{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:53:28Z","timestamp":1791928408608,"version":"4.3.4"},"reference-count":84,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2013NextGeneration EU","award":["643-02\/23-01\/00016"],"award-info":[{"award-number":["643-02\/23-01\/00016"]}]},{"name":"European Union\u2013NextGeneration EU","award":["533-03-23-0006"],"award-info":[{"award-number":["533-03-23-0006"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["KK.01.1.1.02.0007"],"award-info":[{"award-number":["KK.01.1.1.02.0007"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"COST Action","award":["(EU-METAHEART) CA22169"],"award-info":[{"award-number":["(EU-METAHEART) CA22169"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Zinc is an essential micronutrient involved in structural, catalytic, and regulatory functions across all levels of biological organization. Despite substantial advances over the past two decades, the zinc literature remains highly fragmented, with mechanistic, nutritional, and clinical findings often reported in isolation. Additionally, the synergistic interactions between zinc and other micronutrients\u2014particularly minerals and vitamins\u2014are dispersed across multiple research domains, complicating efforts to understand their integrated roles in maintaining homeostasis. Recent developments in artificial intelligence (AI) present new opportunities to consolidate these data, enabling multi-scale analyses of zinc-dependent processes and the broader zinc interactome. Although a complete map of the zinc interactome is not yet feasible, an integrative perspective is needed to contextualize zinc\u2019s contributions within the framework of the hallmarks of health. This narrative review highlights zinc\u2019s involvement in cellular maintenance, metabolic regulation, stress response, and systemic physiological function. It further examines how disruptions in zinc status, alone or in combination with other nutrient imbalances, contribute to clinically relevant disorders. By combining current knowledge across molecular, cellular, and systems biology levels, this review illustrates zinc\u2019s pleiotropic effects on physiological resilience and healthspan, with particular emphasis on its role in nutritional status, homeostatic regulation, and overall human health.<\/jats:p>","DOI":"10.3390\/nu18020336","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:48:08Z","timestamp":1768985288000},"page":"336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Overview of the Zinc Functional Interactome Through Health Hallmarks and Medical Conditions"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4554-3247","authenticated-orcid":false,"given":"Mirela","family":"Pavi\u0107 Vulinovi\u0107","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5788-5480","authenticated-orcid":false,"given":"Vedran","family":"Micek","sequence":"additional","affiliation":[{"name":"Animal Breeding Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-4556","authenticated-orcid":false,"given":"Davorka","family":"Breljak","sequence":"additional","affiliation":[{"name":"Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-0885","authenticated-orcid":false,"given":"Ivana","family":"Vrhovac Maduni\u0107","sequence":"additional","affiliation":[{"name":"Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-9236","authenticated-orcid":false,"given":"Josip","family":"Maduni\u0107","sequence":"additional","affiliation":[{"name":"Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6333-2908","authenticated-orcid":false,"given":"Marija","family":"Ljubojevi\u0107","sequence":"additional","affiliation":[{"name":"Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"mfac051","DOI":"10.1093\/mtomcs\/mfac051","article-title":"The Quintessence of Metallomics, a Harbinger of a Different Life Science Based on the Periodic Table of the Bioelements","volume":"14","author":"Maret","year":"2022","journal-title":"Metallomics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tjnut.2025.01.004","article-title":"The Arcana of Zinc","volume":"155","author":"Maret","year":"2025","journal-title":"J. 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