{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:46:00Z","timestamp":1789411560208,"version":"build-2803163510"},"reference-count":153,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre","doi-asserted-by":"publisher","award":["UMO-2021\/43\/I\/NZ9\/02612"],"award-info":[{"award-number":["UMO-2021\/43\/I\/NZ9\/02612"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft - DFG","doi-asserted-by":"crossref","award":["504983453 (WI 1754\/18)"],"award-info":[{"award-number":["504983453 (WI 1754\/18)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Curcumin, the major polyphenolic constituent of Curcuma longa, has been widely investigated as a hepatoprotective adjunct due to its antioxidant and immunomodulatory properties. This review evaluates the relevance of curcumin for the prevention and management of liver dysfunction and hepatitis in pigs by synthesizing available porcine evidence and integrating mechanistic insights from translational liver injury models where pig-specific data remain limited. Across experimental hepatic injury contexts, curcumin administration is most consistently associated with reduced biochemical and structural indicators of hepatocellular damage, including decreased aminotransferase activity, attenuation of lipid peroxidation, and enhancement of endogenous antioxidant defenses. These effects are mechanistically linked to suppression of pro-inflammatory signaling pathways, particularly NF-\u03baB-related transcriptional activity and inflammasome-associated responses, together with reduced expression of key cytokines such as TNF-\u03b1, IL-1\u03b2, and IL-6. Concurrent activation of Nrf2-centered cytoprotective pathways and induction of phase II antioxidant enzymes (including HO-1, GST, and NQO1) appear to constitute a conserved axis supporting hepatic oxidative stress resilience. In swine-relevant infectious settings, available data further support antiviral activity against selected porcine pathogens, including classical swine fever virus and porcine reproductive and respiratory syndrome virus, potentially mediated through interference with lipid-dependent stages of viral replication and modulation of Kupffer cell activation. Although combination strategies with established hepatoprotective approaches are conceptually attractive, current synergy evidence remains heterogeneous and largely extrapolated. Overall, curcumin represents a plausible adjunct candidate for supporting porcine liver health; however, translation into practice will depend on resolving formulation-dependent bioavailability constraints and strengthening the pig-specific evidence base.<\/jats:p>","DOI":"10.3390\/nu18030408","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T15:48:30Z","timestamp":1769442510000},"page":"408","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hepatoprotective Potential of Curcumin in the Prevention of Liver Dysfunction in a Porcine Model"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8218-477X","authenticated-orcid":false,"given":"Kamila","family":"Kibitlewska","sequence":"first","affiliation":[{"name":"Department of Pig Breeding, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-0349","authenticated-orcid":false,"given":"Varunkumar","family":"Asediya","sequence":"additional","affiliation":[{"name":"Department of Infectious, Invasive Diseases and Veterinary Administration, Faculty of Biological and Veterinary Sciences, Institute of Veterinary Medicine, 87-100 Toru\u0144, Poland"},{"name":"Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-5355","authenticated-orcid":false,"given":"Krzysztof","family":"Karpiesiuk","sequence":"additional","affiliation":[{"name":"Department of Pig Breeding, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-2197","authenticated-orcid":false,"given":"Urszula","family":"Czarnik","sequence":"additional","affiliation":[{"name":"Department of Pig Breeding, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4062-3715","authenticated-orcid":false,"given":"Marek","family":"Lecewicz","sequence":"additional","affiliation":[{"name":"Department of Animal Biochemistry and Biotechnology, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-3995","authenticated-orcid":false,"given":"Pawe\u0142","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Animal Biochemistry and Biotechnology, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-9767","authenticated-orcid":false,"given":"Prarthana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Animal Biochemistry and Biotechnology, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3271-0408","authenticated-orcid":false,"given":"Iwona","family":"Otrocka-Domaga\u0142a","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-5592","authenticated-orcid":false,"given":"\u0141ukasz","family":"Zielonka","sequence":"additional","affiliation":[{"name":"Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, M. 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Mol. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1038\/emm.2015.122","article-title":"Regulation of Glucose Metabolism from a Liver-Centric Perspective","volume":"48","author":"Han","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101238","DOI":"10.1016\/j.molmet.2021.101238","article-title":"Metabolic-Associated Fatty Liver Disease and Lipoprotein Metabolism","volume":"50","author":"Heeren","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0950-351X(96)80771-3","article-title":"Protein Metabolism and Liver Disease","volume":"10","author":"Charlton","year":"1996","journal-title":"Baillieres Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"106761","DOI":"10.1016\/j.jff.2025.106761","article-title":"Exogenous Nucleotides Contribute to the Regulation of Hepatic Glycolipid Metabolism in Young Animals","volume":"127","author":"Tian","year":"2025","journal-title":"J. Funct. Foods"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-0-12-024912-1.50010-7","article-title":"Effect of Diet on Activity of Enzymes Involved in Fatty Acid and Cholesterol Synthesis","volume":"12","author":"Romsos","year":"1974","journal-title":"Adv. Lipid Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1877-1823(09)70016-5","article-title":"Chapter 9 Hepatic Fatty Acid Oxidation and Ketogenesis in Young Pigs","volume":"3","author":"Odle","year":"2005","journal-title":"Biol. Grow. Anim."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hou, Y., Hu, S., Li, X., He, W., and Wu, G. (2020). Amino Acid Metabolism in the Liver: Nutritional and Physiological Significance. Amino Acids in Nutrition and Health: Amino Acids in Systems Function and Health, Springer.","DOI":"10.1007\/978-3-030-45328-2_2"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejps.2011.03.008","article-title":"Drug Metabolism of CYP3A4, CYP2C9 and CYP2D6 Substrates in Pigs and Humans","volume":"43","author":"Lundahl","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Popescu, R.G., R\u0103dulescu, A.L., Georgescu, S.E., and Dinischiotu, A. (2022). Aflatoxins in Feed: Types, Metabolism, Health Consequences in Swine and Mitigation Strategies. Toxins, 14.","DOI":"10.3390\/toxins14120853"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10930-016-9666-x","article-title":"Expression Profiles of IGF-1R Gene and Polymorphisms of Its Regulatory Regions in Different Pig Breeds","volume":"35","author":"Cheng","year":"2016","journal-title":"Protein J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wittauer, E.-M., Oldhafer, F., Augstein, E., Beetz, O., Kleine, M., Schumacher, C., Sieg, L., Eismann, H., Johanning, K., and Bleich, A. (2019). Porcine Model for the Study of Liver Regeneration Enhanced by Non-Invasive 13C-Methacetin Breath Test (LiMAx Test) and Permanent Portal Venous Access. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217488"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Martino, C., Di Luca, A., Bennato, F., Ianni, A., Passamonti, F., Rampacci, E., Henry, M., Meleady, P., and Martino, G. (2024). Label-Free Quantitative Analysis of Pig Liver Proteome after Hepatitis E Virus Infection. Viruses, 16.","DOI":"10.3390\/v16030408"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Deng, H., Zhu, S., Zhu, L., Jian, Z., Zhou, Y., Li, F., Deng, L., Deng, J., Deng, Y., and Lai, S. (2023). Histopathological Changes and Inflammatory Response in Specific Pathogen-Free (SPF) with Porcine Circovirus Type 3 Infection. Animals, 13.","DOI":"10.3390\/ani13030530"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bouwknegt, M., Rutjes, S.A., Reusken, C.B.E.M., Stockhofe-Zurwieden, N., Frankena, K., de Jong, M.C.M., de Roda Husman, A.M., and van der Poel, W.H.M. (2009). The Course of Hepatitis E Virus Infection in Pigs after Contact-Infection and Intravenous Inoculation. BMC Vet. Res., 5.","DOI":"10.1186\/1746-6148-5-7"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1354\/vp.37-6-687","article-title":"Hepatitis and Staging of Hepatic Damage in Pigs Naturally Infected with Porcine Circovirus Type 2","volume":"37","author":"Rosell","year":"2000","journal-title":"Vet. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tvjl.2010.06.018","article-title":"Apoptosis in Postweaning Multisystemic Wasting Syndrome (PMWS) Hepatitis in Pigs Naturally Infected with Porcine Circovirus Type 2 (PCV2)","volume":"189","author":"Resendes","year":"2011","journal-title":"Vet. J."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yang, Y., Shi, R., She, R., Mao, J., Zhao, Y., Du, F., Liu, C., Liu, J., Cheng, M., and Zhu, R. (2015). Fatal Disease Associated with Swine Hepatitis E Virus and Porcine Circovirus 2 Co-Infection in Four Weaned Pigs in China. BMC Vet. Res., 11.","DOI":"10.1186\/s12917-015-0375-z"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2005.06.016","article-title":"Salmonella enterica Serovar Choleraesuis Infection of the Porcine Jejunal Peyer\u2019s Patch Rapidly Induces IL-1\u03b2 and IL-8 Expression","volume":"109","author":"Hyland","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1177\/1040638719883843","article-title":"Emergence of Salmonella enterica Serovar 4,[5],12:I:- As the Primary Serovar Identified from Swine Clinical Samples and Development of a Multiplex Real-Time PCR for Improved Salmonella Serovar-Level Identification","volume":"31","author":"Naberhaus","year":"2019","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tkaczyk, A., and Jedziniak, P. (2021). Mycotoxin Biomarkers in Pigs\u2014Current State of Knowledge and Analytics. Toxins, 13.","DOI":"10.3390\/toxins13080586"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s44187-025-00680-4","article-title":"Comprehensive Review of Aflatoxin Contamination, Its Occurrence, Effects, Management, and Future Perspectives","volume":"5","author":"Syraji","year":"2025","journal-title":"Discov. Food"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Elchaninov, A., Vishnyakova, P., Menyailo, E., Sukhikh, G., and Fatkhudinov, T. (2022). An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179868"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-5793(89)80476-4","article-title":"Interleukin-6 Is the Major Regulator of Acute Phase Protein Synthesis in Adult Human Hepatocytes","volume":"242","author":"Castell","year":"1989","journal-title":"FEBS Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1590\/1678-5150-pvb-5368","article-title":"Hallmarks of Liver Lesions in Pigs Naturally Infected by Hepatitis E Virus Genotype 3","volume":"38","author":"Malheiros","year":"2018","journal-title":"Pesqui. Vet. Bras."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Li, W., Chang, N., and Li, L. (2022). Heterogeneity and Function of Kupffer Cells in Liver Injury. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.940867"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 Inflammasome Activation Results in Hepatocyte Pyroptosis, Liver Inflammation, and Fibrosis in Mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/JLB.3MR0121-277R","article-title":"HMGB1: An Overview of Its Roles in the Pathogenesis of Liver Disease","volume":"110","author":"Ni","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jhep.2015.04.010","article-title":"Heatstroke Induces Liver Injury via IL-1\u03b2 and HMGB1-Induced Pyroptosis","volume":"63","author":"Geng","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.4049\/jimmunol.164.3.1346","article-title":"Effects of Liver-Derived Dendritic Cell Progenitors on Th1- and Th2-Like Cytokine Responses In Vitro and In Vivo","volume":"164","author":"Khanna","year":"2000","journal-title":"J. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.jhep.2017.06.001","article-title":"Hepatic Stellate Cell Activation and Pro-Fibrogenic Signals","volume":"67","author":"Gandhi","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.5812\/hepatmon.5090","article-title":"Oxidative Stress and Benefits of Antioxidant Agents in Acute and Chronic Hepatitis","volume":"12","author":"Esrefoglu","year":"2012","journal-title":"Hepat. Mon."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrgastro.2012.61","article-title":"Activation of NF-\u039aB Signaling in Hepatocytes Induces Liver Fibrosis","volume":"9","author":"Ray","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_34","first-page":"172","article-title":"Function of Mitogen-Activated Protein Kinases in Hepatic Inflammation","volume":"2","author":"Westenberger","year":"2021","journal-title":"J. Cell. Signal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.vetmic.2016.12.036","article-title":"Antagonizing Cytokine-Mediated JAK-STAT Signaling by Porcine Reproductive and Respiratory Syndrome Virus","volume":"209","author":"Yang","year":"2017","journal-title":"Vet. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.3892\/etm.2015.2749","article-title":"Biological and Therapeutic Activities, and Anticancer Properties of Curcumin","volume":"10","author":"Perrone","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"111888","DOI":"10.1016\/j.biopha.2021.111888","article-title":"Pharmacological Properties and Underlying Mechanisms of Curcumin and Prospects in Medicinal Potential","volume":"141","author":"Fu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_38","first-page":"17244","article-title":"Beevers Pharmacological and Clinical Properties of Curcumin","volume":"5","author":"Huang","year":"2011","journal-title":"Botanics"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The Chemistry of Curcumin: From Extraction to Therapeutic Agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska, A., Alves, H., Marques, V., Durazzo, A., Lucarini, M., Alves, T.F., Morsink, M., Willemen, N., Eder, P., and Chaud, M.V. (2020). Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects. Medicina, 56.","DOI":"10.3390\/medicina56070336"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"125235","DOI":"10.1016\/j.colsurfa.2020.125235","article-title":"Curcumin in Silver Nanoparticles Aqueous Solution: Kinetics of Keto-Enol Tautomerism and Effects on AgNPs","volume":"603","author":"Angelini","year":"2020","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cclet.2013.05.006","article-title":"Analysis of Keto-Enol Tautomers of Curcumin by Liquid Chromatography\/Mass Spectrometry","volume":"24","author":"Kawano","year":"2013","journal-title":"Chin. Chem. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.foodhyd.2018.05.012","article-title":"Films Based on \u03ba-Carrageenan Incorporated with Curcumin for Freshness Monitoring","volume":"83","author":"Liu","year":"2018","journal-title":"Food Hydrocoll."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.18388\/abp.2012_2139","article-title":"Curcumin and Curcuminoids in Quest for Medicinal Status","volume":"59","author":"Grynkiewicz","year":"2012","journal-title":"Acta Biochim. Pol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1386-1425(03)00342-1","article-title":"Determination of Acidity Constants of Curcumin in Aqueous Solution and Apparent Rate Constant of Its Decomposition","volume":"60","year":"2004","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Fuloria, S., Mehta, J., Chandel, A., Sekar, M., Rani, N.N.I.M., Begum, M.Y., Subramaniyan, V., Chidambaram, K., Thangavelu, L., and Nordin, R. (2022). A Comprehensive Review on the Therapeutic Potential of Curcuma Longa Linn. in Relation to Its Major Active Constituent Curcumin. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.820806"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Grover, M., Behl, T., Sehgal, A., Singh, S., Sharma, N., Virmani, T., Rachamalla, M., Farasani, A., Chigurupati, S., and Alsubayiel, A.M. (2021). In Vitro Phytochemical Screening, Cytotoxicity Studies of Curcuma Longa Extracts with Isolation and Characterisation of Their Isolated Compounds. Molecules, 26.","DOI":"10.3390\/molecules26247509"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"960004","DOI":"10.1055\/s-2006-960004","article-title":"Pharmacology of Curcuma longa","volume":"57","author":"Ammon","year":"1991","journal-title":"Planta Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hewlings, S.J., and Kalman, D.S. (2017). Curcumin: A Review of Its Effects on Human Health. Foods, 6.","DOI":"10.3390\/foods6100092"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/ptr.6054","article-title":"Turmeric (Curcuma longa) and Its Major Constituent (Curcumin) as Nontoxic and Safe Substances: Review","volume":"32","author":"Soleimani","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_51","first-page":"6677960","article-title":"An Unusual Case of Dietary-Induced Liver Injury during Pregnancy: A Case Report of Probable Liver Injury Due to High-Dose Turmeric Intake and Literature Review","volume":"2024","author":"Haloub","year":"2024","journal-title":"Case Rep. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1071\/HC15942","article-title":"Turmeric","volume":"11","author":"Martini","year":"2019","journal-title":"J. Prim. Health Care"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/mnfr.201800267","article-title":"Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers","volume":"62","author":"Mahale","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Moldoveanu, C.-A., Tomoaia-Cotisel, M., Sevastre-Berghian, A., Tomoaia, G., Mocanu, A., Pal-Racz, C., Toma, V.-A., Roman, I., Ujica, M.-A., and Pop, L.-C. (2024). A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases. Molecules, 30.","DOI":"10.3390\/molecules30010043"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Deng, T., Xu, J., Wang, Q., Wang, X., Jiao, Y., Cao, X., Geng, Q., Zhang, M., Zhao, L., and Xiao, C. (2024). Immunomodulatory Effects of Curcumin on Macrophage Polarization in Rheumatoid Arthritis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1369337"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/ptr.4639","article-title":"A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis","volume":"26","author":"Chandran","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ghafouri-Fard, S., Shoorei, H., Bahroudi, Z., Hussen, B.M., Talebi, S.F., Taheri, M., and Ayatollahi, S.A. (2022). Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders. Biomolecules, 12.","DOI":"10.3390\/biom12010082"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Sharma, R.A., Steward, W.P., and Gescher, A.J. (2007). Pharmacokinetics and pharmacodynamics of curcumin. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Springer.","DOI":"10.1007\/978-0-387-46401-5_20"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Tang, X., Xiong, K., Wassie, T., and Wu, X. (2022). Curcumin and Intestinal Oxidative Stress of Pigs with Intrauterine Growth Retardation: A Review. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.847673"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lao, C.D., Ruffin, M.T., Normolle, D., Heath, D.D., Murray, S.I., Bailey, J.M., Boggs, M.E., Crowell, J., Rock, C.L., and Brenner, D.E. (2006). Dose Escalation of a Curcuminoid Formulation. BMC Complement. Altern. Med., 6.","DOI":"10.1186\/1472-6882-6-10"},{"key":"ref_61","first-page":"651","article-title":"Evaluation of Anti-Inflammatory Property of Curcumin (Diferuloyl Methane) in Patients with Postoperative Inflammation","volume":"24","author":"Satoskar","year":"1986","journal-title":"Int. J. Clin. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Yang, M., Akbar, U., and Mohan, C. (2019). Curcumin in Autoimmune and Rheumatic Diseases. Nutrients, 11.","DOI":"10.3390\/nu11051004"},{"key":"ref_63","unstructured":"(2010). Scientific Opinion on the Re-evaluation of Curcumin (E 100) as a Food Additive. EFSA J., 8, 1679."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1021\/acs.jafc.6b00053","article-title":"Overdose Intake of Curcumin Initiates the Unbalanced State of Bodies","volume":"64","author":"Qiu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.toxrep.2021.06.021","article-title":"Curcumin-Loaded Nanocomplexes: Acute and Chronic Toxicity Studies in Mice and Hamsters","volume":"8","author":"Jantawong","year":"2021","journal-title":"Toxicol. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Moniruzzaman, M., Kim, D., Kim, H., Kim, N., Chin, S., Karthikeyan, A., Han, K., and Min, T. (2023). Evaluation of Dietary Curcumin Nanospheres as Phytobiotics on Growth Performance, Serum Biochemistry, Nutritional Composition, Meat Quality, Gastrointestinal Health, and Fecal Condition of Finishing Pigs. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1127309"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molimm.2019.09.020","article-title":"Curcumin Inhibits LPS-Induced Neuroinflammation by Promoting Microglial M2 Polarization via TREM2\/ TLR4\/ NF-\u039aB Pathways in BV2 Cells","volume":"116","author":"Zhang","year":"2019","journal-title":"Mol. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.1039\/C9FO02159K","article-title":"Curcumin Inhibits Cigarette Smoke-Induced Inflammation via Modulating the PPAR\u03b3-NF-\u039aB Signaling Pathway","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neulet.2015.03.045","article-title":"Curcumin Inhibits A\u03b2-Induced Microglial Inflammatory Responses in Vitro: Involvement of ERK1\/2 and P38 Signaling Pathways","volume":"594","author":"Shi","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11672","DOI":"10.3892\/mmr.2020.11672","article-title":"Curcumin Ameliorates DSS-induced Colitis in Mice by Regulating the Treg\/Th17 Signaling Pathway","volume":"23","author":"Wei","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1017\/S0007114509992510","article-title":"Curcumin Suppresses P38 Mitogen-Activated Protein Kinase Activation, Reduces IL-1\u03b2 and Matrix Metalloproteinase-3 and Enhances IL-10 in the Mucosa of Children and Adults with Inflammatory Bowel Disease","volume":"103","author":"Epstein","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s10787-019-00607-3","article-title":"Curcumin: A Modulator of Inflammatory Signaling Pathways in the Immune System","volume":"27","author":"Kahkhaie","year":"2019","journal-title":"Inflammopharmacology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/ptr.6642","article-title":"Potential Therapeutic Effects of Curcumin Mediated by JAK\/STAT Signaling Pathway: A Review","volume":"34","author":"Ashrafizadeh","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Porro, C., Cianciulli, A., Trotta, T., Lofrumento, D.D., and Panaro, M.A. (2019). Curcumin Regulates Anti-Inflammatory Responses by JAK\/STAT\/SOCS Signaling Pathway in BV-2 Microglial Cells. Biology, 8.","DOI":"10.3390\/biology8030051"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Zhao, H.-M., Xu, R., Huang, X.-Y., Cheng, S.-M., Huang, M.-F., Yue, H.-Y., Wang, X., Zou, Y., Lu, A.-P., and Liu, D.-Y. (2016). Curcumin Suppressed Activation of Dendritic Cells via JAK\/STAT\/SOCS Signal in Mice with Experimental Colitis. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00455"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zhang, X., Wu, J., Ye, B., Wang, Q., Xie, X., and Shen, H. (2016). Protective Effect of Curcumin on TNBS-Induced Intestinal Inflammation Is Mediated through the JAK\/STAT Pathway. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1273-z"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.1038\/s41598-021-87225-8","article-title":"Curcumin Activates Nrf2 through PKC\u03b4-Mediated P62 Phosphorylation at Ser351","volume":"11","author":"Park","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbi.2012.12.010","article-title":"Intra- and Extracellular Antioxidant Capacities of the New Water-Soluble Form of Curcumin (NDS27) on Stimulated Neutrophils and HL-60 Cells","volume":"201","author":"Derochette","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zhang, J., Yan, E., He, J., Zhong, X., Zhang, L., Wang, C., and Wang, T. (2020). Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway. Animals, 10.","DOI":"10.3390\/ani10030539"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Zou, X., Lin, F., Yang, Y., Chen, J., Zhang, H., Li, L., Ouyang, H., Pang, D., and Tang, X. (2022). Cholesterol Biosynthesis Modulates CSFV Replication. Viruses, 14.","DOI":"10.3390\/v14071450"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Du, T., Shi, Y., Xiao, S., Li, N., Zhao, Q., Zhang, A., Nan, Y., Mu, Y., Sun, Y., and Wu, C. (2017). Curcumin Is a Promising Inhibitor of Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus Infection. BMC Vet. Res., 13.","DOI":"10.1186\/s12917-017-1218-x"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/lipd.12023","article-title":"Curcumin Attenuates Lipopolysaccharide-Induced Hepatic Lipid Metabolism Disorder by Modification of m6A RNA Methylation in Piglets","volume":"53","author":"Lu","year":"2018","journal-title":"Lipids"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Ullah, R., Rehman, A., Zafeer, M.F., Rehman, L., Khan, Y.A., Khan, M.A.H., Khan, S.N., Khan, A.U., and Abidi, S.M.A. (2017). Anthelmintic Potential of Thymoquinone and Curcumin on Fasciola gigantica. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0171267"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s00204-025-03973-w","article-title":"Polybrominated Biphenyls Induce Liver Injury by Disrupting the KEAP1\/Nrf2\/SLC7A11 Axis Leading to Impaired GSH Synthesis and Ferroptosis in Hepatocytes","volume":"99","author":"Jin","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"100195","DOI":"10.1016\/j.phanu.2020.100195","article-title":"Curcumin Modulates Long Term Potentiation in Lipopolysaccharide-Treated Rats","volume":"13","author":"Ardeshiri","year":"2020","journal-title":"PharmaNutrition"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0278-6915(85)90245-5","article-title":"Subchronic Oral Toxicity of Turmeric Oleoresin in Pigs","volume":"23","author":"Bille","year":"1985","journal-title":"Food Chem. Toxicol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Farzaei, M.H., Zobeiri, M., Parvizi, F., El-Senduny, F.F., Marmouzi, I., Coy-Barrera, E., Naseri, R., Nabavi, S.M., Rahimi, R., and Abdollahi, M. (2018). Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective. Nutrients, 10.","DOI":"10.3390\/nu10070855"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/hep.31466","article-title":"Transcriptome Profiling Identifies TIGIT as a Marker of T-Cell Exhaustion in Liver Cancer","volume":"73","author":"Ostroumov","year":"2021","journal-title":"Hepatology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The Multiple-Hit Pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Cho, M.J., Kim, Y.J., Yu, W.D., Kim, Y.S., and Lee, J.H. (2021). Microtubule Integrity Is Associated with the Functional Activity of Mitochondria in HEK293. Cells, 10.","DOI":"10.3390\/cells10123600"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41684-025-01588-3","article-title":"Meta-Inflammation and Endotoxemia in a Highly Translational Porcine Model of Diet-Induced Obesity","volume":"54","author":"Henriksen","year":"2025","journal-title":"Lab Anim."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Rickert, D., Simon, R., von Fersen, L., Baumgartner, K., Bertsch, T., Kirschbaum, C., and Erhard, M. (2021). Saliva and Blood Cortisol Measurement in Bottlenose Dolphins (Tursiops truncatus): Methodology, Application, and Limitations. Animals, 12.","DOI":"10.3390\/ani12010022"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12072-020-10121-2","article-title":"How Does Hepatic Lipid Accumulation Lead to Lipotoxicity in Non-Alcoholic Fatty Liver Disease?","volume":"15","author":"Geng","year":"2021","journal-title":"Hepatol. Int."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular Mechanisms of Hepatic Lipid Accumulation in Non-Alcoholic Fatty Liver Disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/hep.22904","article-title":"Nutritional Model of Steatohepatitis and Metabolic Syndrome in the Ossabaw Miniature Swine","volume":"50","author":"Lee","year":"2009","journal-title":"Hepatology"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ramanathan, R., Ali, A.H., and Ibdah, J.A. (2022). Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137280"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Xia, J., Yuan, J., Xin, L., Zhang, Y., Kong, S., Chen, Y., Yang, S., and Li, K. (2014). Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113724"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3748\/wjg.v10.i4.610","article-title":"Effects of Lipopolysaccharides Stimulated Kupffer Cells on Activation of Rat Hepatic Stellate Cells","volume":"10","author":"Zhang","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1128\/CVI.00517-09","article-title":"Dynamic Changes in Inflammatory Cytokines in Pigs Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus","volume":"17","author":"Liu","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver Cirrhosis","volume":"398","author":"Krag","year":"2021","journal-title":"Lancet"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jhep.2019.11.003","article-title":"Guidance for Design and Endpoints of Clinical Trials in Chronic Hepatitis B\u2014Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference\u2021","volume":"72","author":"Cornberg","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.2147\/IJGM.S551494","article-title":"The Gut-Liver Axis: Molecular Mechanisms and Therapeutic Targeting in Liver Disease","volume":"18","author":"Ma","year":"2025","journal-title":"Int. J. Gen. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41392-023-01673-4","article-title":"Gut Liver Brain Axis in Diseases: The Implications for Therapeutic Interventions","volume":"8","author":"Yan","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.2147\/DDDT.S518547","article-title":"Role of Curcumin in Chronic Liver Diseases: A Comprehensive Review","volume":"19","author":"Sun","year":"2025","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Obrzut, O., Gosty\u0144ska-Stawna, A., Kustrzy\u0144ska, K., Stawny, M., and Krajka-Ku\u017aniak, V. (2025). Curcumin: A Natural Warrior Against Inflammatory Liver Diseases. Nutrients, 17.","DOI":"10.3390\/nu17081373"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"25164","DOI":"10.1071\/RD25164","article-title":"Translational Pig Models for Human Diseases","volume":"38","author":"Wolf","year":"2026","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"149","DOI":"10.14740\/wjon1763","article-title":"Pigs: Large Animal Preclinical Cancer Models","volume":"15","author":"Joshi","year":"2024","journal-title":"World J. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Xu, C., Wu, S., Schook, L.B., and Schachtschneider, K.M. (2019). Translating Human Cancer Sequences into Personalized Porcine Cancer Models. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00105"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/0192623315621628","article-title":"Minipigs in Translational Immunosafety Sciences","volume":"44","author":"Christen","year":"2016","journal-title":"Toxicol. Pathol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.stemcr.2015.09.002","article-title":"Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids","volume":"5","author":"Nantasanti","year":"2015","journal-title":"Stem Cell Rep."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kruitwagen, H.S., Oosterhoff, L.A., van Wolferen, M.E., Chen, C., Nantasanti Assawarachan, S., Schneeberger, K., Kummeling, A., van Straten, G., Akkerdaas, I.C., and Vinke, C.R. (2020). Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease. Cells, 9.","DOI":"10.3390\/cells9020410"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Alvites, R.D., Branquinho, M.V., Sousa, A.C., Lopes, B., Sousa, P., Mendon\u00e7a, C., Atayde, L.M., and Maur\u00edcio, A.C. (2021). Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives. Biology, 10.","DOI":"10.3390\/biology10030249"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"394","DOI":"10.26444\/aaem\/148393","article-title":"Antibacterial activity of curcumin\u2014A natural phenylpropanoid dimer from the rhizomes of Curcuma longa L. and its synergy with antibiotics","volume":"29","year":"2022","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Li, M., Abdurexit, M., Xu, Z., Gao, Y., and Zhang, Y. (2024). Inhibitor of P-Glycoprotein\u2013Mediated Drug Transport by Curcumin in Broiler Chickens. Am. J. Vet. Res., 85.","DOI":"10.2460\/ajvr.23.09.0210"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Flory, S., M\u00e4nnle, R., and Frank, J. (2021). The Inhibitory Activity of Curcumin on P-Glycoprotein and Its Uptake by and Efflux from LS180 Cells Is Not Affected by Its Galenic Formulation. Antioxidants, 10.","DOI":"10.3390\/antiox10111826"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Papatsiros, V.G., Papakonstantinou, G.I., Voulgarakis, N., Eliopoulos, C., Marouda, C., Meletis, E., Valasi, I., Kostoulas, P., Arapoglou, D., and Riahi, I. (2024). Effects of a Curcumin\/Silymarin\/Yeast-Based Mycotoxin Detoxifier on Redox Status and Growth Performance of Weaned Piglets under Field Conditions. Toxins, 16.","DOI":"10.3390\/toxins16040168"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"108938","DOI":"10.1016\/j.biopha.2019.108938","article-title":"Therapeutic Effects of Curcumin and Ursodexycholic Acid on Non-Alcoholic Fatty Liver Disease","volume":"115","author":"Gheibi","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.2527\/jas.2013-6495","article-title":"Dietary Plant Extracts Improve Immune Responses and Growth Efficiency of Pigs Experimentally Infected with Porcine Reproductive and Respiratory Syndrome Virus1","volume":"91","author":"Liu","year":"2013","journal-title":"J. Anim. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Tu, T., Zhang, G., Du, C., Luo, Y., Yao, X., Yang, Z., Ren, M., Wang, Y., and Jiang, D. (2024). In Vivo and in Vitro Study on the Combination Extract of Curcuma Zedoaria and Astragalus Membranaceus as an Adjuvant for PRRSV Inactivated Vaccine and Its Preliminary Application in Piglets. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1470297"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Labban, R.S.M., Alfawaz, H.A., Amina, M., Bhat, R.S., Hassan, W.M., and El-Ansary, A. (2022). Synergism between Extracts of Garcinia Mangostana Pericarp and Curcuma in Ameliorating Altered Brain Neurotransmitters, Systemic Inflammation, and Leptin Levels in High-Fat Diet-Induced Obesity in Male Wistar Albino Rats. Nutrients, 14.","DOI":"10.3390\/nu14214630"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kim, H., Hong, J., Lee, J., Jeon, W., Yeo, C., Lee, Y., Baek, S., and Ha, I. (2023). Curcuma Aromatica Salisb. Protects from Acetaminophen-Induced Hepatotoxicity by Regulating the Sirt1\/HO-1 Signaling Pathway. Nutrients, 15.","DOI":"10.3390\/nu15040808"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Vollono, L., Falconi, M., Gaziano, R., Iacovelli, F., Dika, E., Terracciano, C., Bianchi, L., and Campione, E. (2019). Potential of Curcumin in Skin Disorders. Nutrients, 11.","DOI":"10.3390\/nu11092169"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"C\u00f3rdova, A., Drobnic, F., Noriega-Gonz\u00e1lez, D., Caballero-Garc\u00eda, A., Roche, E., and Alvarez-Mon, M. (2023). Is Curcumine Useful in the Treatment and Prevention of the Tendinopathy and Myotendinous Junction Injury? A Scoping Review. Nutrients, 15.","DOI":"10.3390\/nu15020384"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Wici\u0144ski, M., Erdmann, J., Nowacka, A., Ku\u017ami\u0144ski, O., Michalak, K., Janowski, K., Ohla, J., Biernaciak, A., Szambelan, M., and Zabrzy\u0144ski, J. (2023). Natural Phytochemicals as SIRT Activators\u2014Focus on Potential Biochemical Mechanisms. Nutrients, 15.","DOI":"10.3390\/nu15163578"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Carresi, C., Gliozzi, M., Musolino, V., Scicchitano, M., Scarano, F., Bosco, F., Nucera, S., Maiuolo, J., Macr\u00ec, R., and Ruga, S. (2020). The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction. Nutrients, 12.","DOI":"10.3390\/nu12051504"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Szymczak, J., Grygiel-G\u00f3rniak, B., and Cielecka-Piontek, J. (2024). Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice\u2014Preclinical and Clinical Evidence. Nutrients, 16.","DOI":"10.3390\/nu16050741"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Mafra, D., Borges, N., Alvarenga, L., Esgalhado, M., Cardozo, L., Lindholm, B., and Stenvinkel, P. (2019). Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease. Nutrients, 11.","DOI":"10.3390\/nu11030496"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Rodella, U., Honisch, C., Gatto, C., Ruzza, P., and D\u2019Amato T\u00f3thov\u00e1, J. (2023). Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases. Nutrients, 15.","DOI":"10.3390\/nu15102283"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Ammendola, S., and Scotto d\u2019Abusco, A. (2022). Nutraceuticals and the Network of Obesity Modulators. Nutrients, 14.","DOI":"10.3390\/nu14235099"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Castro-Barquero, S., Lamuela-Ravent\u00f3s, R.M., Dom\u00e9nech, M., and Estruch, R. (2018). Relationship between Mediterranean Dietary Polyphenol Intake and Obesity. Nutrients, 10.","DOI":"10.3390\/nu10101523"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Pastor, N., Collado, M.C., and Manzoni, P. (2021). Phytonutrient and Nutraceutical Action against COVID-19: Current Review of Characteristics and Benefits. Nutrients, 13.","DOI":"10.3390\/nu13020464"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Tieu, S., Charchoglyan, A., Wagter-Lesperance, L., Karimi, K., Bridle, B.W., Karrow, N.A., and Mallard, B.A. (2022). Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness. Nutrients, 14.","DOI":"10.3390\/nu14194075"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Gabbianelli, R., Shahar, E., de Simone, G., Rucci, C., Bordoni, L., Feliziani, G., Zhao, F., Ferrati, M., Maggi, F., and Spinozzi, E. (2023). Plant-Derived Epi-Nutraceuticals as Potential Broad-Spectrum Anti-Viral Agents. Nutrients, 15.","DOI":"10.20944\/preprints202310.1217.v1"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Pferschy-Wenzig, E.-M., Pausan, M.R., Ardjomand-Woelkart, K., R\u00f6ck, S., Ammar, R.M., Kelber, O., Moissl-Eichinger, C., and Bauer, R. (2022). Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14102111"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"O\u2019Connor, E., M\u00fcndel, T., and Barnes, M.J. (2022). Nutritional Compounds to Improve Post-Exercise Recovery. Nutrients, 14.","DOI":"10.3390\/nu14235069"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Grabska-Koby\u0142ecka, I., Szpakowski, P., Kr\u00f3l, A., Ksi\u0105\u017cek-Winiarek, D., Koby\u0142ecki, A., G\u0142\u0105bi\u0144ski, A., and Nowak, D. (2023). Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development. Nutrients, 15.","DOI":"10.3390\/nu15153454"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Ansari, P., Khan, J.T., Chowdhury, S., Reberio, A.D., Kumar, S., Seidel, V., Abdel-Wahab, Y.H.A., and Flatt, P.R. (2024). Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review. Nutrients, 16.","DOI":"10.20944\/preprints202408.1739.v1"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Ismaeel, A., Greathouse, K.L., Newton, N., Miserlis, D., Papoutsi, E., Smith, R.S., Eidson, J.L., Dawson, D.L., Milner, C.W., and Widmer, R.J. (2021). Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease. Nutrients, 13.","DOI":"10.3390\/nu13072143"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s11095-008-9735-8","article-title":"Curcumin Inhibits the Activity of ABCG2\/BCRP1, a Multidrug Resistance-Linked ABC Drug Transporter in Mice","volume":"26","author":"Shukla","year":"2009","journal-title":"Pharm. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.addr.2008.08.007","article-title":"Physiological and Pharmacological Roles of ABCG2 (BCRP): Recent Findings in Abcg2 Knockout Mice","volume":"61","author":"Vlaming","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(02)00169-2","article-title":"Mammalian Drug Efflux Transporters of the ATP Binding Cassette (ABC) Family: An Overview","volume":"55","author":"Schinkel","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/clpt.2012.79","article-title":"A Perspective on Efflux Transport Proteins in the Liver","volume":"92","author":"Brouwer","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_143","first-page":"205","article-title":"Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives\u2014A review","volume":"2","author":"Amalraj","year":"2016","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/107555303321223035","article-title":"Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa)","volume":"9","year":"2003","journal-title":"J. Altern. Complement. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/mnfr.201300724","article-title":"The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes","volume":"58","author":"Schiborr","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_147","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2017.09.010","article-title":"Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia: Systematic review and meta-analysis of randomized controlled trials","volume":"128","author":"Bueno","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"156144","DOI":"10.1016\/j.cyto.2023.156144","article-title":"Antioxidant and anti-inflammatory effects of curcumin\/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials","volume":"164","author":"Dehzad","year":"2023","journal-title":"Cytokine"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"105705","DOI":"10.1016\/j.jff.2023.105705","article-title":"Curcumin and its novel formulations for the treatment of hepatocellular carcinoma: New trends and future perspectives in cancer therapy","volume":"108","author":"Meybodi","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures","volume":"15","author":"Peng","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/biof.1932","article-title":"Effect of nano-curcumin on various diseases: A comprehensive review of clinical trials","volume":"49","author":"Hassanizadeh","year":"2023","journal-title":"BioFactors"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1515\/acph-2017-0023","article-title":"Curcumin: Synthesis optimization and in silico interaction with cyclin dependent kinase","volume":"67","author":"Ahmed","year":"2017","journal-title":"Acta Pharm."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/3\/408\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:14:30Z","timestamp":1770182070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/3\/408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":153,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["nu18030408"],"URL":"https:\/\/doi.org\/10.3390\/nu18030408","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]}}}