{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:45:33Z","timestamp":1784133933517,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Lower urinary tract infections (LUTIs) and irritable bowel syndrome (IBS) have been associated with histamine-producing gut dysbiosis, characterized by an overgrowth of histaminogenic bacteria and opportunistic fungi. This study examines the relationship between histaminogenic microbial imbalance, dietary factors, and LUTIs in women with IBS, emphasizing the potential nutritional contributions to microbiota modulation. Methods: A cohort of 188 women was evaluated by analyzing the intestinal microbiota associated with sporadic and recurrent lower urinary tract infections and irritable bowel syndrome, along with a questionnaire on risky eating behaviors. Results: Dysbiosis was associated with an overgrowth of histamine-producing bacteria (Escherichia coli, Enterobacter spp., Clostridium spp.) and Candida albicans, along with a depletion of protective taxa (Lactobacillus, Bifidobacterium). Dysbiosis, characterized by an increase in histamine-producing bacteria (Escherichia coli, Enterobacter spp., Clostridium spp.) and Candida albicans, together with a depletion of protective taxa (Lactobacillus, Bifidobacterium), has been associated with lower urinary tract infections and irritable bowel syndrome. Regarding the increase in histaminogenic flora, significant associations with dietary factors concerned only the frequent consumption of fast food. Conclusions: These findings highlight the role of histamine-driven dysbiosis in sustaining chronic inflammation and susceptibility to LUTIs and IBS, supporting microbiota modulation as a potential preventive and therapeutic strategy.<\/jats:p>","DOI":"10.3390\/nu18010016","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:27:16Z","timestamp":1766154436000},"page":"16","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Histamine-Producing Intestinal Dysbiosis and Its Role in Lower Urinary Tract Infections and Irritable Bowel Syndrome in Young Women"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-5220","authenticated-orcid":false,"given":"Florina","family":"Ru\u021ba","sequence":"first","affiliation":[{"name":"Department of Community Nutrition and Food Safety, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-3329","authenticated-orcid":false,"given":"C\u0103lin","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mardale","sequence":"additional","affiliation":[{"name":"Doctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Maior","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition and Food Safety, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Filip","sequence":"additional","affiliation":[{"name":"Biochemistry and Environmental Chemistry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-4737","authenticated-orcid":false,"given":"Sebastian","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10099","DOI":"10.1039\/D4FO03271C","article-title":"Dietary influences on urinary tract infections: Unraveling the gut microbiota connection","volume":"15","author":"Du","year":"2024","journal-title":"Food Funct."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dominoni, M., Scatigno, A.L., La Verde, M., Bogliolo, S., Melito, C., Gritti, A., Pasquali, M.F., Torella, M., and Gardella, B. (2023). Microbiota Ecosystem in Recurrent Cystitis and the Immunological Microenvironment of Urothelium. Healthcare, 11.","DOI":"10.3390\/healthcare11040525"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Brigida, M., Saviano, A., Petruzziello, C., Manetti, L.L., Migneco, A., and Ojetti, V. (2024). Gut Microbiome Implication and Modulation in the Management of Recurrent Urinary Tract Infection. Pathogens, 13.","DOI":"10.3390\/pathogens13121028"},{"key":"ref_4","first-page":"e28064","article-title":"The Role of Gut-Microbiota in the Pathophysiology and Therapy of Irritable Bowel Syndrome: A Systematic Review","volume":"14","author":"Shrestha","year":"2022","journal-title":"Cureus"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kim, D.S., and Lee, J.W. (2023). Urinary Tract Infection and Microbiome. Diagnostics, 13.","DOI":"10.3390\/diagnostics13111921"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"eabj1895","DOI":"10.1126\/scitranslmed.abj1895","article-title":"Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice","volume":"14","author":"Shimbori","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.15586\/aei.v53i3.1272","article-title":"Mechanisms and implications of histamine-induced reactions and complications","volume":"53","author":"Sultan","year":"2025","journal-title":"Allergol. Immunopathol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-P\u00e9rez, S., Comas-Bast\u00e9, O., Costa-Catala, J., Iduriaga-Platero, I., Veciana-Nogu\u00e9s, M.T., Vidal-Carou, M.C., and Latorre-Moratalla, M.L. (2022). The Rate of Histamine Degradation by Diamine Oxidase Is Compromised by Other Biogenic Amines. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.897028"},{"key":"ref_9","first-page":"12","article-title":"Unveiling the overlooked fungi: The vital role of gut fungi in inflammatory bowel disease and colorectal cancer","volume":"16","author":"Dong","year":"2024","journal-title":"Gut Pathog."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jawhara, S. (2022). How gut bacterial dysbiosis can promote Candida albicans overgrowth during colonic inflammation. Microorganisms, 10.","DOI":"10.3390\/microorganisms10051014"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e146529","DOI":"10.1172\/jci.insight.146529","article-title":"High FODMAP diet causes barrier loss via lipopolysaccharide-mediated mast cell activation","volume":"6","author":"Singh","year":"2021","journal-title":"JCI Insight"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1002\/efd2.181","article-title":"Recent updates on diet-derived gut microbial metabolites","volume":"5","author":"Prasain","year":"2024","journal-title":"eFood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e2310068","DOI":"10.1002\/advs.202310068","article-title":"Diet Mediate the Impact of Host Habitat on Gut Microbiome and Influence Clinical Indexes by Modulating Gut Microbes and Serum Metabolites","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Segal-Isaacson, C.J., Wylie-Rosett, J., and Gans, K.M. (2004). Validation of a short dietary assessment questionnaire: The Rapid Eating and Activity Assessment for Participants short version (REAP-S). Diabetes Educ., 30.","DOI":"10.1177\/014572170403000512"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ru\u021ba, F., Avram, C., Mardale, E., Pribac, M., Suciu, S., and Nyulas, V. (2024). A Perspective on the Interaction Between Recurrent Lower Urinary Tract Infections and Irritable Bowel Syndrome. Nutrients, 16.","DOI":"10.3390\/nu16213613"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ru\u021ba, F., Pribac, M., Mardale, E., Suciu, S., Maior, R., Bogdan, S., and Avram, C. (2024). Associations between Gut Microbiota Dysbiosis and Other Risk Factors in Women with a History of Urinary Tract Infections. Nutrients, 16.","DOI":"10.3390\/nu16111753"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Iqbal, Z.S., Halkj\u00e6r, S.I., Ghathian, K.S.A., Heintz, J.E., and Petersen, A.M. (2024). The Role of the Gut Microbiome in Urinary Tract Infections: A Narrative Review. Nutrients, 16.","DOI":"10.3390\/nu16213615"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2291164","DOI":"10.1080\/19490976.2023.2291164","article-title":"Bifidobacterium mechanisms of immune modulation and tolerance","volume":"15","author":"Gavzy","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/jcag\/gwad061.189","article-title":"A189 investigating the role of bacterial histamine metabolism in visceral hyperalgesia","volume":"7","author":"Ross","year":"2024","journal-title":"J. Can. Assoc. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.14202\/vetworld.2024.2376-2384","article-title":"Microbiological profile and prevalence of histamine-producing bacteria in fresh sardines stored at different temperatures","volume":"17","author":"Khatouf","year":"2024","journal-title":"Vet. World"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-P\u00e9rez, S., Comas-Bast\u00e9, O., Duelo, A., Veciana-Nogu\u00e9s, M.T., Berlanga, M., Latorre-Moratalla, M.L., and Vidal-Carou, M.C. (2022). Intestinal Dysbiosis in Patients with Histamine Intolerance. Nutrients, 14.","DOI":"10.3390\/nu14091774"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Valitutti, F., Mennini, M., Monacelli, G., Fagiolari, G., Piccirillo, M., Di Nardo, G., and Di Cara, G. (2025). Intestinal permeability, food antigens and the microbiome: A multifaceted perspective. Front. Allergy, 5.","DOI":"10.3389\/falgy.2024.1505834"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2167171","DOI":"10.1080\/19490976.2023.2167171","article-title":"Candida albicans can foster gut dysbiosis and systemic inflammation during HIV infection","volume":"5","author":"Zaongo","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mib.2020.05.006","article-title":"The gut, the bad and the harmless: Candida albicans as a commensal and opportunistic pathogen in the intestine","volume":"56","author":"Kumamoto","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41575-025-01092-6","article-title":"Intestinal pH: A major driver of human gut microbiota composition and metabolism","volume":"22","author":"Brinck","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ryodai, Y., Inoue, K.Y., Nishino, K., and Yamasaki, S. (2023). Intestinal and fecal pH in human health. Front. Microbiomes, 2.","DOI":"10.3389\/frmbi.2023.1192316"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/17474124.2023.2230865","article-title":"Histamine-producing bacteria and their role in gastrointestinal disorders","volume":"17","author":"Fiorani","year":"2023","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/bs.pmbts.2022.06.031","article-title":"Gut dysbiosis and metabolic diseases","volume":"191","author":"Bandopadhyay","year":"2022","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104601","DOI":"10.1016\/j.mvr.2023.104601","article-title":"Gut microbiota dysbiosis -associated obesity and its involvement in cardiovascular diseases and type 2 diabetes. A systematic review","volume":"151","author":"Hamjane","year":"2024","journal-title":"Microvasc. Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bucurica, S., Nancoff, A.S., Dutu, M., Mititelu, M.R., Gaman, L.E., Ioni\u021b\u0103-Radu, F., Jinga, M., Maniu, I., and Ru\u021ba, F. (2024). Exploring the Relationship between Lipid Profile, Inflammatory State and 25-OH Vitamin D Serum Levels in Hospitalized Patients. Biomedicines, 12.","DOI":"10.3390\/biomedicines12081686"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.orcp.2015.05.010","article-title":"Age cut-off for type 2 diabetes mellitus screening amongst young adults from Mures District, Romania\u2014A pilot study","volume":"9","author":"Tarcea","year":"2015","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/jn\/nxab312","article-title":"Drinking Water Source and Intake Are Associated with Distinct Gut Microbiota Signatures in US and UK Populations","volume":"152","author":"Vanhaecke","year":"2022","journal-title":"J. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"109903","DOI":"10.1016\/j.isci.2024.109903","article-title":"Sufficient water intake maintains the gut microbiota and immune homeostasis and promotes pathogen elimination","volume":"27","author":"Sato","year":"2024","journal-title":"iScience"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ruta, F., Avram, C., and Raluca Maior, R. (2023). Physico-Chemical and Microbiological Differences between Mains and Bottled Water, in an Area in the Central Area of Romania. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20021115"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Shi, Z. (2019). Gut Microbiota: An Important Link between Western Diet and Chronic Diseases. Nutrients, 11.","DOI":"10.3390\/nu11102287"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-P\u00e9rez, S., Comas-Bast\u00e9, O., Duelo, A., Veciana-Nogu\u00e9s, M.T., Berlanga, M., Vidal-Carou, M.C., and Latorre-Moratalla, M.L. (2022). The dietary treatment of histamine intolerance reduces the abundance of some histamine-secreting bacteria of the gut microbiota in histamine intolerant women. A pilot study. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1018463"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kim, S.J., Kim, S.E., Kim, A.R., Kang, S., Park, M.Y., and Sung, M.K. (2019). Dietary fat intake and age modulate the composition of the gut microbiota and colonic inflammation in C57BL\/6J mice. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1557-9"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/1\/16\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T11:54:38Z","timestamp":1766404478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/1\/16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["nu18010016"],"URL":"https:\/\/doi.org\/10.3390\/nu18010016","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]}}}