{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T05:21:12Z","timestamp":1765516872860,"version":"3.48.0"},"reference-count":45,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Hungarian Hypertension Society","award":["."],"award-info":[{"award-number":["."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Menopause affects every woman worldwide, with varying degrees of severity. In addition to traditional treatments such as hormone replacement therapy, there is also a growing interest in alternative treatments. One possible way to address this need is through the use of placenta extracts. This systematic review is the first to evaluate the efficacy of placental extracts in randomized controlled trials (RCTs). Methods: A systematic search of three databases (MEDLINE, Scopus, Embase) identified studies on placental extract treatment of menopausal symptoms in women, yielding 272 records, with 11 eligible studies. Results: Menopausal severity scores (Kupperman Menopausal Index, Simplified Menopausal Index, Menopausal Rating Scale), somatic and vasomotor symptoms, skin conditions, and certain psychological indicators were significantly improved in the 11 enrolled randomized controlled trials, including perimenopausal and postmenopausal women treated with porcine or human dried, purified placental extract. Placental extract was well tolerated in all studies; no significant side effects or clinically significant laboratory abnormalities were recorded. Conclusions: Porcine and human placental extracts appear to offer potential benefits for alleviating menopausal symptoms.<\/jats:p>","DOI":"10.3390\/nu17243857","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:22:40Z","timestamp":1765376560000},"page":"3857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Placental Extract on Menopausal Symptoms: A Systematic Review"],"prefix":"10.3390","volume":"17","author":[{"given":"S\u00e1ra","family":"Papp","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0560-9053","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"T\u0171\u0171","sequence":"additional","affiliation":[{"name":"School of PhD Studies, Semmelweis University, 1085 Budapest, Hungary"},{"name":"EndoCare Institute, Endocrinology Center, 1095 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Nas","sequence":"additional","affiliation":[{"name":"EndoCare Institute, Endocrinology Center, 1095 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Telkes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"},{"name":"School of PhD Studies, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotti","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-3481","authenticated-orcid":false,"given":"M\u00e1rton","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"V\u00e1rb\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"},{"name":"Department of Obstetrics and Gynecology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-0626","authenticated-orcid":false,"given":"Marianna","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0140-6736(08)60346-3","article-title":"Menopause","volume":"371","author":"Nelson","year":"2008","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpobgyn.2022.03.003","article-title":"Menopause transition: Physiology and symptoms","volume":"81","author":"Talaulikar","year":"2022","journal-title":"Best Pr. 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