{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:18:38Z","timestamp":1790709518508,"version":"4.1.0"},"reference-count":153,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"NIH","doi-asserted-by":"publisher","award":["R01HD111243"],"award-info":[{"award-number":["R01HD111243"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Howard W. and Georgeanna Seegar Jones Endowment"},{"name":"the Ernest and Barbara Bernstein Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Fisetin is a naturally occurring flavonoid, a type of polyphenol found in fruits and vegetables such as strawberries, apples, persimmons, and onions. It has gained increasing attention for its antioxidant properties (enhancement of SOD1 and CAT activity and reduction of ROS), anti-inflammatory effects (suppression of NF-\u03baB signaling), and senotherapeutic activity (senolytic and senomorphic effects). Although numerous studies have examined fisetin in the context of aging and chronic diseases, its role in women\u2019s reproductive health has not been systematically explored. Mechanistically, fisetin regulates several pathophysiological processes, including ovarian aging, fibrosis, angiogenesis, and hormonal regulation, suggesting its potential relevance to female reproductive health and disease. Indeed, emerging evidence indicates that fisetin may support ovarian function and hormonal balance, modulate fibrosis and metabolism in benign gynecologic conditions, and suppress cell growth in gynecologic cancers. Early-phase clinical studies in non-gynecologic conditions suggest an acceptable safety profile, although evidence in reproductive health remains absent. This review summarizes current experimental and clinical evidence, identifies critical gaps in mechanistic understanding, and discusses future directions for advancing fisetin as a promising non-hormonal therapeutic option in reproductive health and diseases.<\/jats:p>","DOI":"10.3390\/nu18030393","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:14:07Z","timestamp":1769426047000},"page":"393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Beneficial Effects of Fisetin, a Senotherapeutic Compound, in Women\u2019s Reproductive Health and Diseases: Evidence from In Vitro to Clinical Studies"],"prefix":"10.3390","volume":"18","author":[{"given":"Samya","family":"El Sayed","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u2019leela","family":"Saiyed","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5814-9367","authenticated-orcid":false,"given":"Valeria I.","family":"Macri","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awurakua","family":"Asamoah-Mensah","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-376X","authenticated-orcid":false,"given":"James H.","family":"Segars","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5595-626X","authenticated-orcid":false,"given":"Md Soriful","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/AOG.0000000000002469","article-title":"Clinical management of endometriosis","volume":"131","author":"Falcone","year":"2018","journal-title":"Obstet. 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