{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:26:22Z","timestamp":1792797982757,"version":"4.5.0"},"reference-count":92,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Ferroptosis is a non-apoptotic form of cell death that is driven by iron and reactive oxygen species (ROS). This process is characterised by lipid peroxidation, which damages cell membranes and distinguishes it from other types of cell death. Excess iron promotes ferroptosis through Fenton chemistry, leading to increased ROS production. While glutathione peroxidase 4 has been identified as a key regulator of this process, other factors, such as the ferroptosis suppressor protein 1 (FSP1), suggest that regulation is more complex. Ferroptosis has been associated with several degenerative diseases, including Alzheimer\u2019s disease, Parkinson\u2019s disease, acute kidney injury, liver disorders, and cancer. The enzyme haemoxygenase-1 (HO-1) plays dual roles: it can promote ferroptosis by releasing iron or provide protection through its antioxidant effects in various organs and tissues. HO-1 increases iron levels through the catabolism of haem which can heighten sensitivity to ferroptosis by influencing iron trafficking and ferritin expression. Conversely, HO-1 has demonstrated nephroprotective effects in cases of renal injury and other disorders. HO-1\u2032s involvement in regulating iron metabolism and its antioxidant capabilities can lead to differing outcomes, highlighting key players in the ferroptosis process. The Nrf2\/HO-1 axis is crucial for its antioxidant properties in various disorders. Moreover, dietary sources can enhance HO-1 induction through Nrf2 regulation. Hence, HO-1 acts as both a modulator and a mediator, presenting new therapeutic targets for cancer, neurodegeneration, and kidney and liver diseases.<\/jats:p>","DOI":"10.3390\/nu17243921","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:32:37Z","timestamp":1765805557000},"page":"3921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Haem Oxygenase-1, Ferroptosis and Disorders\u2014A Narrative Review"],"prefix":"10.3390","volume":"17","author":[{"given":"James","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, School of Life Course and Population Sciences, King\u2019s College London, Franklin-Wilkins-Building, 150 Stamford Street, London SE1 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Refesse","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Life Course and Population Sciences, King\u2019s College London, Franklin-Wilkins-Building, 150 Stamford Street, London SE1 9NH, UK"},{"name":"Faculty of Sciences and Technology, Engineering School (ESIROI), University of Reunion Island\u2019s, Agri-Food, 97410 Saint-Pierre, Reunion Island, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwa","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Life Course and Population Sciences, King\u2019s College London, Franklin-Wilkins-Building, 150 Stamford Street, London SE1 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0607-6909","authenticated-orcid":false,"given":"Gladys O.","family":"Latunde-Dada","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Life Course and Population Sciences, King\u2019s College London, Franklin-Wilkins-Building, 150 Stamford Street, London SE1 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/iub.1616","article-title":"Iron and ferroptosis: A still ill-defined liaison","volume":"69","author":"Doll","year":"2017","journal-title":"IUBMB Life"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1126\/science.122.3168.501","article-title":"Nutrition Needs of Mammalian Cells in Tissue Culture","volume":"122","author":"Eagle","year":"1955","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy","volume":"1861","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: Death by Lipid Peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: Process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"46LT02","DOI":"10.1088\/0957-4484\/27\/46\/46LT02","article-title":"Morphology of the ferritin iron core by aberration corrected scanning transmission electron microscopy","volume":"27","author":"Jian","year":"2016","journal-title":"Nanotechnology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"mfab021","DOI":"10.1093\/mtomcs\/mfab021","article-title":"Chemistry and biology of ferritin","volume":"13","author":"Plays","year":"2021","journal-title":"Metallomics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1111\/febs.16993","article-title":"A guide to ferroptosis, the biological rust of cellular membranes","volume":"291","author":"Veeckmans","year":"2024","journal-title":"FEBS J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"ref_15","first-page":"143","article-title":"Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis","volume":"403","author":"Imai","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: A key regulator of ferroptosis","volume":"29","author":"Li","year":"2023","journal-title":"Trends Mol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Feng, H., and Stockwell, B.R. (2018). Unsolved mysteries: How does lipid peroxidation cause ferroptosis?. PLoS Biol., 16.","DOI":"10.1371\/journal.pbio.2006203"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10565-025-10010-0","article-title":"Insights into emerging mechanisms of ferroptosis: New regulators for cancer therapeutics","volume":"41","author":"Xu","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1172\/JCI5342","article-title":"Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury","volume":"103","author":"Otterbein","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1096\/fasebj.2.10.3290025","article-title":"Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications","volume":"2","author":"Maines","year":"1988","journal-title":"FASEB J."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zou, X.-Y., Cai, L.-Y., Zhang, J., Yuan, Y., Song, J., Hu, Z.-D., Ruan, X.-F., Peng, R., and Zhang, X.-M. (2025). Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia. Front. Mol. Neurosci., 18.","DOI":"10.3389\/fnmol.2025.1585079"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00011-018-1151-x","article-title":"A review on heme oxygenase-1 induction: Is it a necessary evil","volume":"67","author":"Waza","year":"2018","journal-title":"Inflamm. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme oxygenase-1\/carbon monoxide: From basic science to therapeutic applications","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vph.2015.09.004","article-title":"HO-1\/CO system in tumor growth, angiogenesis and metabolism\u2014Targeting HO-1 as an anti-tumor therapy","volume":"74","author":"Loboda","year":"2015","journal-title":"Vascul. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5416728","DOI":"10.1155\/2019\/5416728","article-title":"Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress","volume":"2019","author":"Chen","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.freeradbiomed.2012.03.007","article-title":"Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells","volume":"53","author":"Li","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Vercellotti, G.M., Khan, F.B., Nguyen, J., Chen, C., Bruzzone, C.M., Bechtel, H., Brown, G., Nath, K.A., Steer, C.J., and Hebbel, R.P. (2014). H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice. Front. Pharmacol., 5.","DOI":"10.3389\/fphar.2014.00079"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/BJ20120936","article-title":"Haem oxygenase-1 overexpression alters intracellular iron distribution","volume":"449","author":"Lanceta","year":"2013","journal-title":"Biochem. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1096\/fasebj.13.13.1800","article-title":"Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron","volume":"13","author":"Suttner","year":"1999","journal-title":"FASEB J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"mfad062","DOI":"10.1093\/mtomcs\/mfad062","article-title":"Heme oxygenase-1 increases intracellular iron storage and suppresses inflammatory response of macrophages by inhibiting M1 polarization","volume":"15","author":"Tang","year":"2023","journal-title":"Metallomics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10480","DOI":"10.1074\/jbc.M700240200","article-title":"Non-heme induction of heme oxygenase-1 does not alter cellular iron metabolism","volume":"282","author":"Sheftel","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"24393","DOI":"10.18632\/oncotarget.5162","article-title":"Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death","volume":"6","author":"Kwon","year":"2015","journal-title":"Oncotarget"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2017.12.025","article-title":"Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis","volume":"416","author":"Chang","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1172\/JCI99032","article-title":"Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma","volume":"128","author":"Hassannia","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.redox.2016.12.010","article-title":"Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis","volume":"11","author":"Roh","year":"2017","journal-title":"Redox Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"541","DOI":"10.4254\/wjh.v5.i10.541","article-title":"Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury","volume":"5","author":"Origassa","year":"2013","journal-title":"World J. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.bbadis.2015.07.018","article-title":"Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1\/2-enhanced tubular epithelium proliferation","volume":"1852","author":"Chen","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Schneider","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.cell.2011.10.033","article-title":"Programmed cell death in animal development and disease","volume":"147","author":"Fuchs","year":"2011","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1016\/S0021-9258(18)62745-0","article-title":"Ribonucleotide reductase and cell proliferation: I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas","volume":"245","author":"Elford","year":"1970","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"972913","DOI":"10.1155\/2013\/972913","article-title":"Role of glutathione in cancer progression and chemoresistance","volume":"2013","author":"Traverso","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e02523","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"eLife"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3946320231219348","DOI":"10.1177\/03946320231219348","article-title":"Erastin induces ferroptosis in cervical cancer cells via Nrf2\/HO-1 signaling pathway","volume":"37","author":"Wei","year":"2023","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s13273-022-00322-1","article-title":"Nrf2 suppresses erastin-induced ferroptosis through activating system Xc(-) in ovarian cancer","volume":"20","author":"Li","year":"2024","journal-title":"Mol. Cell. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1002\/jcp.29221","article-title":"Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2\/heme oxygenase-1 signaling pathway in non-small-cell lung cancer","volume":"235","author":"Gai","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.2174\/1389450111009011551","article-title":"Heme oxygenase-1 in tumor biology and therapy","volume":"11","author":"Was","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12645-023-00232-4","article-title":"Induction of ferroptosis by artesunate nanoparticles is an effective therapeutic strategy for hepatocellular carcinoma","volume":"14","author":"Nie","year":"2023","journal-title":"Cancer Nanotechnol."},{"key":"ref_49","first-page":"4745","article-title":"TFAP2A is a novel regulator that modulates ferroptosis in gallbladder carcinoma cells via the Nrf2 signalling axis","volume":"24","author":"Huang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1471-4159.2000.0750304.x","article-title":"Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death","volume":"75","author":"Chen","year":"2000","journal-title":"J. Neurochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.nbd.2017.03.008","article-title":"Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage","volume":"102","author":"Kamalapathy","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41419-020-2256-z","article-title":"VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1073\/pnas.1415518111","article-title":"Synchronized renal tubular cell death involves ferroptosis","volume":"111","author":"Linkermann","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/ndt\/gfae097","article-title":"The biology of ferroptosis in kidney disease","volume":"39","author":"Seibt","year":"2024","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"19395","DOI":"10.1074\/jbc.RA119.010949","article-title":"Pannexin 1 mediates ferroptosis that contributes to renal ischemia\/reperfusion injury","volume":"294","author":"Su","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1007\/s00018-017-2547-4","article-title":"Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure","volume":"74","author":"Dewitz","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"12024","DOI":"10.1073\/pnas.1305538110","article-title":"Two independent pathways of regulated necrosis mediate ischemia\u2013reperfusion injury","volume":"110","author":"Linkermann","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.chembiol.2020.03.016","article-title":"Ferroptosis and Necroptosis in the Kidney","volume":"27","author":"Belavgeni","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMra0801327","article-title":"Rhabdomyolysis and acute kidney injury","volume":"361","author":"Bosch","year":"2009","journal-title":"New Engl. J. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"F539","DOI":"10.1152\/ajprenal.1988.255.3.F539","article-title":"Hemoglobin- and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity","volume":"255","author":"Paller","year":"1988","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8961","DOI":"10.1096\/fj.201900077R","article-title":"Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death","volume":"33","author":"Herencia","year":"2019","journal-title":"FASEB J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1172\/JCI115847","article-title":"Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat","volume":"90","author":"Nath","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/ki.1995.414","article-title":"Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephrotoxicity in the rat","volume":"48","author":"Agarwal","year":"1995","journal-title":"Kidney Int."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/00003246-200003000-00033","article-title":"Protective effect of heme oxygenase induction in ischemic acute renal failure","volume":"28","author":"Shimizu","year":"2000","journal-title":"Crit. Care Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/sj.ki.5002471","article-title":"Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia","volume":"72","author":"Tracz","year":"2007","journal-title":"Kidney Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1053\/j.ajkd.2016.10.037","article-title":"Heme Oxygenase 1 as a Therapeutic Target in Acute Kidney Injury","volume":"69","author":"Bolisetty","year":"2017","journal-title":"Am. J. Kidney Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1172\/JCI67867","article-title":"Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury","volume":"123","author":"Zarjou","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00044.2017","article-title":"Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells","volume":"314","author":"Adedoyin","year":"2018","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_69","first-page":"1","article-title":"C7ORF41 Alleviates Ferroptosis Via the Keap1\/Nrf2\/HO-1 Axis in Endotoxin-Associated Acute Kidney Injury","volume":"2025","author":"Yu","year":"2025","journal-title":"Inflammation"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/10715762.2019.1668936","article-title":"HO-1 mitigates acute kidney injury and subsequent kidney-lung cross-talk","volume":"53","author":"Rossi","year":"2019","journal-title":"Free. Radic. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.mnh.0000437613.88158.d3","article-title":"Heme oxygenase-1 and acute kidney injury","volume":"23","author":"Nath","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5009\/gnl18486","article-title":"Cell Death and Liver Disease","volume":"14","author":"Aizawa","year":"2020","journal-title":"Gut Liver"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/ajh.21075","article-title":"Mechanisms of iron loading and toxicity","volume":"82","author":"Anderson","year":"2007","journal-title":"Am. J. Hematol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Tang, R., Luo, J., Zhu, X., Miao, P., Tang, H., Jian, Y., Ruan, S., Ling, F., and Tang, M. (2023). Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1258870"},{"key":"ref_75","first-page":"291","article-title":"Heme oxygenase-1 exerts pro-apoptotic effects on hepatic stellate cells in vitro through regulation of nuclear factor-\u03baB","volume":"16","author":"Yang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.3748\/wjg.v18.i14.1680","article-title":"Heme oxygenase-1 prevents liver fibrosis in rats by regulating the expression of PPAR\u03b3 and NF-\u03baB","volume":"18","author":"Yang","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.111.186551","article-title":"Heme oxygenase-1 alleviates mouse hepatic failure through suppression of adaptive immune responses","volume":"340","author":"Gu","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1053\/jhep.2002.32467","article-title":"Ex vivo exposure to carbon monoxide prevents hepatic ischemia\/reperfusion injury through p38 MAP kinase pathway","volume":"35","author":"Amersi","year":"2002","journal-title":"Hepatology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1096\/fj.03-0229fje","article-title":"Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury","volume":"17","author":"Berberat","year":"2003","journal-title":"FASEB J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.3748\/wjg.v19.i19.2921","article-title":"Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation","volume":"19","author":"Wang","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/hep.24711","article-title":"Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice","volume":"55","author":"Barikbin","year":"2012","journal-title":"Hepatology"},{"key":"ref_82","first-page":"4081","article-title":"Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress","volume":"20","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.redox.2016.05.003","article-title":"Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration","volume":"9","author":"Carlson","year":"2016","journal-title":"Redox Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/CIRCRESAHA.113.279984","article-title":"Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice","volume":"113","author":"Wortmann","year":"2013","journal-title":"Circ. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"12927","DOI":"10.1007\/s00210-025-04115-w","article-title":"Ferroptosis as a key player in the pathogenesis and intervention therapy in liver injury: Focusing on drug-induced hepatotoxicity","volume":"398","author":"Saeed","year":"2025","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s12253-015-9946-3","article-title":"Ferroptosis is Involved in Acetaminophen Induced Cell Death","volume":"21","author":"Jemnitz","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1111\/ajt.15773","article-title":"Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: Potential role of ferroptosis","volume":"20","author":"Yamada","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1021\/jf800445k","article-title":"Ferulic acid from aleurone determines the antioxidant potency of wheat grain (Triticum aestivum L.)","volume":"56","author":"Anson","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"299","DOI":"10.5582\/ddt.2011.v5.6.299","article-title":"Ferulic acid induces heme oxygenase-1 via activation of ERK and Nrf2","volume":"5","author":"Ma","year":"2011","journal-title":"Drug Discov. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Kose, T., Sharp, P.A., and Latunde-Dada, G.O. (2022). Upregulation of Nrf2 Signalling and the Inhibition of Erastin-Induced Ferroptosis by Ferulic Acid in MIN6 Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415886"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3109\/08923973.2014.953637","article-title":"Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model","volume":"36","author":"Kuo","year":"2014","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Funes, S.C., Rios, M., Fern\u00e1ndez-Fierro, A., Covi\u00e1n, C., Bueno, S.M., Riedel, C.A., Mackern-Oberti, J.P., and Kalergis, A.M. (2020). Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01467"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/24\/3921\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:43:30Z","timestamp":1765806210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/24\/3921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":92,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["nu17243921"],"URL":"https:\/\/doi.org\/10.3390\/nu17243921","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}