{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:12:28Z","timestamp":1790187148430,"version":"4.1.0"},"reference-count":108,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Osteoarthritis (OA) is a leading cause of chronic pain worldwide. This is driven by progressive cartilage degradation, inflammation, oxidative stress, and metabolic dysfunction. Current pharmacologic interventions mostly lead to symptomatic relief without actually affecting disease progression. Thus, there is a growing interest in the development of new interventional methods. Our review seeks to synthesize preclinical, translational, and clinical evidence on the impact nutritional methods have on OA management. Whole-diet approaches, such as Mediterranean and plant-based, have been linked to reduced pain, increased physical function, and positive biomarker changes. Bioactive compounds, including curcumin, polyphenols, omega-3 fatty acids, and select herbal extracts, have shown anti-inflammatory, antioxidant, and chondroprotective effects via NF-\u03baB, Nrf2, AMPK, and SIRT1 pathways. This review particularly focuses on plant-derived substances. Emerging nanoparticle technology with regard to advanced delivery systems shows initial promise in nutraceutical pharmacokinetics and tissue targeting. Overall, nutritional interventions are adjunct interventions to OA management. Although these are not full treatment replacements, dietary modifications and targeted nutraceutical strategies with improved delivery systems may lead to more preventive, personalized, and holistic OA management and care.<\/jats:p>","DOI":"10.3390\/nu18020244","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:17:32Z","timestamp":1768292252000},"page":"244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities"],"prefix":"10.3390","volume":"18","author":[{"given":"Milan","family":"Patel","sequence":"first","affiliation":[{"name":"New York Institute of Technology College of Osteopathic Medicine, Arkansas State University, Jonesboro, AR 72401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Betanzos","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Troka","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Modi","sequence":"additional","affiliation":[{"name":"New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11545, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-1474","authenticated-orcid":false,"given":"George","family":"Nageeb","sequence":"additional","affiliation":[{"name":"School of Medicine, Stanford University, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-0187","authenticated-orcid":false,"given":"Alan D.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Abd-Elsayed","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"ref_1","unstructured":"GBD 2021 Osteoarthritis Collaborators (2023). Global, Regional, and National Burden of Osteoarthritis, 1990\u20132020 and Projections to 2050: A Systematic Analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol., 5, e508\u2013e522."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20892","DOI":"10.1038\/s41598-020-78075-x","article-title":"Nutraceutical Supplements in Management of Pain and Disability in Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"10","author":"Aghamohammadi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/bmjebm-2023-112626","article-title":"Clinical Effect and Contributing Factors of Acupuncture for Knee Osteoarthritis: A Systematic Review and Pairwise and Exploratory Network Meta-Analysis","volume":"29","author":"Liu","year":"2024","journal-title":"BMJ Evid.-Based Med."},{"key":"ref_4","first-page":"521","article-title":"Polyunsaturated Fatty Acids and Chronic Pain: A Systematic Review and Meta-Analysis","volume":"19","author":"Hadrya","year":"2016","journal-title":"Pain Physician"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wang, Y., Cao, Z., Gao, Y., Shao, P., Gao, S., Dong, M., Tian, Z., Feng, Y., Xu, J., and Xiang, C. (2025). Nutritional Interventions for Osteoarthritis: Targeting the Metabolism-Inflammation-Oxidative Stress Axis\u2014Clinical Evidence and Translational Practice. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1661136"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: A disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16044","DOI":"10.1038\/boneres.2016.44","article-title":"Osteoarthritis: Toward a comprehensive understanding of pathological mechanism","volume":"5","author":"Chen","year":"2017","journal-title":"Bone Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Stewart, H.L., and Kawcak, C.E. (2018). The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis. Front. Vet. Sci., 5.","DOI":"10.3389\/fvets.2018.00178"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.joca.2023.06.005","article-title":"Fundamentals of Osteoarthritis: Inflammatory Mediators in Osteoarthritis","volume":"31","author":"Monteagudo","year":"2023","journal-title":"Osteoarthr. Cartil."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.bpa.2020.06.006","article-title":"Treatment recommendations for chronic knee osteoarthritis","volume":"34","author":"Gress","year":"2020","journal-title":"Best Pr. Res. Clin. Anaesthesiol."},{"key":"ref_11","first-page":"1067","article-title":"Cartilage Biomechanics: A Key Factor for Osteoarthritis Regenerative Medicine","volume":"1965","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Molnar, V., Mati\u0161i\u0107, V., and Kodvanj, I. (2021). Cytokines and chemokines involved in osteoarthritis pathogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179208"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.3892\/mmr.2013.1729","article-title":"Tumor necrosis factor-\u03b1 induces ADAMTS-4 expression in human osteoarthritis chondrocytes","volume":"8","author":"Xue","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat Rev. Rheumatol."},{"key":"ref_16","unstructured":"(2022). Surgical Management of Osteoarthritis of the Knee: Evidence-Based Clinical Practice Guideline, American Academy of Orthopaedic Surgeons. Practice Guideline."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/1759720X12467868","article-title":"Role of inflammation in the pathogenesis of osteoarthritis: Latest findings and interpretations","volume":"5","author":"Sokolove","year":"2013","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","article-title":"Macrophages regulate the progression of osteoarthritis","volume":"28","author":"Zhang","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.14336\/AD.2019.1116","article-title":"Infrapatellar Fat Pad and Knee Osteoarthritis","volume":"11","author":"Zeng","year":"2020","journal-title":"Aging Dis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jbspin.2016.02.016","article-title":"Inflammation of the infrapatellar fat pad","volume":"83","author":"Eymard","year":"2016","journal-title":"Jt. Bone Spine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.joca.2018.03.004","article-title":"Systemic and local adipose tissue in knee osteoarthritis","volume":"26","author":"Chang","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis","volume":"16","author":"Hwang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Guo, P., Alhaskawi, A., Moqbel, S.A.A., and Pan, Z. (2025). Recent development of mitochondrial metabolism and dysfunction in osteoarthritis. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1538662"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s13075-019-2081-x","article-title":"The burden of metabolic syndrome on osteoarthritic joints","volume":"21","author":"Dickson","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cytogfr.2018.10.002","article-title":"Pro-inflammatory cytokines: The link between obesity and osteoarthritis","volume":"44","author":"Wang","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00256-020-03550-5","article-title":"Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: Data from the osteoarthritis initiative","volume":"50","author":"Kanthawang","year":"2021","journal-title":"Skelet. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.joca.2012.06.006","article-title":"Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: A 3-year follow-up of the ROAD study","volume":"20","author":"Yoshimura","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ecl.2008.06.007","article-title":"Obesity and free fatty acids","volume":"37","author":"Boden","year":"2008","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0026-0495(91)90046-Y","article-title":"The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage","volume":"40","author":"Lippiello","year":"1991","journal-title":"Metabolism"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8205","DOI":"10.1038\/s41598-017-07963-6","article-title":"High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature","volume":"7","author":"Datta","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Tan, L., Harper, L.R., Armstrong, A., Carlson, C.S., and Yammani, R.R. (2021). Dietary Saturated Fatty Acid Palmitate Promotes Cartilage Lesions and Activates the Unfolded Protein Response Pathway in Mouse Knee Joints. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247237"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"13092","DOI":"10.1038\/srep13092","article-title":"Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1\u03b1 pathway in chondrocytes","volume":"5","author":"Miao","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s11916-024-01275-x","article-title":"The Impact of Nutrition on Pain: A Narrative Review of Recent Literature","volume":"28","author":"Bautista","year":"2024","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12937-024-00962-0","article-title":"Adherence to the Mediterranean Diet and its association with sustainable dietary behaviors, sociodemographic factors, and lifestyle: A cross-sectional study in US University students","volume":"23","author":"Franchini","year":"2024","journal-title":"Nutr. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.22540\/JFSF-02-045","article-title":"The role of Mediterranean diet and its components on the progress of osteoarthritis","volume":"2","author":"Pitaraki","year":"2017","journal-title":"J. Frailty Sarcopenia Falls"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s12603-016-0806-y","article-title":"Effect of a Mediterranean Type Diet on Inflammatory and Cartilage Degradation Biomarkers in Patients with Osteoarthritis","volume":"21","author":"Dyer","year":"2017","journal-title":"J. Nutr. Health Aging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1016\/j.clnu.2018.11.032","article-title":"Mediterranean diet and knee osteoarthritis outcomes: A longitudinal cohort study","volume":"38","author":"Veronese","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Malesza, I.J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., Bartkowiak-Wieczorek, J., and M\u0105dry, E. (2021). High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review. Cells, 10.","DOI":"10.3390\/cells10113164"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.joca.2015.03.014","article-title":"Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: Studies in a rat model","volume":"23","author":"Collins","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/art.39842","article-title":"Review: Metabolic Regulation of Inflammation in Osteoarthritis","volume":"69","author":"Berenbaum","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Lambova, S.N., Batsalova, T., Moten, D., Stoyanova, S., Georgieva, E., Belenska-Todorova, L., Kolchakova, D., and Dzhambazov, B. (2021). Serum Leptin and Resistin Levels in Knee Osteoarthritis-Clinical and Radiologic Links: Towards Precise Definition of Metabolic Type Knee Osteoarthritis. Biomedicines, 9.","DOI":"10.3390\/biomedicines9081019"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"R198","DOI":"10.1186\/ar3529","article-title":"High-fat diet accelerates progression of osteoarthritis after meniscal\/ligamentous injury","volume":"13","author":"Mooney","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Sidhu, S.R.K., Kok, C.W., Kunasegaran, T., and Ramadas, A. (2023). Effect of Plant-Based Diets on Gut Microbiota: A Systematic Review of Interventional Studies. Nutrients, 15.","DOI":"10.3390\/nu15061510"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"110452","DOI":"10.1016\/j.biopha.2020.110452","article-title":"Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols","volume":"129","author":"Ansari","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1038\/s41598-022-13019-1","article-title":"Higher dietary phytochemical index is associated with lower odds of knee osteoarthritis","volume":"12","author":"Amirkhizi","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s13018-025-05625-2","article-title":"The association between dietary fiber intake and osteoarthritis: A cross-sectional study from the 1999\u20132018 U.S. National Health and Nutrition Examination Survey","volume":"20","author":"Lv","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Sir\u0161e, M. (2022). Effect of Dietary Polyphenols on Osteoarthritis-Molecular Mechanisms. Life, 12.","DOI":"10.3390\/life12030436"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Buhrmann, C., Brockmueller, A., Mueller, A.L., Shayan, P., and Shakibaei, M. (2021). Curcumin Attenuates Environment-Derived Osteoarthritis by Sox9\/NF-kB Signaling Axis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147645"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Buhrmann, C., Popper, B., Kunnumakkara, A.B., Aggarwal, B.B., and Shakibaei, M. (2019). Evidence That Calebin A, a Component of Curcuma Longa Suppresses NF-\u03baB Mediated Proliferation, Invasion and Metastasis of Human Colorectal Cancer Induced by TNF-\u03b2 (Lymphotoxin). Nutrients, 11.","DOI":"10.3390\/nu11122904"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/art.22180","article-title":"Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis","volume":"54","author":"Funk","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bcp.2007.01.005","article-title":"Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis","volume":"73","author":"Shakibaei","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"104694","DOI":"10.1016\/j.fitote.2020.104694","article-title":"Boswellia Carteri Extract and 3-O-Acetyl-Alpha-Boswellic Acid Suppress T Cell Function","volume":"146","author":"Reinhardt","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1078\/094471103321648593","article-title":"Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee\u2014A randomized double blind placebo controlled trial","volume":"10","author":"Kimmatkar","year":"2003","journal-title":"Phytomedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4103\/0974-8520.96119","article-title":"Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis)","volume":"32","author":"Gupta","year":"2011","journal-title":"Ayu"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Choi, Y.-J., Jung, J.I., Bae, J., Lee, J.K., and Kim, E.J. (2024). Evaluating the Anti-Osteoarthritis Potential of Standardized Boswellia serrata Gum Resin Extract in Alleviating Knee Joint Pathology and Inflammation in Osteoarthritis-Induced Models. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25063218"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Luk, H.Y., Appell, C., Chyu, M.C., Chen, C.H., Wang, C.Y., Yang, R.S., and Shen, C.L. (2020). Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition. Antioxidants, 9.","DOI":"10.3390\/antiox9111050"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1124\/jpet.103.059220","article-title":"Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) Differentially Inhibits Interleukin-1\u03b2-Induced Expression of Matrix Metalloproteinase-1 and-13 in Human Chondrocytes","volume":"308","author":"Ahmed","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/art.10443","article-title":"Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: Suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB","volume":"46","author":"Singh","year":"2002","journal-title":"Arthritis Rheum."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Huang, H.T., Cheng, T.L., Ho, C.J., Huang, H.H., Lu, C.C., Chuang, S.C., Li, J.Y., Lee, T.C., Chen, S.T., and Lin, Y.S. (2020). Intra-Articular Injection of (-)-Epigallocatechin 3-Gallate to Attenuate Articular Cartilage Degeneration by Enhancing Autophagy in a Post-Traumatic Osteoarthritis Rat Model. Antioxidants, 10.","DOI":"10.3390\/antiox10010008"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5897\/AJPS2015.1345","article-title":"Antimicrobial and antioxidant activities of extracts from medicinal plant ginger (Zingiber officinale) and identification of components by gas chromatography","volume":"9","author":"Aziz","year":"2015","journal-title":"Afr. J. Plant Sci."},{"key":"ref_61","first-page":"241","article-title":"Study on improving bioavailability ratio of anti-inflammatory compound from ginger through nano transdermal delivery","volume":"5","author":"Baskar","year":"2012","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ma, Y., Sun, C., Wang, Z., and Chen, C. (2025). Cartilage extracellular matrix regeneration with 10-gingerol via KEAP1-NRF2-ARE axis for osteoarthritis therapy. Arch. Pharmacal Res., Epub ahead of printing.","DOI":"10.1007\/s12272-025-01579-5"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1016\/j.actbio.2014.08.022","article-title":"An anti-inflammatorycell-free collagen\/resveratrol scaffold for repairing osteochondral defects in rabbits","volume":"10","author":"Wang","year":"2014","journal-title":"Acta Biomater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"9978651","DOI":"10.1155\/2021\/9978651","article-title":"The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2\/NF-\u03baB Pathway in Created Temporomandibular Osteoarthritis","volume":"2021","author":"Li","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.ajpath.2021.05.016","article-title":"Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol","volume":"191","author":"Hecht","year":"2021","journal-title":"Am. J. Pathol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Colletti, A., and Cicero, A.F.G. (2021). Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312920"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Gambari, L., Cellamare, A., Grassi, F., Grigolo, B., Panciera, A., Ruffilli, A., Faldini, C., and Desando, G. (2022). Overview of Anti-Inflammatory and Anti-Nociceptive Effects of Polyphenols to Halt Osteoarthritis: From Preclinical Studies to New Clinical Insights. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415861"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Ofosu, F.K., Daliri, E.B.M., Elahi, F., Chelliah, R., Lee, B.H., and Oh, D.H. (2020). New Insights on the Use of Polyphenols as Natural Preservatives and Their Emerging Safety Concerns. Front. Sustain. Food Syst., 4.","DOI":"10.3389\/fsufs.2020.525810"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Siddiqui, R.A., and Moghadasian, M.H. (2020). Nutraceuticals and Nutrition Supplements: Challenges and Opportunities. Nutrients, 12.","DOI":"10.3390\/nu12061593"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2019.09.024","article-title":"Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages","volume":"145","author":"Hu","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/jcmm.17672","article-title":"Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades","volume":"27","author":"Wang","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.foodchem.2012.11.139","article-title":"A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention","volume":"138","author":"Chen","year":"2013","journal-title":"Food Chem."},{"key":"ref_73","first-page":"2697","article-title":"Kaempferol inhibits interleukin-1\u03b2 stimulated matrix metalloproteinases by suppressing the MAPK-associated ERK and P38 signaling pathways","volume":"18","author":"Huang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Scandiffio, R., Geddo, F., Cottone, E., Querio, G., Antoniotti, S., Gallo, M.P., Maffei, M.E., and Bovolin, P. (2020). Protective Effects of (E)-\u03b2-Caryophyllene (BCP) in Chronic Inflammation. Nutrients, 12.","DOI":"10.3390\/nu12113273"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Far\u00ec, G., Megna, M., Scacco, S., Ranieri, M., Raele, M.V., Noya, E.C., Macchiarola, D., Bianchi, F.P., Carati, D., and Gnoni, A. (2023). Effects of Terpenes on the Osteoarthritis Cytokine Profile by Modulation of IL-6: Double Face versus Dark Knight?. Biology, 12.","DOI":"10.3390\/biology12081061"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Mattiuzzo, E., Faggian, A., Venerando, R., Benetti, A., Belluzzi, E., Abatangelo, G., Ruggieri, P., and Brun, P. (2021). In Vitro Effects of Low Doses of \u03b2-Caryophyllene, Ascorbic Acid and d-Glucosamine on Human Chondrocyte Viability and Inflammation. Pharmaceuticals, 14.","DOI":"10.3390\/ph14030286"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phymed.2018.10.028","article-title":"Terpenes as possible drugs for the mitigation of arthritic symptoms\u2014A systematic review","volume":"57","author":"Carvalho","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"112610","DOI":"10.1016\/j.biopha.2021.112610","article-title":"Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders","volume":"146","author":"Kabir","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Vafaei, S., Wu, X., Tu, J., and Nematollahi-Mahani, S.N. (2022). The Effects of Crocin on Bone and Cartilage Diseases. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.830331"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1007\/s10753-017-0648-8","article-title":"Crocin Attenuates Joint Pain and Muscle Dysfunction in Osteoarthritis Rat","volume":"40","author":"Lei","year":"2017","journal-title":"Inflammation"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00011-012-0546-3","article-title":"Anti-arthritic effects of crocin in interleukin-1\u03b2-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model","volume":"62","author":"Ding","year":"2013","journal-title":"Inflamm. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12937-025-01087-8","article-title":"Relationship between serum carotenoids and osteoarthritis or degenerative arthritis: A cross-sectional study using the National Health and Nutrition Examination Survey","volume":"24","author":"Zhu","year":"2025","journal-title":"Nutr. J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00109-020-01972-1","article-title":"Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-\u03baB\/HIF-2\u03b1 axis","volume":"98","author":"Zhou","year":"2020","journal-title":"J. Mol. Med."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Yabas, M., Orhan, C., Er, B., Tuzcu, M., Durmus, A.S., Ozercan, I.H., Sahin, N., Bhanuse, P., Morde, A.A., and Padigaru, M. (2021). A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediators. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.609629"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.1021\/acs.analchem.6b00199","article-title":"Intracellular Delivery of Poorly Soluble Polyphenols: Elucidating the Interplay of Self-Assembling Nanocarriers and Human Chondrocytes","volume":"88","author":"Kann","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Yakubu, J., and Pandey, A.V. (2024). Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16050637"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2147\/JIR.S205390","article-title":"Evaluation of the Efficacy and Safety of Capsule Longvida\u00ae Optimized Curcumin (Solid Lipid Curcumin Particles) in Knee Osteoarthritis: A Pilot Clinical Study","volume":"12","author":"Gupte","year":"2019","journal-title":"J. Inflamm. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"708152","DOI":"10.1155\/2015\/708152","article-title":"Whole-Foods, Plant-Based Diet Alleviates the Symptoms of Osteoarthritis","volume":"2015","author":"Clinton","year":"2015","journal-title":"Arthritis"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"25549","DOI":"10.52965\/001c.25549","article-title":"A Comprehensive Review of Viscosupplementation in Osteoarthritis of the Knee","volume":"13","author":"Peck","year":"2021","journal-title":"Orthop. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.2147\/IJN.S518935","article-title":"Nanomaterial-Based Drug Delivery Systems Targeting Functional Cells for Osteoarthritis Treatment: Mechanisms, Challenges and Future Prospects","volume":"20","author":"Kong","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Guo, Z., Lin, J., Sun, K., Guo, J., Yao, X., Wang, G., Hou, L., Xu, J., Guo, J., and Guo, F. (2022). Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway. Front. Pharmacol., 13, Erratum in Front. Pharmacol. 2023, 14, 1199951. https:\/\/doi.org\/10.3389\/fphar.2023.1199951.","DOI":"10.3389\/fphar.2023.1199951"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.joca.2014.12.016","article-title":"Inflammation and intracellular metabolism: New targets in OA","volume":"23","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/bjsports-2016-097333","article-title":"Dietary Supplements for Treating Osteoarthritis: A Systematic Review and Meta-Analysis","volume":"52","author":"Liu","year":"2017","journal-title":"Br. J. Sports Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e000935","DOI":"10.1136\/bmjsem-2020-000935","article-title":"Therapeutic Effects of Turmeric or Curcumin Extract on Pain and Function for Individuals with Knee Osteoarthritis: A Systematic Review","volume":"7","author":"Paultre","year":"2021","journal-title":"BMJ Open Sport Exerc. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41430-025-01622-0","article-title":"The Effectiveness of Dietary Intervention in Osteoarthritis Management: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"79","author":"Asadi","year":"2025","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Navarro, S.L., White, E., Kantor, E.D., Zhang, Y., Rho, J., Song, X., Milne, G.L., Lampe, P.D., and Lampe, J.W. (2015). Randomized Trial of Glucosamine and Chondroitin Supplementation on Inflammation and Oxidative Stress Biomarkers and Plasma Proteomics Profiles in Healthy Humans. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117534"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e20143","DOI":"10.1016\/j.heliyon.2023.e20143","article-title":"A Standardized Nutraceutical Supplement Contributes to Pain Relief, Improves Quality of Life and Regulates Inflammation in Knee Osteoarthritis Patients; A Randomized Clinical Trial","volume":"9","author":"Valsamidou","year":"2023","journal-title":"Heliyon"},{"key":"ref_98","first-page":"2604","article-title":"Therapeutic potential of hyaluronic acid\/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in vitro evaluation in chondrocytes","volume":"42","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"8305","DOI":"10.1038\/s41598-025-93124-z","article-title":"Osteoarthritis burden and inequality from 1990 to 2021: A systematic analysis for the global burden of disease Study 2021","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/1747-0080.12781","article-title":"The effects of dietary patterns and food groups on symptomatic osteoarthritis: A systematic review","volume":"80","author":"Zeng","year":"2023","journal-title":"Nutr. Diet."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Morales-Ivorra, I., Romera-Baures, M., Roman-Vi\u00f1as, B., and Serra-Majem, L. (2018). Osteoarthritis and the Mediterranean Diet: A Systematic Review. Nutrients, 10.","DOI":"10.3390\/nu10081030"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.amjmed.2022.09.026","article-title":"Liver Injury Associated with Turmeric\u2014A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]","volume":"136","author":"Navarro","year":"2023","journal-title":"Am. J. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e2425822","DOI":"10.1001\/jamanetworkopen.2024.25822","article-title":"Estimated Exposure to 6 Potentially Hepatotoxic Botanicals in US Adults","volume":"7","author":"Likhitsup","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/cld.1254","article-title":"Green tea extract-associated acute liver injury: Case report and review","volume":"20","author":"Grajecki","year":"2022","journal-title":"Clin. Liver Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/art.41142","article-title":"2019 American College of Rheumatology\/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee","volume":"72","author":"Kolasinski","year":"2020","journal-title":"Arthritis Rheum."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Sato, B.Y.S., Chong, S.I., Souza, N.M.P., Lazo, R.E.L., Pontarolo, R., Rego, F.G.M., Ferreira, L.M., and Sari, M.H.M. (2025). Nanocarriers Containing Curcumin and Derivatives for Arthritis Treatment: Mapping the Evidence in a Scoping Review. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17081022"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Gambaro, F.M., Ummarino, A., Torres And\u00f3n, F., Ronzoni, F., Di Matteo, B., and Kon, E. (2021). Drug Delivery Systems for the Treatment of Knee Osteoarthritis: A Systematic Review of In Vivo Studies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179137"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"rbaf048","DOI":"10.1093\/rb\/rbaf048","article-title":"A review of nanomaterials in osteoarthritis treatment and immune modulation","volume":"12","author":"Deng","year":"2025","journal-title":"Regen. Biomater."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/2\/244\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:28:34Z","timestamp":1768292914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/2\/244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":108,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["nu18020244"],"URL":"https:\/\/doi.org\/10.3390\/nu18020244","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]}}}