{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:37:47Z","timestamp":1792798667496,"version":"4.5.0"},"reference-count":100,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Endometriosis is a chronic, oestrogen-dependent inflammatory condition affecting approximately 10% of women of reproductive age, frequently associated with chronic pelvic pain, dysmenorrhoea and infertility, substantially impairing quality of life. While pharmacological and surgical therapies represent the standard of care, growing evidence indicates that lifestyle and dietary factors play an important complementary role in symptom management and may influence disease progression. Regular physical activity appears to attenuate systemic inflammation, improve hormonal regulation and support psychological well-being. Dietary patterns rich in anti-inflammatory components, particularly Mediterranean-diets and low-inflammatory diets, have been associated with reduced pain and improved gastrointestinal symptoms, whereas high consumption of red and processed meats may increase disease risk. Micronutrients and selected supplements, including vitamins C, E and D, magnesium, zinc, folate, omega-3 fatty acids, N-acetylcysteine, curcumin, probiotics and green tea polyphenols, show promising but variable evidence for symptom relief. Additional lifestyle factors, such as avoiding endocrine-disrupting chemicals, moderating alcohol intake, ensuring adequate sleep and managing psychological stress, may further modulate inflammatory and hormonal pathways relevant to the disorder. Overall, current evidence indicates that integrating lifestyle interventions alongside conventional treatments offers clinically relevant benefits, although larger, well-designed clinical studies are needed to clarify the magnitude of these effects and to explore further promising lifestyle-based therapeutic approaches.<\/jats:p>","DOI":"10.3390\/nu18010142","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T09:18:56Z","timestamp":1767345536000},"page":"142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Role of Lifestyle and Diet in the Treatment of Endometriosis: A Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0859-8194","authenticated-orcid":false,"given":"D\u00f3ra","family":"Boroncsok","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Semmelweis University, 1088 Budapest, Hungary"},{"name":"School of PhD Studies, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fil\u00f3","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University, 1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-0626","authenticated-orcid":false,"given":"Marianna","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-3572","authenticated-orcid":false,"given":"Hajnalka","family":"V\u00e1g\u00f3","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-1869","authenticated-orcid":false,"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-7668","authenticated-orcid":false,"given":"G\u00e1bor","family":"Sobel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-018-0008-5","article-title":"Endometriosis","volume":"4","author":"Zondervan","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Muhaidat, N., Saleh, S., Fram, K., Nabhan, M., Almahallawi, N., Alryalat, S.A., Elfalah, M., and Elfalah, M. (2021). Prevalence of endometriosis in women undergoing laparoscopic surgery for various gynaecological indications at a Jordanian referral centre: Gaining insight into the epidemiology of an important women\u2019s health problem. BMC Women\u2019s Health, 21.","DOI":"10.1186\/s12905-021-01530-y"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Maddern, J., Grundy, L., Castro, J., and Brierley, S.M. (2020). Pain in Endometriosis. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.590823"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/eurpub\/ckad216","article-title":"Prevalence, diagnostic delay and economic burden of endometriosis and its impact on quality of life: Results from an Eastern Mediterranean population","volume":"34","author":"Swift","year":"2024","journal-title":"Eur. J. Public Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.rbmo.2019.10.007","article-title":"Pathogenesis of endometriosis: Look no further than John Sampson","volume":"40","author":"Yovich","year":"2020","journal-title":"Reprod. Biomed. Online"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0015-0282(16)47713-7","article-title":"Diethylstilbestrol exposure in utero and endometriosis in infertile females","volume":"41","author":"Stillman","year":"1984","journal-title":"Fertil. Steril."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0022-5347(17)55627-X","article-title":"Endometriosis of the male urinary system: A case report","volume":"124","author":"Schrodt","year":"1980","journal-title":"J. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Monnin, N., Fattet, A.J., and Koscinski, I. (2023). Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030978"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4274\/jcrpe.galenos.2019.2019.S0217","article-title":"Dysmenorrhea, Endometriosis and Chronic Pelvic Pain in Adolescents","volume":"12","author":"Sachedina","year":"2020","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e070750","DOI":"10.1136\/bmj-2022-070750","article-title":"Pathophysiology, diagnosis, and management of endometriosis","volume":"379","author":"Horne","year":"2022","journal-title":"BMJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"hoac009","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE guideline: Endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Human. Reprod. Open"},{"key":"ref_13","unstructured":"(2024). National Institute for Health and Care Excellence: Guidelines. Endometriosis: Diagnosis and Management, National Institute for Health and Care Excellence (NICE)."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jama.2025.2975","article-title":"Endometriosis: A Review","volume":"334","author":"Mackenzie","year":"2025","journal-title":"JAMA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00404-025-08124-1","article-title":"Endometriosis and infertility: Pathophysiology, treatment strategies, and reproductive outcomes","volume":"312","author":"Elizur","year":"2025","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e4957","DOI":"10.1097\/MD.0000000000004957","article-title":"Physical activity and endometriosis risk in women with infertility or pain: Systematic review and meta-analysis","volume":"95","author":"Ricci","year":"2016","journal-title":"Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Tennfjord, M.K., Gabrielsen, R., and Tellum, T. (2021). Effect of physical activity and exercise on endometriosis-associated symptoms: A systematic review. BMC Womens Health, 21.","DOI":"10.1186\/s12905-021-01500-4"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Xie, M., Qing, X., Huang, H., Zhang, L., Tu, Q., Guo, H., and Zhang, J. (2025). The effectiveness and safety of physical activity and exercise on women with endometriosis: A systematic review and meta-analysis. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0317820"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s43032-020-00205-7","article-title":"The Link Between Stress and Endometriosis: From Animal Models to the Clinical Scenario","volume":"27","author":"Appleyard","year":"2020","journal-title":"Reprod. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ijgo.14898","article-title":"Endometriosis and physical activity: A narrative review","volume":"163","author":"Tourny","year":"2023","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/acm.2015.0343","article-title":"The Practice of Hatha Yoga for the Treatment of Pain Associated with Endometriosis","volume":"23","author":"Barros","year":"2017","journal-title":"J. Altern. Complement. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejogrb.2012.02.029","article-title":"Effects of progressive muscular relaxation training on anxiety, depression and quality of life of endometriosis patients under gonadotrophin-releasing hormone agonist therapy","volume":"162","author":"Zhao","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.0001-6349.2005.00558.x","article-title":"The effect of physical training on bone mineral density in women with endometriosis treated with GnRH analogs: A pilot study","volume":"84","author":"Freyschuss","year":"2005","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.apmr.2023.06.020","article-title":"Effect of a Multimodal Supervised Therapeutic Exercise Program on Quality of Life, Pain, and Lumbopelvic Impairments in Women With Endometriosis Unresponsive to Conventional Therapy: A Randomized Controlled Trial","volume":"104","author":"Peinado","year":"2023","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e059280","DOI":"10.1136\/bmjopen-2021-059280","article-title":"Associations between physical exercise patterns and pain symptoms in individuals with endometriosis: A cross-sectional mHealth-based investigation","volume":"12","author":"Ensari","year":"2022","journal-title":"BMJ Open"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Martire, F.G., Costantini, E., d\u2019Abate, C., Capria, G., Piccione, E., and Andreoli, A. (2025). Endometriosis and Nutrition: Therapeutic Perspectives. J. Clin. Med., 14.","DOI":"10.3390\/jcm14113987"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/nutrit\/nuae120","article-title":"Eating for Optimization: Unraveling the Dietary Patterns and Nutritional Strategies in Endometriosis Management","volume":"83","author":"Sacinti","year":"2025","journal-title":"Nutr. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cirillo, M., Argento, F.R., Becatti, M., Fiorillo, C., Coccia, M.E., and Fatini, C. (2023). Mediterranean Diet and Oxidative Stress: A Relationship with Pain Perception in Endometriosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914601"},{"key":"ref_29","first-page":"162","article-title":"Endometriosis and nutrition-recommending a Mediterranean diet decreases endometriosis-associated pain: An experimental observational study","volume":"1","author":"Ott","year":"2012","journal-title":"J. Aging Res. Clin. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/2284026520967599","article-title":"Dietary Inflammatory Index score and risk of developing endometriosis: A case\u2013control study","volume":"13","author":"Felipe","year":"2021","journal-title":"J. Endometr. Pelvic Pain Disord."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Liu, P., Maharjan, R., Wang, Y., Zhang, Y., Zhang, Y., Xu, C., Geng, Y., and Miao, J. (2023). Association between dietary inflammatory index and risk of endometriosis: A population-based analysis. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1077915"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Abulughod, N., Valakas, S., and El-Assaad, F. (2024). Dietary and Nutritional Interventions for the Management of Endometriosis. Nutrients, 16.","DOI":"10.3390\/nu16233988"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/ajo.12594","article-title":"Endometriosis in patients with irritable bowel syndrome: Specific symptomatic and demographic profile, and response to the low FODMAP diet","volume":"57","author":"Moore","year":"2017","journal-title":"Aust. New Zealand J. Obstet. Gynaecol."},{"key":"ref_34","first-page":"499","article-title":"Gluten-free diet: A new strategy for management of painful endometriosis related symptoms?","volume":"67","author":"Marziali","year":"2012","journal-title":"Minerva Chir."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Brouns, F., Van Haaps, A., Keszthelyi, D., Venema, K., Bongers, M., Maas, J., and Mijatovic, V. (2023). Diet associations in endometriosis: A critical narrative assessment with special reference to gluten. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1166929"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Borghini, R., Porpora, M.G., Casale, R., Marino, M., Palmieri, E., Greco, N., Donato, G., and Picarelli, A. (2020). Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study. Nutrients, 12.","DOI":"10.3390\/nu12020341"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"359","DOI":"10.12688\/f1000research.142586.2","article-title":"Holistic approaches to living well with endometriosis","volume":"13","author":"Desai","year":"2024","journal-title":"F1000Res"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yamamoto, A., Harris, H.R., Vitonis, A.F., Chavarro, J.E., and Missmer, S.A. (2018). A prospective cohort study of meat and fish consumption and endometriosis risk. Am. J. Obstet. Gynecol., 219.","DOI":"10.1016\/j.ajog.2018.05.034"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Neri, L.C.L., Quintiero, F., Fiorini, S., Guglielmetti, M., Ferraro, O.E., Tagliabue, A., Gardella, B., and Ferraris, C. (2025). Diet and Endometriosis: An Umbrella Review. Foods, 14.","DOI":"10.3390\/foods14122087"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Qi, X., Zhang, W., Ge, M., Sun, Q., Peng, L., Cheng, W., and Li, X. (2021). Relationship Between Dairy Products Intake and Risk of Endometriosis: A Systematic Review and Dose-Response Meta-Analysis. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.701860"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/humrep\/dey014","article-title":"Fruit and vegetable consumption and risk of endometriosis","volume":"33","author":"Harris","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Barnard, N.D., Holtz, D.N., Schmidt, N., Kolipaka, S., Hata, E., Sutton, M., Znayenko-Miller, T., Hazen, N.D., Cobb, C., and Kahleova, H. (2023). Nutrition in the prevention and treatment of endometriosis: A review. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1089891"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.freeradbiomed.2011.05.017","article-title":"Vitamins C and E: Beneficial effects from a mechanistic perspective","volume":"51","author":"Traber","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5529741","DOI":"10.1155\/2021\/5529741","article-title":"The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial","volume":"2021","author":"Amini","year":"2021","journal-title":"Pain Res. Manag."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.trsl.2012.05.001","article-title":"Antioxidant supplementation reduces endometriosis-related pelvic pain in humans","volume":"161","author":"Santanam","year":"2013","journal-title":"Transl. Res."},{"key":"ref_46","first-page":"17","article-title":"A prospective cohort study of Vitamins B, C, E, and multivitamin intake and endometriosis","volume":"5","author":"Darling","year":"2013","journal-title":"J. Endometr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s42000-019-00166-w","article-title":"Association between vitamin D and endometriosis: A systematic review","volume":"19","author":"Kalaitzopoulos","year":"2020","journal-title":"Hormones"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sassi, F., Tamone, C., and D\u2019Amelio, P. (2018). Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients, 10.","DOI":"10.3390\/nu10111656"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1080\/09513590.2021.1878138","article-title":"The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis","volume":"37","author":"Mehdizadehkashi","year":"2021","journal-title":"Gynecol. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1007\/s43032-024-01701-w","article-title":"Effect of Dietary Interventions on Endometriosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"31","author":"Meneghetti","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.12659\/MSM.901838","article-title":"Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial","volume":"22","author":"Almassinokiani","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/ajcn\/nqaa096","article-title":"Supplementation with vitamin D or \u03c9-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): A double-blind, randomized, placebo-controlled trial","volume":"112","author":"Nodler","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Lisowska-Myjak, B., Skar\u017cy\u0144ska, E., Wr\u00f3bel, M., Ma\u0144ka, G., Kiecka, M., Lipa, M., Warzecha, D., Spaczy\u0144ski, R., Piekarski, P., and Banaszewska, B. (2023). Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097828"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","article-title":"Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate\u2019s role","volume":"3","author":"Crider","year":"2012","journal-title":"Adv. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1158\/1055-9965.EPI-23-0121","article-title":"Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case-Control Study from the Ovarian Cancer Association Consortium","volume":"32","author":"Gersekowski","year":"2023","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1002\/jcp.26401","article-title":"Novel dietary supplement association reduces symptoms in endometriosis patients","volume":"233","author":"Signorile","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1172\/JCI115807","article-title":"Magnesium relaxes arterial smooth muscle by decreasing intracellular Ca2+ without changing intracellular Mg2+","volume":"89","author":"Singer","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_58","first-page":"e2022159","article-title":"Dietary supplements for treatment of endometriosis: A review","volume":"93","author":"Ayhan","year":"2022","journal-title":"Acta Biomed."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.fertnstert.2007.01.053","article-title":"Hormonal suppression treatment or dietary therapy versus placebo in the control of painful symptoms after conservative surgery for endometriosis stage III\u2013IV. A randomized comparative trial","volume":"88","author":"Sesti","year":"2007","journal-title":"Fertil. Steril."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.freeradbiomed.2004.07.007","article-title":"Antioxidant effect of zinc in humans","volume":"37","author":"Prasad","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.reprotox.2017.09.001","article-title":"Decreased zinc and increased lead blood levels are associated with endometriosis in Asian Women","volume":"74","author":"Lai","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"102830","DOI":"10.1016\/j.jogoh.2024.102830","article-title":"The effects of oral nutritional supplements on endometriosis-related pain: A narrative review of clinical studies","volume":"53","author":"Julio","year":"2024","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1093\/humrep\/deq044","article-title":"A prospective study of dietary fat consumption and endometriosis risk","volume":"25","author":"Missmer","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1007\/s43032-025-01985-6","article-title":"The Role of the Microbiome in Endometriosis","volume":"32","author":"Sanabani","year":"2025","journal-title":"Reprod. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Abokhrais, I.M., Denison, F.C., Whitaker, L.H.R., Saunders, P.T.K., Doust, A., Williams, L.J., and Horne, A.W. (2020). A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1). PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0230055"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Nodler, J.L., Harris, H.R., Chavarro, J.E., Frazier, A.L., and Missmer, S.A. (2020). Dairy consumption during adolescence and endometriosis risk. Am. J. Obstet. Gynecol., 222.","DOI":"10.1016\/j.ajog.2019.09.010"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"240702","DOI":"10.1155\/2013\/240702","article-title":"A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine","volume":"2013","author":"Porpora","year":"2013","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Anastasi, E., Scaramuzzino, S., Viscardi, M.F., Viggiani, V., Piccioni, M.G., Cacciamani, L., Merlino, L., Angeloni, A., Muzii, L., and Porpora, M.G. (2023). Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20064686"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures","volume":"15","author":"Peng","year":"2021","journal-title":"Drug Des. Devel Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"285","DOI":"10.23736\/S0026-4784.20.04615-8","article-title":"Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies","volume":"72","author":"Fadin","year":"2020","journal-title":"Minerva Ginecol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1210\/js.2017-00053","article-title":"The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clinical Trial","volume":"1","author":"Gross","year":"2017","journal-title":"J. Endocr. Soc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2147\/IJWH.S36825","article-title":"Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain","volume":"4","author":"Maia","year":"2012","journal-title":"Int. J. Womens Health"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.biopha.2017.04.078","article-title":"Resveratrol and endometriosis: In vitro and animal studies and underlying mechanisms (Review)","volume":"91","author":"Arablou","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Go\u0142\u0105bek-Grenda, A., Juzwa, W., Kaczmarek, M., and Olejnik, A. (2024). Resveratrol and Its Natural Analogs Mitigate Immune Dysregulation and Oxidative Imbalance in the Endometriosis Niche Simulated in a Co-Culture System of Endometriotic Cells and Macrophages. Nutrients, 16.","DOI":"10.20944\/preprints202408.1840.v1"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Mokra, D., Joskova, M., and Mokry, J. (2022). Therapeutic Effects of Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010340"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Markowska, A., Kojs, Z., Antoszczak, M., Markowska, J., and Huczy\u0144ski, A. (2025). Epigallocatechin Gallate as a Potential Therapeutic Agent in Endometriosis: A Narrative Review. Nutrients, 17.","DOI":"10.3390\/nu17132068"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1210\/clinem\/dgac197","article-title":"Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study","volume":"107","author":"Sulaj","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"eaai8700","DOI":"10.1126\/scitranslmed.aai8700","article-title":"Fasting-mimicking diet and markers\/risk factors for aging, diabetes, cancer, and cardiovascular disease","volume":"9","author":"Wei","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/toxsci\/56.2.374","article-title":"Subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates the pathophysiology of endometriosis in the cynomolgus monkey","volume":"56","author":"Yang","year":"2000","journal-title":"Toxicol. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/humrep\/dev026","article-title":"Increased levels of dioxin-like substances in adipose tissue in patients with deep infiltrating endometriosis","volume":"30","author":"Mattioli","year":"2015","journal-title":"Hum. Reprod."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1093\/humrep\/deg254","article-title":"High plasma concentrations of di-(2-ethylhexyl)-phthalate in women with endometriosis","volume":"18","author":"Cobellis","year":"2003","journal-title":"Hum. Reprod."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/aje\/kwh275","article-title":"Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors","volume":"160","author":"Missmer","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"106.e101","DOI":"10.1016\/j.ajog.2013.05.039","article-title":"A metaanalysis on alcohol consumption and risk of endometriosis","volume":"209","author":"Parazzini","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"432","DOI":"10.26574\/maedica.2023.18.3.432","article-title":"An Evaluation of the Effect of Lifestyle on the Incidence of Endometriosis","volume":"18","author":"Vahiddastjerdi","year":"2023","journal-title":"Maedica"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e006325","DOI":"10.1136\/bmjopen-2014-006325","article-title":"Tobacco smoking and risk of endometriosis: A systematic review and meta-analysis","volume":"4","author":"Bravi","year":"2014","journal-title":"BMJ Open"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Kechagias, K.S., Katsikas Triantafyllidis, K., Kyriakidou, M., Giannos, P., Kalliala, I., Veroniki, A.A., Paraskevaidi, M., and Kyrgiou, M. (2021). The Relation between Caffeine Consumption and Endometriosis: An Updated Systematic Review and Meta-Analysis. Nutrients, 13.","DOI":"10.3390\/nu13103457"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ppe.12516","article-title":"Modifiable life style factors and risk for incident endometriosis","volume":"33","author":"Hemmert","year":"2019","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1089\/jwh.2016.5795","article-title":"Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample","volume":"26","author":"Saha","year":"2017","journal-title":"J. Womens Health"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Schernhammer, E.S., Vitonis, A.F., Rich-Edwards, J., and Missmer, S.A. (2011). Rotating nightshift work and the risk of endometriosis in premenopausal women. Am. J. Obstet. Gynecol., 205.","DOI":"10.1016\/j.ajog.2011.06.002"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/EDE.0b013e31816b7378","article-title":"Shift work, hCLOCK T3111C polymorphism, and endometriosis risk","volume":"19","author":"Marino","year":"2008","journal-title":"Epidemiology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"102418","DOI":"10.1016\/j.jogoh.2022.102418","article-title":"Endometriosis and environmental factors: A critical review","volume":"51","author":"Coiplet","year":"2022","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.pain.2013.02.025","article-title":"Efficacy of melatonin in the treatment of endometriosis: A phase II, randomized, double-blind, placebo-controlled trial","volume":"154","author":"Schwertner","year":"2013","journal-title":"Pain"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejogrb.2004.11.019","article-title":"Body mass index in endometriosis","volume":"121","author":"Ferrero","year":"2005","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5114\/pm.2022.116437","article-title":"Impact of lifestyle and diet on endometriosis: A fresh look to a busy corner","volume":"21","author":"Habib","year":"2022","journal-title":"Menopause Rev.\/Przegl\u0105d Menopauzalny"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"90","DOI":"10.23736\/S0026-4806.19.06350-X","article-title":"Psychological stress levels in women with endometriosis: Systematic review and meta-analysis of observational studies","volume":"111","author":"Brasil","year":"2020","journal-title":"Minerva Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/1933719112438443","article-title":"Stress exacerbates endometriosis manifestations and inflammatory parameters in an animal model","volume":"19","author":"Cuevas","year":"2012","journal-title":"Reprod. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1177\/1933719117741374","article-title":"Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression","volume":"25","author":"Rivera","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/ejp.1939","article-title":"A single-blind, randomized, pilot study of a brief mindfulness-based intervention for the endometriosis-related pain management","volume":"26","author":"Moreira","year":"2022","journal-title":"Eur. J. Pain"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-023-03346-9","article-title":"Psychological interventions improve quality of life despite persistent pain in endometriosis: Results of a 3-armed randomized controlled trial","volume":"32","author":"Hansen","year":"2023","journal-title":"Qual. Life Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/0167482X.2012.729625","article-title":"Physical therapy and psychological intervention normalize cortisol levels and improve vitality in women with endometriosis","volume":"33","author":"Garcia","year":"2012","journal-title":"J. Psychosom. Obstet. Gynaecol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/1\/142\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T09:25:15Z","timestamp":1767345915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/1\/142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":100,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["nu18010142"],"URL":"https:\/\/doi.org\/10.3390\/nu18010142","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]}}}