{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:57:19Z","timestamp":1789106239062,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Andalusian Health System"},{"name":"Persan Farma"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Malnutrition is highly prevalent in patients with acute leukemia and is frequently underrecognized at diagnosis. Traditional screening tools based on anthropometry often fail to identify early nutritional deterioration. This study aimed to evaluate the prognostic utility of a comprehensive morphofunctional assessment\u2014including bioelectrical impedance vector analysis (BIVA), handgrip strength (HGS), and muscle ultrasound\u2014conducted at diagnosis and after induction therapy, to evaluate the prognostic association with 12-month mortality. Methods: In this prospective cohort study, 52 adult patients with newly diagnosed acute leukemia were enrolled between November 2022 and November 2024 at two tertiary hospitals in M\u00e1laga, Spain. Nutritional status was determined using GLIM criteria. Morphofunctional assessment included BIVA-derived phase angle (PhA), HGS via dynamometry, and rectus femoris ultrasound. A second evaluation was performed prior to haematopoietic stem cell transplantation. Mortality at 12 months was the primary outcome. Logistic regression and ROC analysis were used to assess prognostic associations. Results: At baseline, 65.4% of patients were classified as malnourished. After three months, patients showed significant declines in PhA (\u22120.55\u00b0, p &lt; 0.001), body cell mass (\u22123.15 kg, p &lt; 0.01), skeletal muscle mass (\u22121.66 kg, p &lt; 0.01), and rectus femoris cross-sectional area (\u22120.36 cm2, p = 0.011). Baseline malnutrition (OR = 6.88; 95% CI: 1.17\u201340.38; p = 0.033) and PhA decline \u2265 0.90\u00b0 were both independently associated with higher 12-month mortality. Conclusions: Early morphofunctional assessment using GLIM criteria, BIVA, and muscle ultrasound identifies patients at nutritional and functional risk. PhA decline during treatment was associated with higher 12-month mortality, supporting the need for early, personalized nutritional intervention in leukemia care.<\/jats:p>","DOI":"10.3390\/nu18030374","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:52:38Z","timestamp":1769190758000},"page":"374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioelectrical Impedance and GLIM Criteria Identify Early Nutritional Deterioration and Mortality in Acute Leukemia Patients Undergoing Chemotherapy"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1115-5715","authenticated-orcid":false,"given":"Lara","family":"Dalla Rovere","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition, Quironsalud Malaga Hospital, 29004 M\u00e1laga, Spain"},{"name":"Department of Medicine and Dermatology, M\u00e1laga University, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-4658","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Tapia Guerrero","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Regional Universitario M\u00e1laga, IBIMA BIONAND Platform, Malaga Biomedical Research Institute, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-0040","authenticated-orcid":false,"given":"Viyey K.","family":"Doulatram-Gamgaram","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Regional Universitario M\u00e1laga, IBIMA BIONAND Platform, Malaga Biomedical Research Institute, 29590 M\u00e1laga, Spain"},{"name":"CIBERDEM, Carlos III Health Institute (ISCIII), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5131-4478","authenticated-orcid":false,"given":"Mar\u00eda","family":"Garcia-Olivares","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Quironsalud Malaga Hospital, 29004 M\u00e1laga, Spain"},{"name":"Department of Medicine and Dermatology, M\u00e1laga University, 29010 M\u00e1laga, Spain"},{"name":"Endocrinology and Nutrition Department, Hospital Universitario Virgen de la Victoria M\u00e1laga, IBIMA BIONAND Platform, Malaga Biomedical Research Institute, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7139-0047","authenticated-orcid":false,"given":"Bel\u00e9n","family":"del Arco-Romualdo","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Regional Universitario M\u00e1laga, IBIMA BIONAND Platform, Malaga Biomedical Research Institute, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Gonzalo-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Regional Universitario M\u00e1laga, IBIMA BIONAND Platform, Malaga Biomedical Research Institute, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-7358","authenticated-orcid":false,"given":"Mar\u00eda Rosario Vallejo","family":"Mora","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Regional Universitario M\u00e1laga, IBIMA BIONAND Platform, Malaga Biomedical Research Institute, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Barrios","family":"Decoud","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Regional Universitario M\u00e1laga, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0446-8172","authenticated-orcid":false,"given":"Carola D\u00edaz","family":"Aizp\u00fan","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Regional Universitario M\u00e1laga, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0739-2567","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"S\u00e1nchez-Torralvo","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Regional Universitario M\u00e1laga, IBIMA BIONAND Platform, Malaga Biomedical Research Institute, 29590 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Herola-Cobos","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Quironsalud Malaga Hospital, 29004 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Hardy-A\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Quironsalud Malaga Hospital, 29004 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Hernandez-Sanchez","sequence":"additional","affiliation":[{"name":"Department of Haematology, Quironsalud Malaga Hospital, 29004 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8570-184X","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Garc\u00eda-Almeida","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Quironsalud Malaga Hospital, 29004 M\u00e1laga, Spain"},{"name":"Department of Medicine and Dermatology, M\u00e1laga University, 29010 M\u00e1laga, Spain"},{"name":"CIBERDEM, Carlos III Health Institute (ISCIII), 28031 Madrid, Spain"},{"name":"Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 M\u00e1laga, Spain"},{"name":"CIBEROBN, Carlos III Health Institute (ISCIII), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7646-2899","authenticated-orcid":false,"given":"Gabriel","family":"Olveira","sequence":"additional","affiliation":[{"name":"Department of Medicine and Dermatology, M\u00e1laga University, 29010 M\u00e1laga, Spain"},{"name":"Endocrinology and Nutrition Department, Hospital Regional Universitario M\u00e1laga, IBIMA BIONAND Platform, Malaga Biomedical Research Institute, 29590 M\u00e1laga, Spain"},{"name":"CIBERDEM, Carlos III Health Institute (ISCIII), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0140-6736(19)33018-1","article-title":"Acute lymphoblastic leukaemia","volume":"395","author":"Malard","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(23)00108-3","article-title":"Acute myeloid leukaemia","volume":"401","author":"DiNardo","year":"2023","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e9663","DOI":"10.1097\/MD.0000000000009663","article-title":"Severe malnutrition evaluated by patient-generated subjective global assessment results in poor outcome among adult patients with acute leukemia: A retrospective cohort 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