{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:35:17Z","timestamp":1787236517030,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovation Research Team Project of Hainan Natural Science Foundation","award":["322CXTD525"],"award-info":[{"award-number":["322CXTD525"]}]},{"DOI":"10.13039\/501100013142","name":"Key Research and Development Project of Hainan Province","doi-asserted-by":"crossref","award":["ZDYF2024XDNY277"],"award-info":[{"award-number":["ZDYF2024XDNY277"]}],"id":[{"id":"10.13039\/501100013142","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013142","name":"Key Research and Development Project of Hainan Province","doi-asserted-by":"crossref","award":["ZDYF2024HXGG002"],"award-info":[{"award-number":["ZDYF2024HXGG002"]}],"id":[{"id":"10.13039\/501100013142","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Team of the National Tropical Agricultural Science Center as part of the Chinese Academy of Tropical Agricultural Science","award":["CATASCXTD202304"],"award-info":[{"award-number":["CATASCXTD202304"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund of Chinese Academy of Tropical Agricultural Sciences","award":["1630012025118"],"award-info":[{"award-number":["1630012025118"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund of Chinese Academy of Tropical Agricultural Sciences","award":["1630142022009"],"award-info":[{"award-number":["1630142022009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Inflammation is a critical pathological process implicated in numerous diseases. Methods: In this study, a water-soluble polysaccharide was extracted from the fruit pulp of Artocarpus heterophyllus Lam. (namely, JFP-Ps), and the anti-inflammatory properties and underlying mechanisms were investigated. Inflammatory responses were induced in RAW264.7 macrophages through lipopolysaccharide (LPS) stimulation. Results: JFP-Ps markedly diminished the production of nitric oxide (NO) and reactive oxygen species (ROS); reduced LPS-induced cell apoptosis by increasing glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activity; and decreased pro-inflammatory cytokine levels, including interleukin-1\u03b2 (IL-1\u03b2), interleukin-6 (IL-6), and tumor necrosis factor-\u03b1 (TNF-\u03b1). JFP-Ps decreased inflammatory responses by inhibiting the production of gene and protein expression associated with the MAPK\/ERK pathway. Additionally, metabolomic profiling revealed that LPS stimulation increased ether lipid metabolism while it decreased pantothenate and coenzyme A biosynthesis. These metabolic changes were partially reversed by JFP-Ps through inhibiting the synthesis of branched-chain amino acids. Conclusions: JFP-Ps may exert anti-inflammatory effects by concurrently modulating oxidative stress, inflammatory signaling, and metabolic reprogramming in macrophages.<\/jats:p>","DOI":"10.3390\/nu17243879","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:30:17Z","timestamp":1765528217000},"page":"3879","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti-Inflammatory Effect of a Polysaccharide Derived from Artocarpus heterophyllus Lam. Pulp on Lipopolysaccharide-Stimulated RAW264.7 Macrophages Through Inhibiting MAPK\/ERK Signaling Pathway"],"prefix":"10.3390","volume":"17","author":[{"given":"Benyan","family":"Bai","sequence":"first","affiliation":[{"name":"The Key Laboratory of Environmental Pollution Monitoring and Disease Control, School of Public Health, Ministry of Education, Guizhou Medical University, Guiyang 561113, China"},{"name":"Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China"},{"name":"Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province, Wanning 571533, China"},{"name":"National Center of Important Tropical Crops Engineering and Technology Research, Wanning 571533, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panjie","family":"Xu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Environmental Pollution Monitoring and Disease Control, School of Public Health, Ministry of Education, Guizhou Medical University, Guiyang 561113, China"},{"name":"Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2963-1853","authenticated-orcid":false,"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China"},{"name":"Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province, Wanning 571533, China"},{"name":"National Center of Important Tropical Crops Engineering and Technology Research, Wanning 571533, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5383-4791","authenticated-orcid":false,"given":"Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China"},{"name":"Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province, Wanning 571533, China"},{"name":"National Center of Important Tropical Crops Engineering and Technology Research, Wanning 571533, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China"},{"name":"Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province, Wanning 571533, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Environmental Pollution Monitoring and Disease Control, School of Public Health, Ministry of Education, Guizhou Medical University, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-1567","authenticated-orcid":false,"given":"Kexue","family":"Zhu","sequence":"additional","affiliation":[{"name":"Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China"},{"name":"Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province, Wanning 571533, China"},{"name":"National Center of Important Tropical Crops Engineering and Technology Research, Wanning 571533, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","article-title":"TNF biology, pathogenic mechanisms and emerging therapeutic strategies","volume":"12","author":"Kalliolias","year":"2016","journal-title":"Nat. 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