{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T21:23:16Z","timestamp":1769462596815,"version":"3.49.0"},"reference-count":52,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Funds of the European Union"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Consumption of fruits of different origins with specific (poly)phenolic profiles can modulate the gene expression of enzymes and the levels of metabolites in a photoperiod-dependent manner. However, there is little information on how this affects the profile of hepatic and muscular fatty acids (FAs) and how it interferes with metabolic pathways. This study aimed to determine whether consuming local or non-local cherries alters liver and muscle FA profiles under different photoperiods, and to identify the associated changes in metabolic gene expression and serum metabolites. Methods: Seventy-two Fischer 344 rats, fed a standard diet and either vehicle (VH), Local Cherry (LC), or non-Local Cherry (nLC), were exposed to different hours of light to simulate photoperiods (winter, spring\/autumn, or summer) for 7 weeks. The FA profiles of the liver and muscle were determined using GC-FID, and the gene expression of key enzymes involved in FA metabolism was evaluated. Moreover, the composition of hydrophilic and lipophilic metabolites in the serum and liver was analyzed using nuclear magnetic resonance (NMR), and pathway analysis was performed. Results: Consumption of cherries in season (18 h of light) decreased saturated FAs levels in the liver, mainly palmitate, compared to their respective VH; interestingly, this effect was not observed in other photoperiods. Furthermore, muscle polyunsaturated FA (PUFAs) decreased, possibly due to increased oxidation. Conclusions: Seasonal cherry consumption improves the hepatic lipid profile and increases muscular oxidation. Future studies are needed to better define these effects and uncover the differences in lipid metabolism in response to cherry consumption.<\/jats:p>","DOI":"10.3390\/nu18020345","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:31:46Z","timestamp":1769009506000},"page":"345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chrononutritional Effects of Cherry Consumption on Hepatic Lipid Profile"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-8064","authenticated-orcid":false,"given":"Maria Josefina","family":"Ruiz de Azua","sequence":"first","affiliation":[{"name":"Universitat Rovira i Virgili, Departament de Bioqu\u00edmica i Biotecnologia, Nutrigenomics Research Group, 43007 Tarragona, Spain"},{"name":"Nutrigenomics Research Group, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"},{"name":"Center of Environmental Food and Toxicological Technology (TecnATox), C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-0160","authenticated-orcid":false,"given":"Francesca","family":"Manocchio","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili, Departament de Bioqu\u00edmica i Biotecnologia, Nutrigenomics Research Group, 43007 Tarragona, Spain"},{"name":"Nutrigenomics Research Group, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"},{"name":"Center of Environmental Food and Toxicological Technology (TecnATox), C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-2340","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Cruz-Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili, Departament de Bioqu\u00edmica i Biotecnologia, Nutrigenomics Research Group, 43007 Tarragona, Spain"},{"name":"Nutrigenomics Research Group, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6529-1345","authenticated-orcid":false,"given":"Anna","family":"Arola-Arnal","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili, Departament de Bioqu\u00edmica i Biotecnologia, Nutrigenomics Research Group, 43007 Tarragona, Spain"},{"name":"Nutrigenomics Research Group, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"},{"name":"Center of Environmental Food and Toxicological Technology (TecnATox), C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0985-219X","authenticated-orcid":false,"given":"Carolina","family":"Gerstner","sequence":"additional","affiliation":[{"name":"C\u00e1tedra Bromatolog\u00eda y Nutrici\u00f3n, Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Universidad Nacional del Litoral, Santa Fe 3000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-4924","authenticated-orcid":false,"given":"Claudio","family":"Bernal","sequence":"additional","affiliation":[{"name":"C\u00e1tedra Bromatolog\u00eda y Nutrici\u00f3n, Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Universidad Nacional del Litoral, Santa Fe 3000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-8253","authenticated-orcid":false,"given":"Manuel","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili, Departament de Bioqu\u00edmica i Biotecnologia, Nutrigenomics Research Group, 43007 Tarragona, Spain"},{"name":"Nutrigenomics Research Group, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"},{"name":"Center of Environmental Food and Toxicological Technology (TecnATox), C\/Marcel\u00b7l\u00ed Domingo 1, 43007 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1039\/C4MB00443D","article-title":"Fatty Acid Biosynthesis Revisited: Structure Elucidation and Metabolic Engineering","volume":"11","author":"Beld","year":"2015","journal-title":"Mol. Biosyst."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bordoni, L., Petracci, I., Zhao, F., Min, W., Pierella, E., Assmann, T.S., Martinez, J.A., and Gabbianelli, R. (2021). Nutrigenomics of Dietary Lipids. Antioxidants, 10.","DOI":"10.3390\/antiox10070994"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"931","DOI":"10.17219\/acem\/31243","article-title":"PUFAs: Structures, Metabolism and Functions","volume":"24","author":"Nowak","year":"2015","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.physbeh.2017.03.040","article-title":"Maxson & Mitchell Energy Metabolism in the Liver","volume":"176","author":"Bunney","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_5","first-page":"e14607","article-title":"Mechanisms of Muscle Insulin Resistance and the Cross-Talk with Liver and Adipose Tissue","volume":"8","author":"Nayak","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"He, Q., Chen, Y., Wang, Z., He, H., and Yu, P. (2023). Cellular Uptake, Metabolism and Sensing of Long-Chain Fatty Acids. Front. Biosci. Landmark, 28.","DOI":"10.31083\/j.fbl2801010"},{"key":"ref_7","first-page":"1700","article-title":"Polyphenols and Their Benefits: A Review","volume":"20","author":"Rasouli","year":"2017","journal-title":"Int. J. Food Prop."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/biof.1443","article-title":"Flavonoids as Putative Modulators of \u03944-, \u03945-, and \u03946-Desaturases: Studies in Cultured Hepatocytes, Myocytes, and Adipocytes","volume":"44","author":"Pallauf","year":"2018","journal-title":"BioFactors"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Durazzo, A., Wei, Z., Anad\u00f3n, A., K\u00fchn, G., Pallauf, K., Schulz, C., Birringer, M., Diaz-Rica, B., De Pascual-Teresa, S., and Rimbach, G. (2018). Resveratrol Modulates Desaturase Expression and Fatty Acid Composition of Cultured Hepatocytes. Front. Nutr., 5.","DOI":"10.3389\/fnut.2018.00106"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4196\/kjpp.2015.19.2.151","article-title":"The Effect of Polyphenols Isolated from Cynanchi Wilfordii Radix with Anti-Inflammatory, Antioxidant, and Anti-Bacterial Activity","volume":"19","author":"Jeong","year":"2015","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Dayem, A.A., Choi, H.Y., Yang, G.M., Kim, K., Saha, S.K., and Cho, S.G. (2016). The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms. Nutrients, 8.","DOI":"10.3390\/nu8090581"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mosele, J.I., and Motilva, M.J. (2021). Phenol Biological Metabolites as Food Intake Biomarkers, a Pending Signature for a Complete Understanding of the Beneficial Effects of the Mediterranean Diet. Nutrients, 13.","DOI":"10.3390\/nu13093051"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kelley, D.S., Adkins, Y., and Laugero, K.D. (2018). A Review of the Health Benefits of Cherries. Nutrients, 10.","DOI":"10.3390\/nu10030368"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Dziadek, K., Kope\u0107, A., Pi\u0105tkowska, E., and Leszczy\u0144ska, T. (2019). High-Fructose Diet-Induced Metabolic Disorders Were Counteracted by the Intake of Fruit and Leaves of Sweet Cherry in Wistar Rats. Nutrients, 11.","DOI":"10.3390\/nu11112638"},{"key":"ref_15","first-page":"149","article-title":"What Is Xenohormesis?","volume":"3","author":"Baur","year":"2008","journal-title":"Am. J. Pharmacol. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s12192-010-0206-x","article-title":"Xenohormesis: Health Benefits from an Eon of Plant Stress Response Evolution","volume":"15","author":"Hooper","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Arola-Arnal, A., and Su\u00e1rez, M. (2022). Do You Have Problems When Reproducing Bioactivities of Food or Food Components? The Importance of Biological Rhythms. Nutrients, 14.","DOI":"10.3390\/nu14214607"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100232","DOI":"10.1016\/j.advnut.2024.100232","article-title":"Effects of (Poly)Phenols on Circadian Clock Gene\u2013Mediated Metabolic Homeostasis in Cultured Mammalian Cells: A Scoping Review","volume":"15","author":"Sulaimani","year":"2024","journal-title":"Adv. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Torres-Fuentes, C., Schellekens, H., Cryan, J.F., Esp\u00edn, J.C., and Muguerza, B. (2025). Interplay between (Poly)Phenols, Gut Microbiota, and Biological Rhythms: Outlook for a New Paradigm in Brain Health. Crit. Rev. Food Sci. Nutr., 1\u201316.","DOI":"10.1080\/10408398.2025.2559367"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Manocchio, F., Bravo, F.I., Helfer, G., and Muguerza, B. (2024). Cherries with Different Geographical Origins Regulate Neuroprotection in a Photoperiod-Dependent Manner in F344 Rats. Antioxidants, 13.","DOI":"10.3390\/antiox13010072"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ruiz de Azua, M.J., Cruz-Carri\u00f3n, \u00c1., Muguerza, B., Arola-Arnal, A., and Suarez, M. (2021). Seasonal Consumption of Cherries from Different Origins Affects Metabolic Markers and Gene Expression of Lipogenic Enzymes in Rat Liver: A Preliminary Study. Nutrients, 13.","DOI":"10.3390\/nu13103643"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Cruz-Carri\u00f3n, \u00c1., de Azua, M.J.R., Mulero, M., Arola-Arnal, A., and Su\u00e1rez, M. (2020). Oxidative Stress in Rats Is Modulated by Seasonal Consumption of Sweet Cherries from Different Geographical Origins: Local vs. Non-Local. Nutrients, 12.","DOI":"10.3390\/nu12092854"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e70126","DOI":"10.1002\/mnfr.70126","article-title":"Photoperiod-Dependent Effects of Phenolic-Enriched Fruit Extracts on Postprandial Triacylglyceride Levels and Acute Inflammatory Responses in F344 Rats","volume":"69","author":"Manocchio","year":"2025","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ross, A.W., Helfer, G., Russell, L., Darras, V.M., and Morgan, P.J. (2011). Thyroid Hormone Signalling Genes Are Regulated by Photoperiod in the Hypothalamus of F344 Rats. PloS ONE, 6.","DOI":"10.1371\/journal.pone.0021351"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.coemr.2020.01.001","article-title":"Endocrine Drivers of Photoperiod Response","volume":"11","author":"Helfer","year":"2020","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jnutbio.2018.09.013","article-title":"Cherry Consumption out of Season Alters Lipid and Glucose Homeostasis in Normoweight and Cafeteria-Fed Obese Fischer 344 Rats","volume":"63","author":"Caimari","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A Rapid Method of Total Lipid Extraction and Purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"ref_28","unstructured":"Sa\u00edn, J. (2014). \u00c1cidos Grasos Trans Dietarios: Interacci\u00f3n Nutricional Con Las Diferentes Familias de \u00c1cidos Grasos Insaturados. [Ph.D. Thesis, Universidad Nacional del Litoral]."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3989\/gya.0692141","article-title":"Fatty Acid Composition of Soybean\/Sunflower Mix Oil, Fish Oil and Butterfat Applying the AOCS Ce 1j-07 Method","volume":"66","author":"Masson","year":"2015","journal-title":"Grasas Y Aceites"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Palacios-Jordan, H., Mart\u00edn-Gonz\u00e1lez, M.Z., Su\u00e1rez, M., Aragon\u00e8s, G., Muguerza, B., Rodr\u00edguez, M.A., and Blad\u00e9, C. (2020). The Disruption of Liver Metabolic Circadian Rhythms by a Cafeteria Diet Is Sex-Dependent in Fischer 344 Rats. Nutrients, 12.","DOI":"10.3390\/nu12041085"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1248\/bpb.b16-00470","article-title":"Fatty Acid \u03b2-Oxidation Plays a Key Role in Regulating Cis-Palmitoleic Acid Levels in the Liver","volume":"39","author":"Kawabata","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"13230","DOI":"10.1016\/S0021-9258(18)69295-6","article-title":"Construction and Sequence of CDNA for Rat Liver Stearyl Coenzyme A Desaturase","volume":"261","author":"Thiede","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1194\/jlr.M054429","article-title":"Hepatic Oleate Regulates Adipose Tissue Lipogenesis and Fatty Acid Oxidation","volume":"56","author":"Burhans","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1194\/jlr.M028787","article-title":"Elovl5 Regulates the MTORC2-Akt-FOXO1 Pathway by Controlling Hepatic Cis-Vaccenic Acid Synthesis in Diet-Induced Obese Mice","volume":"54","author":"Tripathy","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.amjcard.2012.04.027","article-title":"Red Blood Cell Membrane Concentration of Cis-Palmitoleic and Cis-Vaccenic Acids and Risk of Coronary Heart Disease","volume":"110","author":"Matthan","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1124\/jpet.111.184341","article-title":"Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes","volume":"339","author":"Mei","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride Accumulation Protects against Fatty Acid-Induced Lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.29219\/fnr.v65.4527","article-title":"Pentadecanoic Acid Promotes Basal and Insulin-Stimulated Glucose Uptake in C2C12 Myotubes","volume":"65","author":"Fu","year":"2021","journal-title":"Food Nutr. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3945\/ajcn.114.092601","article-title":"Prospective Association of Fatty Acids in the de Novo Lipogenesis Pathway with Risk of Type 2 Diabetes: The Cardiovascular Health Study","volume":"101","author":"Wenjie","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zheng, J.S., Sharp, S.J., Imamura, F., Koulman, A., Schulze, M.B., Ye, Z., Griffin, J., Guevara, M., Huerta, J.M., and Kr\u00f6ger, J. (2017). Association between Plasma Phospholipid Saturated Fatty Acids and Metabolic Markers of Lipid, Hepatic, Inflammation and Glycaemic Pathways in Eight European Countries: A Cross-Sectional Analysis in the EPIC-InterAct Study. BMC Med., 15.","DOI":"10.1186\/s12916-017-0968-4"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"975","DOI":"10.33594\/000000282","article-title":"Mono- and Polyunsaturated Fatty Acids Counter Palmitate-Induced Mitochondrial Dysfunction in Rat Skeletal Muscle Cells","volume":"54","author":"Nisr","year":"2020","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1210\/en.2010-1369","article-title":"Oleate Blocks Palmitate-Induced Abnormal Lipid Distribution, Endoplasmic Reticulum Expansion and Stress, and Insulin Resistance in Skeletal Muscle","volume":"152","author":"Peng","year":"2011","journal-title":"Endocrinology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1423-0127-21-13","article-title":"Protection of Palmitic Acid-Mediated Lipotoxicity by Arachidonic Acid via Channeling of Palmitic Acid into Triglycerides in C2C12","volume":"21","author":"Cheon","year":"2014","journal-title":"J. Biomed. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cavaliere, G., Trinchese, G., Bergamo, P., De Filippo, C., Raso, G.M., Gifuni, G., Putti, R., Moni, B.H., Canani, R.B., and Meli, R. (2016). Polyunsaturated Fatty Acids Attenuate Diet Induced Obesity and Insulin Resistance, Modulating Mitochondrial Respiratory Uncoupling in Rat Skeletal Muscle. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149033"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2739721","DOI":"10.1155\/2017\/2739721","article-title":"Oleate Prevents Palmitate-Induced Atrophy via Modulation of Mitochondrial ROS Production in Skeletal Myotubes","volume":"2017","author":"Lee","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/advances\/nmaa142","article-title":"Diet Regulation of Long-Chain PUFA Synthesis: Role of Macronutrients, Micronutrients, and Polyphenols on \u0394-5\/\u0394-6 Desaturases and Elongases 2\/5","volume":"12","author":"Mutch","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"102614","DOI":"10.1016\/j.cis.2022.102614","article-title":"Revealing Local Molecular Distribution, Orientation, Phase Separation, and Formation of Domains in Artificial Lipid Layers: Towards Comprehensive Characterization of Biological Membranes","volume":"301","author":"Lupa","year":"2022","journal-title":"Adv. Colloid. Interface Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1080\/10408398.2015.1030064","article-title":"Health Benefits of Anthocyanins and Molecular Mechanisms: Update from Recent Decade","volume":"57","author":"Li","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-319-27511-6_6","article-title":"Adipokines in Healthy Skeletal Muscle and Metabolic Disease","volume":"900","author":"Coles","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1079\/BJN19870046","article-title":"Differential Oxidation of Saturated and Unsaturated Fatty Acids in Vivo in the Rat","volume":"57","author":"Leyton","year":"1987","journal-title":"Br. J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jnutbio.2014.05.003","article-title":"Chronic Intake of Proanthocyanidins and Docosahexaenoic Acid Improves Skeletal Muscle Oxidative Capacity in Diet-Obese Rats","volume":"25","author":"Casanova","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_52","unstructured":"Pfaffl, M.W. (2004). Quantification strategies in real-time PCR. A-Z of Quantitative PCR, International University Line."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/2\/345\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:20:58Z","timestamp":1769426458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/2\/345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["nu18020345"],"URL":"https:\/\/doi.org\/10.3390\/nu18020345","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]}}}