{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:57:11Z","timestamp":1789469831050,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"K.A., M.\u00c1.L.-E., S.D.-A. and E.M.-N."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Intermittent hypobaric hypoxia (IHH) induces various physiological and metabolic adaptations. This study aimed to investigate the effects of a seven-day IHH exposure on nutritional status, body composition, gut microbiota, movement intensity, and energy expenditure in 10 workers. Methods: A pre\u2013post comparative design was employed, with measurements taken at the beginning and end of the exposure period. Nutritional status, body composition, and phase angle (PhA) were assessed via bioelectrical impedance analysis (BIA). Gut microbiota composition was analyzed through fecal DNA extraction and qPCR for specific bacterial families. Movement intensity and energy expenditure were monitored using accelerometry. An initial statistical analysis was performed, which included paired t-tests and Wilcoxon signed-rank tests. Results: A significant increase in PhA (mean difference: 0.40; p = 0.0053 for t-test, p = 0.0136 for Wilcoxon) and a significant decrease in BMI (mean difference: \u22120.38; p = 0.0311 for t-test, p = 0.0546 for Wilcoxon). Conclusions: While the original paper reported no significant changes in nutritional status or body composition, our re-analysis suggests a significant change in BMI. The original paper also reported significant changes in specific gut bacterial families (butyrate-producing bacteria, p = 0.037; Lactobacillus species, p = 0.006). Physical activity levels remained consistently low.<\/jats:p>","DOI":"10.3390\/nu17243919","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:32:37Z","timestamp":1765805557000},"page":"3919","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Body Composition, Microbiome and Physical Activity in Workers Under Intermittent Hypobaric Hypoxia"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-5051","authenticated-orcid":false,"given":"Jorge","family":"Torres-Mej\u00edas","sequence":"first","affiliation":[{"name":"Doctoral Program in Physical Activity Sciences, Faculty of Education Sciences, Universidad Cat\u00f3lica del Maule, Talca 3530000, Chile"},{"name":"Centro de Investigaci\u00f3n Andino para la Altitud Geogr\u00e1fica, CIAAG, Santiago 7500000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karem","family":"Arriaza","sequence":"additional","affiliation":[{"name":"High Altitude Medicine Research Center (CEIMA), Arturo Prat University, Iquique 1100000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mena","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Andino para la Altitud Geogr\u00e1fica, CIAAG, Santiago 7500000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelina","family":"Rivarola","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Andino para la Altitud Geogr\u00e1fica, CIAAG, Santiago 7500000, Chile"},{"name":"Escuela de Nutrici\u00f3n, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba PC 5000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Paredes","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Andino para la Altitud Geogr\u00e1fica, CIAAG, Santiago 7500000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husam","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Andino para la Altitud Geogr\u00e1fica, CIAAG, Santiago 7500000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Atacama Large Millimeter\/Submillimeter Array, ALMA Observatory, Santiago 7630355, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Soza","sequence":"additional","affiliation":[{"name":"Atacama Large Millimeter\/Submillimeter Array, ALMA Observatory, Santiago 7630355, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Pino-Villal\u00f3n","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Salud, Universidad Santo Tom\u00e1s, Santiago 8370003, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-634X","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"L\u00f3pez-Espinoza","sequence":"additional","affiliation":[{"name":"Carrera de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Ciencias de la Salud, Universidad Adventista de Chile, Chill\u00e1n 3780000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-3676","authenticated-orcid":false,"given":"Samuel","family":"Duran-Ag\u00fcero","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Ciencias de la Rehabilitaci\u00f3n y Calidad de Vida, Sede Los Leones, Universidad San Sebasti\u00e1n, Santiago 7500000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1557-2285","authenticated-orcid":false,"given":"Eugenio","family":"Merellano-Navarro","sequence":"additional","affiliation":[{"name":"Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Cat\u00f3lica del Maule, Talca 3530000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2102463118","DOI":"10.1073\/pnas.2102463118","article-title":"Global and country-level estimates of human population at high altitude","volume":"118","author":"Tremblay","year":"2021","journal-title":"Proc. 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