR-29a Expression, Reducing Mesangial Fibrosis in a Model of Diabetic Fibrotic Kidney via Modulation of CB1R Signaling. Processes, 9.","DOI":"10.3390\/pr9040694"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.18632\/aging.101250","article-title":"Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs","volume":"9","author":"McCubrey","year":"2017","journal-title":"Aging"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Chen, F., Xu, K., Han, Y., Ding, J., Ren, J., Wang, Y., Ma, Z., and Cao, F. (2024). Mitochondrial dysfunction in pancreatic acinar cells: Mechanisms and therapeutic strategies in acute pancreatitis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1503087"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.hbpd.2023.12.008","article-title":"Mitochondrial dysfunction in the pathogenesis of acute pancreatitis","volume":"24","author":"Chen","year":"2025","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Davi, F., Iaconis, A., Cordaro, M., Di Paola, R., and Fusco, R. (2025). Nutraceutical Strategies for Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases. Foods, 14.","DOI":"10.3390\/foods14132193"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/bph.14169","article-title":"Dihydrodiosgenin protects against experimental acute pancreatitis and associated lung injury through mitochondrial protection and PI3K\u03b3\/Akt inhibition","volume":"175","author":"Shen","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Li, X., Wang, T., Zhou, Q., Li, F., Liu, T., Zhang, K., Wen, A., Feng, L., Shu, X., and Tian, S. (2024). Isorhamnetin alleviates mitochondrial injury in severe acute pancreatitis via modulation of KDM5B\/HtrA2 signaling pathway. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073784"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"155629","DOI":"10.1016\/j.phymed.2024.155629","article-title":"Rhizoma Alismatis Decoction improved mitochondrial dysfunction to alleviate SASP by enhancing autophagy flux and apoptosis in hyperlipidemia acute pancreatitis","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_173","first-page":"3027","article-title":"Curcumin protects the pancreas from acute pancreatitis via the mitogen-activated protein kinase signaling pathway","volume":"20","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/ijmm.2016.2809","article-title":"Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects","volume":"39","author":"Xiong","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.12659\/MSM.909557","article-title":"Curcumin Attenuates Inflammation in a Severe Acute Pancreatitis Animal Model by Regulating TRAF1\/ASK1 Signaling","volume":"24","author":"Yu","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Coman, L.I., Balaban, D.V., Dumbrav\u0103, B.F., P\u0103unescu, H., Marin, R.-C., Costescu, M., Dima, L., Jinga, M., and Coman, O.A. (2025). Targeting Oxidative Stress in Acute Pancreatitis: A Critical Review of Antioxidant Strategies. Nutrients, 17.","DOI":"10.3390\/nu17152390"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3892\/mmr.2013.1773","article-title":"Emodin attenuates calcium overload and endoplasmic reticulum stress in AR42J rat pancreatic acinar cells","volume":"9","author":"Wu","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.3748\/wjg.14.2343","article-title":"Effect of Chaiqinchengqi decoction on sarco\/endoplasmic reticulum Ca2+-ATPase mRNA expression of pancreatic tissues in acute pancreatitis rats","volume":"14","author":"Xue","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Xiao, J., Huang, K., Lin, H., Xia, Z., Zhang, J., Li, D., and Jin, J. (2020). Mogroside IIE inhibits digestive enzymes via suppression of interleukin 9\/interleukin 9 receptor signalling in acute pancreatitis. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00859"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.3748\/wjg.v13.i42.5612","article-title":"Induction of apoptosis by artemisinin relieving the severity of inflammation in caerulein-induced acute pancreatitis","volume":"13","author":"Zhao","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Zhou, Z., Choi, J.-W., Shin, J.Y., Kim, D.-U., Kweon, B., Oh, H., Kim, Y.-C., Song, H.-J., Bae, G.-S., and Park, S.-J. (2021). Betulinic acid ameliorates the severity of acute pancreatitis via inhibition of the NF-\u03baB signaling pathway in mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136871"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Siriviriyakul, P., Sriko, J., Somanawat, K., Chayanupatkul, M., Klaikeaw, N., and Werawatganon, D. (2022). Genistein attenuated oxidative stress, inflammation, and apoptosis in L-arginine induced acute pancreatitis in mice. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03689-9"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"107246","DOI":"10.1016\/j.intimp.2020.107246","article-title":"Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-\u03baB\/SIRT1 and apoptosis signaling in acute pancreatitis model","volume":"90","author":"Bansod","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"174279","DOI":"10.1016\/j.ejphar.2021.174279","article-title":"Targeting HMGB1\/TLR4\/NF-\u03baB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats","volume":"906","author":"Abdelmageed","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1142\/S0192415X15500640","article-title":"Rosmarinic acid attenuates sodium taurocholate-induced acute pancreatitis in rats by inhibiting nuclear factor-\u03baB activation","volume":"43","author":"Fan","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Nagy-P\u00e9nzes, M., Hajn\u00e1dy, Z., Regdon, Z., Dem\u00e9ny, M.\u00c1., Kov\u00e1cs, K., El-Hamoly, T., Mal\u00e9th, J., Hegyi, P., Heged\u0171s, C., and Vir\u00e1g, L. (2022). Tricetin reduces inflammation and acinar cell injury in Cerulein-induced acute pancreatitis: The role of oxidative stress-induced DNA damage signaling. Biomedicines, 10.","DOI":"10.3390\/biomedicines10061371"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.biopha.2018.05.080","article-title":"Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-\u03baB signal pathways in mice","volume":"105","author":"Ma","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.bbrc.2018.07.101","article-title":"Dihydromyricetin inhibits caerulin-induced TRAF3-p38 signaling activation and acute pancreatitis response","volume":"503","author":"Jia","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Zhang, R., Asikaer, A., Chen, Q., Wang, F., Lan, J., Liu, Y., Hu, L., Zhao, H., and Duan, H. (2024). Network pharmacology and in vitro experimental verification unveil glycyrrhizin from glycyrrhiza glabra alleviates acute pancreatitis via modulation of MAPK and STAT3 signaling pathways. BMC Complement. Med. Ther., 24.","DOI":"10.1186\/s12906-024-04372-x"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1097\/MPA.0b013e3181b28d11","article-title":"Green tea polyphenols ameliorate pancreatic injury in cerulein-induced murine acute pancreatitis","volume":"38","author":"Babu","year":"2009","journal-title":"Pancreas"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopha.2016.04.048","article-title":"Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways","volume":"82","author":"Chen","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Zhao, X., Li, F., Wen, A., Yu, X., Xu, X., Wan, C., Cao, Y., Xin, G., and Huang, W. (2024). Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: Insights from network pharmacology and in vitro\/in vivo experiments. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1485915"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Yang, J., Tang, X., Ke, X., Dai, Y., and Shi, J. (2022). Triptolide suppresses NF-\u03baB-mediated inflammatory responses and activates expression of Nrf2-mediated antioxidant genes to alleviate caerulein-induced acute pancreatitis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031252"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1007\/s43440-021-00320-5","article-title":"Chlorogenic acid reduces inflammation in murine model of acute pancreatitis","volume":"73","author":"Tarasiuk","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1002\/ptr.6200","article-title":"Withaferin A, a novel compound of Indian ginseng (Withania somnifera), ameliorates C erulein-induced acute pancreatitis: Possible role of oxidative stress and inflammation","volume":"32","author":"Tiruveedi","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.bmcl.2017.01.014","article-title":"Phenolic compounds isolated from Dioscorea zingiberensis protect against pancreatic acinar cells necrosis induced by sodium taurocholate","volume":"27","author":"Du","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"00368504211026118","DOI":"10.1177\/00368504211026118","article-title":"Protective effects of baicalin on caerulein-induced AR42J pancreatic acinar cells by attenuating oxidative stress through miR-136-5p downregulation","volume":"104","author":"Zhao","year":"2021","journal-title":"Sci. Prog."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ejphar.2007.10.068","article-title":"Effects of resveratrol on calcium regulation in rats with severe acute pancreatitis","volume":"580","author":"Wang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"111733","DOI":"10.1016\/j.cellsig.2025.111733","article-title":"Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis","volume":"131","author":"Chen","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/MPA.0000000000000877","article-title":"Effects of berberine on acute necrotizing pancreatitis and associated lung injury","volume":"46","author":"Choi","year":"2017","journal-title":"Pancreas"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Zhang, D., Li, L., Li, J., Wei, Y., Tang, J., Man, X., and Liu, F. (2022). Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats. Biomed. Pharmacother., 153.","DOI":"10.1016\/j.biopha.2022.113461"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3892\/mmr.2021.11926","article-title":"Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis","volume":"23","author":"Wang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1007\/s10528-024-10686-9","article-title":"Albiflorin Alleviates Severe Acute Pancreatitis-Associated Liver Injury by Inactivating P38MAPK\/NF-\u03baB Signaling Pathway","volume":"62","author":"Li","year":"2024","journal-title":"Biochem. Genet."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.pan.2018.08.001","article-title":"Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4\/MyD88\/p38 MAPK and ERS inhibition","volume":"18","author":"Zheng","year":"2018","journal-title":"Pancreatology"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Wen, E., Cao, Y., He, S., Zhang, Y., You, L., Wang, T., Wang, Z., He, J., and Feng, Y. (2024). The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02439-y"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"109123","DOI":"10.1016\/j.intimp.2022.109123","article-title":"Salidroside alleviates severe acute pancreatitis-triggered pancreatic injury and inflammation by regulating miR-217-5p\/YAF2 axis","volume":"111","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3892\/mmr.2023.13095","article-title":"Catechin hydrate ameliorates cerulein-induced chronic pancreatitis via the inactivation of TGF-\u03b2\/Smad2 signaling","volume":"28","author":"Kweon","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1142\/S0192415X21500944","article-title":"Psidium guajava flavonoids prevent NLRP3 inflammasome activation and alleviate the pancreatic fibrosis in a chronic pancreatitis mouse model","volume":"49","author":"Zhang","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Jia, S., Chen, Q., Liu, X., Li, Y., Wang, L., Li, X., and Hu, S. (2024). Efficacy of integrated traditional Chinese and western medicine in managing mild-moderate acute pancreatitis: A real-world clinical perspective analysis. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1429546"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1002\/ptr.7958","article-title":"Nano-curcumin supplementation in patients with mild and moderate acute pancreatitis: A randomized, placebo-controlled trial","volume":"37","author":"Chegini","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_211","first-page":"2256","article-title":"Chinese herbal medicine therapy for hyperlipidemic acute pancreatitis: A systematic review and meta-analysis of randomized controlled trials","volume":"27","author":"Guo","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1186\/s13063-022-06792-x","article-title":"AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): Study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial","volume":"23","author":"Chen","year":"2022","journal-title":"Trials"},{"key":"ref_213","unstructured":"(2025, December 02). Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-Center, Single-Blinded, Randomized Controlled Trial, Available online: https:\/\/clinicaltrials.gov\/study\/NCT02947932."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jtcme.2016.05.005","article-title":"Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives\u2013A review","volume":"7","author":"Amalraj","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_215","first-page":"1","article-title":"Effects of Chai-Qin-Cheng-Qi decoction (\u67f4\u82a9\u627f\u6c14\u6c64) on acute pancreatitis-associated lung injury in mice with acute necrotizing pancreatitis","volume":"19","author":"Huang","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"3265368","DOI":"10.1155\/2016\/3265368","article-title":"Key molecular mechanisms of chaiqinchengqi decoction in alleviating the pulmonary albumin leakage caused by endotoxemia in severe acute pancreatitis rats","volume":"2016","author":"Wu","year":"2016","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"153328","DOI":"10.1016\/j.phymed.2020.153328","article-title":"Chaiqin chengqi decoction alleviates severity of acute pancreatitis via inhibition of TLR4 and NLRP3 inflammasome: Identification of bioactive ingredients via pharmacological sub-network analysis and experimental validation","volume":"79","author":"Wen","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"153996","DOI":"10.1016\/j.phymed.2022.153996","article-title":"Temporal metabolic trajectory analyzed by LC-MS\/MS based targeted metabolomics in acute pancreatitis pathogenesis and Chaiqin Chengqi decoction therapy","volume":"99","author":"Huang","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"156393","DOI":"10.1016\/j.phymed.2025.156393","article-title":"Traditional Chinese medicine Chaiqinchengqi decoction for patients with acute pancreatitis: A randomized clinical trial","volume":"138","author":"Deng","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_220","first-page":"2045053","article-title":"Treatment of hyperlipidemic acute pancreatitis with modified Dachengqi decoction combining with conventional therapy based on \u201csix-hollow-organs to be unblocked\u201d theory","volume":"9","author":"Liu","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"10-4238","DOI":"10.4238\/gmr.15028787","article-title":"Modified Da Chengqi granules improvement in immune function in early severe acute pancreatitis patients","volume":"15","author":"Jiang","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.3748\/wjg.v13.i34.4566","article-title":"Preparation method of an ideal model of multiple organ injury of rat with severe acute pancreatitis","volume":"13","author":"Zhang","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"pkCSM: Predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures","volume":"58","author":"Pires","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"9.12.1","DOI":"10.1002\/0471141755.ph0912s49","article-title":"Overview on the Rule of Five","volume":"49","author":"Pollastri","year":"2010","journal-title":"Curr. Protoc. Pharmacol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"534","DOI":"10.7150\/ijms.51618","article-title":"The role of pancreatic infiltrating innate immune cells in acute pancreatitis","volume":"18","author":"Peng","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"C938","DOI":"10.1152\/ajpcell.00582.2006","article-title":"Oxidant-impaired intracellular Ca2+ signaling in pancreatic acinar cells: Role of the plasma membrane Ca2+-ATPase","volume":"293","author":"Bruce","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.semarthrit.2015.06.013","article-title":"Colchicine\u2014Update on mechanisms of action and therapeutic uses","volume":"Volume 45","author":"Leung","year":"2015","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"ref_228","unstructured":"Sadiq, N.M., Robinson, K.J., and Terrell, J.M. (2017). Colchicine. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3892\/etm.2022.11120","article-title":"Role of antioxidants and oxidative stress in the evolution of acute pancreatitis","volume":"23","author":"Florescu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/ars.2008.2109","article-title":"Role of oxidative stress in pancreatic inflammation","volume":"11","author":"Leung","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1089\/ars.2011.4068","article-title":"Organellar dysfunction in the pathogenesis of pancreatitis","volume":"15","author":"Gukovsky","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1053\/j.gastro.2012.10.037","article-title":"Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis","volume":"144","author":"Shalbueva","year":"2013","journal-title":"Gastroenterology"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/24\/3841\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:27:34Z","timestamp":1765344454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/24\/3841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":232,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["nu17243841"],"URL":"https:\/\/doi.org\/10.3390\/nu17243841","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]}}}