{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:27:02Z","timestamp":1788211622302,"version":"build-2803163510"},"reference-count":105,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Special Project of Zaozhuang City, Shandong Province, China","award":["2024SFQZX014"],"award-info":[{"award-number":["2024SFQZX014"]}]},{"name":"111 project from the Education Ministry of China","award":["B18053"],"award-info":[{"award-number":["B18053"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron is an essential trace element that participates in multiple physiological processes, including oxygen transport, electron transfer, DNA synthesis, and red blood cell production. Iron loss is particularly severe among athletes, so maintaining iron homeostasis is crucial for sports nutrition and health. Excess iron, iron deficiency, and ferroptosis can lead to muscle disorders and health issues, including sarcopenia, muscular atrophy, myocardial fibrosis, skeletal muscle injury, cardiovascular disease, and metabolic disorders. Maintaining iron homeostasis within physiological limits is essential for athletes to sustain high-intensity performance and accelerate recovery. Therefore, a comprehensive review of the effects of iron homeostasis and ferroptosis on muscle health is significant for identifying potential therapeutic targets and developing new disease treatment and prevention strategies. This paper systematically reviews research progress on targeted therapies for iron overload and ferroptosis in muscle diseases, clarifies the impact of iron on athletes\u2019 physiological functions and competitive performance, and explores the potential application of iron in precision nutritional regulation. It aims to provide new insights for preventing exercise-induced muscle injury, myocardial damage, and overtraining syndrome in athletes.<\/jats:p>","DOI":"10.3390\/nu18010139","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T09:18:56Z","timestamp":1767345536000},"page":"139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Potential Role of Iron Homeostasis and Ferroptosis in Exercise Nutrition and Health"],"prefix":"10.3390","volume":"18","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongdi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-3086","authenticated-orcid":false,"given":"Jiaqiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cannas, D., Loi, E., Serra, M., Firinu, D., Valera, P., and Zavattari, P. 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